New Molecular and Organelle Alterations Linked to Down Syndrome Heart Disease by Leslye Venegas-Zamora, Leslye Venegas-Zamora, Francisco Bravo-Acuña, Francisco Bravo-Acuña, Francisco Sigcho, Francisco Sigcho, Wileidy Gomez, Wileidy Gomez, José Bustamante-Salazar, José Bustamante-Salazar, Zully Pedrozo, Zully Pedrozo, Zully Pedrozo, Valentina Parra, Valentina Parra, Valentina Parra

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Exercise Intervention Modulates Synaptic Plasticity by Inhibiting Excessive Microglial Activation via Exosomes by Chen Li, Jiayi Hu, Wenhong Liu, Changkai Ke, Chuan Huang, Yifan Bai, Bingchen Pan, Junyi Wang, Chunxiao Wan

“…This study intended to further explore the intrinsic mechanism of neuroprotection by exosome release after exercise.MethodsRats were randomly divided into four groups: the sham operation (SHAM), middle cerebral artery occlusion (MCAO) with sedentary intervention (SED-MCAO), MCAO with exercise intervention (EX-MCAO), and MCAO with exercise intervention and exosome injection (EX-MCAO-EXO). …”
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Mice with a deletion of the major central myelin protein exhibit hypersensitivity to noxious thermal stimuli: involvement of central sensitization by Bérengère Petit, Fabrice Giraudet, Céline Béchon, Laurent Bardin, Paul Avan, Odile Boespflug-Tanguy, Mélina Bégou

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Neuronal nitric oxide synthase required for erythropoietin modulation of heart function in mice by Jeeyoung Lee, Heather M. Rogers, Danielle A. Springer, Constance T. Noguchi

“…In animal models, nitric oxide synthase (NOS) contributes to EPO activities including erythropoiesis, neuroprotection, and cardioprotection against ischemia-reperfusion injury. …”
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Metabotropic glutamate receptor 5 inhibits α-synuclein-induced microglia inflammation to protect from neurotoxicity in Parkinson’s disease by Ya-Nan Zhang, Jing-Kai Fan, Li Gu, Hui-Min Yang, Shu-Qin Zhan, Hong Zhang

“…Targeting metabotropic glutamate receptor 5 (mGluR5) has been an attractive strategy to mediate microglia activation for neuroprotection, which might be an essential regulator to modulate α-syn-induced neuroinflammation for the treatment of PD. …”
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Regulatory role of the endocannabinoid system on glial cells toward cognitive function in Alzheimer’s disease: a systematic review and meta-analysis of animal studies by Kamaruzzaman, Mohd Amir, Romli, Muhammad Hibatullah, Abas, Razif, Vidyadaran, Sharmili, Baharuldin, Mohamad Taufik Hidayat, Nasaruddin, Muhammad Luqman, Thirupathirao, Vishnumukkala, Sura, Sreenivasulu, Warsito, Kabul, Mohd Nor, Nurul Huda, Azwaruddin, Muhammad Amsyar, Alshawsh, Mohammed Abdullah, Mohd Moklas, Mohamad Aris

“…Trends were observed toward neuroprotection, as represented by decreased levels of glial cell markers including glial fibrillary acid protein (SMD = −1.47; 95% CI: −2.56 to −0.38, p = 0.008) and Iba1 (SMD = −1.67; 95% CI: −2.56 to −0.79, p = 0.0002). …”

Hypothermic total liquid ventilation after experimental aspiration-associated acute respiratory distress syndrome by Jérôme Rambaud, Fanny Lidouren, Michaël Sage, Matthias Kohlhauer, Mathieu Nadeau, Étienne Fortin-Pellerin, Philippe Micheau, Luca Zilberstein, Nicolas Mongardon, Jean-Damien Ricard, Megumi Terada, Patrick Bruneval, Alain Berdeaux, Bijan Ghaleh, Hervé Walti, Renaud Tissier

“…Abstract Background Ultrafast cooling by total liquid ventilation (TLV) provides potent cardio- and neuroprotection after experimental cardiac arrest. However, this was evaluated in animals with no initial lung injury, whereas out-of-hospital cardiac arrest is frequently associated with early-onset pneumonia, which may lead to acute respiratory distress syndrome (ARDS). …”
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Granulocyte-colony stimulating factor gene therapy as a novel therapeutics for stroke in a mouse model by Janet M. Menzie-Suderam, Jigar Modi, Hongyaun Xu, Andrew Bent, Paula Trujillo, Kristen Medley, Eugenia Jimenez, Jessica Shen, Michael Marshall, Rui Tao, Howard Prentice, Jang-Yen Wu

“…Granulocyte-colony stimulating factor is a growth factor (G-CSF) with a plethora of beneficial effects, including neuroprotection. Clinical application of human G-CSF (hG-CSF) is limited due to its plasma half-life of 4 h. …”
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Propofol postconditioning ameliorates hypoxia/reoxygenation induced H9c2 cell apoptosis and autophagy via upregulating forkhead transcription factors under hyperglycemia by Rong-Hui Han, He-Meng Huang, Hong Han, Hao Chen, Fei Zeng, Xiang Xie, Dan-Yong Liu, Yin Cai, Liang-Qing Zhang, Xin Liu, Zheng-Yuan Xia, Jing Tang

