Hapticophagia in Iron Deficiency Anaemia and Oral Submucous Fibrosis- Two Sides of the Same Coin by P Poornachitra, Arvind Muthukrishnan

“…The food cravings originate in the hippocampus, the memory center, and nucleus accumbens, the pleasure centre, are an interplay of an imbalance of neuropeptides such as dopamine, serotonin, and leptin with endorphins released after chewing the craved item which mirrors the pathway of addiction [8,9]. …”
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Parkinson’s LRRK2-G2019S risk gene mutation drives sex-specific behavioral and cellular adaptations to chronic variable stress by Christopher A. Guevara, Christopher A. Guevara, Christopher A. Guevara, Kumayl Alloo, Kumayl Alloo, Kumayl Alloo, Swati Gupta, Swati Gupta, Romario Thomas, Romario Thomas, Pamela del Valle, Pamela del Valle, Pamela del Valle, Alexandra R. Magee, Alexandra R. Magee, Alexandra R. Magee, Deanna L. Benson, Deanna L. Benson, Deanna L. Benson, George W. Huntley, George W. Huntley, George W. Huntley

“…The density of cFos-activated neurons across brain regions in both male and female Lrrk2G2019S mice was generally lower compared to stressed Lrrk2WT mice, except for the nucleus accumbens of male Lrrk2G2019S mice, where cFos-labeled cell density was significantly higher than all other groups. …”
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The mesolimbic system and the loss of higher order network features in schizophrenia when learning without reward by Elizabeth Martin, Elizabeth Martin, Asadur Chowdury, Asadur Chowdury, John Kopchick, Patricia Thomas, Dalal Khatib, Usha Rajan, Caroline Zajac-Benitez, Luay Haddad, Alireza Amirsadri, Alfred J. Robison, Katherine N. Thakkar, Jeffrey A. Stanley, Vaibhav A. Diwadkar

“…Our results provide substantial support for these predictions where we observed a loss of network features between the brain’s sub-circuits for a) learning (including the hippocampus and prefrontal cortex) and b) reward processing (specifically constituents of the mesolimbic system that included the ventral tegmental area and the nucleus accumbens. Our findings motivate a renewed appraisal of the relationship between reward and cognition in schizophrenia and we discuss their relevance for putative behavioral interventions.…”
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Poststress social isolation exerts anxiolytic effects by activating the ventral dentate gyrus by Huiyang Lei, Huaqing Shu, Rui Xiong, Ting He, Jingru Lv, Jiale Liu, Guilin Pi, Dan Ke, Qun Wang, Xifei Yang, Jian-Zhi Wang, Ying Yang

“…There were no significant differences between the two groups in the other anxiety- and social-related brain regions, such as prelimbic cortex, infralimbic cortex, nucleus accumbens, etc. These data indicate that vDG is closely related to the differential phenotypes between the poststress social isolation and poststress social contact groups. …”
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Neuroimmune circuits involved in β-lactoglobulin-induced food allergy by Luísa Lemos, Helder Carvalho Assis, Juliana Lima Alves, Daniela Silva Reis, Maria Cecilia Campos Canesso, Mariana Almeida Oliveira, Thais Garcias Moreira, Barbara Kaori Miranda Sato, Luara Augusta Batista, Julia Gomes Lenzi, Muiara Aparecida Moraes, Luciana Melo, Bruna Resende, Danielle Aguiar, Bruno Rezende Souza, Denise Carmona Cara, Ana Cristina Gomes-Santos, Ana Maria Caetano Faria

“…On the other hand, when mice were sensitized to OVA and received a mixture of BLG and OVA in the oral challenge, mice preferred to drink this mixture, despite their aversion to OVA, which was associated with neuron activation in the nucleus accumbens, an area related to reward behavior. …”
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Brain tissue- and cell type-specific eQTL Mendelian randomization reveals efficacy of FADS1 and FADS2 on cognitive function by Xueyan Wu, Lei Jiang, Hongyan Qi, Chunyan Hu, Xiaojing Jia, Hong Lin, Shuangyuan Wang, Lin Lin, Yifang Zhang, Ruizhi Zheng, Mian Li, Tiange Wang, Zhiyun Zhao, Min Xu, Yu Xu, Yuhong Chen, Jie Zheng, Yufang Bi, Jieli Lu

