Ketamine-based Sedation Use in Mechanically Ventilated Critically Ill Patients with COVID-19: A Multicenter Cohort Study by Ohoud Aljuhani, Khalid Al Sulaiman, Ghazwa B. Korayem, Ali F. Altebainawi, Abdulrahman Alshaya, Majed Nahari, Khuzama Alsamnan, Munirah A. Alkathiri, Bodoor S. Al-Dosari, Abeer A. Alenazi, Samiah Alsohimi, Lina I. Alnajjar, Mashael Alfaifi, Nora AlQussair, Reem M. Alanazi, Munirah F. Alhmoud, Nadin L. Alanazi, Hadeel Alkofide, Aljawharah M. Alenezi, Ramesh Vishwakarma

“…Backgrounds: Ketamine possesses analgesia, anti-inflammation, anticonvulsant, and neuroprotection properties. However, the evidence that supports its use in mechanically ventilated critically ill patients with COVID-19 is insufficient. …”
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Evaluation of the impact of continuous Kangaroo Mother Care (KMC) initiated immediately after birth compared to KMC initiated after stabilization in newborns with birth weight 1.0... by E. A. Adejuyigbe, I. Agyeman, P. Anand, H. C. Anyabolu, S. Arya, E. N. Assenga, S. Badhal, N. W. Brobby, H. K. Chellani, N. Chopra, P. K. Debata, Q. Dube, T. Dua, L. Gadama, R. Gera, C. K. Hammond, S. Jain, F. Kantumbiza, K. Kawaza, E. N. Kija, P. Lal, M. Mallewa, M. K. Manu, A. Mehta, T. Mhango, H. E. Naburi, S. Newton, I. Nyanor, P. A. Nyako, O. J. Oke, A. Patel, G. Phlange-Rhule, R. Sehgal, R. Singhal, N. Wadhwa, A. B. Yiadom

“…Discussion Immediate KMC can potentially reduce low-birth-weight-associated complications such as respiratory disease, hypothermia, hypoglycemia, and infection that can result in impaired neurocognitive development. Neuroprotection may also be mediated by improved physiological stabilization that may lead to better maturation of neural pathways, reduced risk of hypoxia, positive parental impact, improved sleep cycles, and improved stress responses. …”
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SGLT2 and DPP4 inhibitors improve Alzheimer’s disease–like pathology and cognitive function through distinct mechanisms in a T2D–AD mouse model by A Young Sim, Da Hyun Choi, Jong Youl Kim, Eun Ran Kim, A-ra Goh, Yong-ho Lee, Jong Eun Lee

“…Recent studies have demonstrated that anti-diabetic drugs sodium–glucose cotransporter-2 inhibitor (SGLT2-i) and dipeptidyl peptidase-4 inhibitor (DPP4-i) improve insulin sensitivity and provide neuroprotection. However, the effects of these two inhibitors on the brain metabolism and insulin resistance remain uninvestigated. …”
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An analytical longitudinal observational study on the association of Vitamin D insufficiency in subjects with primary (idiopathic) demyelinating optic neuritis using visual evoked... by Nirja Agasti, Amar Kumar Misra, Manamita Mandal, Bijendra Mohanty, Soumit Roy, Joydeep Mukherjee, Jasodhara Chaudhuri

“…Vitamin D acts as an anti-inflammatory agent and may confer neuroprotection. Visual evoked potential (VEP) and optical coherence tomography (OCT) are emerging tools for demyelinating diseases. …”
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An engineered monomer binding-protein for α-synuclein efficiently inhibits the proliferation of amyloid fibrils by Emil Dandanell Agerschou, Patrick Flagmeier, Theodora Saridaki, Céline Galvagnion, Daniel Komnig, Laetitia Heid, Vibha Prasad, Hamed Shaykhalishahi, Dieter Willbold, Christopher M Dobson, Aaron Voigt, Bjoern Falkenburger, Wolfgang Hoyer, Alexander K Buell

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Hypoxia mimetic activity of VCE-004.8, a cannabidiol quinone derivative: implications for multiple sclerosis therapy by Carmen Navarrete, Francisco Carrillo-Salinas, Belén Palomares, Miriam Mecha, Carla Jiménez-Jiménez, Leyre Mestre, Ana Feliú, Maria L. Bellido, Bernd L. Fiebich, Giovanni Appendino, Marco A. Calzado, Carmen Guaza, Eduardo Muñoz

