Interferon-gamma ameliorates experimental autoimmune encephalomyelitis by inducing homeostatic adaptation of microglia by Juan E. Tichauer, Gabriel Arellano, Gabriel Arellano, Eric Acuña, Luis F. González, Nirmal R. Kannaiyan, Paola Murgas, Concepción Panadero-Medianero, Jorge Ibañez-Vega, Paula I. Burgos, Eileah Loda, Stephen D. Miller, Moritz J. Rossner, Peter J. Gebicke-Haerter, Peter J. Gebicke-Haerter, Rodrigo Naves

“…However, the mechanisms whereby IFN-γ may promote neuroprotection in EAE and its effects on central nervous system (CNS)-resident cells have remained an enigma for more than 30 years. …”
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17α-Ethinyl estradiol-3-sulfate increases survival and hemodynamic functioning in a large animal model of combined traumatic brain injury and hemorrhagic shock: a randomized contro... by Andrew R. Mayer, Andrew B. Dodd, Julie G. Rannou-Latella, David D. Stephenson, Rebecca J. Dodd, Josef M. Ling, Carissa J. Mehos, Cidney R. Robertson-Benta, Sharvani Pabbathi Reddy, Rachel E. Kinsler, Meghan S. Vermillion, Andrew P. Gigliotti, Veronik Sicard, Amy L. Lloyd, Erik B. Erhardt, Jessica M. Gill, Chen Lai, Vivian A. Guedes, Irshad H. Chaudry

“…The primary objective of this study was to determine if 17α-ethinyl estradiol-3-sulfate (EE-3-SO4) increases survival, promotes more rapid cardiovascular recovery, or confers neuroprotection relative to Placebo following TBI + HS. …”
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Population and evolutionary genetics of the PAH locus to uncover overdominance and adaptive mechanisms in phenylketonuria: Results from a multiethnic study by Abderrahim Oussalah, Elise Jeannesson-Thivisol, Céline Chéry, Pascal Perrin, Pierre Rouyer, Thomas Josse, Aline Cano, Magalie Barth, Alain Fouilhoux, Karine Mention, François Labarthe, Jean-Baptiste Arnoux, François Maillot, Catherine Lenaerts, Cécile Dumesnil, Kathy Wagner, Daniel Terral, Pierre Broué, Loic De Parscau, Claire Gay, Alice Kuster, Antoine Bédu, Gérard Besson, Delphine Lamireau, Sylvie Odent, Alice Masurel, Rosa-Maria Rodriguez-Guéant, François Feillet, Jean-Louis Guéant, Fares Namour

“…Among the non-PAH loci potentially associated with population divergence, two reached exome-wide significance: SSPO (SCO-spondin) and DBH (dopamine beta-hydroxylase), involved in neuroprotection and metabolic adaptation, respectively. …”
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Harmonization of multi-center diffusion tensor tractography in neonates with congenital heart disease: Optimizing post-processing and application of ComBat by Benjamin Meyers, Vincent K. Lee, Lauren Dennis, Julia Wallace, Vanessa Schmithorst, Jodie K. Votava-Smith, Vidya Rajagopalan, Elizabeth Herrup, Tracy Baust, Nhu N. Tran, Jill V. Hunter, Daniel J. Licht, J. William Gaynor, Dean B. Andropoulos, Ashok Panigrahy, Rafael Ceschin

“…Advanced brain imaging of neonatal macrostructure and microstructure, which has prognosticating importance, is more frequently being incorporated into multi-center trials of neonatal neuroprotection. Multicenter neuroimaging studies, designed to overcome small sample sized clinical cohorts, are essential but lead to increased technical variability. …”
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Regulatory role of the endocannabinoid system on glial cells toward cognitive function in Alzheimer’s disease: A systematic review and meta-analysis of animal studies by Mohd Amir Kamaruzzaman, Mohd Amir Kamaruzzaman, Muhammad Hibatullah Romli, Razif Abas, Sharmili Vidyadaran, Mohamad Taufik Hidayat Baharuldin, Muhammad Luqman Nasaruddin, Vishnumukkala Thirupathirao, Sreenivasulu Sura, Sreenivasulu Sura, Kabul Warsito, Nurul Huda Mohd Nor, Muhammad Amsyar Azwaruddin, Mohammed Abdullah Alshawsh, Mohammed Abdullah Alshawsh, Mohamad Aris Mohd Moklas

