Low Effectiveness of the Introduction of pmaxGFP into Primary Human Coronary Endothelial Cells Using Cell-Penetrating Peptides and Nuclear-Localization Sequences in Non-Covalent Interactions by Wioletta Zielińska, Maciej Gagat, Klaudia Mikołajczyk, Marta Hałas-Wiśniewska, Alina Grzanka

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Nuclear Import of Arabidopsis Poly(ADP-Ribose) Polymerase 2 Is Mediated by Importin-α and a Nuclear Localization Sequence Located Between the Predicted SAP Domains by Chao Chen, Raffaella De Masi, Ruth Lintermann, Lennart Wirthmueller

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The Effect of the Anticipated Nuclear Localization Sequence of ‘<i>Candidatus</i> Phytoplasma mali’ SAP11-like Protein on Localization of the Protein and Destabilization of TCP Transcription Factor by Alisa Strohmayer, Timothy Schwarz, Mario Braun, Gabi Krczal, Kajohn Boonrod

“…We also identified a 17 amino acid stretch previously predicted to be a nuclear localization sequence that is important for the binding of some of the TCPs, which results in a crinkled leaf and silique phenotype in transgenic <i>A. thaliana</i>. …”
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(111)In-labeled trastuzumab (Herceptin) modified with nuclear localization sequences (NLS): an Auger electron-emitting radiotherapeutic agent for HER2/neu-amplified breast cancer. by Costantini, D, Chan, C, Cai, Z, Vallis, K, Reilly, R

“…UNLABELLED: The cytotoxicity and tumor-targeting properties of the anti-HER2/neu monoclonal antibody trastuzumab modified with peptides (CGYGPKKKRKVGG) harboring the nuclear localization sequence ([NLS] italicized) of simian virus 40 large T-antigen and radiolabeled with (111)In were evaluated. …”

Deletion of the nuclear localization sequence and C-terminus of parathyroid hormone–related protein decreases osteogenesis and chondrogenesis but increases adipogenesis and myogenesis in murine bone marrow stromal cells by Blake E Hildreth, Krista M Hernon, Wessel P Dirksen, John Leong, Wachiraphan Supsavhad, Prosper N Boyaka, Thomas J Rosol, Ramiro E Toribio

“…We hypothesized that the nuclear localization sequence and C-terminus are involved. MicroRNA and gene expression analyses were performed on bone marrow stromal cells from mice lacking the nuclear localization sequence and C-terminus ( Pthrp Δ/Δ ) and age-matched controls. …”
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Indium-111 labeled anti-CD33 monoclonal antibodies (mAbs) modified with nuclear-localizing sequences (NLS) kill mitoxantrone-resistant HL-60 acute myelogenous leukemia (AML) cells by Kersemans, V, Cornelissen, B, Dick, J, Reilly, R

Protoparvovirus Knocking at the Nuclear Door by Elina Mäntylä, Michael Kann, Maija Vihinen-Ranta

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Tailoring the Structure of Cell Penetrating DNA and RNA Binding Nucleopeptides by Stefano Tomassi, Caterina Ieranò, Alessandra Del Bene, Antonia D’Aniello, Maria Napolitano, Giuseppina Rea, Federica Auletta, Luigi Portella, Anna Capiluongo, Vincenzo Mazzarella, Rosita Russo, Angela Chambery, Stefania Scala, Salvatore Di Maro, Anna Messere

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A nuclear targeting system in <it>Plasmodium falciparum</it> by Kochakarn Theerarat, Songprakhon Pucharee, Tinikul Ruchanok, Kumpornsin Krittikorn, Uthaipibull Chairat, Wittayacom Kanjana, Chookajorn Thanat

“…</p> <p>Results</p> <p>The nuclear localization sequence of Gal4 is functional in <it>P. falciparum</it>. …”
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Interaction with LC8 is required for Pak1 nuclear import and is indispensable for zebrafish development. by Christine M Lightcap, Gabor Kari, Luis E Arias-Romero, Jonathan Chernoff, Ulrich Rodeck, John C Williams

