Mesenchymal Stem Cells (MSCs) Coculture Protects [Ca²⁺]_i Orchestrated Oxidant Mediated Damage in Differentiated Neurons In Vitro by Adel Alhazzani, Prasanna Rajagopalan, Zaher Albarqi, Anantharam Devaraj, Mohamed Hessian Mohamed, Ahmed Al-Hakami, Harish C. Chandramoorthy

“…Cell-therapy modalities using mesenchymal stem (MSCs) in experimental strokes are being investigated due to the role of MSCs in neuroprotection and regeneration. It is necessary to know the sequence of events that occur during stress and how MSCs complement the rescue of neuronal cell death mediated by [Ca²⁺]_i and reactive oxygen species (ROS). …”
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Preventive action of benztropine on platinum-induced peripheral neuropathies and tumor growth by Olivier Cerles, Tânia Cristina Gonçalves, Sandrine Chouzenoux, Evelyne Benoit, Alain Schmitt, Nathaniel Edward Bennett Saidu, Niloufar Kavian, Christiane Chéreau, Camille Gobeaux, Bernard Weill, Romain Coriat, Carole Nicco, Frédéric Batteux

“…Benztropine also prevented the decrease in neuronal density in the paws of mice injected with oxaliplatin. The neuroprotection conferred by benztropine against chemotherapeutic drugs was associated with a lower expression of inflammatory cytokines and extended to diabetic-induced peripheral neuropathy in mice. …”
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Spatio-temporal expression profile of NGF and the two-receptor system, TrkA and p75NTR, in experimental autoimmune encephalomyelitis by Nickoleta Delivanoglou, Marina Boziki, Paschalis Theotokis, Evangelia Kesidou, Olga Touloumi, Nikolina Dafi, Evangelia Nousiopoulou, Roza Lagoudaki, Nikolaos Grigoriadis, Ioannis Charalampopoulos, Constantina Simeonidou

“…The expression pattern of NGF, TrkA, and p75NTR is described in detail, suggesting possible functional roles in neuroprotection, neuroregeneration, and remyelination by direct and indirect effects on the components of the immune system.…”
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Omega-3 Polyunsaturated Fatty Acid Attenuates Uremia-Induced Brain Damage in Mice by Eun-Ji Kim, Young Rok Ham, Jin Ah Shin, Jin Young Jeong, Ki Ryang Na, Kang Wook Lee, Jwa-Jin Kim, Dae Eun Choi

“…In these injuries, ω-3 PUFA plays an important role in neuroprotection through PI(3)K-Akt signaling.…”
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An active fraction from Spatholobus suberectus dunn inhibits the inflammatory response by regulating microglia activation, switching microglia polarization from M1 to M2 and suppre... by Molu Ban, Hua Su, Xianbiao Zeng, Chunxia Chen, Shuguang Zhou, Xiaoyu Chen, Zhihuan Nong

“…SSD possesses various pharmacological activities, such as circulation invigoration, neuroprotection, and anti-inflammatory. The objective of this research was to examine the anti-neuroinflammatory effects and molecular mechanisms of an active fraction from SSD (ASSD) in vitro culture BV2 cells, a type of mouse microglia cell line. …”
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Detection and Quantification of Neurotrophin-3 (NT-3) and Nerve Growth Factor (NGF) Levels in Early Second Trimester Amniotic Fluid: Investigation into a Possible Correlation with... by Nikolaos Machairiotis, Dionysios Vrachnis, Nikolaos Antonakopoulos, Nikolaos Loukas, Alexandros Fotiou, Vasilios Pergialiotis, Sofoklis Stavros, Aimilia Mantzou, Georgios Maroudias, Christos Iavazzo, Christina Kanaka-Gantenbein, Petros Drakakis, Theodore Troupis, Konstantinos Vlasis, Nikolaos Vrachnis

“…Nerve growth factor (NGF) and neurotrophin-3 (NT-3) are two neurotrophins that are mainly involved in the neuroprotection process, namely promotion of growth and differentiation, maintenance, and survival of neurons. …”
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Genome-wide transcriptome analysis using RNA-Seq reveals a large number of differentially expressed genes in a transient MCAO rat model by Lyudmila V. Dergunova, Ivan B. Filippenkov, Vasily V. Stavchansky, Alina E. Denisova, Vadim V. Yuzhakov, Sergey A. Mozerov, Leonid V. Gubsky, Svetlana A. Limborska