“…Trends were observed toward neuroprotection, as represented by decreased levels of glial cell markers including glial fibrillary acid protein (SMD = −1.47; 95% CI: −2.56 to −0.38, p = 0.008) and Iba1 (SMD = −1.67; 95% CI: −2.56 to −0.79, p = 0.0002). …”
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Cost-effective therapeutic hypothermia treatment device for hypoxic ischemic encephalopathy by Allen RH, Acharya S, Kulikowicz E, Lee JK, O'Donnell N, Moore E, Kim R, Ammanuel S, Buchbinder N, Kim JJ, Lee RW, Johnston MV

“…Our device costs a maximum of 40 dollars and is simple enough to be used in neonatal intensive care units in developing countries.Keywords: therapeutic hypothermia, evaporative cooling, hypoxic ischemic encephalopathy, birth asphyxia, neuroprotection…”
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Randomized Controlled Study of a Remote Flipped Classroom Neuro-otology Curriculum by Frederick Robert Carrick, Frederick Robert Carrick, Frederick Robert Carrick, Mahera Abdulrahman, Ahmed Hankir, Ahmed Hankir, Maksim Zayaruzny, Maksim Zayaruzny, Kinda Najem, Kinda Najem, Palita Lungchukiet, Palita Lungchukiet, Roger A. Edwards

“…Subjects were randomized into a “control” group attending a traditional classroom and a “trial” group of equal numbers participating in an online synchronous Internet streaming classroom using the Adobe Connect e-learning platform.InterventionsSubjects were randomized into a “control” group attending a traditional classroom and a “treatment” group of equal numbers participating in an online synchronous Internet streaming classroom.Main outcome measuresPre- and post-multiple choice examinations of VOR, Movement, Head Turns, Head Tremor, Neurodegeneration, Inferior Olivary Complex, Collateral Projections, Eye Movement Training, Visual Saccades, Head Saccades, Visual Impairment, Walking Speed, Neuroprotection, Autophagy, Hyperkinetic Movement, Eye and Head Stability, Oscilllatory Head Movements, Gaze Stability, Leaky Neural Integrator, Cervical Dystonia, INC and Head Tilts, Visual Pursuits, Optokinetic Stimulation, and Vestibular Rehabilitation.MethodsAll candidates took a pretest examination of the subject material. …”
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Predicting 2-year neurodevelopmental outcomes in extremely preterm infants using graphical network and machine learning approachesResearch in context by Sandra E. Juul, Thomas R. Wood, Kendell German, Janessa B. Law, Sarah E. Kolnik, Mihai Puia-Dumitrescu, Ulrike Mietzsch, Semsa Gogcu, Bryan A. Comstock, Sijia Li, Dennis E. Mayock, Patrick J. Heagerty, Rajan Wadhawan, Sherry E. Courtney, Tonya Robinson, Kaashif A. Ahmad, Ellen Bendel-Stenzel, Mariana Baserga, Edmund F. LaGamma, L. Corbin Downey, Raghavendra Rao, Nancy Fahim, Andrea Lampland, Ivan D. Frantz, III, Janine Khan, Michael Weiss, Maureen M. Gilmore, Nishant Srinivasan, Jorge E. Perez, Victor McKay

“…Methods: Using a prospective database of 692 infants from the Preterm Epo Neuroprotection (PENUT) Trial, which was carried out between December 2013 and September 2016, we developed three predictive algorithms of increasing complexity using a Bayesian Additive Regression Trees (BART) machine learning approach to predict both NDI and continuous Bayley Scales of Infant and Toddler Development 3rd ed subscales at 2 year follow-up using: 1) the 5 variables used in the National Institute of Child Health and Human Development (NICHD) Extremely Preterm Birth Outcomes Tool, 2) 21 variables associated with outcomes in extremely preterm (EP) infants, and 3) a hypothesis-free approach using 133 potential variables available for infants in the PENUT database. …”
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EETs/sEHi alleviates nociception by blocking the crosslink between endoplasmic reticulum stress and neuroinflammation in a central poststroke pain model by Tongtong Liu, Ting Li, Xuhui Chen, Zuofan Li, Miaomiao Feng, Wenlong Yao, Li Wan, Chuanhan Zhang, Yue Zhang

