Habituation or sensitization of brain response to food cues: Temporal dynamic analysis in an functional magnetic resonance imaging study by Peyman Ghobadi-Azbari, Rasoul Mahdavifar Khayati, Hamed Ekhtiari

“…Neuro-behavioral relationships were investigated with Pearson’s correlation tests and group factor analysis (GFA).ResultsA linear mixed-effect model revealed a trend for the time-by-condition interactions in the left medial amygdala [t(289) = 2.21, β = 0.1, P = 0.028], right lateral amygdala [t(289) = 2.01, β = 0.26, P = 0.045], right nucleus accumbens (NAc) [t(289) = 2.81, β = 0.13, P = 0.005] and left dorsolateral prefrontal cortex (DLPFC) [t(289) = 2.58, β = 0.14, P = 0.01], as well as in the left superior temporal cortex [42 Area: t(289) = 2.53, β = 0.15, P = 0.012; TE1.0_TE1.2 Area: t(289) = 3.13, β = 0.27, P = 0.002]. …”
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Computational modeling of threat learning reveals links with anxiety and neuroanatomy in humans by Rany Abend, Diana Burk, Sonia G Ruiz, Andrea L Gold, Julia L Napoli, Jennifer C Britton, Kalina J Michalska, Tomer Shechner, Anderson M Winkler, Ellen Leibenluft, Daniel S Pine, Bruno B Averbeck

“…Results indicate that greater anxiety severity related specifically to slower safety learning and slower extinction of response to safe stimuli. Nucleus accumbens gray-matter volume moderated learning-anxiety associations. …”
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Martial Arts “Kendo” and the Motivation Network During Attention Processing: An fMRI Study by Hironobu Fujiwara, Hironobu Fujiwara, Hironobu Fujiwara, Tsukasa Ueno, Sayaka Yoshimura, Kei Kobayashi, Takashi Miyagi, Naoya Oishi, Toshiya Murai

“…Resting-state fMRI revealed that KPs had a significantly lower FC than NKPs between the right nucleus accumbens and right frontal eye field (FEF) within the motivation network. …”
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Neural Correlates of Smartphone Dependence in Adolescents by Olga Tymofiyeva, Justin P. Yuan, Justin P. Yuan, Roma Kidambi, Chiung-Yu Huang, Eva Henje, Eva Henje, Mark L. Rubinstein, Namasvi Jariwala, Jeffrey E. Max, Tony T. Yang, Duan Xu

“…Based on previous literature on the neurobiology of addiction, we hypothesized a disruption of network centrality of three nodes in the mesolimbic network: Nucleus Accumbens, anterior cingulate cortex, and amygdala. …”
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Sperm DNA methylation alterations from cannabis extract exposure are evident in offspring by Rose Schrott, Jennifer L. Modliszewski, Andrew B. Hawkey, Carole Grenier, Zade Holloway, Janequia Evans, Erica Pippen, David L. Corcoran, Edward D. Levin, Susan K. Murphy

“…Changes validated in exposed F0 sperm at Metastasis Suppressor 1-Like Protein (Mtss1l) were also present in F1 hippocampal and nucleus accumbens (NAc) of the exposed group compared to controls. …”
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Mapping of the FGF14:Nav1.6 complex interface reveals FLPK as a functionally active peptide modulating excitability by Aditya K. Singh, Paul A. Wadsworth, Cynthia M. Tapia, Giuseppe Aceto, Syed R. Ali, Haiying Chen, Marcello D'Ascenzo, Jia Zhou, Fernanda Laezza

“…In medium spiny neurons in the nucleus accumbens, where both FGF14 and Nav1.6 are abundantly expressed, FLPK significantly increased firing frequency by a mechanism consistent with the ability of the tetrapeptide to interfere with Nav1.6 inactivation and potentiate persistent Na+ currents. …”
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Neural networks associated with body composition in frontotemporal dementia by Rebekah M. Ahmed, Ramon Landin‐Romero, Cheng T. Liang, Julia M. Keogh, Elana Henning, Cherie Strikwerda‐Brown, Emma M. Devenney, John R. Hodges, Matthew C. Kiernan, I. Sadaf Farooqi, Olivier Piguet