“…The FoxO transcription factors are reported to play critical roles in activating cardiomyocyte survival signaling throughout the process of cellular injuries induced by oxidative stress and are also involved in hypoxic postconditioning mediated neuroprotection, however, the role of FoxO in postconditioning mediated protection in the heart and in particular in high glucose condition is unknown. …”
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Improving the protective effects of aFGF for peripheral nerve injury repair using sulfated chitooligosaccharides by Yanmei Liu, Fenglin Yu, Beibei Zhang, Meng Zhou, Yu Bei, Yifan Zhang, Jianzhong Tang, Yan Yang, Yadong Huang, Qi Xiang, Yueping Zhao, Qian Liang, Yang Liu

“…Keywords: Acidic fibroblast growth factor, Neuroprotection, Peripheral nerve injury, RSC96 cells, Sulfated chitooligosaccharides…”
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Efek Proteksi Otak Metamizol Intravena Sebagai Farmakologik Hipotermi Terhadap Suhu Inti Dan Kadar Interleukin-6 Pada Pasien Cedera Kepala Berat by Muhammad Erias, Ruli Herman Sitanggang, Tatang Bisri

“…Circulating interleukin-6 (IL-6) and neuroprotection from temperature has a strong relation with improve outcome. …”
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缺血性卒中药物防治相关中国指南的系统评价 Systematic Evaluation of Chinese Guidelines on Pharmacotherapy for Ischemic Stroke by 乔寒子，廖文静，倪小佳，朱庆斌，林浩，罗旭飞，陈耀龙，蔡业峰

“…The control of blood pressure of ischemic stroke should follow the principle of individuation firstly.The efficacy of neuroprotectant was still in need of a lot of clinical trials. …”
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Ketone bodies metabolism during ischemic and reperfusion brain injuries following bilateral occlusion of common carotid arteries in rats Metabolismo dos corpos cetônicos durante as... by Mário Henrique Girão Faria, Luis Roberto Franklin Muniz, Paulo Roberto Leitão de Vasconcelos

“…There was an increased cerebral uptake of ketone bodies following brain ischemia, reaffirming these metabolites as alternative energy substrates under conditions of cerebral metabolic stress as well as its potential role on neuroprotection. The greatest changes in ketone bodies metabolism were verified at initial minutes of recirculation as a result of the reperfusion injury phenomenon.…”
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Cerebral Semaphorin3D is a novel risk factor for age-associated cognitive impairment by Chien-Yuan Chen, Yung-Mei Chao, Ching-Chang Cho, Cheng-Sheng Chen, Wei-Yong Lin, Yi-Hung Chen, Marlène Cassar, Cecilia S. Lu, Jenq-Lin Yang, Julie Y. H. Chan, Suh-Hang H. Juo

“…Abstract Background We previously reported that miR-195 exerts neuroprotection by inhibiting Sema3A and cerebral miR-195 levels decreased with age, both of which urged us to explore the role of miR-195 and miR-195-regulated Sema3 family members in age-associated dementia. …”
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The effect of four-week intermittent fasting from dawn to sunset on circulating brain-derived neurotrophic factor levels in subjects with metabolic syndrome and healthy subjects by Mustafa M. Abdulsada, Zoe R. Wilhelm, Antone R. Opekun, Sridevi Devaraj, Prasun K. Jalal, Ayse L. Mindikoglu

“…BDNF also promotes neurogenesis, neuroplasticity, and neuroprotection. There are conflicting reports regarding how intermittent fasting affects circulating BDNF levels. …”
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Roles of astrocytic connexin-43, hemichannels, and gap junctions in oxygen-glucose deprivation/reperfusion injury induced neuroinflammation and the possible regulatory mechanisms o... by Xiang Yin, Liangshu Feng, Di Ma, Ping Yin, Xinyu Wang, Shuai Hou, Yulei Hao, Jingdian Zhang, Meiying Xin, Jiachun Feng

“…Both SalB and CBX inhibited abnormal astrocytic hemichannel opening and ATP release and switched the activated microglial phenotype from M1 to M2, thus providing effective neuroprotection. Application of Gap19 or Gap26 showed similar results with CBX. …”
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Histopathologic comparison of dexmedetomidine's and thiopental's cerebral protective effects on focal cerebral ischemia in rats by Ebru Çanakçı, Sevilay Akalp Özmen, Mustafa Ferhat Çolak, Hüsnü Kürşad

“…Keywords: Brain ischemia, Dexmedetomidine, Thiopental, Neuroprotection, Palavras-chave: Isquemia encefálica, Dexmedetomidina, Tiopental, Neuroproteção…”
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S(+) cetamina em baixas doses: atualização S(+) cetamina en bajas dosis: actualización Low S(+) ketamine doses: a review by Ana Luft, Florentino Fernandes Mendes

“…Promising effects, such as neuroprotection and improvement of long-term outcomes, require further studies. …”
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Acute maternal oxidant exposure causes susceptibility of the fetal brain to inflammation and oxidative stress by Feroz Akhtar, Christopher A. Rouse, Gabriel Catano, Marcus Montalvo, Sarah L. Ullevig, Reto Asmis, Kusum Kharbanda, Shivani K. Maffi

“…Antioxidants such as glutathione (GSH) and CuZnSOD are perturbed, and their manipulation provides evidence for neuroprotection. However, the cellular and molecular effects of GSH alteration in utero on fetal microglia activation and inflammation remain elusive. …”
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Neoroprotective effects of tocotrienol-rich fraction and α-tocopherol of vitamin E against glutamate toxicity on astrocyte-neuronal mono-culture and co-culture systems by Yap, Hui Min

“…In recent studies, palm tocotrienolrich fraction (TRF) has been shown to exhibit better neuroprotection than alphatocopherol against glutamate toxicity. …”
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