“…Abstract Background The transient middle cerebral artery occlusion (tMCAO) model is used for studying the molecular mechanisms of ischemic damage and neuroprotection. Numerous studies have demonstrated the role of individual genes and associated signaling pathways in the pathogenesis of ischemic stroke. …”
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Antioxidant effect of grape seed extract corrects experimental autoimmune encephalomyelitis behavioral dysfunctions, demyelination, and glial activation by Maha Mabrouk, Maha Mabrouk, Maha Mabrouk, Maha Mabrouk, Mohamed El Ayed, Mohamed El Ayed, Amélie Démosthènes, Amélie Démosthènes, Youssef Aissouni, Youssef Aissouni, Ezzedine Aouani, Ezzedine Aouani, Laurence Daulhac-Terrail, Laurence Daulhac-Terrail, Meherzia Mokni, Meherzia Mokni, Mélina Bégou, Mélina Bégou

“…Plant polyphenols are endowed with many therapeutic benefits through alleviating oxidative stress and inflammation, thus providing neuroprotection in MS. We presently evaluated the curative effect of grape seed extract (GSE) in an experimental autoimmune encephalomyelitis (EAE) mouse model of MS.Experimental approachSix-week-old C57Bl/6J females were subjected to the EAE paradigm (using myelin oligodendrocyte glycoprotein peptide fragment (35-55), complete Freund’s adjuvant, and pertussis toxin) and then chronically treated with GSE from day 10 to day 30 post-induction. …”
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A scalable solution for isolating human multipotent clinical-grade neural stem cells from ES precursors by Dasa Bohaciakova, Marian Hruska-Plochan, Rachel Tsunemoto, Wesley D. Gifford, Shawn P. Driscoll, Thomas D. Glenn, Stephanie Wu, Silvia Marsala, Michael Navarro, Takahiro Tadokoro, Stefan Juhas, Jana Juhasova, Oleksandr Platoshyn, David Piper, Vickie Sheckler, Dara Ditsworth, Samuel L. Pfaff, Martin Marsala

“…Consequently, the transplantation of neurogenic/gliogenic precursors into the CNS for the purpose of cell replacement or neuroprotection in humans with injury or disease has not achieved widespread testing and implementation. …”
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The renin-angiotensin system in central nervous system tumors and degenerative diseases by Simon Haron, Ethan J Kilmister, Paul F Davis, Stanley S Stylli, Theo Mantamadiotis, Andrew H Kaye, Sean R Hall, Swee T Tan, Agadha C Wickremesekera

“…The main effector of the RAS is ATII which exerts its effect by binding to AT1R and AT2R through two competitive arms: an ACE1/ATII/AT1R axis, which is involved in regulating oxidative stress and neuroinflammation pathways, and an ATII/AT2R and/or ATII/ACE2/Ang(1-7)/MasR axis that potentiates neuroprotection pathways. Alterations of these axes are associated with cellular dysfunction linked to CNS diseases. …”
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The Added Value of Intraventricular Hemorrhage on the Radiomics Analysis for the Prediction of Hematoma Expansion of Spontaneous Intracerebral Hemorrhage by Te-Chang Wu, Yan-Lin Liu, Jeon-Hor Chen, Yang Zhang, Tai-Yuan Chen, Ching-Chung Ko, Min-Ying Su

“…A reliable radiomics model may provide a robust tool to help manage ICH patients and to enroll high-risk ICH cases into anti-expansion or neuroprotection drug trials.…”
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Identification of programmed cell death-related gene signature and associated regulatory axis in cerebral ischemia/reperfusion injury by Jun Shu, Lu Yang, Wenshi Wei, Li Zhang

“…This may offer new insights into the potential mechanisms underlying cell death during cerebral I/R injury and provide new therapeutic targets for neuroprotection.…”
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Haptoglobin Regulates Macrophage/Microglia‐Induced Inflammation and Prevents Ischemic Brain Damage Via Binding to HMGB1 by Mayuka Morimoto, Takafumi Nakano, Saki Egashira, Keiichi Irie, Kiyoshi Matsuyama, Momoka Wada, Yoshihiko Nakamura, Yutaka Shigemori, Hiroyasu Ishikura, Yuta Yamashita, Kazuhide Hayakawa, Kazunori Sano, Kenichi Mishima

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Methylmercury Causes Neurodegeneration and Downregulation of Myelin Basic Protein in the Spinal Cord of Offspring Rats after Maternal Exposure by Diane Cleydes Baía da Silva, Leonardo Oliveira Bittencourt, Daiane Claydes Baia-da-Silva, Victoria Santos Chemelo, Luciana Eiró-Quirino, Priscila Cunha Nascimento, Márcia Cristina Freitas Silva, Marco Aurelio M. Freire, Walace Gomes-Leal, Maria Elena Crespo-Lopez, Rafael Rodrigues Lima