“…Changes in body composition also correlated to grey matter atrophy involving a distributed neural network that included the hippocampus, amygdala, nucleus accumbens, insula, cingulate, and cerebellum – structures known to be central to autonomic control – as well as the thalamus, putamen, accumbens, and caudate, which are involved in reward processing. …”
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Mitochondria DNA copy number, mitochondria DNA total somatic deletions, Complex I activity, synapse number, and synaptic mitochondria number are altered in schizophrenia and bipola... by Sujan C. Das, Brooke E. Hjelm, Brandi L. Rollins, Adolfo Sequeira, Ling Morgan, Audrey A. Omidsalar, Alan F. Schatzberg, Jack D. Barchas, Francis S. Lee, Richard M. Myers, Stanley J. Watson, Huda Akil, William E. Bunney, Marquis P. Vawter

“…Mitochondria DNA (mtDNA) copy number (CN), mtDNA common deletion (CD), mtDNA total deletion, complex I activity, synapse number, and synaptic mitochondria number were studied in the postmortem human dorsolateral prefrontal cortex (DLPFC), superior temporal gyrus (STG), primary visual cortex (V1), and nucleus accumbens (NAc) of controls (CON), and subjects with schizophrenia (SZ), and bipolar disorder (BD). …”
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Alpha1-adrenergic receptor blockade in the ventral tegmental area attenuates acquisition of cocaine-induced pavlovian associative learning by Wojciech B. Solecki, Michał Kielbinski, Joanna Bernacka, Joanna Bernacka, Katarzyna Gralec, Adam Klasa, Kamil Pradel, Karolina Rojek-Sito, Ryszard Przewłocki

“…In addition, both α1-AR immunoreactivity in the VTA and its role in phasic DA release in the nucleus accumbens (NAc) were assessed. We demonstrated cellular localization of α1-AR expression in the VTA, providing a neuroanatomical substrate for the α1-AR mechanism. …”
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Gene expression profiling in nucleus pulposus of human ruptured lumbar disc herniation by Xiaochun Li, Xiaochun Li, Xueqiang Shen, Xueqiang Shen, Zhiqiang Wang, Zhiqiang Wang, Hong Jiang, Hong Jiang, Zhijia Ma, Zhijia Ma, Pengfei Yu, Pengfei Yu, Zhenhan Yu, Zhenhan Yu, Xiang Qian, Xiang Qian, Jintao Liu, Jintao Liu

“…Moreover, CCL5, AQP3 and SDC4 may improve the chemotaxis of stem cell migration for self-healing of damaged disc tissue, increase water uptake by nucleus accumbens cells, and inhibit the inflammatory response, thus delaying the process of intervertebral disc degeneration.…”
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Acupuncture attenuates comorbid anxiety- and depressive-like behaviors of atopic dermatitis through modulating neuroadaptation in the brain reward circuit in mice by Mijung Yeom, Sora Ahn, Sun-Young Jang, Jae-Hwan Jang, Youngrye Lee, Dae-Hyun Hahm, Hi-Joon Park

“…In addition, biochemical changes in the brain reward regions were investigated by immunoblotting for the expression of tyrosine hydroxylase (TH), dopamine D1 receptor (D1R), phospho-dopamine and cAMP-regulated phosphoprotein-32 kDa (pDARPP-32), phospho-cAMP response element binding protein (pCREB), ΔFosB, and brain-derived neurotrophic factor (BDNF) in the nucleus accumbens, dorsolateral striatum, and ventral tegmental area. …”
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The Relationship Between Socioeconomic Status and Brain Volume in Children and Adolescents With Prenatal Alcohol Exposure by Kristina A. Uban, Kristina A. Uban, Eric Kan, Jeffrey R. Wozniak, Sarah N. Mattson, Claire D. Coles, Elizabeth R. Sowell

“…General linear modeling was utilized to examine associations between SES and subcortical brain volumes for youth with PAE compared to Controls.ResultsGroup by SES interactions were observed within the hippocampus (HPC), nucleus accumbens (NAc) and ventral diencephalon (vDC) (corrected p values <0.05), where positive associations (e.g., higher SES related to larger subcortical volumes) were observed within Controls, but not youth with PAE. …”
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Gestational Exposure to Sodium Valproate Disrupts Fasciculation of the Mesotelencephalic Dopaminergic Tract, With a Selective Reduction of Dopaminergic Output From the Ventral Tegm... by Ágota Ádám, Róbert Kemecsei, Verónica Company, Raquel Murcia-Ramón, Iris Juarez, László I. Gerecsei, Gergely Zachar, Diego Echevarría, Eduardo Puelles, Salvador Martínez, András Csillag

