Effect of statins on sirtuin 1 and endothelial nitric oxide synthase expression in young patients with a history of premature myocardial infarction by Aylin Hatice Yamaç, Ülkan Kılıç

“…Objective: The present study was an investigation of the effect of statins on the expression of circulating sirtuin 1 (SIRT1) and endothelial nitric oxide synthase (eNOS) proteins, and on the distribution of single nucleotide polymorphisms (SNPs) of the SIRT1 gene in patients with a history of premature myocardial infarction (PMI). …”
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Exercise Training Has Contrasting Effects in Myocardial Infarction and Pressure Overload Due to Divergent Endothelial Nitric Oxide Synthase Regulation by Elza D. van Deel, Yanti Octavia, Monique C. de Waard, Martine de Boer, Dirk J. Duncker

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Inducible Nitric Oxide Synthase Embedded in Alginate/Polyethyleneimine Hydrogel as a New Platform to Explore NO-Driven Modulation of Biological Function by Shaimaa Maher, Lauren A. Smith, Celine A. El-Khoury, Haitham Kalil, Khalid Sossey-Alaoui, Mekki Bayachou

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Endothelial nitric oxide synthase alterations are independent of turbulence in the aorta of patients with a unicuspid aortic valveCentral MessagePerspective by Brittany Balint, PhD, Catherine Kollmann, MD, Simon Gauer, MD, Jan M. Federspiel, MD, Hans-Joachim Schäfers, MD, PhD

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Endothelial nitric oxide synthase (eNOS)-NO signaling axis functions to promote the growth of prostate cancer stem-like cells by Weijie Gao, Yuliang Wang, Shan Yu, Zhu Wang, Taiyang Ma, Andrew Man-Lok Chan, Peter Ka-Fung Chiu, Chi-Fai Ng, Dinglan Wu, Franky Leung Chan

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Metastatic Melanoma Progression Is Associated with Endothelial Nitric Oxide Synthase Uncoupling Induced by Loss of eNOS:BH4 Stoichiometry by Fabiana Henriques Machado de Melo, Diego Assis Gonçalves, Ricardo Xisto de Sousa, Marcelo Yudi Icimoto, Denise de Castro Fernandes, Francisco R. M. Laurindo, Miriam Galvonas Jasiulionis

“…Dysfunctional endothelial nitric oxide synthase (eNOS) produces superoxide anion (O₂^−•) and contributes to the establishment of a pro-oxidant environment in melanoma. …”
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Hepatocellular Protein Arginine Methyltransferase 1 Suppresses Alcohol‐Induced Hepatocellular Carcinoma Formation by Inhibition of Inducible Nitric Oxide Synthase by Jie Zhao, Maura O'Neil, Michael Schonfeld, Amberly Komatz, Steven A. Weinman, Irina Tikhanovich

“…Asymmetric dimethyl arginine, produced by PRMT1, is a potent inhibitor of nitric oxide synthases. PRMT1 is implicated in the development of several types of tumors and cardiovascular disease. …”
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Chronic treatment with the nitric oxide synthase inhibitor, L-NAME, attenuates estradiol-mediated improvement of learning and memory in ovariectomized rats by Hamid Azizi-Malekabadi, Mahmoud Hosseini, Fatima Saffarzadeh, Reza Karami, Fatimeh Khodabandehloo

“…OBJECTIVE: The present study was carried out to evaluate the effect of the nitric oxide synthase (NOS) inhibitor, N (G)-nitro-L-arginine methyl ester (L-NAME), on the ability of estradiol to improve learning in OVX rats using the Morris water maze. …”
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Post-training nitric oxide synthase inhibition in the CA1 region of rat hippocampus does not impair spatial memory consolidation by Majlessi Nahid, Bozorgmehr Tahereh, Choopani Samira, Azizi Zahra

Zinc Thiolate Reactivity toward Nitrogen Oxides: Insights into the Interaction of Zn[superscript 2+] with S-Nitrosothiols and Implications for Nitric Oxide Synthase by Kozhukh, Julia, Lippard, Stephen J.

“…Zinc thiolate complexes containing N[subscript 2]S tridentate ligands were prepared to investigate their reactivity toward reactive nitrogen species, chemistry proposed to occur at the zinc tetracysteine thiolate site of nitric oxide synthase (NOS). The complexes are unreactive toward nitric oxide (NO) in the absence of dioxygen, strongly indicating that NO cannot be the species directly responsible for S-nitrosothiol formation and loss of Zn[superscript 2+] at the NOS dimer interface in vivo. …”
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Reversal of cardiac hypertrophy and fibrosis from pressure overload by tetrahydrobiopterin: efficacy of recoupling nitric oxide synthase as a therapeutic strategy. by Moens, A, Takimoto, E, Tocchetti, C, Chakir, K, Bedja, D, Cormaci, G, Ketner, E, Majmudar, M, Gabrielson, K, Halushka, M, Mitchell, J, Biswal, S, Channon, K, Wolin, MS, Alp, N, Paolocci, N, Champion, H, Kass, D

