Polymorphism in ADAM33 gene associated with asthmatics in West Bengal, India - An investigation by in-silico analysis by Saheen Sultana, M.Sc, Priyajit Banerjee, Ph.D, Indranil Ganai, M.Sc, Arghya Laha, Ph.D, Nasima Sultana, M.Sc, Himani Biswas, Ph.D, Nimai Chandra Saha, D.Sc, Saibal Moitra, Ph.D, Sanjoy Podder, Ph.D

“…The present study investigated possible association of rs2280090 (T1), rs2280091 (T2) and rs3918396 (S1) single nucleotide polymorphisms (SNPs) of ADAM33 with aeroallergen induced asthma in West Bengal population, India. …”
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Prevalence and genomic characterization of rotavirus group A genotypes in piglets from southern highlands and eastern Tanzania by Joseph J. Malakalinga, Gerald Misinzo, George M. Msalya, Mariana J. Shayo, Rudovick R. Kazwala

“…The VP7 gene of G9, the VP4 gene of P[6] and NSP4 (E1) gene of some genotypes clustered together and closely related to humans origin or porcine-human reassortant strains with nucleotide similarities ranging from 97.90% to 99.74% from neighboring countries, implying possibility intragenogroup reassortment and interspecies transmission. …”
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Phylogenomics, phenotypic, and functional traits of five novel (Earth-derived) bacterial species isolated from the International Space Station and their prevalence in metagenomes by Anna C. Simpson, Pratyay Sengupta, Flora Zhang, Asif Hameed, Ceth W. Parker, Nitin K. Singh, Georgios Miliotis, Punchappady D. Rekha, Karthik Raman, Christopher E. Mason, Kasthuri Venkateswaran

“…For all strains, the gyrB gene exhibited < 93% similarity with closely related species, which proved effective in categorizing these ISS strains as novel species. Average nucleotide identity and digital DNA–DNA hybridization values, when compared to any known bacterial species, were < 94% and <50% respectively for all species described here. …”
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Genetic causal relationship between age at menarche and benign oesophageal neoplasia identified by a Mendelian randomization study by Yani Su, Yani Su, Yani Su, Yunfeng Hu, Yiwei Xu, Yiwei Xu, Yiwei Xu, Mingyi Yang, Fangcai Wu, Fangcai Wu, Fangcai Wu, Yuhui Peng, Yuhui Peng, Yuhui Peng

“…The leave-one-out analysis was used to detect whether the MR analysis was affected by single nucleotide polymorphisms (SNPs). In addition, the MR robust adjusted profile score (MR-RAPS) method was used to assess the robustness of MR analysis.ResultsThe random-effects IVW results showed that AAMA had a negative genetic causal relationship with BON (odds ratio [OR] = 0.285 [95% confidence interval [CI]: 0.130-0.623], P = 0.002). …”
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Molecular test of Paget's disease of bone in families not linked to SQSTM1 gene mutations by Yang You, David Simonyan, Alexandre Bureau, Edith Gagnon, Caroline Albert, Jason R. Guertin, Jean-Eric Tarride, Jacques P. Brown, Laëtitia Michou

“…Disease-causing mutations of the SQSTM1 gene have been linked to PDB in about 40 % of families whereas genes linked to the remaining families are unknown. Several single nucleotide polymorphisms (SNPs) have been associated with PDB in unrelated patient non-carriers of a SQSTM1 mutation. …”
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Mutations of TP53 and genes related to homologous recombination repair in breast cancer with germline BRCA1/2 mutations by Jinyong Kim, Kyeonghun Jeong, Hyeji Jun, Kwangsoo Kim, Jeong Mo Bae, Myung Geun Song, Hanbaek Yi, Songyi Park, Go-un Woo, Dae-Won Lee, Tae-Yong Kim, Kyung-Hun Lee, Seock-Ah Im

