Homoarginine, the methylene homologue of arginine, as a substrate of human arginine:glycine amidinotransferase and arginases by E. S. Alekseevskaya, T. F. Subbotina, A. A. Zhloba

“…Thus, the present study established that hArg may be considered as a substrate of AGAT additionally to nitric oxide synthases. Metabolic value of hArg, in addition to regulation of vascular tone, can be associated with cell energy metabolism. …”
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A Novel Polysaccharide from <i>Auricularia</i><i>Auricula</i> Alleviates Thrombosis Induced by Carrageenan in Mice by Chun Bian, Lanyang Ji, Hang Qu, Zhenyu Wang

“…The antithrombotic activity of AAP-b2 was found to be related to the inhibition of platelet activation by regulation of endothelial nitric oxide synthases (eNOs), endothelin-1 (ET-1), prostacyclin (PGI2) and thromboxane B2 (TXB2), along with the enhancement of anticoagulant activity by affecting antithrombin III (AT-III) and protein C (PC) pathways.…”
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Anti-Inflammatory Effects of the Novel PIM Kinase Inhibitor KMU-470 in RAW 264.7 Cells through the TLR4-NF-κB-NLRP3 Pathway by Hye Suk Baek, Hyeon Ji Min, Victor Sukbong Hong, Taeg Kyu Kwon, Jong Wook Park, Jinho Lee, Shin Kim

“…We demonstrated that KMU-470 suppressed the production of nitric oxide and inducible nitric oxide synthases that are induced by LPS in RAW 264.7 cells. …”
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p38 mediates mechanical allodynia in a mouse model of type 2 diabetes by Hong Yu, Hayes John M, Oh Sang, Dauch Jacqueline R, Cheng Hsinlin T, Feldman Eva L

“…In addition, we detected higher levels of inflammatory mediators, including cyclooxygenase (COX) 2, inducible nitric oxide synthases (iNOS), and tumor necrosis factor (TNF)-α in LDRG neurons of db/db mice compared to non-diabetic db+ mice. …”
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Ultrasound Guidance Enhances the Efficiency of Brachial Plexus Block and Ameliorates the Vascular Injury Compared with Nerve Stimulator Guidance in Hand Surgery Patients by Liandi Li, Yanjing Zhao, Ling Guo, Xie Lv, Guanghao Yu

“…Reactive oxygen species (ROS) levels were measured by dichloro-dihydro-fluorescein diacetate staining and serum levels of nitric oxide (NO), nitric oxide synthases (NOS), tumor necrosis factor (TNF)-α, and monocyte chemoattractant protein 1 (MCP1) were evaluated by ELISA. …”
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Peripheralized sepiapterin reductase inhibition as a safe analgesic therapy by Shane J. F. Cronin, Nick A. Andrews, Alban Latremoliere

“…BH4 is an essential cofactor for aromatic amino acid hydroxylases, nitric oxide synthases, and alkylglycerol monooxygenase so a lack of BH4 leads to a range of symptoms in the periphery and central nervous system (CNS). …”
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Activity of Zearalenone in the Porcine Intestinal Tract by Magdalena Gajęcka, Łukasz Zielonka, Maciej Gajęcki

“…The accompanying hyperestrogenism led to changes in mRNA activity of selected enzymes (cytochrome P450, hydroxysteroid dehydrogenases, nitric oxide synthases) and receptors (estrogen and progesterone receptors), and it stimulated post-translational modifications which play an important role in non-genomic mechanisms of signal transmission. …”
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Influence of low-intensity electromagnetic fields on endothelial function in patients with chronic heart failure by Bokeria O.L., Kuular A.M.

