Effects of bariatric surgery on the central nervous system and eating behavior in humans: a systematic review on the neuroimaging studies by Hélio Tonelli, Fernanda Mattias Sartori, João Caetano Dallegrave Marchesini, João Batista Marchesini, Denise Gianoti Tonelli

“…CONCLUSIONS: Bariatric surgery might normalize the activity of central areas concerned with reward and incentive salience processing, as the nucleus accumbens and mesencephalic tegmental ventral area, as well as circuitries processing behavioral inhibition, as the dorsolateral prefrontal cortex.…”
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Neurodevelopmental disruption of cortico-striatal function caused by degeneration of habenula neurons. by Young-A Lee, Yukiori Goto

“…Given that the monoamine systems are highly vulnerable to neurodevelopmental insults, damages in the habenula during early neurodevelopment may cause devastating effects on the wide-spread brain areas targeted by monoamine innervations.Using a battery of behavioral, anatomical, and biochemical assays, we examined the impacts of neonatal damage in the habenula on neurodevelopmental sequelae of the prefrontal cortex (PFC) and nucleus accumbens (NAcc) and associated behavioral deficits in rodents. …”
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Basic and Translational Research on Proteinase-Activated Receptors: Regulation of Nicotine Reward by the Tissue Plasminogen Activator (tPA) – Plasmin System via Proteinase-Activate... by Taku Nagai, Toshitaka Nabeshima, Kiyofumi Yamada

“…We show that the tissue plasminogen activator (tPA) – plasmin system regulates nicotine-induced reward and dopamine release in the nucleus accumbens (NAc) by activating proteinase-activated receptor 1 (PAR1). …”
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Sensorimotor and Pain Modulation Brain Abnormalities in Trigeminal Neuralgia: A Paroxysmal, Sensory-Triggered Neuropathic Pain. by Danielle D Desouza, Massieh Moayedi, David Q Chen, Karen D Davis, Mojgan Hodaie

“…We further determined the contribution of long-term TN on GM plasticity.Cortical thickness and subcortical GM volume were measured from high-resolution 3T T1-weighted MRI scans in 24 patients with right-sided TN and 24 healthy control participants.TN patients had increased GM volume in the sensory thalamus, amygdala, periaqueductal gray, and basal ganglia (putamen, caudate, nucleus accumbens) compared to healthy controls. The patients also had greater cortical thickness in the contralateral primary somatosensory cortex and frontal pole compared to controls. …”
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The association between areas of secondary hyperalgesia and volumes of the caudate nuclei and other pain relevant brain structures-A 3-tesla MRI study of healthy men. by Morten S Hansen, Mohammad S Asghar, Jørn Wetterslev, Christian B Pipper, Johan Mårtensson, Lino Becerra, Anders Christensen, Janus D Nybing, Inger Havsteen, Mikael Boesen, Jørgen B Dahl

“…RESULTS:We found no significant associations between the size of the area of secondary hyperalgesia and the volume of the caudate nuclei or of the following structures: primary somatosensory cortex, anterior and mid cingulate cortex, putamen, nucleus accumbens, globus pallidus, insula and the cerebellum. …”
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Activation of RMTg projections to the VTA reverse cocaine-induced molecular adaptation in the reward system by A. Khayat, R. Yaka

“…Our study demonstrates that enhancing the GABAergic inputs from the RMTg to the VTA can mitigate cocaine-induced molecular changes in key regions, namely the VTA, nucleus accumbens (NAc), and prefrontal cortex (PFC). Specifically, we found that cocaine-induced alteration in the phosphorylation state of ERK (pERK) and GluA1 on serine 845 (S845) and serine 831 (S831), that play a major role in plasticity by controlling the activity and trafficking of AMPA receptors, were significantly reversed following optic stimulation of RMTg afferents to the VTA. …”
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Corticofugal GABAergic projection neurons in the mouse frontal cortex by Ryohei eTomioka, Kenji eSakimura, Yuchio eYanagawa

“…Injections of the Cre-dependent adeno-associated virus into glutamate decarboxylase 67-Cre knock-in mice revealed neocortical GABAergic projections widely to the forebrain, including the cerebral cortices, caudate putamen, ventral pallidum, lateral globus pallidus, nucleus accumbens, and olfactory tubercle. Minor GABAergic projections were also found in the mediodorsal thalamic nucleus, diagonal band of Broca, medial globus pallidus, substantial nigra, and dorsal raphe nucleus. …”
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Short- and long-term cognitive effects of chronic cannabinoids administration in late-adolescence rats. by Hila Abush, Irit Akirav

“…The impairing effects of chronic WIN on short-term memory in the water maze and the object recognition tasks as well as long-term potentiation (LTP) in the ventral subiculum (vSub)-nucleus accumbens (NAc) pathway were temporary as they lasted only 24 h or 10 d after withdrawal. …”
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Sound evoked fos-like immunoreactivity in the big brown bat by Angeles Salles, Shirley Marino Lee, Cynthia F. Moss

“…We focused our investigation on five relevant brain areas; three within the canonical auditory pathway (auditory cortex, inferior colliculus and medial geniculate body) and two that are involved in the processing of emotive stimulus content (amygdala and nucleus accumbens). In this manuscript we report c-fos staining of the areas of interest after exposure to conspecific calls. …”
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Insulin replacement prevents the acquisition but not the expression of morphine-induced conditioned place preference in streptozotocin-induced diabetic rats by Rezvan Hassanpour, Atieh Chizari, Amir-Hossein Bayat, Ronak Azizbeigi, Maedeh Mahmoudi, Zahra Mousavi, Abbas Haghparast

