Dietary Macronutrient Intake May Influence the Effects of TCF7L2 rs7901695 Genetic Variants on Glucose Homeostasis and Obesity-Related Parameters: A Cross-Sectional Population-Base... by Witold Bauer, Edyta Adamska-Patruno, Urszula Krasowska, Monika Moroz, Joanna Fiedorczuk, Przemyslaw Czajkowski, Dorota Bielska, Maria Gorska, Adam Kretowski

“…We recruited 810 participants (47.5% men and 52.5% women), 18–79 years old (mean age, 42.1 (±14.5) years), who were genotyped for the common TCF7L2 rs7901695 single-nucleotide polymorphism (SNP), and anthropometric measurements, body composition, body fat distribution (visceral (VAT) and subcutaneous adipose tissue (SAT) content), blood glucose and insulin concentrations after fasting and during OGTTs, and HbA1c were assessed. …”
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Rapid antigen detection test for respiratory syncytial virus diagnosis as a diagnostic tool by Flávio da Silva Mesquita, Danielle Bruna Leal de Oliveira, Daniela Crema, Célia Miranda Nunes Pinez, Thaís Cristina Colmanetti, Luciano Matsumia Thomazelli, Alfredo Elias Gilio, Sandra Elisabeth Vieira, Marina Baquerizo Martinez, Viviane Fongaro Botosso, Edison Luiz Durigon

“…Samples with discordant results were analyzed by real time PCR and nucleotide sequencing. Results: From 313 positive samples by immunofluorescence assays, 282 (90%) were also positive by the rapid antigen detection test, two were positive only by rapid antigen detection test, 33 were positive only by immunofluorescence assays, and 171 were positive by both methods. …”
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Ultra-high resolution X-ray structure of orthorhombic bovine pancreatic Ribonuclease A at 100K by David R. Lisgarten, Rex A. Palmer, Jon B. Cooper, Claire E. Naylor, Rosemary C. Talbert, Brendan J. Howlin, John N. Lisgarten, Janez Konc, Shabir Najmudin, Carina M. C. Lobley

“…The form of the Ribonuclease A enzyme used in both the present study and in 3RN3 (Howlin et al. in Acta Crystallogr A 45:851–861, 1989) includes a sulphate anion which occupies approximately the same location as the $${\text{PO}}_{4}^{2 - }$$ PO 4 2 - phosphate group in protein nucleotide complexes (Borkakoti et al. in J Mol Biol 169:743–755, 1983). …”
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Comparative Genomics Provides Insights into the Taxonomy of <i>Azoarcus</i> and Reveals Separate Origins of <i>Nif</i> Genes in the Proposed <i>Azoarcus</i> and <i>Aromatoleum</i>... by Roberto Tadeu Raittz, Camilla Reginatto De Pierri, Marta Maluk, Marcelo Bueno Batista, Manuel Carmona, Madan Junghare, Helisson Faoro, Leonardo M. Cruz, Federico Battistoni, Emanuel de Souza, Fábio de Oliveira Pedrosa, Wen-Ming Chen, Philip S. Poole, Ray A. Dixon, Euan K. James

“…The origin of diazotrophy in <i>Azoarcus-Aromatoleum</i> was also investigated by comparing full-length sequences of <i>nif</i> genes, and by physiological measurements of nitrogenase activity using the acetylene reduction assay. Based on average nucleotide identity (ANI) and whole genome analyses, three major groups could be discerned: (i) <i>Azoarcus</i> comprising <i>Az. communis</i>, <i>Az. indigens</i> and <i>Az. olearius</i>, and two unnamed species complexes, (ii) <i>Aromatoleum</i> Group 1 comprising <i>Ar. anaerobium</i>, <i>Ar. aromaticum</i>, <i>Ar. bremense</i>, and <i>Ar. buckelii</i>, and (iii) <i>Aromatoleum</i> Group 2 comprising <i>Ar. diolicum</i>, <i>Ar. evansii</i>, <i>Ar. petrolei</i>, <i>Ar. toluclasticum</i>, <i>Ar. tolulyticum</i>, <i>Ar. toluolicum,</i> and <i>Ar. toluvorans</i>. …”
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Efforts towards the synthesis of fully N-differentiated heparin-like glycosaminoglycans; and, Investigations into the mechanism of inactivation of RTPR by gemcitabine triphosphate by Lohman, Gregory J. S

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Analysis of mouse models of insulin secretion disorders by Kaizik, S

“…</p> <ol type="1"> <li>Loss of nicotinamide nucleotide transhydrogenase (Nnt) function is linked to ROS-mediated uncoupling of mitochondrial metabolism and reduced insulin secretion. …”

Genome-wide genetic analyses highlight MAPK signalling in the pathogenesis of endometriosis by UImari, O, Rahmioglu, N, Nyholt, D, Vincent, K, Missmer, S, Becker, C, Morris, A, Montgomery, G, Zondervan, K