“…The concentration of an inhibitor of nitric oxide synthases, asymmetric dimethylar-ginine in blood before and after the exposure to the intervention by low-intensity electromagnetic fields was studied. …”
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Sub-cellular targeting of constitutive NOS in health and disease. by Zhang, Y, Casadei, B

“…Constitutive nitric oxide synthases (NOSs) are ubiquitous enzymes that play a pivotal role in the regulation of myocardial function in health and disease. …”

Roles for endothelial cell and macrophage Gch1 and tetrahydrobiopterin in atherosclerosis progression by Douglas, G, Hale, A, Patel, J, Chuaiphichai, S, Al Haj Zen, A, Rashbrook, V, Trelfa, L, Crabtree, M, McNeill, E, Channon, K

“…GTP cyclohydrolase I (GTPCH) catalyses the first and rate-limiting reaction in the synthesis of tetrahydrobiopterin (BH4), an essential cofactor for nitric oxide synthases (NOS). Both eNOS and iNOS have been implicated in the progression of atherosclerosis, with opposing effects in eNOS and iNOS knockout mice. …”

Mast cell tetrahydrobiopterin contributes to itch in mice by Zschiebsch, K, Fischer, C, Wilken-Schmitz, A, Geisslinger, G, Channon, K, Watschinger, K, Tegeder, I

“…GTP cyclohydrolase (GCH1) governs de novo synthesis of the enzyme cofactor, tetrahydrobiopterin (BH4), which is essential for biogenic amine production, bioactive lipid metabolism and redox coupling of nitric oxide synthases. Overproduction of BH4 via upregulation of GCH1 in sensory neurons is associated with nociceptive hypersensitivity in rodents, and neuron‐specific GCH1 deletion normalizes nociception. …”

Transport Stress Induced Cardiac NO-NOS Disorder Is Mitigated by Activating Nrf2/HO-1/NQO1 Antioxidant Defense Response in Newly Hatched Chicks by Hao-Liang Xu, Hui Li, Rong-Kun Bao, Yi-Xi Tang, Ahmed Ibrahim Ahmed Elsherbeni, Hassan Bayoumi Ali Gharib, Jin-Long Li, Jin-Long Li, Jin-Long Li

“…In short, transport stress-induced nitric oxide (NO)—nitric oxide synthases (NOS) system metabolic disorders and cardiac oxidative stress are mitigated by activating the nuclear factor-erythroid 2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1)/NAD(P)H quinone oxidoreductase-1 (NQO1) antioxidant defense response in newly hatched chicks.…”
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An Analysis of the Multifaceted Roles of Heme in the Pathogenesis of Cancer and Related Diseases by Tianyuan Wang, Adnin Ashrafi, Pouya Modareszadeh, Alexander R. Deese, Maria Del Carmen Chacon Castro, Parinaz Sadat Alemi, Li Zhang

“…These include BTB and CNC homology 1 (BACH1), tumor suppressor P53 protein, progesterone receptor membrane component 1 protein (PGRMC1), cystathionine-β-synthase (CBS), soluble guanylate cyclase (sGC), and nitric oxide synthases (NOS). This review provides an in-depth analysis of heme function in influencing diverse molecular and cellular processes germane to disease pathogenesis and the modes by which heme modulates the activities of cellular proteins involved in the development of cancer and other common diseases.…”
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The Antioxidant Activities of <i>Betula etnensis</i> Rafin. Ethanolic Extract Exert Protective and Anti-diabetic Effects on Streptozotocin-Induced Diabetes in Rats by Giuseppe Antonio Malfa, Barbara Tomasello, Rosaria Acquaviva, Alfonsina La Mantia, Francesco Pappalardo, Monica Ragusa, Marcella Renis, Claudia Di Giacomo

“…Furthermore, oxidative stress markers particularly, lipid hydroperoxides (LOOH) and nitrite/nitrate levels, non-proteic thiol groups (RSH), γ-glutamyl-cysteine-synthetase (γ-GCS) activities and expression, heme oxygenase-1 (HO-1), endothelial and inducible nitric oxide synthases (i-NOS e-NOS) expression, significantly changed by streptozocin treatment, were markedly restored both in plasma and tissues together with nuclear sirtuins activity (Sirt1). …”
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Ascorbate mediates the non-enzymatic reduction of nitrite to nitric oxide by Juan Du, Milos R. Filipović, Brett A. Wagner, Garry R. Buettner

