Brain Monoamine Dysfunction in Response to Predator Scent Stress Accompanies Stress-Susceptibility in Female Rats by Courtney S. Wilkinson, Harrison L. Blount, Marek Schwendt, Lori A. Knackstedt

“…Using a predator scent stress (PSS) rodent model of PTSD, we sought to determine if stress-susceptible female rats show altered monoamine concentrations in brain regions associated with PTSD: the medial prefrontal cortex (mPFC), nucleus accumbens (NAc), and dorsal (dHIPP) and ventral (vHIPP) hippocampus. …”
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Ventral pallidum GABA and glutamate neurons drive approach and avoidance through distinct modulation of VTA cell types by Lauren Faget, Lucie Oriol, Wen-Chun Lee, Vivien Zell, Cody Sargent, Andrew Flores, Nick G. Hollon, Dhakshin Ramanathan, Thomas S. Hnasko

“…However, VP glutamate neurons evoked dopamine in aversion-associated ventromedial nucleus accumbens (NAc), but reduced dopamine release in reward-associated dorsomedial NAc. …”
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Hyperactive behavioral phenotypes and an altered brain monoaminergic state in male offspring mice with perinatal hypothyroidism by Toyoshi Umezu, Taizo Kita, Masatoshi Morita

“…Significant decreases in dopamine (DA) and serotonin turnover were observed in the striatum (ST), nucleus accumbens, hypothalamus, and hippocampus in male mice with perinatal hypothyroidism. …”
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Cannabis use is associated with potentially heritable widespread changes in autism candidate gene DLGAP2 DNA methylation in sperm by Rose Schrott, Kelly Acharya, Nilda Itchon-Ramos, Andrew B. Hawkey, Erica Pippen, John T. Mitchell, Scott H. Kollins, Edward D. Levin, Susan K. Murphy

“…Adult male rats exposed to delta-9-tetrahydrocannabinol (THC) showed differential DNA methylation at Dlgap2 in sperm (p < 0.03), as did the nucleus accumbens of rats whose fathers were exposed to THC prior to conception (p < 0.05). …”
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Glucokinase neurons of the paraventricular nucleus of the thalamus sense glucose and decrease food consumption by Sébastien Kessler, Gwenaël Labouèbe, Sophie Croizier, Sevasti Gaspari, David Tarussio, Bernard Thorens

“…Summary: The paraventricular nucleus of the thalamus (PVT) controls goal-oriented behavior through its connections to the nucleus accumbens (NAc). We previously characterized Glut2aPVT neurons that are activated by hypoglycemia, and which increase sucrose seeking behavior through their glutamatergic projections to the NAc. …”
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Altered resting-state functional connectivity within corticostriatal and subcortical-striatal circuits in chronic pain by Su Hyoun Park, Anne K. Baker, Vinit Krishna, Sean C. Mackey, Katherine T. Martucci

“…It has been demonstrated that in patients with chronic back pain, altered nucleus accumbens (NAcc)—medial prefrontal cortex (MPFC) circuit fMRI-based activity is predictive of patient outcome. …”
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Unravelling the differential functions and regulation of striatal neuron sub-populations in motor control, reward and motivational processes by Sabrina eEna, Alban eDe Kerchove D'ExaErde, Serge N Schiffmann

“…The dorsal striatum, caudate-putamen, is primarily implicated in motor functions whereas the ventral striatum, the nucleus accumbens, is essential for motivation and drug reinforcement. …”
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Neural Substrates of Brand Love: An Activation Likelihood Estimation Meta-Analysis of Functional Neuroimaging Studies by Shinya Watanuki, Hiroyuki Akama

“…Finally, those for romantic love were detected in the hedonic, strong passionate, and intimate-related regions, such as the nucleus accumbens and ventral tegmental area. Thus, the common regions of brain activation between brand and romantic love were in the dorsal striatum. …”
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Preclinical and clinical evidence for suppression of alcohol intake by apremilast by Kolter B. Grigsby, Regina A. Mangieri, Amanda J. Roberts, Marcelo F. Lopez, Evan J. Firsick, Kayla G. Townsley, Alan Beneze, Jessica Bess, Toby K. Eisenstein, Joseph J. Meissler, John M. Light, Jenny Miller, Susan Quello, Farhad Shadan, Michael Skinner, Heather C. Aziz, Pamela Metten, Richard A. Morrisett, John C. Crabbe, Marisa Roberto, Howard C. Becker, Barbara J. Mason, Angela R. Ozburn

“…Using site-directed drug infusions and electrophysiology, we uncovered that apremilast may act to lessen drinking in mice by increasing neural activity in the nucleus accumbens, a key brain region in the regulation of alcohol intake. …”
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Electrophysiological and imaging evidence of sustained inhibition in limbic and frontal networks following deep brain stimulation for treatment refractory obsessive compulsive diso... by Hye Ran Park, In Hyang Kim, Hyejin Kang, Kevin W McCairn, Dong Soo Lee, Bung-Nyun Kim, Dong Gyu Kim, Sun Ha Paek