“…Materials and methods Data of the breast cancer patients with pathogenic gBRCA1/2 mutations and qualified targeted next-generation sequencing, SNUH FiRST cancer panel, were analyzed. Single nucleotide polymorphisms, small insertions, and deletions were analyzed with functional annotations using ANNOVAR. …”
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The causal relationship between immune cells and different kidney diseases: A Mendelian randomization study by Pang Lei, Ding Zijun, Chai Hongqiang, Shuang Weibing

“…Instrumental variables and single nucleotide polymorphic loci were identified (P < 5 × 10−8. …”
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Incidence, genetic diversity, and antimicrobial resistance profiles of Vibrio parahaemolyticus in seafood in Bangkok and eastern Thailand by Chartchai Changsen, Somsak Likhitrattanapisal, Kamonwan Lunha, Wiyada Chumpol, Surasak Jiemsup, Anuphap Prachumwat, Darin Kongkasuriyachai, Supawadee Ingsriswang, Soraya Chaturongakul, Aekarin Lamalee, Suganya Yongkiettrakul, Sureemas Buates

“…A phylogenomic tree was built from nucleotide sequences by UBCG2.0 and RAxML softwares. …”
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Molecular characterization and classification of Trypanosoma spp. Venezuelan isolates based on microsatellite markers and kinetoplast maxicircle genes by E. Sánchez, T. Perrone, G. Recchimuzzi, I. Cardozo, N. Biteau, PM Aso, A. Mijares, T. Baltz, D. Berthier, L. Balzano-Nogueira, MI Gonzatti

“…These maxicircle sequences were analyzed by nucleotide BLAST and aligned toorthologous genes from the Trypanozoon subgenus by MUSCLE tools. …”
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Cloning and Expression Pattern of rnd1 and Its Involvement in Disease Resistance in Japanese Flounder (Paralichthys olivaceus) by Ziwei ZHANG, Lei WANG, Kaimin LI, Sheng LU, Weiwei ZHENG, Songlin CHEN

“…On phylogenetic tree, PoRnd1 was clustered with Rnd1 from other fish species. The single-nucleotide polymorphism (SNP) locus associated with E. tarda resistance is located at 4 575 720 bp on chromosome 14 of Japanese flounder. …”
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The Novel Porcine Parvoviruses: Current State of Knowledge and Their Possible Implications in Clinical Syndromes in Pigs by Diana S. Vargas-Bermudez, Jose Dario Mogollon, Camila Franco-Rodriguez, Jairo Jaime

“…Additionally, it is considered that the genome of PVs has mutation rates similar to those of ssRNA viruses, that is, in the order of 10⁻⁵–10⁻⁴ nucleotide/substitution/year. These mutations manifest mainly in the VP protein, constituting the viral capsid, affecting virulence, tropism, and viral antigenicity. …”
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Genomics and cellulolytic, hemicellulolytic, and amylolytic potential of Iocasia fonsfrigidae strain SP3-1 for polysaccharide degradation by Sobroney Heng, Sawannee Sutheeworapong, Verawat Champreda, Ayaka Uke, Akihiko Kosugi, Patthra Pason, Rattiya Waeonukul, Ruben Michael Ceballos, Khanok Ratanakhanokchai, Chakrit Tachaapaikoon

“…Although phylogenetic analysis based on 16S rRNA gene indicates that strain SP3-1 belongs to the genus Iocasia with 99.58% average nucleotide sequence identity to Iocasia fonsfrigida NS-1T, strain SP3-1 is uniquely an extreme haloalkaliphile. …”
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Influence of GAS5/MicroRNA‐223‐3p/P2Y12 Axis on Clopidogrel Response in Coronary Artery Disease by Yan‐Ling Liu, Xiao‐Lei Hu, Pei‐Yuan Song, He Li, Mu‐Peng Li, Yin‐Xiao Du, Mo‐Yun Li, Qi‐Lin Ma, Li‐Ming Peng, Ming‐Yu Song, Xiao‐Ping Chen

