A novel murine model of autoimmune dysautonomia by α3 nicotinic acetylcholine receptor immunization by Makoto Yamakawa, Shunya Nakane, Eikichi Ihara, Nozomu Tawara, Hiroko Ikeda, Yoko Igarashi, Yoshihiro Komohara, Koutaro Takamatsu, Tokunori Ikeda, Tokunori Ikeda, Yusuke Tomita, Shoichi Murai, Yukio Ando, Akihiro Mukaino, Yoshihiro Ogawa, Mitsuharu Ueda

“…We aimed to establish a novel murine model of autoimmune autonomic ganglionopathy (AAG), which represents autoimmune dysautonomia, associated with MHC class II to understand its pathomechanism and the pathogenicity of nicotinic acetylcholine receptor (nAChR) antibodies. The amino acid sequence of the mouse nAChRα3 protein was analyzed using an epitope prediction tool to predict the possible MHC class II binding mouse nAChRα3 peptides. …”
Get full text

State-dependent binding of cholesterol and an anionic lipid to the muscle-type Torpedo nicotinic acetylcholine receptor by Anna Ananchenko, Rui Yan Gao, François Dehez, John E. Baenziger

“…Abstract The ability of the Torpedo nicotinic acetylcholine receptor (nAChR) to undergo agonist-induced conformational transitions requires the presence of cholesterol and/or anionic lipids. …”
Get full text

The Expression of the Alpha7 Nicotinic Acetylcholine Receptor and the Effect of Smoking in Curdlan-Administered SKG Mice by Young-Eun Kim, Jae-Hyun Lee, Eun-Ju Lee, Do Hoon Kim, Mi Ryeong Jeong, Seokchan Hong, Chang-Keun Lee, Bin Yoo, Jeehee Youn, Eun-Ju Chang, Yong-Gil Kim

Subjects: “…alpha7 nicotinic acetylcholine receptor…”
Get full text

Menthol acts as a positive allosteric modulator on nematode levamisole sensitive nicotinic acetylcholine receptors by Shivani Choudhary, Djordje S. Marjianović, Colin R. Wong, Xiaoyu Zhang, Melanie Abongwa, Joel R. Coats, Saša M. Trailović, Richard J. Martin, Alan P. Robertson

“…Previous studies have shown nicotinic acetylcholine receptors (nAChRs) to be possible targets for naturally occurring plant metabolites such as carvacrol and carveol. …”
Get full text

Deficiency of α7 Nicotinic Acetylcholine Receptor Attenuates Bleomycin-Induced Lung Fibrosis in Mice by Peiyu Sun, Ling Li, Caiqi Zhao, Mengyao Pan, Zhikang Qian, Xiao Su

“…Abstract α7 nicotinic acetylcholine receptor (α7 nAChR, coded by Chrna7) is indispensable in dampening proinflammatory responses. …”
Get full text

Molecular dynamics study of water and Na⁺ ions in models of the pore region of the nicotinic acetylcholine receptor by Smith, G, Sansom, M

“…The nicotinic acetylcholine receptor (nAChR) is an integral membrane protein that forms ligand-gated and cation-selective channels. …”

Structural and dynamic studies of the gamma-M4 trans-membrane domain of the nicotinic acetylcholine receptor. by Williamson, P, Zandomeneghi, G, Barrantes, F, Watts, A, Meier, B

“…A structural characterization of a synthetic peptide corresponding to the fourth transmembrane domain (M4-TMD) of the gamma-subunit of the nicotinic acetylcholine receptor from Torpedo californica has been undertaken. …”

Cholesterol modulates the organization of the gammaM4 transmembrane domain of the muscle nicotinic acetylcholine receptor. by de Almeida, R, Loura, L, Prieto, M, Watts, A, Fedorov, A, Barrantes, F

“…A 28-mer gammaM4 peptide, obtained by solid-state synthesis and corresponding to the fourth transmembrane segment of the nicotinic acetylcholine receptor gamma-subunit, possesses a single tryptophan residue (Trp453), making it an excellent model for studying peptide-lipid interactions in membranes by fluorescence spectroscopy. …”

Neonicotinoid insecticides display partial and super agonist actions on native insect nicotinic acetylcholine receptors. by Brown, L, Ihara, M, Buckingham, S, Matsuda, K, Sattelle, D

“…Nicotinic acetylcholine receptors (nAChRs) are present in high density in insect nervous tissue and are targeted by neonicotinoid insecticides. …”

The fourth transmembrane domain of the muscle nicotinic acetylcholine receptor epsilon subunit is not required for channel function by Beeson, D, Newland, C, Croxen, R, Vincent, A

