低温预榨-亚临界正丁烷提取光皮梾木油的理化性质及表征Physicochemical properties and characterization of Cornus wilsoniana fruit oil prepared by low temperature pre-pressing-subcritical n-butane extract... by 吴经芝1，2,吴红枚1,肖静晶1,2，3，4,李昌珠2，3，4,肖志红2，3，4 WU Jingzhi1,2, WU Hongmei1, XIAO Jingjing1,2,3,4, LI Changzhu2,3,4, XIAO Zhihong2,3,4

“…The acid value, iodine value, saponification value, and refractive index of Cornus wilsoniana fruit oil were 1.50 mgKOH/g, 100.24 gI/100 g, 189.71 mgKOH/g and 1.472 9, respectively. …”
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Electrical impedance tomography for titration of positive end-expiratory pressure in acute respiratory distress syndrome patients with chronic obstructive pulmonary disease by Xuesong Liu, Xiao Liu, Jue Meng, Dongdong Liu, Yongbo Huang, Ling Sang, Yonghao Xu, Zhiheng Xu, Weiqun He, Sibei Chen, Rong Zhang, Xiaoqing Liu, Yimin Li

“…In the COPD group, the PEEP level titrated by EIT was lower than that titrated by the ARDSnet protocol (6.93 ± 1.69 cm H2O vs. 10.43 ± 1.20 cm H2O, P < 0.001), as was the global inhomogeneity (GI) index (0.397 ± 0.040 vs. 0.446 ± 0.052, P = 0.001), plateau airway pressure (16.50 ± 4.35 cm H2O vs. 20.93 ± 5.37 cm H2O, P = 0.001), dead space ventilation ratio (48.29 ± 6.78% vs. 55.14 ± 8.85%, P < 0.001), ventilation ratio (1.63 ± 0.33 vs. 1.87 ± 0.33, P < 0.001), and mechanical power (13.92 ± 2.18 J/min vs. 15.87 ± 2.53 J/min, P < 0.001). …”
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Pharmacological hallmarks of allostery at the M4 muscarinic receptor elucidated through structure and dynamics by Ziva Vuckovic, Jinan Wang, Vi Pham, Jesse I Mobbs, Matthew J Belousoff, Apurba Bhattarai, Wessel AC Burger, Geoff Thompson, Mahmuda Yeasmin, Vindhya Nawaratne, Katie Leach, Emma T van der Westhuizen, Elham Khajehali, Yi-Lynn Liang, Alisa Glukhova, Denise Wootten, Craig W Lindsley, Andrew Tobin, Patrick Sexton, Radostin Danev, Celine Valant, Yinglong Miao, Arthur Christopoulos, David M Thal

“…By determining the cryo-electron microscopy structures of the M4 mAChR, bound to a cognate Gi1 protein and in complex with ACh, Ipx, LY298-Ipx, and VU154-Ipx, and applying molecular dynamics simulations, we determine key molecular mechanisms underlying allosteric pharmacology. …”
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Discovery of a highly selective VEGFR2 kinase inhibitor CHMFL-VEGFR2-002 as a novel anti-angiogenesis agent by Zongru Jiang, Li Wang, Xuesong Liu, Cheng Chen, Beilei Wang, Wenliang Wang, Chen Hu, Kailin Yu, Ziping Qi, Qingwang Liu, Aoli Wang, Jing Liu, Guangchen Hong, Wenchao Wang, Qingsong Liu

“…CHMFL-VEGFR2-002 displayed potent inhibitory activity against VEGFR2 kinase in the biochemical assay (IC50 = 66 nmol/L) and VEGFR2 autophosphorylation in cells (EC50s ∼100 nmol/L) as well as potent anti-proliferation effect against VEGFR2 transformed BaF3 cells (GI50 = 150 nmol/L). In addition, CHMFL-VEGFR2-002 also displayed good anti-angiogenesis efficacy in vitro and exhibited good in vivo PK (pharmacokinetics) profile with bioavailability over 49% and anti-angiogenesis efficacy in both zebrafish and mouse models without apparent toxicity. …”
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Selected Abstracts of the 8th International Congress of UENPS; Bucharest (Romania); October 3rd-5th 2018; Session “Nutrition of the preterm infant” by --- Various Authors