“…Combined with the previously reported EET/sEHi effects on antinociception and neuroprotection, therapy with agents that target EET signaling may serve as a multi-functional approach in central neuropathic pain by attenuating ER stress, excessive neuroinflammation, and subsequent central sensitization. …”
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A meta‐analysis comparing first‐line immunosuppressants in neuromyelitis optica by Jonathan Giovannelli, Jonathan Ciron, Mikael Cohen, Ho‐Jin Kim, Su‐Hyun Kim, Jan‐Patrik Stellmann, Ingo Kleiter, Morgan McCreary, Benjamin M. Greenberg, Romain Deschamps, Bertrand Audoin, Elisabeth Maillart, Caroline Papeix, Nicolas Collongues, Bertrand Bourre, David Laplaud, Xavier Ayrignac, Françoise Durand‐Dubief, Aurélie Ruet, Sandra Vukusic, Romain Marignier, Luc Dauchet, Hélène Zephir, NEMOS (Neuromyelitis Optica Study Group in Germany), NOMADMUS (Neuromyelitis Optica study Group in France), OFSEP (Observatoire Français de la Sclérose en Plaques) investigators

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Application of hyperbaric oxygen therapy in post-stroke patients by Piotr Dzięgielewski, Emilia Mikołajewska, Aleksander Goch

“…Hyperbaric oxygen therapy in post-stroke patients   Piotr Dzięgielewski1, Emilia Mikołajewska1,2,3, Aleksander Goch1,4   1 Department of Physiotherapy, Ludwik Rydygier Collegium Medium in Bydgoszcz, Nicolaus Copernicus University in Toruń 2 Rehabilitation Clinic, The 10th Clinical Military Hospital with Policlinic, Bydgoszcz, Poland 3 Neurocognitive Laboratory, Interdisciplinary Center for Modern Technologies, Nicolaus Copernicus University in Toruń 4 Cardiology and Cardiosurgery Clinic, The 10th Clinical Military Hospital with Policlinic, Bydgoszcz, Poland       Corresponding author: Emilia Mikołajewska Rehabilitation Clinic Military Clinical Hospital No. 10 and Polyclinic Powstańców Warszawy 5 85-681 Bydgoszcz, Poland e-mail: e.mikolajewska@wp.pl, emiliam@cm.umk.pl www: http://emikolajewska.netstrefa.eu     Keywords: neurorehabilitation; physiotherapy; stroke; neurological deficit; brain edema; hyperbaric oxygen therapy; HBOT; neuroprotection; neurotherapeutic effect.   Abstract   Stroke is regarded as the major cause of brain damage, chronic neurological impairments, functional deficits, and long-term disability worldwide. …”
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Ethyl Pyruvate Increases Post-Ischemic Levels of Mitochondrial Energy Metabolites: A ¹³C-Labeled Cerebral Microdialysis Study by Kevin H. Nygaard, Jesper F. Havelund, Troels H. Nielsen, Carl-Henrik Nordström, Nils. J. Færgeman, Frantz R. Poulsen, Jan Bert Gramsbergen, Axel Forsse

“…Ethyl pyruvate (EP) is a putative neuroprotectant, supposedly targeting mitochondrial energy metabolism, but its effect on cerebral energy metabolism has never been described using microdialysis. …”
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Anti-inflammatory protein TSG-6 secreted by bone marrow mesenchymal stem cells attenuates neuropathic pain by inhibiting the TLR2/MyD88/NF-κB signaling pathway in spinal microglia by Hao Yang, Lingmin Wu, Huimin Deng, Yuanli Chen, Huanping Zhou, Meiyun Liu, Shaochen Wang, Li Zheng, Lina Zhu, Xin Lv

