The Synthetic Flavonoid Hidrosmin Improves Endothelial Dysfunction and Atherosclerotic Lesions in Diabetic Mice by Luna Jiménez-Castilla, Lucas Opazo-Ríos, Gema Marin-Royo, Macarena Orejudo, Raquel Rodrigues-Diez, Constanza Ballesteros-Martínez, Manuel Soto-Catalán, Teresa Caro-Ordieres, Inés Artaiz, Tatiana Suarez-Cortés, Arturo Zazpe, Gonzalo Hernández, Marcelino Cortés, José Tuñón, Ana M. Briones, Jesús Egido, Carmen Gómez-Guerrero

“…Ex vivo, hidrosmin induced vascular relaxation that was blocked by nitric oxide synthase (NOS) inhibition. In vitro, hidrosmin stimulated endothelial NOS activity and NO production and downregulated hyperglycemia-induced inflammatory and oxidant genes in vascular smooth muscle cells. …”
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Phomaketide A Inhibits Lymphangiogenesis in Human Lymphatic Endothelial Cells by Huai-Ching Tai, Tzong-Huei Lee, Chih-Hsin Tang, Lei-Po Chen, Wei-Cheng Chen, Ming-Shian Lee, Pei-Chi Chen, Chih-Yang Lin, Chih-Wen Chi, Yu-Jen Chen, Cheng-Ta Lai, Shiou-Sheng Chen, Kuang-Wen Liao, Chien-Hsing Lee, Shih-Wei Wang

“…Mechanistic investigations revealed that phomaketide A reduced LECs-induced lymphangiogenesis via vascular endothelial growth factor receptor-3 (VEGFR-3), protein kinase Cδ (PKCδ), and endothelial nitric oxide synthase (eNOS) signalings. Furthermore, human proteome array analysis indicated that phomaketide A significantly enhanced the protein levels of various protease inhibitors, including cystatin A, serpin B6, tissue factor pathway inhibitor (TFPI), and tissue inhibitor matrix metalloproteinase 1 (TIMP-1). …”
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Aromadendrin inhibits PMA-induced cytokine formation/NF-κB activation in A549 cells and ovalbumin-induced bronchial inflammation in mice by Jin-Mi Park, Ji-Won Park, Juhyun Lee, Seung-Ho Kim, Da-Yun Seo, Kyung-Seop Ahn, Sang-Bae Han, Jae-Won Lee

“…In ovalbumin-induced AA mice, the levels of cells, such as eosinophils, Th2 cytokines, MCP-1 in bronchoalveolar lavage fluid, IgE in serum, and inducible nitric oxide synthase/cyclooxygenase-2 expression in the lung tissue were upregulated, which were all suppressed by ARO. …”
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Inhalative as well as Intravenous Administration of H₂S Provides Neuroprotection after Ischemia and Reperfusion Injury in the Rats’ Retina by Stefanie Scheid, Max Goeller, Wolfgang Baar, Jakob Wollborn, Hartmut Buerkle, Günther Schlunck, Wolf Lagrèze, Ulrich Goebel, Felix Ulbrich

“…H₂S treatment also reduced apoptotic and inflammatory markers, such as caspase-3, intracellular adhesion molecule 1 (ICAM-1), vascular endothelial growth factor (VEGF), and inducible nitric oxide synthase (iNOS). The protective effect of H₂S was partly abolished by the ERK1/2 inhibitor PD98059. …”
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Alleviative effects of pinostrobin against cadmium-induced renal toxicity in rats by reducing oxidative stress, apoptosis, inflammation, and mitochondrial dysfunction by Muhammad Umar Ijaz, Sabahat Shahzadi, Ali Hamza, Rabia Azmat, Haseeb Anwar, Tayyaba Afsar, Huma Shafique, Mashooq Ahmad Bhat, Ahmed M. Naglah, Mohamed A. Al-Omar, Suhail Razak

“…Moreover, Cd exposure considerably increased the levels of inflammatory indices, including interleukin-1b (IL-1b), tumor necrosis factor-a (TNF-a), interleukin-6 (IL-6), nuclear factor kappa-B (NF-kB), inducible nitric oxide synthase (iNOS), and cyclooxygenase-2 (COX-2) activity. …”
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P2Y12 receptor mediates microglial activation via RhoA/ROCK pathway in the trigeminal nucleus caudalis in a mouse model of chronic migraine by Feng Jing, Yixin Zhang, Ting Long, Wei He, Guangcheng Qin, Dunke Zhang, Lixue Chen, Jiying Zhou