“…PROTEIN CONTENT OF FRESH HUMAN MILK AND VARIABILITY RELATED TO PRESERVATION METHODS IN THE NICU • L. Păduraru, G.I. Zonda, A.L. Avasiloaiei, M. Moscalu, D.C. Dimitriu, M. …”
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Hidropisia fetal: análise de 80 casos Fetal hydrops: analysis of 80 cases by André Ricardo Araujo da Silva, Júlio Cezar Laura Alzegui, Maria Célia de Freitas Leite da Costa, Maria Aparecida Pereira Tristão, Susie Andries Nogueira, Jussara Pereira do Nascimento

“…Isoimunização Rh (grupo imune - GI) foi diagnosticada em 13 casos (16,2%), restando portanto 67 casos (83,8%) considerados como devidos a causas não imunes (grupo não imune - GNI). …”
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Impaired mRNA splicing and proteostasis in preadipocytes in obesity-related metabolic disease by Julia Sánchez-Ceinos, Rocío Guzmán-Ruiz, Oriol Alberto Rangel-Zúñiga, Jaime López-Alcalá, Elena Moreno-Caño, Mercedes Del Río-Moreno, Juan Luis Romero-Cabrera, Pablo Pérez-Martínez, Elsa Maymo-Masip, Joan Vendrell, Sonia Fernández-Veledo, José Manuel Fernández-Real, Jurga Laurencikiene, Mikael Rydén, Antonio Membrives, Raul M Luque, José López-Miranda, María M Malagón

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Comparison of Coping Skills in Peptic Ulcer, Irritable Bowel Syndrome and Normal People by SHA Kharamin, H Nilli, A Mohamadi, GH Mobashery

“…AGA Clinical Symposium - Rome III: New Criteria for the Functional GI Disorders: 2006 May. 20-25: Los Angeles, California: USA. 26.Van Heck GL, Vinger Hoets AJ, Van Hout GC. …”
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Erratum to 'IgE allergy diagnostics and other relevant tests in allergy, a World Allergy Organization position paper' [World Allergy Organ J 13/2 (2020) 100080] by Ignacio J. Ansotegui, Giovanni Melioli, Giorgio Walter Canonica, Luis Caraballo, Elisa Villa, Motohiro Ebisawa, Giovanni Passalacqua, Eleonora Savi, Didier Ebo, R.Maximiliano Gómez, Olga Luengo Sánchez, John J. Oppenheimer, Erika Jensen-Jarolim, David A. Fischer, Tari Haahtela, Martti Antila, Jean J. Bousquet, Victoria Cardona, Wen Chin Chiang, Pascal M. Demoly, Lawrence M. DuBuske, Marta Ferrer Puga, Roy Gerth van Wijk, Sandra Nora González Díaz, Alexei Gonzalez-Estrada, Edgardo Jares, Ayse Füsun Kalpaklioğlu, Luciana Kase Tanno, Marek L. Kowalski, Dennis K. Ledford, Olga Patricia Monge Ortega, Mário Morais-Almeida, Oliver Pfaar, Lars K. Poulsen, Ruby Pawankar, Harald E. Renz, Antonino G. Romano, Nelson A. Rosário Filho, Lanny Rosenwasser, Mario A. Sánchez Borges, Enrico Scala, Gian-Enrico Senna, Juan Carlos Sisul, Mimi L.K. Tang, Bernard Yu-Hor Thong, Rudolf Valenta, Robert A. Wood, Torsten Zuberbier

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Integrating NGS-derived mutational profiling in the diagnosis of multiple lung adenocarcinomas by Nicole Ezer, Hangjun Wang, Andrea Gomez Corredor, Pierre Olivier Fiset, Ayesha Baig, Léon C. van Kempen, George Chong, Marianne S.M. Issac, Richard Fraser, Alan Spatz, Jean-Baptiste Riviere, Philippe Broët, Jonathan Spicer, Sophie Camilleri-Broët, MD, PhD