“…Nitric oxide (NO•) generated by nitric oxide synthases is involved in many physiological and pathophysiological processes. …”
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LC-MS Fingerprinting Development for Standardized Precipitate from <em>Agastache mexicana</em>, Which Induces Antihypertensive Effect through NO Production and Calcium Channel Bloc... by Karla Catalina Cruz-Torres, Samuel Estrada-Soto, Luis Arias-Durán, Gabriel Navarrete-Vázquez, Julio César Almanza-Pérez, Beatriz Mora-Ramiro, Irene Perea-Arango, Emanuel Hernández-Núñez, Rafael Villalobos-Molina, Gabriela Carmona-Castro, Irma-Martha Medina-Díaz, Gabriela Ávila-Villarreal

“…In the ex vivo experiments, preincubation with L-NAME (nonspecific inhibitor of nitric oxide synthases) reduced the relaxation induced by PP<i>Am</i>; nevertheless, preincubation with indomethacin (nonspecific inhibitor of cyclooxygenases) did not generate any change in the vasorelaxation, and an opposed effect was observed to the contraction generated by CaCl₂ addition. …”
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Dilation of Pregnant Rat Uterine Arteries with Phenols from Extra Virgin Olive Oil Is Endothelium-Dependent and Involves Calcium and Potassium Channels by Milena Esposito, Mariacarmela Gatto, Marilyn J. Cipolla, Ira M. Bernstein, Maurizio Mandalà

“…To elucidate the underlying mechanisms, additional experiments were conducted with specific inhibitors: L-NAME/L-NNA (10⁻⁴ M) for nitric oxide synthases, ODQ (10⁻⁵ M) for guanylate cyclase, Verapamil (10⁻⁵ M) for the L-type calcium channel, Ryanodine (10⁻⁵ M) + 2-APB (3 × 10⁻⁵ M) for ryanodine and the inositol triphosphate receptors, respectively, and Paxilline (10⁻⁵ M) for the large-conductance calcium-activated potassium channel. …”
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<i>Holarrhena pubescens</i> Wall. ex G. Don Extracts Inhibit LPS-Irritated Oxidative Stress in Dendritic Cells by Yinyan Yin, Bangyue Zhou, Lirong Bai, Danni Feng, Tao Qin, Chunmei Li

“…Our results indicated that <i>H. pubescens</i> extracts with different doses (25 μg/mL, 50 μg/mL, 100 μg/mL) reduced the reactive oxygen species (ROS) level, and weakened the nitric oxide synthases (NOS) activity and nitric oxide (NO) level in LPS (100 ng/mL)-irritated DCs. …”
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Methylenedioxy Piperamide-Derived Compound D5 Regulates Inflammatory Cytokine Secretion in a Culture of Human Glial Cells by Sajad Shahbazi, Tara Zakerali

“…During the inflammatory process, various pro-inflammatory cytokines, chemokines, and enzymes—such as interleukin 1-β (IL1-β), tumor necrosis factor-α (TNF-α), interleukin 6 (IL-6), inducible nitric oxide synthases (iNOS), inhibitory kappa kinase (IKK), and inducible nitric oxide (NO)—are over-expressed in response to every stimulus. …”
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The Potential Liver, Brain, and Embryo Toxicity of Titanium Dioxide Nanoparticles on Mice by Xiaochuan Jia, Shuo Wang, Lei Zhou, Li Sun

“…We also found that the activities of constitutive nitric oxide synthases (cNOS), inducible NOS (iNOS), and acetylcholinesterase, and the levels of nitrous oxide and glutamic acid were changed in the brain after nano-TiO2 exposure. …”
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