“…We also found a reduction in the abundance of dopaminergic ventral tegmental (VTA) neurons, accompanied by diminished tissue level of DA in ventrobasal telencephalic regions (including the nucleus accumbens (NAc), olfactory tubercle, BST, substantia innominata). …”
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Mitigating Effects of <i>Liriope platyphylla</i> on Nicotine-Induced Behavioral Sensitization and Quality Control of Compounds by Dahye Yoon, In Soo Ryu, Woo Cheol Shin, Minhan Ka, Hyoung-Geun Kim, Eun Young Jang, Oc-Hee Kim, Young-Seob Lee, Joung-Wook Seo, Dae Young Lee

“…The extract of <i>L. platyphylla</i> significantly attenuated the repeated nicotine-induced DAT protein expression in the nucleus accumbens (NAc), but there was no effect on increased TH protein expression in the dorsal striatum. …”
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fMRI detects bilateral brain network activation following unilateral chemogenetic activation of direct striatal projection neurons by Yuki Nakamura, Yukari Nakamura, Assunta Pelosi, Boucif Djemai, Clément Debacker, Denis Hervé, Jean-Antoine Girault, Tomokazu Tsurugizawa

“…After clozapine (CLZ) stimulation of the excitatory DREADD expressed in D1-neurons, the fractional amplitude of low frequency fluctuations (fALFF) increased bilaterally in the medial thalamus, nucleus accumbens and cortex. In addition, we found that the gamma-band of local field potentials was increased in the stimulated DS and cortex bilaterally. …”
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Alcohol Co-Administration Changes Mephedrone-Induced Alterations of Neuronal Activity by Milo Grotell, Bjørnar den Hollander, Aaro Jalkanen, Essi Törrönen, Jouni Ihalainen, Elena de Miguel, Mateusz Dudek, Mikko I. Kettunen, Petri Hyytiä, Markus M. Forsberg, Esko Kankuri, Esa R. Korpi

“…These effects were most profound in brain regions which are known to have high dopamine and serotonin activities including hippocampus, nucleus accumbens and caudate-putamen. In the regions showing the strongest activation changes, no morphological changes were observed in spine analysis. …”
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Social isolation postweaning alters reward-related dopamine dynamics in a region-specific manner in adolescent male rats by Valeria Lallai, Cristina Congiu, Giulia Craig, Letizia Manca, Yen-Chu Chen, Angeline J. Dukes, Christie D. Fowler, Laura Dazzi

“…Three weeks later, extracellular dopamine concentrations were examined in the medial prefrontal cortex (mPFC) and nucleus accumbens shell (NAc) during a feeding bout. Surprisingly, opposing effects were found in which increased mPFC dopamine concentrations were observed in group housed, but not isolated, rats. …”
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Methylation of the tyrosine hydroxylase gene is dysregulated by cocaine dependence in the human striatum by Kathryn Vaillancourt, Gang G. Chen, Laura Fiori, Gilles Maussion, Volodymyr Yerko, Jean-François Théroux, Carl Ernst, Benoit Labonté, Erin Calipari, Eric J. Nestler, Corina Nagy, Naguib Mechawar, Deborah C. Mash, Gustavo Turecki

“…We generated methylomic profiles of the nucleus accumbens using human postmortem brains from a cohort of individuals with cocaine dependence and healthy controls (n = 25 per group). …”
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Genetic labeling reveals spatial and cellular expression pattern of neuregulin 1 in mouse brain by Chen-Yun Ding, Yan-Ting Ding, Haifeng Ji, Yao-Yi Wang, Xinwen Zhang, Dong-Min Yin

“…In the striatum, Nrg1 is highly expressed in the Drd1-positive medium spiny neurons (MSNs) in the shell of nucleus accumbens (NAc) that project to substantia nigra pars reticulata (SNr). …”
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Altered Expression of Genes Associated with Major Neurotransmitter Systems in the Reward-Related Brain Regions of Mice with Positive Fighting Experience by Dmitry A. Smagin, Anna G. Galyamina, Irina L. Kovalenko, Natalia N. Kudryavtseva

“…The aim of this work was to study differentially expressed genes (DEGs) in the main reward-related brain regions, including the ventral tegmental area (VTA), dorsal striatum (STR), ventral striatum (nucleus accumbens, NAcc), prefrontal cortex (PFC), and midbrain raphe nuclei (MRNs), in male mice with 20-day positive fighting experience in daily agonistic interactions. …”
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