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Controlling opioid receptor functional selectivity by targeting distinct subpockets of the orthosteric site by Rajendra Uprety, Tao Che, Saheem A Zaidi, Steven G Grinnell, Balázs R Varga, Abdelfattah Faouzi, Samuel T Slocum, Abdullah Allaoa, András Varadi, Melissa Nelson, Sarah M Bernhard, Elizaveta Kulko, Valerie Le Rouzic, Shainnel O Eans, Chloe A Simons, Amanda Hunkele, Joan Subrath, Ying Xian Pan, Jonathan A Javitch, Jay P McLaughlin, Bryan L Roth, Gavril W Pasternak, Vsevolod Katritch, Susruta Majumdar

“…The lead compounds, MP1207 and MP1208, displayed MOR/KOR Gi-partial agonism with diminished arrestin signaling, showed efficient analgesia with attenuated liabilities, including respiratory depression and conditioned place preference and aversion in mice. …”
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Exploiting frequent and specific expression of PRL3 in pediatric solid tumors for first-in-child use of PRL3-zumab humanized antibody by Amos Hong Pheng Loh, Min Thura, Abhishek Gupta, Sheng Hui Tan, Kelvin Kam Yew Kuan, Koon Hwee Ang, Khurshid Merchant, Kenneth Tou En Chang, Hui Yi Yon, Yong Chen, Mathew Hern Wang Cheng, Arjandas Mahadev, Matthew Chau Hsien Ng, Michaela Su-Fern Seng, Prasad Iyer, Pei Ling Chia, Shui Yen Soh, Qi Zeng

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BNP facilitates NMB-encoded histaminergic itch via NPRC-NMBR crosstalk by Qing-Tao Meng, Xian-Yu Liu, Xue-Ting Liu, Juan Liu, Admire Munanairi, Devin M Barry, Benlong Liu, Hua Jin, Yu Sun, Qianyi Yang, Fang Gao, Li Wan, Jiahang Peng, Jin-Hua Jin, Kai-Feng Shen, Ray Kim, Jun Yin, Ailin Tao, Zhou-Feng Chen

“…Moreover, natriuretic peptides (NP) signal through the Gi-couped inhibitory cGMP pathway that is supposed to inhibit neuronal activity, raising the question of how BNP may transmit itch information. …”
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Pedestal structure and stability in high-performance plasmas on Alcator C-Mod by Walk, John Reel, Jr

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Perspektiver by Cathinka Dahl Hambro

“…Med dette søker han å «utvide rommet for hvordan vi snakker om kritiske utvekslinger» (s. 152) og å gi lærere verktøy for å diskutere religion i undervisningen. …”
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La Red de Investigación en Actividades Preventivas y Promoción de la Salud (redIAPP): una red de referencia e impulsora de la investigación en atención primaria by Bonaventura Bolibar Ribas, Joan Llobera-Cànaves, Luis García-Ortiz, Juan-Ángel Bellón, Rafel Ramos, Javier García-Campayo, Álvaro Sánchez-Pérez, Ana Claveria, Vicente Martínez, Enric Vicens, César Minué, Vicente Gil-Guillen, Anna Berenguera, Anna Moleras-Serra

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Maestros granadinos de la edilicia [albañiles, canteros y carpinteros], según los protocolos notariales del Archivo Histórico del Arzobispado de Granada by Lázaro Gila Medina