“…</p> <h4>Main Results and the Role of Chance</h4> <p>The first genome-wide association analysis for Stage A endometriosis revealed a novel locus, rs144240142 (P = 6.45 × 10−8, OR = 1.71, 95% CI = 1.23–2.37), an intronic single-nucleotide polymorphism (SNP) within MAP3K4. This SNP was not associated with Stage B disease (P = 0.086). …”

Crystallographic studies on the structure of vitamin b12 and related compounds by Pickworth, J

“…</p> <p>The atomic arrangement suggested has been confirmed by other workers for vitamin B₁₂, except that, during the hydrolysis, a hydroxyl group has been introduced into the molecule to glve a lactone (or loctam) ring, and an inversion has occurred so that the nucleotide group in the vitamin is replaced by a cyanide group, and the cyanide group by chloride.…”

Phenotypic and genomic characterization of Kedah-Kelantan bulls and comparative assessment of semen characteristics by Sirajul, Islam Mohammed

“…The genomic part of the study on the two KK bulls revealed an average number of single nucleotide polymorphisms (SNPs), insertions and deletions (InDels), structural variations (SVs), and copy number variation (CNVs) of 8,823,792 (85%); 1,573,661 (15%); 30,547 (0%), and 24,254 (0%), respectively. …”
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Molecular Characterization of ESBL Producing Klebsiella Species Isolated from Several Major Hospitals in Iran by Ghafourian, Sobhan

“…K.pneumoniae producing ESBLs more detected in RTI with P ≤ 0.03.The results also showed significance different in to blaSHV that was dominant gene responsible for ESBLs production P ≤ 0.049 but no significant difference observed in blaTEM and blaSHV. Based on the nucleotide variations of the five selected genetic loci, twenty-five different STs could be identified among thirty K.pneumoniae producing ESBLs isolates. …”
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Mechanism of methicillin-resistant Staphylococcus aureus biofilm degradation by bacteriophages by Dakheel, Khulood Hamid

“…MS/MS analysis of the proteins in the biofilms induced in bacteria after phage treatments revealed that the phage infections up-regulated several metabolic pathways including those involved in energy conversion, protein metabolism, nucleotide metabolism and pathways involved in the generation of oxidants and antioxidants. …”
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Expressing the gene encoding 34-kilodalton outer membrane protein of Brucella melitensis for development of a recombinant vaccine by Yulianna Puspitasari, .

“…The gene encodes a deduced protein of 309 amino acids. Analysis of the nucleotide sequence of Omp 34 kDa gene of Brucella melitensis strain 293 revealed 100% homology to the porin of Brucella melitensis bv. 1 strain 16M and 99% to 98% homology to the Brucella melitensis porin (Omp2a) and (Omp2b) genes. …”
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Macrophage RIPK3 triggers inflammation and cell death via the XBP1–Foxo1 axis in liver ischaemia–reperfusion injury by Xiaoye Qu, Tao Yang, Xiao Wang, Dongwei Xu, Yeping Yu, Jun Li, Longfeng Jiang, Qiang Xia, Douglas G. Farmer, Bibo Ke

“…IR stress activated RIPK3, inositol-requiring transmembrane kinase/endoribonuclease 1α (IRE1α), x-box binding protein 1 (XBP1), nucleotide-binding oligomerisation domain-containing protein 1 (NOD1), NF-κB, forkhead box O1 (Foxo1), calcineurin A, and TRPM7 in ischaemic livers. …”
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Gas Chromatography–Mass Spectrometry Profiling of Volatile Metabolites Produced by Some <i>Bacillus</i> spp. and Evaluation of Their Antibacterial and Antibiotic Activities by Moldir Koilybayeva, Zhanserik Shynykul, Gulbaram Ustenova, Krzysztof Waleron, Joanna Jońca, Kamilya Mustafina, Akerke Amirkhanova, Yekaterina Koloskova, Raushan Bayaliyeva, Tamila Akhayeva, Mereke Alimzhanova, Aknur Turgumbayeva, Gulden Kurmangaliyeva, Aigerim Kantureyeva, Dinara Batyrbayeva, Zhazira Alibayeva

“…Phylogenetic analysis proved that five bacterial isolates BSS12, BSS13, BSS16, BSS21, and BSS25 showed 99% nucleotide sequence similarities with <i>Bacillus safensis</i> AS-08, <i>Bacillus cereus</i> WAB2133, <i>Bacillus acidiproducens</i> NiuFun, <i>Bacillus toyonesis</i> FORT 102, and <i>Bacillus thuringiensis</i> F3, respectively. …”
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Screening and Characterization of Polymorphic SSR Markers Based on Whole Genome Sequencing of Cobia (Rachycentron canadum) by Qian MA, Yuwei WU, Liuyong WANG, Xiaolong ZHAO, Qiling ZHOU, Gang CHEN, Jiansheng HUANG

