Epigenetic and 3D chromatin landscape modulation from pluripotent to expanded-potential stem cells por Zeng, Yingying

“...According to these findings, this nuclear receptor factor and MIR work cooperatively to maintain pluripotent ESCs, and they play different regulatory roles in EPSCs....”
Ligazón do recurso

Molecular Cloning And Characterisation Of 5'-Untranslated And Promoter Regions Of Peroxisome Proliferator Activated Receptor Alpha (PPARa) From Human[QP552.T68 C548 2003 f rb]. por PPSKJ, Pusat Pengajian Sains Kajihayat

“...Peroxisome proliferator-activated receptor alpha (PPARα) is a ligand-activated transcription factor which belongs to the nuclear receptor superfamily and regulates gene transcription by heterodimerizing with retinoic X receptor (RXR). ...”
Ligazón do recurso

Molecular actions of PPARα in lipid metabolism and inflammation por Bougarne, N, Weyers, B, Desmet, S, Deckers, J, Ray, D, Staels, B, De Bosscher, K

“...Peroxisome proliferator–activated receptor α (PPARα) is a nuclear receptor of clinical interest as a drug target in various metabolic disorders. ...”

Peroxisome proliferator-activated receptor-γ cofactors in neurodegeneration por Katsouri, L, Blondrath, K, Sastre, M

“...However, very little is know about other PPARγ cofactors in the brain, such as the receptor-interacting protein 140, as well as the nuclear receptor corepressor, which seems to be required for normal neural development at specific embryonic stages. ...”

Thyroid hormone receptor beta and NCOA4 regulate terminal erythrocyte differentiation por Gao, Xiaofei, Lee, Hsiang-Ying, Li, Wenbo, Barrasa, M. Inmaculada, Ma, Qi, Elmes, Russell R., Rosenfeld, Michael G., Platt, Randall Jeffrey, Lodish, Harvey F

“...Keywords: thyroid hormone; erythropoiesis; NCOA4; nuclear receptor...”
Ligazón do recurso
Ligazón do recurso

Direct regulation of pluripotency genes by Nr5a2. por Shue, Bing Hong.

“...Nuclear receptor subfamily 5 group A member 2 (Nr5a2), also known as Liver Receptor Homolog -1 or LRH-1, is an orphan nuclear receptor found to be involved in important metabolic processes such as bile acid metabolism, steroidogenesis and liver development. ...”
Ligazón do recurso

Investigating the role of PPARβ/δ in retinal vascular remodeling using Pparβ/δ-deficient mice por Ho, Sze Yuan, Kwan, Yuet Ping, Qiu, Beiying, Tan, Alison, Murray, Hannah Louise, Barathi, Veluchamy Amutha, Tan, Nguan Soon, Cheung, Gemmy Chui Ming, Wong, Tien Yin, Wahli, Walter, Wang, Xiaomeng

“...Peroxisome proliferator-activated receptor (PPAR)β/δ is a member of the nuclear receptor superfamily of transcription factors, which plays fundamental roles in cell proliferation and differentiation, inflammation, adipogenesis, and energy homeostasis. ...”
Ligazón do recurso

Subplate in the developing cortex of mouse and human. por Wang, W, Hoerder-Suabedissen, A, Oeschger, F, Bayatti, N, Ip, B, Lindsay, S, Supramaniam, V, Srinivasan, L, Rutherford, M, Møllgård, K, Clowry, G, Molnár, Z

“...Our results suggest that connective tissue growth factor- and nuclear receptor-related 1-positive cells are two distinct cell populations of the human subplate. ...”

SDR-type human hydroxysteroid dehydrogenases involved in steroid hormone activation. por Wu, X, Lukacik, P, Kavanagh, K, Oppermann, U

“...This reversible reaction constitutes an important pre-receptor control mechanism for nuclear receptor ligands of the androgen, estrogen and glucocorticoid classes, since the conversion "switches" between receptor ligands and their inactive metabolites. ...”

Glucocorticoid receptor isoforms direct distinct mitochondrial programs to regulate ATP production por Morgan, D, Poolman, T, Williamson, A, Wang, Z, Clark, N, Ma'Ayan, A, Whetton, A, Brass, A, Matthews, L, Ray, D

“...The glucocorticoid receptor (GR), a nuclear receptor and major drug target, has a highly conserved minor splice variant, GRγ, which differs by a single arginine within the DNA binding domain. ...”

Metabolic conversion as a pre-receptor control mechanism for lipophilic hormones. por Nobel, S, Abrahmsen, L, Oppermann, U

“...The majority of physiological effects mediated by steroids, retinoids and thyroids is accomplished by binding to members of the nuclear receptor superfamily of ligand activated transcription factors. ...”