“…Activation of the hypoxia-inducible factor (HIF) can have a beneficial role in MS by modulating the immune response and favoring neuroprotection and axonal regeneration. Methods We investigated the effects of VCE-004.8 on the HIF pathway in different cell types. …”
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Transmembrane Peptides as Inhibitors of Protein-Protein Interactions: An Efficient Strategy to Target Cancer Cells? by Camille Albrecht, Camille Albrecht, Aline Appert-Collin, Aline Appert-Collin, Dominique Bagnard, Dominique Bagnard, Sébastien Blaise, Sébastien Blaise, Béatrice Romier-Crouzet, Béatrice Romier-Crouzet, Roman G. Efremov, Roman G. Efremov, Hervé Sartelet, Hervé Sartelet, Laurent Duca, Laurent Duca, Pascal Maurice, Pascal Maurice, Amar Bennasroune, Amar Bennasroune

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Electroacupuncture Pretreatment Alleviates Cerebral Ischemic Injury Through α7 Nicotinic Acetylcholine Receptor-Mediated Phenotypic Conversion of Microglia by Zhi Ma, Zengli Zhang, Fuhai Bai, Tao Jiang, Chaoying Yan, Qiang Wang

“…In conclusion, EA pretreatment alleviates cerebral ischemic injury through α7nAChR-mediated phenotypic conversion of microglia, which may be a new mechanism for the EA pretreatment-induced neuroprotection against cerebral ischemia.…”
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Properly scaled and targeted AAV2-NRTN (neurturin) to the substantia nigra is safe, effective and causes no weight loss: Support for nigral targeting in Parkinson's disease by Raymond T. Bartus, Lamar Brown, Alistair Wilson, Brian Kruegel, Joao Siffert, Eugene M. Johnson, Jr., Jeffrey H. Kordower, Christopher D. Herzog

“…Finally, low AAV2-NRTN doses provided significant neuroprotection against 6-OHDA toxicity, establishing a wide therapeutic index for nigral targeting. …”
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Cell death inhibitors protect against brain damage caused by cardiac ischemia/reperfusion injury by Suchan Liao, Nattayaporn Apaijai, Ying Luo, Jun Wu, Titikorn Chunchai, Kodchanan Singhanat, Busarin Arunsak, Juthipong Benjanuwattra, Nipon Chattipakorn, Siriporn C. Chattipakorn

“…Although apoptosis, necroptosis, and ferroptosis inhibitors provided neuroprotection against cerebral I/R injury, the effects of these cell death inhibitors on the brain following cardiac I/R injury have never been investigated. …”
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Effect of curcumin on autophagy apoptosis and histocytic renovation in mice after traumatic brain injury by Yao⁃qi WANG, Hai⁃yang FU, Pan CHANG

“…Therefore,it may induce neuroprotection and promote nerual renovaion after fraumatic brain injury.…”
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Dataset on inflammation induced after lumbar puncture by Jaspreet Kaur, Eller Conti

“…Western blots were performed with the collected CSF which showed high expression of glial markers such as GFAP, Iba-1 and S100 which has shown to target S100B with no expression of A1 (or A2, play an important role in neuroprotection) astrocytes which have recently been shown to be produced by microglia at the site of injury [9]. …”
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Effects of Aging on Neural Stem/Progenitor Cells and Oligodendrocyte Precursor Cells after Focal Cerebral Ischemia in Spontaneously Hypertensive Rats by Anna C. Liang, Emiri T. Mandeville, Takakuni Maki, Akihiro Shindo, Angel T. Som, Naohiro Egawa, Kanako Itoh, Tsu Tshen Chuang, John D. Mcneish, Julie C. Holder, Josephine Lok, Eng H. Lo, Ken Arai

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Pentylenetetrazole-Induced Seizures Are Increased after Kindling, Exhibiting Vitamin-Responsive Correlations to the Post-Seizures Behavior, Amino Acids Metabolism and Key Metabolic... by Vasily A. Aleshin, Anastasia V. Graf, Artem V. Artiukhov, Alexander L. Ksenofontov, Lev G. Zavileyskiy, Maria V. Maslova, Victoria I. Bunik