“…Methods and Results A total of 444 patients with CAD receiving dual antiplatelet therapy from 2017 to 2018 were enrolled to evaluate the effect of GAS5 single nucleotide polymorphism rs55829688 on platelet reactivity index. …”
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Multifaceted Defects in Monocytes in Different Phases of Chronic Hepatitis B Virus Infection: Lack of Restoration after Antiviral Therapy by Debangana Dey, Sourina Pal, Bidhan Chandra Chakraborty, Ayana Baidya, Soham Bhadra, Ranajoy Ghosh, Soma Banerjee, S. K. Mahiuddin Ahammed, Abhijit Chowdhury, Simanti Datta

“…We demonstrated that high levels of hepatitis B virus surface antigen and IL-4 potentiate these defects in monocytes via β-catenin induction while therapy with the nucleotide analog tenofovir fails to restore monocyte function. …”
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Relationship between PIWIL1 gene polymorphisms and epithelial ovarian cancer susceptibility among southern Chinese woman: a three-center case–control study by Shanshan Liu, Yaping Yan, Zhizhong Cui, Haipeng Feng, Fengmei Zhong, Ziguang Liu, Yan Li, Xiang Ou, Wenjuan Li

“…The study analyzed the relationship between five functional single nucleotide polymorphisms (SNPs) in the PIWIL1 gene and EOC risk. …”
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Influence of Genetics on the Response to Omalizumab in Patients with Severe Uncontrolled Asthma with an Allergic Phenotype by Susana Rojo-Tolosa, José Antonio Sánchez-Martínez, Laura Elena Pineda-Lancheros, José María Gálvez-Navas, María Victoria González-Gutiérrez, Gonzalo Jiménez-Gálvez, Cristina Pérez-Ramírez, Concepción Morales-García, Alberto Jiménez-Morales

“…Its effectiveness could be influenced by clinical variables and single nucleotide polymorphisms (SNPs) in one or more of the genes involved in the mechanism of action and process of response to omalizumab, and these could be used as predictive biomarkers of response. …”
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FLT3 VARIANTS IN PATIENTS WITH ACUTE MYELOID LEUKEMIA FROM AMAZONAS STATE, BRAZIL by MOD Santos, TCD Santos, GSP Braz, LPS Mourão, ROD Santos, WO Azevedo, AM Tarragô, LNM Passos, GAV Silva

“…Methods: The study population was composed of 18 AML patients. The nucleotide sequencing was performed in bone marrow samples, sequencing directed for ITD and TKD region (exon 9-24). …”
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Interactive effects between CDHR3 genotype and rhinovirus species for diagnosis and severity of respiratory tract infections in hospitalized children by Yu P. Song, Man F. Tang, Agnes S. Y. Leung, Kin P. Tao, Oi M. Chan, Gary W. K. Wong, Paul K. S. Chan, Renee W. Y. Chan, Ting F. Leung

“…Allele A of single-nucleotide polymorphism (SNP) CDHR3_rs6967330 upregulates epithelial expression of RV-C receptors which results in more severe asthma exacerbations in children. …”
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Molecular Identification and Phylogenetic Analysis of Peanut mottle virus in Soybean Fields in the North of Iran by J. Ramezani Avval Reiabi, M. Mehrvar

“…The RT-PCR amplified fragments of 700 and 1450 bp with degenerate primers for potyviruses and CP-specific primer pairs for PeMoV, respectively, whereas no fragment was amplified from the healthy plants. The nucleotide sequence of the coat protein region of this isolate shared 88.56-95.80% identity with the corresponding sequence of other GenBank isolates. …”
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In silico analysis of missense variants of the C1qA gene related to infection and autoimmune diseases by Mohammed Y. Behairy, Ph.D, ALi A. Abdelrahman, Ph.D, Hoda Y. Abdallah, Ph.D, Emad El-Deen A. Ibrahim, Ph.D, Anwar A. Sayed, Ph.D, Marwa M. Azab, Ph.D

“…These defects could arise from missense single nucleotide polymorphisms (SNPs) and their deleterious impacts on protein structure and function. …”
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