“…Recently, we showed that the LC8 binding site on Pak1 is adjacent to the nuclear localization sequence (NLS) required for Pak1 nuclear import. …”
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Fragile X family members have important and non-overlapping functions by Winograd Claudia, Ceman Stephanie

“…They share significant homology in the protein functional domains, including the Tudor domains, the nuclear localization sequence, a protein-protein interaction domain, the KH1 and KH2 domains and the nuclear export sequence. …”
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Identification of a subunit of NADH-dehydrogenase as a p49/STRAP-binding protein by Zhong Ying, Helms Scott, Azhar Gohar, Zhang Xiaomin, Wei Jeanne Y

“…The p49/STRAP protein contains four classic nuclear localization sequence motifs, and it was observed to be present predominantly in the nucleus. …”
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Insights into the pleiotropic roles of ZNF703 in cancer by Shuang Wang, Rong Liu

“…ZNF703 lacks a nuclear localization sequence despite its function requiring nuclear DNA binding. …”
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FUS-NLS/Transportin 1 complex structure provides insights into the nuclear targeting mechanism of FUS and the implications in ALS. by Chunyan Niu, Jiayu Zhang, Feng Gao, Liuqing Yang, Minze Jia, Haining Zhu, Weimin Gong

“…The C-terminal nuclear localization sequence of FUsed in Sarcoma (FUS-NLS) is critical for its nuclear import mediated by transportin (Trn1). …”
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Split-Cre complementation restores combination activity on transgene excision in hair roots of transgenic tobacco. by Mengling Wen, Yuan Gao, Lijun Wang, Lingyu Ran, Jiahui Li, Keming Luo

“…Moreover, the restored recombination efficiency of split-Cre proteins fused with the nuclear localization sequence (NLS) was higher than that of intact Cre in transgenic lines. …”
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Shugoshin 1 is dislocated by KSHV-encoded LANA inducing aneuploidy. by Fengchao Lang, Zhiguo Sun, Yonggang Pei, Rajnish Kumar Singh, Hem Chandra Jha, Erle S Robertson

“…The N-terminal nuclear localization sequence domain of LANA was essential for LANA and Bub1 interaction, reversed LANA inhibited phosphorylation of H2A and Cdc20, and attenuated LANA-induced aneuploidy and cell proliferation. …”
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Design and biological characterization of novel cell-penetrating peptides preferentially targeting cell nuclei and subnuclear regions by Anja Gronewold, Mareike Horn, Ines Neundorf

“…Within this study, we report about the design and biological characterization of novel cell-penetrating peptides (CPPs) with selective suborganelle-targeting properties. The nuclear localization sequence N50, as well as the nucleoli-targeting sequence NrTP, respectively, were fused to a shortened version of the cell-penetrating peptide sC18. …”
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Principles and medical applications of gene editing by CRISPR / Cas by Rolando Sánchez Artigas, María Teresa Díaz Armas, Raisa Rodríguez Duque, Pedro Enrique Miguel Soca

“…The introduction of the system into the cell interior occurs with plasmids, RNA or ribonucleoproteins. A nuclear localization sequence allows CRISPR / Cas9 to enter the nucleus. …”
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Adenomatous Polyposis Coli Interacts with Flap Endonuclease 1 to Block Its Nuclear Entry and Function by Aruna S. Jaiswal, Melissa L. Armas, Tadahide Izumi, Phyllis R. Strauss, Satya Narayan

“…We show here that APC binds to the nuclear localization sequence of Fen1 (Lys365Lys366Lys367), which prevents entry of Fen1 into the nucleus and participation in Pol-β-directed long-patch BER. …”
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CaMKIIdelta Subtypes: Localization and Function by Charles Burdis Burns Gray, Joan eHeller Brown

“…The CaMKIIδB mRNA sequence contains a 33bp insert not present in δC that codes for an 11-amino acid nuclear localization sequence (NLS). This review will focus on the localization and function of the CaMKIIδ subtypes δB and δC and the role of these subtypes in arrhythmias, contractile dysfunction, gene transcription, and the regulation of Ca2+ handling.…”
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