“…<span> </span><span>Durant</span>e<span> </span><span>e</span>l<span> </span><span>v</span><span>eran</span>o<span> </span><span>d</span>e<span> </span><span>200</span>1<span> </span>v<span>aciamo</span>s<span> </span><span>lo</span>s<span> </span><span>fo</span>n<span>do</span>s<span> </span><span>notariale</span>s<span> </span><span>conse</span><span>r</span>v<span>ado</span>s<span> </span><span>e</span>n<span> </span><span>dich</span>o<span> </span><span>arch</span>i<span>v</span>o<span> </span><span>par</span>a<span> </span><span>completa</span>r<span> </span><span>aquell</span>a<span> </span><span>e</span><span>xtens</span>a<span> </span><span>mon</span>o<span>g</span><span>rafía</span>,<span> </span><span>titulad</span>a<span> </span><span><em>“Maest</em></span><span><em>r</em></span><span><em>os d</em></span><em>e</em><span><em> </em></span><span><em>canterí</em></span><em>a</em><span><em> </em></span><em>y</em><span><em> </em></span><span><em>albañilerí</em></span><em>a</em><span><em> </em></span><span><em>e</em></span><em>n</em><span><em> </em></span><span><em>l</em></span><em>a</em><span><em> </em></span><span><em>G</em></span><span><em>r</em></span><span><em>anad</em></span><em>a</em><span><em> </em></span><span><em>Moderna</em></span><em>,</em><span><em> </em></span><span><em>s</em></span><span><em>e</em></span><span><em>gú</em></span><em>n</em><span><em> </em></span><span><em>lo</em></span><em>s</em><span><em> </em></span><span><em>escribano</em></span><em>s</em><span><em> </em></span><span><em>d</em></span><em>e</em><span><em> </em></span><span><em>l</em></span><em>a</em><span><em> </em></span><span><em>Ciudad</em></span><em>”</em><span><em> </em></span>,<span> </span><span>pu</span><span>b</span><span>licad</span>a<span> </span><span>e</span>n<span> </span><span>2000, </span><span>g</span><span>racia</span>s<span> </span><span>a</span>l<span> </span><span>patrocini</span>o<span> </span><span>de</span>l<span> </span><span>Col</span><span>e</span><span>gi</span>o<span> </span><span>Notaria</span>l<span> </span><span>d</span>e<span> </span><span>Granada.…”
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Essential Control of the Function of the Striatopallidal Neuron by Pre-coupled Complexes of Adenosine A2A-Dopamine D2 Receptor Heterotetramers and Adenylyl Cyclase by Sergi Ferré, Jordi Bonaventura, Wendy Zhu, Candice Hatcher-Solis, Jaume Taura, Jaume Taura, César Quiroz, Ning-Sheng Cai, Estefanía Moreno, Verónica Casadó-Anguera, Alexxai V. Kravitz, Kimberly R. Thompson, Dardo G. Tomasi, Gemma Navarro, Arnau Cordomí, Leonardo Pardo, Carme Lluís, Carmen W. Dessauer, Nora D. Volkow, Vicent Casadó, Francisco Ciruela, Francisco Ciruela, Diomedes E. Logothetis, Daniel Zwilling

“…The A2AR-D2R heteromer has a tetrameric structure, with two homodimers, which allows not only multiple allosteric interactions between different orthosteric ligands, agonists, and antagonists, but also the canonical Gs-Gi antagonistic interaction at the level of AC5. …”
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The cellular prion protein controls the mesenchymal-like molecular subtype and predicts disease outcome in colorectal cancerResearch in context by Delphine Le Corre, Alexandre Ghazi, Ralyath Balogoun, Camilla Pilati, Thomas Aparicio, Séverine Martin-Lannerée, Laetitia Marisa, Fatima Djouadi, Virginie Poindessous, Carole Crozet, Jean-François Emile, Claire Mulot, Karine Le Malicot, Valérie Boige, Hélène Blons, Aurélien de Reynies, Julien Taieb, François Ghiringhelli, Jaafar Bennouna, Jean-Marie Launay, Pierre Laurent-Puig, Sophie Mouillet-Richard

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Using Prudence When Prescribing by Dallas Ducar

“…REFERENCES [1] http://www.cdc.gov/nchs/data/databriefs/db42.htm#frequently [2] http://www.apa.org/monitor/2011/09/psychotherapy.aspx [3] Spielmans GI et al, J Nerv Ment Dis 2011;199:142–149 [4] http://www.psychiatrictimes.com/articles/combining-drug-therapy-and-psychotherapy-depression [5] Teasdale, J. …”
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