“…Conclusions The present study demonstrated a paracrine mechanism by which intrathecal injection of BMSCs targets the TLR2/MyD88/NF-κB pathway in spinal cord dorsal horn microglia to elicit neuroprotection and sustained neuropathic pain relief via TSG-6 secretion.…”
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Selected Lectures of the XXIII National Congress of the Italian Society of Neonatology (Società Italiana di Neonatologia, SIN); Milan (Italy); September 25th-28th, 2017 by --- Various Authors

“…KANGAROO MOTHER CARE (KMC) AND NEU­ROPROTECTION • G. Calciolari, C. Artese, N. Bertoncelli, E. …”
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2019—2021年国家自然科学基金脑血管病领域面上项目结题情况分析 Analysis on the Completion Condition of General Projects in the Field of Cerebrovascular Diseases of National Natural Science Foundation of Chin... by 邓柳丽，肖世华

“…Keyword cluster analysis showed that the basic research hotspots in the field of cerebrovascular diseases were inflammatory response, microglia, neuroprotection and nerve regeneration. Conclusions Research achievements of general projects in the field of cerebrovascular diseases of National Natural Science Foundation of China were of various types, were mainly papers and talent training, supported by comprehensive colleges and universities with unbalanced geographical distribution, and research directions were relatively concentrated, which were mainly ischemic cerebrovascular diseases.…”
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Ginkgo Flavonol Glycosides or Ginkgolides Tend to Differentially Protect Myocardial or Cerebral Ischemia–Reperfusion Injury via Regulation of TWEAK-Fn14 Signaling in Heart and Brai... by Guangxu Xiao, Guangxu Xiao, Ming Lyu, Ming Lyu, Ming Lyu, Yule Wang, Yule Wang, Shuang He, Shuang He, Xinyan Liu, Xinyan Liu, Jingyu Ni, Jingyu Ni, Lan Li, Lan Li, Guanwei Fan, Jihong Han, Xiumei Gao, Xiaoying Wang, Xiaoying Wang, Yan Zhu, Yan Zhu

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Associations between meeting 24-hour movement guidelines and quality of life among children and adolescents with autism spectrum disorder by Chuidan Kong, Aiguo Chen, Sebastian Ludyga, Fabian Herold, Sean Healy, Mengxian Zhao, Alyx Taylor, Notger G. Müller, Arthur F. Kramer, Sitong Chen, Mark S. Tremblay, Liye Zou

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Factors influencing appropriate use of interventions for management of women experiencing preterm birth: A mixed-methods systematic review and narrative synthesis by Rana Islamiah Zahroh, Alya Hazfiarini, Katherine E. Eddy, Joshua P. Vogel, Ӧzge Tunçalp, Nicole Minckas, Fernando Althabe, Olufemi T. Oladapo, Meghan A. Bohren

“…Health outcomes of preterm newborns can be improved with appropriate use of antenatal corticosteroids (ACSs) to promote fetal lung maturity, tocolytics to delay birth, magnesium sulphate for fetal neuroprotection, and antibiotics for preterm prelabour rupture of membranes. …”
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Inducible nitric oxide synthase inhibitor, 1400W, mitigates DFP-induced long-term neurotoxicity in the rat model by Marson Putra, Shaunik Sharma, Meghan Gage, Grace Gasser, Andy Hinojo-Perez, Ashley Olson, Adriana Gregory-Flores, Sreekanth Puttachary, Chong Wang, Vellareddy Anantharam, Thimmasettappa Thippeswamy

“…In this study, we used diisopropylfluorophosphate (DFP), a seizurogenic CNA to investigate the long-term impact of its acute exposure on the brain and its mitigation by an inducible nitric oxide synthase (iNOS) inhibitor, 1400W as a neuroprotectant in the rat model. Several experimental studies have demonstrated that DFP-induced seizures and/or status epilepticus (SE) causes permanent brain injury, even after the countermeasure medication (atropine, oxime, and diazepam). …”
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Evaluation of serum vitamin D and retinal nerve fibre layer thickness among type 2 diabetes mellitus patient with non proliferative diabetic retinopathy by Hooi, Tan Boon

“…Other than calcium homeostasis and bone metabolism, vitamin D is found to serve as neuroprotection and prevention of angiogenesis. There is a lack of study on the relation between vitamin D and retinal neurodegeneration changes. …”
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