“…Results The protein levels of P2Y12R, GTP-RhoA, ROCK2, CGRP, c-fos, and inducible nitric oxide synthase (iNOS) in the TNC were increased after recurrent NTG injection. …”
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Resveratrol Improves Paclitaxel-Induced Cognitive Impairment in Mice by Activating SIRT1/PGC-1α Pathway to Regulate Neuronal State and Microglia Cell Polarization by Liu X, Tang M, He TY, Zhao S, Li HZ, Li Z, Guo YX, Wang XL

“…Western blotting was applied to detect protein expression of receptor-interacting protein (RIP3), mixed lineage kinase domain-like protein (MLKL), silencing information regulator 2 related enzyme 1 (SIRT1), peroxisome proliferator activated receptor coactivator-1 (PGC-1α), NADPH oxidase 2 (NOX2), NOX4, postsynaptic density zone 95 (PSD95), arginase-1 (Arg-1) and inducible nitric oxide synthase (iNOS). Immunofluorescence of RIP3, MLKL, Arg-1, Iba-1 and iNOS was conducted to observe the apoptosis of hippocampal cells and the polarization of microglia. qRT-PCR was performed to detect BDNF mRNA expressions. …”
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Therapeutic Aspects of <i>Prunus cerasus</i> Extract in a Rabbit Model of Atherosclerosis-Associated Diastolic Dysfunction by Reka Szekeres, Daniel Priksz, Rita Kiss, Dana Diana Romanescu, Mariann Bombicz, Balazs Varga, Rudolf Gesztelyi, Anna Szilagyi, Barbara Takacs, Vera Tarjanyi, Beata Pelles-Tasko, Ildiko Forgacs, Judit Remenyik, Zoltan Szilvassy, Bela Juhasz

“…Dyslipidemia, impaired endothelial function, and signs of diastolic dysfunction were evident in hypercholesterolemic rabbits, accompanied by a reduced cardiac expression of eNOS (endothelial nitric oxide synthase), PKG, and SERCA2a (sarco/endoplasmic reticulum calcium ATPase 2a). …”
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Protective effects and mechanisms of N-acetylcysteine on indomethacin-induced intestinal injury in a porcine model by Qian Zhang, Wenkai Liu, Qian Li, Yitong Zeng, Mengjun Wu, Tao Wu, Shuangshuang Guo, Lei Wang, Di Zhao, Dan Yi, Yongqing Hou

“…Moreover, the content of nitric oxide was restored to a normal level with the reduction of nitric oxide synthase activity. NAC administration ameliorated intestinal injury in IDMT-challenged piglets by enhancing antioxidant and anti-inflammatory functions and modulating arginine metabolism in the small intestine.…”
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Macrophages, Nitric Oxide and microRNAs Are Associated with DNA Damage Response Pathway and Senescence in Inflammatory Bowel Disease by Sohn, Jane J., Schetter, Aaron J., Yfantis, Harris G., Ridnour, Lisa A., Horikawa, Izumi, Kahn, Mohammed A., Robles, Ana I., Hussain, S. Perwez, Goto, Akiteru, Bowman, Elise D., Hofseth, Lorne J., Bartkova, Jirina, Bartek, Jiri, Wogan, Gerald N., Wink, David A., Harris, Curtis C.

“…Interestingly, macrophage-induced senescence was partly dependent on nitric oxide synthase, and clinically relevant NO• levels alone induced senescence. …”
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Impaired systemic tetrahydrobiopterin bioavailability and increased dihydrobiopterin in adult falciparum malaria : association with disease severity, impaired microvascular functio... by Yeo, Tsin W., Lampah, Daniel A., Kenangalem, Enny, Tjitra, Emiliana, Price, Ric N., Weinberg, J. Brice, Hyland, Keith, Granger, Donald L., Anstey, Nicholas M.

“…Tetrahydrobiopterin (BH4) is a co-factor required for catalytic activity of nitric oxide synthase (NOS) and amino acid-monooxygenases, including phenylalanine hydroxylase. …”
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Modulation of inflammation and endothelial activation with spaceflight travel: tocotrienols as atheroprotective agents / Suhaila Abd Muid by Abd Muid, Suhaila

“…The objectives of this study were to investigate (i) the effects of spaceflight travel on the protein and gene expression of inflammation and endothelial activation, nuclear factor kappa B (NFkB) and endothelial nitric oxide synthase (eNOS) in human ECs compared to ground controls, (ii) the protein and gene expression of inflammation and endothelial activation, NFkB, signal transducer and activator of transcription-3 (STAT-3) and eNOS in revived live human ECs compared to matched controls (iii) the effects of TEMF, pure TCT isomers, and a-TOC on inflammation, endothelial activation, monocytes binding activity, NFkB and eNOS, and (iv) the most potent pure TCT isomers on the inhibition of the inflammation, endothelial activation, monocytes binding activity, NFkB and eNOS biomarkers in lipopolysaccharides (LPS) stimulated human ECs. …”
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Identification of commonly used medicinal plants in Kangkar Pulai and their therapeutic evaluation as anti-diabetic by Alsarhan, Ali Ata Zidan