Synthetic α-Conotoxin Mutants as Probes for Studying Nicotinic Acetylcholine Receptors and in the Development of Novel Drug Leads by Christopher J. Armishaw

Subjects: Get full text

UFR2709, a Nicotinic Acetylcholine Receptor Antagonist, Decreases Ethanol Intake in Alcohol-Preferring Rats by Gabriel Quiroz, Ramón Sotomayor-Zárate, Juan Pablo González-Gutierrez, Franco Vizcarra, Felipe Moraga, Isabel Bermudez, Miguel Reyes-Parada, Miguel Reyes-Parada, María Elena Quintanilla, Diego Lagos, Mario Rivera-Meza, Patricio Iturriaga-Vásquez, Patricio Iturriaga-Vásquez

“…Brain nicotinic acetylcholine receptors (nAChRs), a heterogeneous family of pentameric acetylcholine-gated cation channels, have been suggested as molecular targets for the treatment of alcohol abuse and dependence. …”
Get full text

Symmetry-adapted Markov state models of closing, opening, and desensitizing in α 7 nicotinic acetylcholine receptors by Yuxuan Zhuang, Rebecca J. Howard, Erik Lindahl

“…Abstract α7 nicotinic acetylcholine receptors (nAChRs) are homopentameric ligand-gated ion channels with critical roles in the nervous system. …”
Get full text

A release of local subunit conformational heterogeneity underlies gating in a muscle nicotinic acetylcholine receptor by Mackenzie J. Thompson, Farid Mansoub Bekarkhanechi, Anna Ananchenko, Hugues Nury, John E. Baenziger

Get full text

Natural Compounds Interacting with Nicotinic Acetylcholine Receptors: From Low-Molecular Weight Ones to Peptides and Proteins by Denis Kudryavtsev, Irina Shelukhina, Catherine Vulfius, Tatyana Makarieva, Valentin Stonik, Maxim Zhmak, Igor Ivanov, Igor Kasheverov, Yuri Utkin, Victor Tsetlin

Subjects: Get full text

Differential Modulation of GABAA and NMDA Receptors by an α7-nicotinic Acetylcholine Receptor Agonist in Chronic Glaucoma by Xujiao Zhou, Xujiao Zhou, Xujiao Zhou, Yuan Zong, Yuan Zong, Yuan Zong, Rong Zhang, Xuejin Zhang, Shenghai Zhang, Jihong Wu, Jihong Wu, Jihong Wu, Jihong Wu, Xinghuai Sun, Xinghuai Sun, Xinghuai Sun, Xinghuai Sun

“…Presynaptic modulation of γ-aminobutyric acid (GABA) release by an alpha7 nicotinic acetylcholine receptor (α7-nAChR) agonist promotes retinal ganglion cell (RGC) survival and function, as suggested by a previous study on a chronic glaucomatous model from our laboratory. …”
Get full text

Inhibition of the nicotinic acetylcholine receptors by cobra venom α-neurotoxins: is there a perspective in lung cancer treatment? by Angela Alama, Cristina Bruzzo, Zita Cavalieri, Alessandra Forlani, Yuri Utkin, Ida Casciano, Massimo Romani

“…Nicotine exerts its oncogenic effects through the binding to nicotinic acetylcholine receptors (nAChRs) and the activation of downstream pathways that block apoptosis and promote neo-angiogenesis. …”
Get full text

Nicotine Causes Nephrotoxicity through the Induction of NLRP6 Inflammasome and Alpha7 Nicotinic Acetylcholine Receptor by Cai-Mei Zheng, Yu-Hsuan Lee, I-Jen Chiu, Yu-Jhe Chiu, Li-Chin Sung, Yung-Ho Hsu, Hui-Wen Chiu

Subjects: Get full text

C-Reactive Protein Stimulates Nicotinic Acetylcholine Receptors to Control ATP-Mediated Monocytic Inflammasome Activation by Katrin Richter, Sabrina Sagawe, Andreas Hecker, Mira Küllmar, Ingolf Askevold, Jelena Damm, Sarah Heldmann, Michael Pöhlmann, Sophie Ruhrmann, Michael Sander, Klaus-Dieter Schlüter, Sigrid Wilker, Inke R. König, Inke R. König, Wolfgang Kummer, Winfried Padberg, Arik J. Hone, J. Michael McIntosh, J. Michael McIntosh, J. Michael McIntosh, Anna Teresa Zakrzewicz, Christian Koch, Veronika Grau

Subjects: Get full text

Correction: The Role of α7 Nicotinic Acetylcholine Receptor in Modulation of Heart Rate Dynamics in Endotoxemic Rats

Get full text