“…Our goal is to reveal the molecular mechanisms of the changes upon repeated challenges of this balance, suggesting knowledge-based neuroprotection. To address this goal, a set of metabolic indicators in the post-seizure rat brain cortex is compared before and after pharmacological kindling with pentylenetetrazole (PTZ). …”
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Balancing Herbal Medicine and Functional Food for Prevention and Treatment of Cardiometabolic Diseases through Modulating Gut Microbiota by Ming Lyu, Ming Lyu, Yue-fei Wang, Yue-fei Wang, Guan-wei Fan, Guan-wei Fan, Guan-wei Fan, Xiao-ying Wang, Xiao-ying Wang, Shuang-yong Xu, Yan Zhu, Yan Zhu

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Aggf1 attenuates neuroinflammation and BBB disruption via PI3K/Akt/NF-κB pathway after subarachnoid hemorrhage in rats by Qiquan Zhu, Budbazar Enkhjargal, Lei Huang, Tongyu Zhang, Chengmei Sun, Zhiyi Xie, Pei Wu, Jun Mo, Jiping Tang, Zongyi Xie, John H. Zhang

“…To investigate the underlying neuroprotection mechanism, Aggf1 small interfering RNA (Aggf1 siRNA) and PI3K-specific inhibitor LY294002 were administered through intracerebroventricular (i.c.v.) before SAH induction. …”
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Mild pentachlorophenol-mediated uncoupling of mitochondria depletes ATP but does not cause an oxidized redox state or dopaminergic neurodegeneration in Caenorhabditis elegans by Zachary R. Markovich, Jessica H. Hartman, Ian T. Ryde, Kathleen A. Hershberger, Abigail S. Joyce, Patrick L. Ferguson, Joel N. Meyer

“…These findings support the premise of mild uncoupling-mediated neuroprotection, but are inconsistent with proposed broad “mitochondrial dysfunction”-mediated neurodegeneration models, and highlight the utility of the C. elegans model for studying mitochondrial and neurotoxicity. …”
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Criterios diagnósticos de la muerte encefálica según la resolución 90 del Ministerio de Salud Pública Diagnostic criteria of encephalic death according to Resolution 90 from Health... by Calixto Machado, Jesús Pérez-Nellar, Claudio Scherle

“…A cardio-respiratory arrest only leads to death when anoxia and ischemia are enough prolonged to destroy the intracranial structures, considering also the possibility that subject be or not under the neuroprotection effect, like in the cases of accidental hypothermia. …”
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Bardoxolone methyl inhibits the infection of rabies virus via Nrf2 pathway activation in vitro by Ying Lin Chi, Yuan Xie, Shu Qing Liu, Wu Yang Zhu

“…Our study provides a therapeutic strategy for RABV inhibition and neuroprotection during viral infection.…”
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Effects of COVID-19 Home Confinement on Eating Behaviour and Physical Activity: Results of the ECLB-COVID19 International Online Survey by Achraf Ammar, Michael Brach, Khaled Trabelsi, Hamdi Chtourou, Omar Boukhris, Liwa Masmoudi, Bassem Bouaziz, Ellen Bentlage, Daniella How, Mona Ahmed, Patrick Müller, Notger Müller, Asma Aloui, Omar Hammouda, Laisa Liane Paineiras-Domingos, Annemarie Braakman-Jansen, Christian Wrede, Sofia Bastoni, Carlos Soares Pernambuco, Leonardo Mataruna, Morteza Taheri, Khadijeh Irandoust, Aïmen Khacharem, Nicola L. Bragazzi, Karim Chamari, Jordan M. Glenn, Nicholas T. Bott, Faiez Gargouri, Lotfi Chaari, Hadj Batatia, Gamal Mohamed Ali, Osama Abdelkarim, Mohamed Jarraya, Kais El Abed, Nizar Souissi, Lisette Van Gemert-Pijnen, Bryan L. Riemann, Laurel Riemann, Wassim Moalla, Jonathan Gómez-Raja, Monique Epstein, Robbert Sanderman, Sebastian V. W. Schulz, Achim Jerg, Ramzi Al-Horani, Taiysir Mansi, Mohamed Jmail, Fernando Barbosa, Fernando Ferreira-Santos, Boštjan Šimunič, Rado Pišot, Andrea Gaggioli, Stephen J. Bailey, Jürgen M. Steinacker, Tarak Driss, Anita Hoekelmann, On Behalf of the ECLB-COVID19 Consortium

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