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Evaluation of the role of miR-31-dependent reduction in dystrophin and nNOS on atrial-fibrillation-induced electrical remodelling in man by Reilly, S, Liu, X, Carnicer, R, Rajakumar, T, Sayeed, R, Krasopoulos, G, Verheule, S, Fulga, T, Schotten, U, Casadei, B

“…We aimed to evaluate the role of miR-31-dependent reduction in dystrophin and neuronal nitric oxide synthase (nNOS, also known as NOS1) on atrial electrical properties and atrial fibrillation inducibility.We recruited 258 patients (209 patients in sinus rhythm and 49 with permanent atrial fibrillation) from the John Radcliffe Hospital, Oxford, UK; written informed consent was obtained from each participant. …”

The requirement for endothelial cell tetrahydrobiopterin in health and disease by Chuaiphichai, S

“…<p>Tetrahydrobiopterin (BH4) is an essential cofactor for endothelial nitric oxide synthase (eNOS) function and nitric oxide (NO) generation. …”

Pivotal role of GABAergic neurons of the basolateral amygdala in relaying hippocampal and serotonergic information by Bocchio, M

“…</p> <p>Finally, I report a novel GABAergic neuron type of the BLA that expresses high levels of neuronal nitric oxide synthase (nNOS). These cells are instead hyperpolarized by 5-HT via 5-HT_1A receptors, representing the first example of a BLA inhibitory neuron inhibited by this neuromodulator. …”

Brewers's rice modulates oxidative stress in azoxymethane-mediated colon carcinogenesis in rats by Tan, Bee Ling, Mohd Esa, Norhaizan, Huynh, Ky, Yeap, Swee Keong, Hamzah, Hazilawati, Karim, Roselina

“…Results: The overall analyses demonstrated that the dietary administration of brewers' rice in AOM-induced rat colon carcinogenesis resulted in the transcriptional upregulation of GSK3β, inducible nitric oxide synthase (iNOS), Nrf2, and HO-1. We discovered that the dietary administration of brewers' rice downregulated the β-catenin and NF-κB mRNA levels. …”
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Healing properties of epidermal growth factor and tocotrienol-rich fraction formulation in deep partial-thickness burn wound model by Guo, Hui-Fang

“…This formulation was capable of promoting the recovery of the dermis and attenuate the oxidative stress by down regulating the expression of IL-6, TNF-α, inducible nitric oxide synthase (iNOS), matrix metalloproteinase-2 (MMP-2), tissue inhibitor of metalloproteinase-2 (TIMP-2), transforming growth factor-β1 (TGF-β1), vascular endothelial growth factor-A (VEGF-A) and Collagen-1. …”
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Biological activities of locally isolated thermophilic fungi by Al-Bajalany, Laith Yaseen Arif

“…For the thermophilic fungus Myceliophthora thermophi/a, the extract concentrate inhibited 50.43% of the inducible nitric oxide synthase in a measurements dose dependent manner at 250μg mL- 1, while kept up 91.13% of macrophage RAW 264.7 cell lines induced by LPS/IFN-y demonstrating their obvious anti-inflammatory activity.…”
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The effect of acupuncture on oxidative stress in animal models of vascular dementia: a systematic review and meta-analysis by Qiong-Nan Bao, Man-Ze Xia, Jing Xiong, Yi-Wei Liu, Ya-Qin Li, Xin-Yue Zhang, Zheng-Hong Chen, Jin Yao, Ke-Xin Wu, Wan-Qi Zhong, Shao-Jun Xu, Zi-Han Yin, Fan-Rong Liang

“…The meta-analysis indicated that, overall, acupuncture significantly reduced the expression of pro-oxidants including reactive oxygen species (standardized mean differences [SMDs] = -4.29, 95% confidence interval [CI]: -6.26, -2.31), malondialdehyde (SMD = -2.27, 95% CI: -3.07, -1.47), nitric oxide (SMD = -0.85, 95% CI: -1.50, -0.20), and nitric oxide synthase (SMD = -1.01, 95% CI: -1.69, -0.34) and enhanced the levels of anti-oxidants including super oxide dismutase (SMD = 2.80, 95% CI: 1.98, 3.61), glutathione peroxidase (SMD = 1.32, 95% CI: -0.11, 2.76), and catalase (SMD = 1.31, 95% CI: 0.05, 2.58) in VaD animal models. …”
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