Synthesis, in-vivo anti-diabetic & anticancer activities and molecular modelling studies of tetrahydrobenzo[d]thiazole tethered nicotinohydrazide derivatives por Suri Babu Patchipala, Pasupuleti Visweswara Rao, Amrutha V Audipudi, Hari babu Bollikolla

“...In addition, the in-silico binding studies of the potential compounds 11f and 11g with human PPAR-γ protein complexed with Retinoid X Receptor (RXR) alpha Nuclear Receptor showed good interactions when compared to the standard drug Rosiglitazone. ...”
Ligazón do recurso
Ligazón do recurso

Synthesis, in-vivo anti-diabetic & anticancer activities and molecular modelling studies of tetrahydro benzo[d]thiazole tethered nicotinohydrazide derivatives por Suri Babu Patchipala, Visweswara Rao Pasupuleti, Amrutha V Audipudi, Hari babu Bollikolla

“...In addition, the in-silico binding studies of the potential compounds 11f and 11g with human PPAR-c protein complexed with Retinoid X Receptor (RXR) alpha Nuclear Receptor showed good interactions when compared to the standard drug Rosiglitazone. ...”
Ligazón do recurso
Ligazón do recurso

The maternal interleukin-17a pathway in mice promotes autism-like phenotypes in offspring por Choi, Gloria, Yim, Yeong Shin, Wong, Helen, Kim, Sangdoo, Kim, Hyunju, Kim, Sangwon V., Hoeffer, Charles A., Littman, Dan R., Huh, Jun R.

“...Using both genetic mutants and blocking antibodies in mice, we show that retinoic acid receptor–related orphan nuclear receptor gamma t (RORγt)–dependent effector T lymphocytes [for example, T helper 17 (T[subscript H]17) cells] and the effector cytokine interleukin-17a (IL-17a) are required in mothers for MIA-induced behavioral abnormalities in offspring. ...”
Ligazón do recurso
Ligazón do recurso

Cancer-associated fibroblasts in tumor microenvironment - accomplices in tumor malignancy por Liao, Zehuan, Tan, Zhen Wei, Zhu, Pengcheng, Tan, Nguan Soon

“...Molecular characterization of CAFs also underscores the importance of Notch and specific nuclear receptor signaling in the activation of CAFs. This review consolidates recent findings of CAFs and highlights areas for future investigations....”
Ligazón do recurso

Insights into the role of PPARβ/δ in NAFLD por Tan, Nguan Soon, Wahli, Walter, Chen, Jiapeng, Montagner, Alexandra

“...Obesity-related metabolic disorders may be improved by activation of the nuclear receptor peroxisome proliferator-activated receptor (PPAR)β/δ, which is involved in metabolic processes and other functions. ...”
Ligazón do recurso
Ligazón do recurso

Molecular docking analysis of curcumin analogues as human neutrophil elastase inhibitors por Narayanaswamy, Radhakrishnan, Lam, Kok Wai, Abas, Faridah, Ismail, Intan Safinar

“...With regard to bioact-ivity score, compound 17 has exhibited least score towards nuclear receptor ligand (0.05) and enzyme inhibitor (0.10) compared to all other ligands. ...”

Molecular Pathways: Dietary Regulation of Stemness and Tumor Initiation by the PPAR-  Pathway por Beyaz, Semir, Yilmaz, Omer

“...Peroxisome proliferator-activated receptor delta (PPAR-8) is a nuclear receptor transcription factor that regulates gene expression during development and disease states, such as cancer. ...”
Ligazón do recurso
Ligazón do recurso

High-fat diet-activated fatty acid oxidation mediates intestinal stemness and tumorigenicity por Mana, Miyeko D, Hussey, Amanda M, Tzouanas, Constantine N, Imada, Shinya, Barrera Millan, Yesenia, Bahceci, Dorukhan, Saiz, Dominic R, Webb, Anna T, Lewis, Caroline A, Carmeliet, Peter, Mihaylova, Maria M, Shalek, Alex K, Yilmaz, Ömer H

“...Although PPAR (peroxisome proliferator-activated receptor) nuclear receptor activity has been proposed to facilitate these effects, their exact role is unclear. ...”
Ligazón do recurso

The quaternary architecture of RARβ–RXRα heterodimer facilitates domain–domain signal transmission por Chandra, V, Wu, D, Li, S, Potluri, N, Kim, Y, Rastinejad, F

“...Assessing the physical connections and allosteric communications in multi-domain nuclear receptor (NR) polypeptides has remained challenging, with few crystal structures available to show their overall structural organizations. ...”