The rapid divergence of the ecdysone receptor is a synapomorphy for Mecopterida that clarifies the Strepsiptera problem by Bonneton, F, Brunet, F, Kathirithamby, J, Laudet, V

“… <p style="text-align:justify;"> In arthropods, the regulation by ecdysteroids is mediated by the heterodimer between the ecdysone receptor (ECR; NR1H1) and ultraspiracle (USP/RXR; NR2B4) nuclear receptors. Both ECR and USP/RXR ligand‐binding domains experienced a strong acceleration of evolutionary rate in Diptera and Lepidoptera, which belong to the superorder Mecopterida. …”

Molecular components of the circadian clock regulate HIV-1 replication by Borrmann, H, Ulkar, G, Kliszczak, AE, Ismed, D, Schilling, M, Magri, A, Harris, JM, Balfe, P, Vasudevan, S, Borrow, P, Zhuang, X, McKeating, JA

“…Importantly, we show differential binding of the nuclear receptors REV-ERB and ROR to the HIV-long terminal repeat at different circadian times, demonstrating a dynamic interplay in time-of-day regulation of HIV-1 transcription. …”

Small-molecule inhibition of general transcriptional regulators in cancer by Reddy, Jessica

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Distinct recognition modes of FXXLF and LXXLL motifs by the androgen receptor. by Dubbink, H, Hersmus, R, Verma, C, van der Korput, H, Berrevoets, C, van Tol, J, Ziel-van der Made, A, Brinkmann, A, Pike, A, Trapman, J

“…Among nuclear receptors, the androgen receptor (AR) is unique in that its ligand-binding domain (LBD) interacts with the FXXLF motif in the N-terminal domain, resembling coactivator LXXLL motifs. …”

The role of lipid metabolism in T lymphocyte differentiation and survival by Howie, D, Ten Bokum, A, Necula, A, Cobbold, S, Waldmann, H

“…FA residues also become incorporated into hormones and signaling moieties. FAs signal via nuclear receptors and their channeling, between storage as triacyl glycerides or oxidation as fuel, may play a role in survival or death of the cell. …”

Transcriptional and translational expression of PPARY in the human colorectal cancer dell llne, colo 205 by Yaacob, Nik Soriani

“…Peroxisome proliferator-activated receptors (PPARs) are ligand-dependent transcription factors of the nuclear hormone receptor superfamily that includes the receptor for steroid, retinoid and thyroid hormone. These nuclear receptors are characterised by their ability to bind to specific DNA sequences and, when activated by a ligand, PPARs regulate the expression of various genes and their functions (Auwerx 1999; Vamecq eta/., 1999). …”
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Paradoxical activation of AMPK by glucose drives selective EP300 activity in colorectal cancer by Gutiérrez-Salmerón, M, Manuel García-Martínez, JM, Martínez-Useros, J, Fernández-Aceñero, MJ, Viollet, B, Olivier, S, Chauhan, J, Lucena, SR, De la Vieja, A, Goding, CR, Chocarro-Calvo, A, García-Jiménez, C

“…Consequently, EP300 is redirected away from nuclear receptors that promote differentiation towards β-catenin, a driver of proliferation and colorectal tumorigenesis. …”

Long non-coding RNAs as regulators of the endocrine system by Sun, Lei, Knoll, Marko, Lodish, Harvey F

“…We also address the associations of lncRNAs with nuclear receptors involved in major hormonal signalling pathways, such as estrogen and androgen receptors, and the relevance of these associations in certain endocrine cancers.…”
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The chromatin landscape of high-grade serous ovarian cancer metastasis identifies regulatory drivers in post-chemotherapy residual tumour cells by Croft, W, Pounds, R, Jeevan, D, Singh, K, Balega, J, Sundar, S, Williams, A, Ganesan, R, Kehoe, S, Ott, S, Zuo, J, Yap, J, Moss, P

“…An OC chemoresistant tumour subpopulation known to be present prior to treatment, and characterised by stress-associated gene expression, is enriched post chemotherapy. Nuclear receptors RORa, NR2F6 and HNF4G are uncovered as candidate transcriptional drivers of these cells whilst closure of binding sites for E2F2 and E2F4 indicate post-treated tumour having low proliferative capacity. …”

Peroxisome proliferator-activated receptors and their novel ligands as candidates for the treatment of non-alcoholic fatty liver disease by Fougerat, Anne, Montagner, Alexandra, Loiseau, Nicolas, Guillou, Hervé, Wahli, Walter

“…Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors that regulate many functions that are disturbed in NAFLD, including glucose and lipid metabolism, as well as inflammation. …”
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Globalized bipartite local model for drug-target interaction prediction by Mei, Jian-Ping, Kwoh, Chee Keong, Yang, Peng, Li, Xiaoli, Zheng, Jie