“…Abstract Insulin receptors have distributed in all brain regions, including the nucleus Accumbens (NAc), and where is implicated in the reward properties of drugs. …”
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Dopamine systems and biological rhythms: Let’s get a move on by Qijun Tang, Dina R. Assali, Ali D. Güler, Ali D. Güler, Ali D. Güler, Andrew D. Steele

“…Here we review experiments focused on delineating dopamine signaling in the suprachiasmatic nucleus, nucleus accumbens, and dorsal striatum to mediate a range of biological rhythms including photoentrainment, activity cycles, rest phase eating of palatable food, diet-induced obesity, and food anticipatory activity. …”
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Cortical and subcortical activities during food rewards versus social interaction in rats by Florbela Rocha-Almeida, Ana R. Conde-Moro, Antonio Fernández-Ruiz, José M. Delgado-García, Agnès Gruart

“…LFP analysis revealed a decrease in nucleus accumbens (NAc) spectral power following social interaction, accompanied by specific alterations in delta and theta bands within the medial prefrontal cortex (mPFC). …”
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Random Forest Segregation of Drug Responses May define Regions of Biological Significance by Qasim eBukhari, David eBorsook, Markus eRudin, Markus eRudin, Lino eBecerra

“…RF analysis was able to identify drug effects based on differential phMRI responses in the hippocampus, amygdala, nucleus accumbens, superior colliculus and the lateral and posterior thalamus for drug vs. saline. …”
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Cocaine-Induced Endocannabinoid Mobilization in the Ventral Tegmental Area by Huikun Wang, Tyler Treadway, Daniel P. Covey, Joseph F. Cheer, Carl R. Lupica

“…The disinhibition of DA neurons by cocaine-mobilized 2-AG is also functionally relevant because it augments DA release in the nucleus accumbens in vivo. Our results identify a mechanism through which the eCB system can regulate the rewarding and addictive properties of cocaine.…”
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Light affects behavioral despair involving the clock gene Period 1. by Iwona Olejniczak, Jürgen A Ripperger, Federica Sandrelli, Anna Schnell, Anna Schnell, Laureen Mansencal-Strittmatter, Katrin Wendrich, Ka Yi Hui, Andrea Brenna, Naila Ben Fredj, Urs Albrecht

“…RNA sequence analysis in the mesolimbic dopaminergic system revealed profound changes of gene expression after a light pulse at ZT22. In the nucleus accumbens (NAc), sensory perception of smell and G-protein coupled receptor signaling were affected the most. …”
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Paradoxical Neuroethical Crisis of Agency and Identity in an Obsessive-Compulsive Disorder Deep Brain Stimulation Patient by B. Carr

“…Methods Case-report of a 60+-year-old gentleman with a history of childhood-onset, treatment refractory OCD with a 15-year history of bilateral DBS lead placed via a ventral caudate/ ventral striatum trajectory through the anterior limb of the internal capsule to the nucleus accumbens. Results Years later he was only minimally improved above baseline; yet now with a few-years increasing degree of distress over a perceived atrophy of his capabilities that he felt was validated through what he described as his failure of artificial bionics. …”
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Fyn Signaling Is Compartmentalized to Dopamine D1 Receptor Expressing Neurons in the Dorsal Medial Striatum by Khanhky Phamluong, Emmanuel Darcq, Su Wu, Samuel A. Sakhai, Dorit Ron

“…Here we report that Fyn is activated in response to 15 min D1 receptor (D1R) but not D2 receptor (D2R) stimulation specifically in the dorsomedial striatum (DMS) of mice but not in the other substriatal regions, the dorsolateral striatum (DLS), and the nucleus accumbens (NAc). Once activated Fyn phosphorylates its substrate GluN2B, and we show that GluN2B is phosphorylated only in the DMS but not in the other striatal regions. …”
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Volumes of brain structures in captive wild-type and laboratory rats: 7T magnetic resonance in vivo automatic atlas-based study. by Marlena Welniak-Kaminska, Michal Fiedorowicz, Jaroslaw Orzel, Piotr Bogorodzki, Klaudia Modlinska, Rafal Stryjek, Anna Chrzanowska, Wojciech Pisula, Pawel Grieb

“…Relative volumes of phylogenetically older structures, such as hippocampus, amygdala, nucleus accumbens and olfactory nuclei, also displayed certain strain-related differences. …”
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Cefazolin and ceftriaxone attenuate the cue-primed reinstatement of alcohol-seeking by Ana eWeiland, Steven eGarcia, Lori A Knackstedt

“…CEFAZ had no effect on cocaine reinstatement, a behavior that has been strongly tied to altered glutamate homeostasis in the nucleus accumbens. Thus the ability of CEFAZ to attenuate alcohol reinstatement likely does not involve the glial modulation of glutamate levels. …”
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Central melanocortins regulate the motivation for sucrose reward. by Rahul Pandit, Esther M van der Zwaal, Mieneke C M Luijendijk, Maike A D Brans, Andrea J van Rozen, Ralph J A Oude Ophuis, Louk J M J Vanderschuren, Roger A H Adan, Susanne E la Fleur

“…MC receptors are widely expressed in both hypothalamic and extra-hypothalamic brain regions, including nuclei involved in food reward and motivation, such as the nucleus accumbens (NAc) and the ventral tegmental area. …”
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