“…Among these SSR (with 1–6 nucleotide as repeat units), the top three repeat types were mononucleotide, dinucleotide, and trinucleotide, accounting for 50.49%, 30.23% and 14.02% of the total detected SSRs, respectively. …”
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Development and characterization of acidic-pH-tolerant mutants of Zymomonas mobilis through adaptation and next-generation sequencing-based genome resequencing and RNA-Seq by Qing Yang, Yongfu Yang, Ying Tang, Xia Wang, Yunhao Chen, Wei Shen, Yangyang Zhan, Junjie Gao, Bo Wu, Mingxiong He, Shouwen Chen, Shihui Yang

“…WGR result indicated that compared to wild-type ZM4, 3.5M and 3.6M have seven and five single nucleotide polymorphisms (SNPs), respectively, among which four are shared in common. …”
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Investigating the Causal Relationship of C-Reactive Protein with 32 Complex Somatic and Psychiatric Outcomes: A Large-Scale Cross-Consortium Mendelian Randomization Study. by Bram P Prins, Ali Abbasi, Anson Wong, Ahmad Vaez, Ilja Nolte, Nora Franceschini, Philip E Stuart, Javier Guterriez Achury, Vanisha Mistry, Jonathan P Bradfield, Ana M Valdes, Jose Bras, Aleksey Shatunov, PAGE Consortium, International Stroke Genetics Consortium, Systemic Sclerosis consortium, Treat OA consortium, DIAGRAM Consortium, CARDIoGRAMplusC4D Consortium, ALS consortium, International Parkinson’s Disease Genomics Consortium, Autism Spectrum Disorder Working Group of the Psychiatric Genomics Consortium, CKDGen consortium, GERAD1 Consortium, International Consortium for Blood Pressure, Schizophrenia Working Group of the Psychiatric Genomics Consortium, Inflammation Working Group of the CHARGE Consortium, Chen Lu, Buhm Han, Soumya Raychaudhuri, Steve Bevan, Maureen D Mayes, Lam C Tsoi, Evangelos Evangelou, Rajan P Nair, Struan F A Grant, Constantin Polychronakos, Timothy R D Radstake, David A van Heel, Melanie L Dunstan, Nicholas W Wood, Ammar Al-Chalabi, Abbas Dehghan, Hakon Hakonarson, Hugh S Markus, James T Elder, Jo Knight, Dan E Arking, Timothy D Spector, Bobby P C Koeleman, Cornelia M van Duijn, Javier Martin, Andrew P Morris, Rinse K Weersma, Cisca Wijmenga, Patricia B Munroe, John R B Perry, Jennie G Pouget, Yalda Jamshidi, Harold Snieder, Behrooz Z Alizadeh

“…The first GRS consisted of four single nucleotide polymorphisms (SNPs) in the CRP gene (GRSCRP), and the second consisted of 18 SNPs that were significantly associated with CRP levels in the largest genome-wide association study (GWAS) to date (GRSGWAS). …”
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THE COEXİSTENCE OF NOVEL MUTATİONS OF FX, DİMETHYLGLYCİNE DEHYDROGENASE GENES WİTH FAMİLİAL EPİSODİC PAİN SYNDROME: A CASE REPORT by Hatice Mine Çakmak

“…Tranexamic acid is preferred for menorrhagia, nosebleeds, presurgery, and surgery to prevent excessive factor administration (8,9).Our study showed mild FX deficiency with a nucleotide protein change of NM_000504.4:c.785 G>A p.Gly262Asp, and a novel mutation of FX deficiency. …”
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Association between genetically proxied PCSK9 inhibition and prostate cancer risk: A Mendelian randomisation study by Si Fang, James Yarmolinsky, Dipender Gill, Caroline J. Bull, Claire M. Perks, George Davey Smith, Tom R. Gaunt, Tom G. Richardson

“…<h4>Methods and findings</h4> Single-nucleotide polymorphisms (SNPs) associated with LDL-c (P < 5 × 10−8) from the Global Lipids Genetics Consortium genome-wide association study (GWAS) (N = 1,320,016) and located in and around the HMGCR, NPC1L1, and PCSK9 genes were used to proxy the therapeutic inhibition of these targets. …”
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Hypertensive phenotype signs in men with different genetic polymorphisms of aldosterone synthase and angiotensin II type 1 receptors by Susanna A. Tykhonova, Veronika P. Piskovatska

“…Пісковацька Susanna Tykhonova, Veronika Piskovatska   Одеський національний  медичний університет Odessa National Medical University   Abstract. Single-nucleotide polymorphisms of renin-angiotensin-aldosterone system are widely discussed as the predictors of arterial hypertension, hypertensive target-organ damage, and antihypertensive treatment response. …”
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