“…Good performance of BLMN has been observed in the experiment of predicting interactions between drugs and four important categories of targets. For the Nuclear Receptors dataset, where there are more chances for the presented strategy to be applied, 20% improvement in terms of AUPR was achieved. …”
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The relationship between steroidogenic factor 1 and DAX-1 expression and in vitro gonadotropin secretion in human pituitary adenomas. by Aylwin, S, Welch, J, Davey, C, Geddes, J, Wood, D, Besser, G, Grossman, AB, Monson, J, Burrin, J

“…The orphan nuclear receptors, steroidogenic factor 1 (SF-1) and DAX-1, are involved in gonadotroph differentiation, and SF-1 has been shown to activate the LH-beta and glycoprotein hormone alpha-subunit (alpha GSU) gene promoters. …”

Circadian regulation of human immunodeficiency virus type 1 replication by Borrmann, H

“…We show binding of clock factors to the viral genome and reveal time differential binding of circadian nuclear receptors REV-ERB and ROR, which compete for binding to a ROR response element in the HIV-1 promoter. …”

The role of fibroblast PPARβ/δ in skin homeostasis by Sng, Ming Keat

“…Peroxisome proliferator-activated receptor β/δ (PPARβ/δ) is one member of the PPAR family of nuclear receptors, and the predominant subtype found in the epidermis and dermis. …”
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Differential expression of the adult specifier E93 in the strepsipteran Xenos vesparum Rossi suggests a role in female neoteny by Chafino, S, López-Escardó, D, Benelli, G, Kovac, H, Casacuberta, E, Franch-Marro, X, Kathirithamby, J, Martín, D

“…The specific up-regulation of XvE93 and XvBr-C in the female cephalothorax seems to be the result of an increase in 20-hydroxyecdysone (20E) signaling in this region for we detected higher expression levels of the 20E-dependent nuclear receptors XvHR3 and XvE75 in the cephalothorax. …”

Exploration and development of PPAR modulators in health and disease : an update of clinical evidence by Cheng, Hong Sheng, Tan, Wei Ren, Low, Zun Siong, Marvalim, Charlie, Lee, Justin Yin Hao, Tan, Nguan Soon

“…Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors that govern the expression of genes responsible for energy metabolism, cellular development, and differentiation. …”
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PPARs and tumor microenvironment : the emerging roles of the metabolic master regulators in tumor stromal–epithelial crosstalk and carcinogenesis by Cheng, Hong Sheng, Yip, Yun Sheng, Lim, Eldeen Kai Yi, Wahli, Walter, Tan, Nguan Soon

“…Consisting of three isotypes, PPARα, γ, and β/δ, these nuclear receptors are regarded as the master metabolic regulators which govern many aspects of the body energy homeostasis and cell fate. …”
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Delineation of critical amino acids in activation function 1 of progesterone receptor for recruitment of transcription coregulators by Woo, Amanda Rui En, Sze, Siu Kwan, Chung, Hwa Hwa, Lin, Valerie Chun Ling

“…The activation functions AF1 and AF2 of nuclear receptors mediate the recruitment of coregulators in gene regulation. …”
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Activation function 1 of progesterone receptor is required for mammary development and regulation of RANKL during pregnancy by Lee, Shi Hao, Yap, Yeannie H. Y., Lim, Chew Leng, Woo, Amanda Rui En, Lin, Valerie Chun Ling

“…Progesterone receptor (PGR) is a member of the nuclear receptor superfamily of transcription factors. …”
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Fatty acid oxidation is a druggable gateway regulating cellular plasticity for driving metastasis in breast cancer by Loo, Ser Yue, Toh, Li Ping, Xie, William Haowei, Pathak, Elina, Tan, Wilson, Ma, Siming, Lee, May Yin, Shatishwaran, S., Yeo, Joanna Zhen Zhen, Yuan, Ju, Ho, Yin Ying, Peh, Esther Kai Lay, Muniandy, Magendran, Torta, Federico, Chan, Jack, Tan, Tira J., Sim, Yirong, Tan, Veronique, Tan, Benita, Madhukumar, Preetha, Yong, Wei Sean, Ong, Kong Wee, Wong, Chow Yin, Tan, Puay Hoon, Yap, Yoon Sim, Deng, Lih-Wen, Dent, Rebecca, Foo, Roger, Wenk, Markus R., Lee, Soo Chin, Ho, Ying Swan, Lim, Elaine Hsuen, Tam, Wai Leong

“…Retinoids bind cognate nuclear receptors, which target lipid metabolism genes, thereby redirecting fatty acids for β-oxidation in the mesenchymal cell state towards lipid storage in the epithelial cell state. …”
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