“…Oxidative stress linked to nitric oxide synthase (NOS) uncoupling may play an important role. …”

Genetic polymorphism on endothelial nitric oxide synthase affects endothelial activation and inflammatory response during the acute phase of myocardial infarction. by Antoniades, C, Tousoulis, D, Vasiliadou, C, Pitsavos, C, Chrysochoou, C, Panagiotakos, D, Tentolouris, C, Marinou, K, Koumallos, N, Stefanadis, C

“… OBJECTIVES: This study sought to evaluate the effect of genetic polymorphism G894T on endothelial nitric oxide synthase (eNOS); on the risk for myocardial infarction (MI); and on the release of von Willebrand factor (vWF), interleukin (IL)-6, IL-1b, and oxidized low-density lipoprotein (ox-LDL) levels during the acute phase of MI and one year after the event. …”

Targeted neuronal nitric oxide synthase transgene delivery into stellate neurons reverses impaired intracellular calcium transients in prehypertensive rats. by Li, D, Nikiforova, N, Lu, C, Wannop, K, McMenamin, M, Lee, C, Buckler, K, Paterson, D

“…Neurons from the prehypertensive SHR ganglia had a significantly higher depolarization evoked [Ca(2+)](i) transient that was also associated with decreased expression of neuronal nitric oxide synthase (nNOS), β1 subunit of soluble guanylate cyclase and cGMP when compared with the Wistar-Kyoto rat ganglia. …”

OSTEOCYTIC EXPRESSION OF NITRIC OXIDE SYNTHASE ISOFORMS IN THE FEMORAL NECK CORTEX: A CASE-CONTROL STUDY OF INTRACAPSULAR HIP FRACTURE by Caballero-Alias, A, Loveridge, N, Lyon, A, Reeve, J

Up-regulation of miR-31 in human atrial fibrillation begets the arrhythmia by depleting dystrophin and neuronal nitric oxide synthase. by Reilly, S, Liu, X, Carnicer, R, Recalde, A, Muszkiewicz, A, Jayaram, R, Carena, M, Wijesurendra, R, Stefanini, M, Surdo, N, Lomas, O, Ratnatunga, C, Sayeed, R, Krasopoulos, G, Rajakumar, T, Bueno-Orovio, A, Verheule, S, Fulga, T, Rodriguez, B, Schotten, U, Casadei, B

“…We show that atrial-specific up-regulation of microRNA-31 (miR-31) in goat and human AF depletes neuronal nitric oxide synthase (nNOS) by accelerating mRNA decay and alters nNOS subcellular localization by repressing dystrophin translation. …”

Glu298Asp endothelial nitric oxide synthase gene polymorphism interacts with environmental and dietary factors to influence endothelial function. by Leeson, C, Hingorani, A, Mullen, M, Jeerooburkhan, N, Kattenhorn, M, Cole, T, Muller, D, Lucas, A, Humphries, SE, Deanfield, J

“…An endothelial nitric oxide synthase (eNOS) gene polymorphism (Glu298Asp) has been associated with cardiovascular disease. …”

The Glu298-Asp endothelial nitric oxide synthase gene polymorphism interacts with environmental and dietary factors to influence endothelial function by Leeson, C, Hingorani, A, Mullen, M, Jeerooburkhan, N, Kattenhorn, M, Muller, D, Lucas, A, Humphries, SE, Deanfield, J

Neuronal nitric oxide synthase (NOS1) regulates beta-adrenergic contraction and calcium handling in isolated murine ventricular myocytes by Zhang, Y, Sears, C, Ashley, E, Kim, Y, Casadei, B

Impaired regulation of neuronal nitric oxide synthase and heart rate during exercise in mice lacking one nNOS allele. by Danson, E, Mankia, K, Golding, S, Dawson, T, Everatt, L, Cai, S, Channon, K, Paterson, D

“…We tested the hypothesis that a single allele deletion of neuronal nitric oxide synthase (nNOS) would impair the neural control of heart rate following physical training, and that this phenotype could be restored following targeted gene transfer of nNOS. …”

Up-regulation of miR-31 in human atrial fibrillation begets the arrhythmia by depleting dystrophin and neuronal nitric oxide synthase by Reilly, S, Liu, X, Carnicer, R, Recalde, A, Muszkiewicz, A, Jayaram, R, Carena, M, Wijesurendra, R, Stefanini, M, Surdo, N, Lomas, O, Ratnatunga, C, Sayeed, R, Krasopoulos, G, Rajakumar, T, Bueno-Orovio, A, Verheule, S, Fulga, T, Rodriguez, B, Schotten, U, Casadei, B

“…We show that atrial-specific up-regulation of microRNA-31 (miR-31) in goat and human AF depletes neuronal nitric oxide synthase (nNOS) by accelerating mRNA decay and alters nNOS subcellular localization by repressing dystrophin translation. …”