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Exosomes Derived from MicroRNA-146a-5p-Enriched Bone Marrow Mesenchymal Stem Cells Alleviate Intracerebral Hemorrhage by Inhibiting Neuronal Apoptosis and Microglial M1 Polarizatio... by Duan S, Wang F, Cao J, Wang C

“…Finally, we observed that miR-146a-5p directly targeted interleukin-1 receptor-associated kinase1 (IRAK1) and nuclear factor of activated T cells 5 (NFAT5), which contributed to the inflammation response and the polarization of M1 microglia/macrophages.Conclusion: We demonstrated that miR-146a-5p-riched BMSCs-Exos could offer neuroprotection and functional improvements after ICH through reducing neuronal apoptosis, and inflammation associated with the inhibition of microglial M1 polarization by downregulating the expression of IRAK1 and NFAT5.Keywords: intracerebral hemorrhage, microRNA-146a-5p, exosomes, apoptosis, microglial M1 polarization…”
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Sanguinarine Attenuates Neuropathic Pain by Inhibiting P38 MAPK Activated Neuroinflammation in Rat Model by Yu C, Li P, Wang YX, Zhang KG, Zheng ZC, Liang LS

“…Sanguinarine (SG) is a natural plant medicine with anti-inflammatory and neuroprotection effects. This study aimed to investigate the effect of SG on chronic constriction injury (CCI)-induced neuropathic pain.Materials and Methods: CCI rat model was established and rats were randomly divided into sham group, sham + SG group (6.25 mg/kg), CCI group, CCI + SG group (1.00, 2.50 and 6.25 mg/kg). …”
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The Impact of Stem Cells on Electron Fluxes, Proton Translocation, and ATP Synthesis in Kidney Mitochondria after Ischemia/Reperfusion by Hellen J. V. Beiral, Clara Rodrigues-Ferreira, Aline M. Fernandes, Sabrina R. Gonsalez, Nicoli C. Mortari, Christina M. Takiya, Martha M. Sorenson, Cícero Figueiredo-Freitas, Antonio Galina, Adalberto Vieyra

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Abstract Number ‐ 8: HEMERA 1 CarboxyHEMoglobin OxygEn delivery for Revascularization in Acute Stroke: Phase 1 Clinical Trial by Italo Linfante, Ricardo Hanel, Rwoof Reshi, Wayne M Clark, Guilherme C Dabus, David Lieberskind, Raul G Nogueira

“…Introduction Despitehigh rates ofrecanalizationafter mechanical thrombectomy(MT),only 33–71% of patients achieve functional independence at 90 days.Experimental ischemia hashighlightedthe complexity of several pathophysiological events occurring at the level of the neurovascular unit and has revealed potential targets for neuroprotection. Apossible target is to increasebloodflow in the collateral circulationwhile delivering high levels of oxygen in the ischemic area.Hemoglobin based oxygen carriers (HBOC) as a transfusion media that can treat ischemic tissue have been investigatedfor a decade. …”
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Scutellarin protects oxygen/glucose-deprived astrocytes and reduces focal cerebral ischemic injury by Jing-Bo Sun, Yan Li, Ye-Feng Cai, Yan Huang, Shu Liu, Patrick KK Yeung, Min-Zhen Deng, Guang-Shun Sun, Prince LM Zilundu, Qian-Sheng Hu, Rui-Xin An, Li-Hua Zhou, Li-Xin Wang, Xiao Cheng

“…However, the mechanisms by which scutellarin mediates neuroprotection in cerebral ischemia remain unclear. The interaction between scutellarin and nicotinamide adenine dinucleotide phosphate oxidase 2 (NOX2) was assessed by molecular docking study, which showed that scutellarin selectively binds to NOX2 with high affinity. …”
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Wireless Sensing of Lower Lip and Thumb-Index Finger ‘Ramp-and-Hold’ Isometric Force Dynamics in a Small Cohort of Unilateral MCA Stroke: Discussion of Preliminary Findings by Steven Barlow, Rebecca Custead, Jaehoon Lee, Mohsen Hozan, Jacob Greenwood

“…Biomechanical measures of fine force and MVCF performance in adult stroke survivors provide valuable information on the profile of residual motor function which can help inform clinical treatment strategies and quantitatively monitor the efficacy of rehabilitation or neuroprotection strategies.…”
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