“…Targets of stimulation were the anterior limb of the internal capsule (ALIC) in two cases, and the nucleus accumbens (NAc) in the remaining cohort. The clinical profiles were quantified by the Yale-Brown obsessive-compulsive scale (Y-BOCS). …”
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Administration of the GABA_Areceptor antagonist picrotoxin into rat supramammillary nucleus induces c-Fos in reward-related brain structures. Supramammillary picrotoxin... by Shin Rick, Ikemoto Satoshi

“…This manipulation also increased c-Fos expression in structures including the ventral tegmental area, medial shell of the nucleus accumbens, medial prefrontal cortex, septal area, preoptic area, lateral hypothalamic area and dorsal raphe nucleus.…”
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Chronic pramipexole treatment increases tolerance for sucrose in normal and ventral tegmental lesioned rats. by David eDARDOU, Carine eChassain, Franck eDurif, Franck eDurif

“…In addition, we noted that the change in sucrose consumption was sustained by an increase of the expression of the dopamine 3 receptor in the core and the shell regions of the nucleus accumbens. The present results may suggest that long term stimulation of the dopamine 3 receptor in animals induces a strong increase in sucrose consumption, indicating an effect of this receptor on certain pathological aspects of food eating.…”
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Effect of illumination level [18F]FDG-PET brain uptake in free moving mice. by Alexandra de Francisco, Yolanda Sierra-Palomares, María Felipe, Daniel Calle, Manuel Desco, Lorena Cussó

“…The results showed that [18F]FDG uptake is higher in darkness than in light condition in mouse nucleus accumbens, hippocampus, midbrain, hindbrain, and cerebellum. …”
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Neuroimaging of pain in animal models: a review of recent literature by Joyce T. Da Silva, David A. Seminowicz

“…On the other hand, in chronic pain models, brain activity was observed in regions commonly associated with emotion and motivation, including prefrontal cortex, anterior cingulate cortex, hippocampus, amygdala, basal ganglia, and nucleus accumbens. Neuroimaging of pain in animals holds great promise for advancing our knowledge of brain function and allowing us to expand human subject research. …”
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Prefrontal contributions to mental resilience: Lessons from rodent studies of stress and antidepressant actions by Ryota Shinohara, Tomoyuki Furuyashiki

“…Whereas dopamine neurons projecting to the nucleus accumbens potentiated by chronic stress promote stress susceptibility, dopamine neurons projecting to the mPFC activated upon acute stress contribute to dendritic growth of mPFC neurons via dopamine D1 receptors, leading to stress resilience. …”
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Methamphetamine-induced region-specific transcriptomic and epigenetic changes in the brain of male rats by Benpeng Miao, Xiaoyun Xing, Viktoriia Bazylianska, Pamela Madden, Anna Moszczynska, Bo Zhang

“…Here we examined the effects of binge METH on the GRN in the nucleus accumbens, dentate gyrus, Ammon’s horn, and subventricular zone in male rats. …”
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Clinical manifestations of combined methamphetamine with morphine and their effects on brain dopamine and 5-hydroxytryptamine release in mice by Shing-Hwa Liu, Shoei-Yn Lin-Shiau, Alice Chien Chang, Kuo-Cheng Lan

“…The mechanisms underlying the interaction between MA and morphine were explored by measuring the extracellular levels of DA and 5-HT in the shell of the nucleus accumbens using an in vivo microdialysis technique. …”
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Optogenetic dissection of amygdala functioning by Ryan eLalumiere

“…Findings from such studies have provided evidence that particular patterns of activity in basolateral amygdala glutamatergic neurons are related to memory consolidation processes, while other work has indicated the critical nature of amygdala inputs to the prefrontal cortex and nucleus accumbens in regulating behavior dependent on those downstream structures. …”
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A Role of BDNF in the Depression Pathogenesis and a Potential Target as Antidepressant: The Modulator of Stress Sensitivity “Shati/Nat8l-BDNF System” in the Dorsal Striatum by Hajime Miyanishi, Atsumi Nitta

“…We reviewed a novel finding of BDNF function in the dorsal striatum, which induces vulnerability to social stress, in addition to recent research progress regarding the brain regional functions of BDNF, including the prefrontal cortex, hippocampus, and nucleus accumbens. Striatal BDNF is regulated by Shati/Nat8l, an <i>N</i>-acetyltransferase through epigenetic regulation. …”
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Experience-dependent information routing through the basolateral amygdala shapes behavioral outcomes by Pantelis Antonoudiou, Bradly T. Stone, Phillip L.W. Colmers, Aidan Evans-Strong, Eric Teboul, Najah L. Walton, Grant L. Weiss, Jamie Maguire

“…Here we demonstrate that previous positive (enriched environment [EE]) or negative (chronic unpredictable stress [CUS]) experiences differentially influence the activity of populations of BLA principal neurons projecting to either the nucleus accumbens core or bed nucleus of the stria terminalis. …”
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