Visualizing the architectures and interactions of nuclear receptors by Khorasanizadeh, S, Rastinejad, F

“…Nuclear receptors (NRs) are master regulators of broad genetic programs in metazoans. …”

Enteric microbiota–gut–brain axis from the perspective of nuclear receptors by Duszka, Kalina, Wahli, Walter

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An improved method for quantitative ChIP studies of nuclear receptor function by Hunter, A, Narang, N, Baxter, M, Ray, D, Poolman, T

“…Chromatin immunoprecipitation (ChIP) is a valuable tool for the endocrine researcher, providing a means to measure the recruitment of hormone-activated nuclear receptors, for example. However, the technique can be challenging to perform and has multiple experimental steps, risking introduction of error at each. …”

Functional regulation of ppars through post-translational modifications by Brunmeir, Reinhard, Xu, Feng

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Exploiting vulnerabilities of cancer by targeting nuclear receptors of stromal cells in tumor microenvironment by Cheng, Hong Sheng, Lee, Jeannie Xue Ting, Wahli, Walter, Tan, Nguan Soon

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Molecular mechanism of transcriptional activation of NR4A nuclear receptor subfamily by Yoo, Jun Yeob

“…This study presents the first solution structure of the Nor1 ligand-binding domain calculated by NMR spectroscopy, which is also the first NMR structure of any nuclear receptor ligand-binding domains. The Nor1-LBD NMR structures reveal a conserved structural portrait with other family members (NR4A1 and A2). …”
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Hepatic circadian clock oscillators and nuclear receptors integrate microbiome-derived signals by Montagner, Alexandra, Korecka, Agata, Polizzi, Arnaud, Lippi, Yannick, Blum, Yuna, Canlet, Cécile, Tremblay-Franco, Marie, Gautier-Stein, Amandine, Burcelin, Rémy, Yen, Yi-Chun, Je, Hyunsoo Shawn, Maha, Al-Asmakh, Mithieux, Gilles, Arulampalam, Velmurugesan, Lagarrigue, Sandrine, Guillou, Hervé, Pettersson, Sven, Wahli, Walter

“…Mice exposed to microbes typically exhibit characterized activities of nuclear receptors, some of which (PPARα, LXRβ) regulate specific liver gene expression networks, but these activities are profoundly changed in GF mice. …”
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Transcriptional control of physiological and pathological processes by the nuclear receptor PPARβ/δ by Tan, Nguan Soon, Vázquez-Carrera, Manuel, Montagner, Alexandra, Sng, Ming Keat, Guillou, Hervé, Wahli, Walter

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Hepatic Fasting-Induced PPARα Activity Does Not Depend on Essential Fatty Acids by Polizzi, Arnaud, Fouché, Edwin, Ducheix, Simon, Lasserre, Frédéric, Marmugi, Alice P., Mselli-Lakhal, Laila, Loiseau, Nicolas, Wahli, Walter, Guillou, Hervé, Montagner, Alexandra

Subjects: “…nuclear receptors…”
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Nuclear receptor NR4A is required for patterning at the ends of the planarian anterior-posterior axis by Li, Dayan, McMann, Conor L., Reddien, Peter

“…We identified a gene, nr4A, that is required for anterior- and posterior-pole localization to axis extremes. nr4A encodes a nuclear receptor expressed predominantly in planarian muscle, including strongly at AP-axis ends and the poles. nr4A RNAi causes patterning gene expression domains to retract from head and tail tips, and ectopic anterior and posterior anatomy (e.g., eyes) to iteratively appear more internally. …”
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Molecular characterisation of DHR38: the Drosophila ortholog of NR4A family of nuclear receptors by Parnaik, Tanvi Rajesh

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Targeting nuclear receptors in cancer-associated fibroblasts as concurrent therapy to inhibit development of chemoresistant tumors by Chan, Jeremy Soon Kiat, Sng, Ming Keat, Teo, Zi Qiang, Chong, Han Chung, Twang, Jing Shun, Tan, Nguan Soon

“…Although CAF-derived soluble factors have been investigated for tumor stroma-directed therapy, the underlying transcriptional programs that enable the oncogenic functions of CAFs remain poorly understood. Nuclear receptors (NRs), a large family of ligand-responsive transcription factors, are pharmacologically viable targets for the suppression of CAF-facilitated oncogenesis. …”
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Nuclear Receptor Unfulfilled Regulates Axonal Guidance and Cell Identity of Drosophila Mushroom Body Neurons by Lin, S, Huang, Y, Lee, T

Interactions between PPAR alpha and triiodothyronine nuclear receptors altered cardiac phenotype and phosphocreatine metabolism by Zhang, W, ten Hove, M, Neubauer, S, Clarke, K

Expression of COUP-TFII nuclear receptor in restricted GABAergic neuronal populations in the adult rat hippocampus. by Fuentealba, P, Klausberger, T, Karayannis, T, Suen, W, Huck, J, Tomioka, R, Rockland, K, Capogna, M, Studer, M, Morales, M, Somogyi, P

“…The COUP-TFII nuclear receptor, also known as NR2F2, is expressed in the developing ventral telencephalon and modulates the tangential migration of a set of subpallial neuronal progenitors during forebrain development. …”

Development of novel agonists for the orphan nuclear receptor, Nurr1 : a therapeutic strategy for Parkinson’s disease by Toh, Hui Ting

“…Till date, Nurr1 remains an orphan nuclear receptor due to the lack of identified endogenous ligands. …”
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Nuclear Receptor 4A2 Is Differentially Expressed In Animal Models Of RA During Inflammation and Resolution by Everett, J, McCann, F, Palfreeman, A, Shaw, A, Gravallese, E, Mix, K

Structural and molecular characterization of ligands activating the orphan nuclear receptor Nurr1 (NR4A2) by Ng, Xin Yi

“…This study focuses on Nurr1, an orphan nuclear receptor, due to its essential role in the survival and maintenance of dopaminergic neurons in the substantia nigra of the brain. …”
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Hepatic PPARα is critical in the metabolic adaptation to sepsis by Paumelle, Réjane, Haas, Joel T., Hennuyer, Nathalie, Baugé, Eric, Deleye, Yann, Mesotten, Dieter, Langouche, Lies, Vanhoutte, Jonathan, Cudejko, Céline, Wouters, Kristiaan, Hannou, Sarah Anissa, Legry, Vanessa, Lancel, Steve, Lalloyer, Fanny, Polizzi, Arnaud, Smati, Sarra, Gourdy, Pierre, Vallez, Emmanuelle, Bouchaert, Emmanuel, Derudas, Bruno, Dehondt, Hélène, Gheeraert, Céline, Fleury, Sébastien, Tailleux, Anne, Montagner, Alexandra, Wahli, Walter, Van Den Berghe, Greet, Guillou, Hervé, Dombrowicz, David, Staels, Bart

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Peroxisome proliferator-activated receptors and caloric restriction-common pathways affecting metabolism, health, and longevity by Duszka, Kalina, Gregor, András, Guillou, Hervé, König, Jürgen, Wahli, Walter

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