“…Tissue-specific MR showed an effect of increased FADS1 expression in cerebellar hemisphere and FADS2 expression in nucleus accumbens basal ganglia on maintaining cognitive function, while decreased FADS1 expression in nine brain tissues on maintaining cognitive function [colocalization probability (PP.H4) ranged from 71.7% to 100.0%]. …”
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A Novel and Selective Dopamine Transporter Inhibitor, <i>(S)</i>-MK-26, Promotes Hippocampal Synaptic Plasticity and Restores Effort-Related Motivational Dysfunctions by Shima Kouhnavardi, Alev Ecevitoglu, Vladimir Dragačević, Fabrizio Sanna, Edgar Arias-Sandoval, Predrag Kalaba, Michael Kirchhofer, Jana Lubec, Marco Niello, Marion Holy, Martin Zehl, Matthias Pillwein, Judith Wackerlig, Rita Murau, Andrea Mohrmann, Kathryn R. Beard, Harald H. Sitte, Ernst Urban, Claudia Sagheddu, Marco Pistis, Roberto Plasenzotti, John D. Salamone, Thierry Langer, Gert Lubec, Francisco J. Monje

“…Moreover, in in vivo microdialysis experiments, (<i>S</i>)-MK-26 significantly increased extracellular DA levels in the prefrontal cortex and in nucleus accumbens core and shell. These studies highlight (<i>S</i>)-MK-26 as a potent enhancer of transsynaptic DA and promoter of synaptic plasticity, with predominant beneficial effects on effort-related behaviors, thus proposing therapeutic potentials for (<i>S</i>)-MK-26 in the treatment of low-effort exertion and motivational dysfunctions characteristic of depression and aging-related disorders.…”
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Reward system neurodynamics during menstrual pain modulated by COMT Val158Met polymorphisms by Pei-Shan Hsu, Pei-Shan Hsu, Pei-Shan Hsu, Ching-Hsiung Liu, Ching-Hsiung Liu, Ching-Ju Yang, Ching-Ju Yang, Ching-Ju Yang, Ching-Ju Yang, Lin-Chien Lee, Lin-Chien Lee, Wei-Chi Li, Wei-Chi Li, Wei-Chi Li, Hsiang-Tai Chao, Ming-Wei Lin, Li-Fen Chen, Li-Fen Chen, Li-Fen Chen, Li-Fen Chen, Jen-Chuen Hsieh, Jen-Chuen Hsieh, Jen-Chuen Hsieh, Jen-Chuen Hsieh

“…Distinct FC patterns was observed between Val/Val homozygotes and Met carriers, specifically between the nucleus accumbens (NAc) and prefrontal cortex, NAc and inferior parietal lobe, ventral tegmental area (VTA) and prefrontal cortex, VTA and precentral gyrus, and VTA and superior parietal lobe. …”
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Shape analysis of subcortical structures in obsessive‐compulsive disorder and the relationship with comorbid anxiety, depression, and medication use: A meta‐analysis by the OCD Bra... by Jean‐Paul Fouche, Nynke A. Groenewold, Tatum Sevenoaks, Sarah Heany, Christine Lochner, Pino Alonso, Marcelo C. Batistuzzo, Narcis Cardoner, Christopher R. K. Ching, Stella J. deWit, Boris Gutman, Marcelo Q. Hoexter, Neda Jahanshad, Minah Kim, Jun Soo Kwon, David Mataix‐Cols, Jose M. Menchon, Euripedes C. Miguel, Takashi Nakamae, Mary L. Phillips, Jesus Pujol, Yuki Sakai, Je‐Yeon Yun, Carles Soriano‐Mas, Paul M. Thompson, Kei Yamada, Dick J. Veltman, Odile A. vanden Heuvel, Dan J. Stein

“…OCD patients with comorbid depression had lower shape surface area in the thalamus, caudate nucleus, putamen, hippocampus, and nucleus accumbens and higher shape surface area in the pallidum. …”
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A worldwide study of subcortical shape as a marker for clinical staging in Parkinson’s disease by Max A. Laansma, Yuji Zhao, Eva M. van Heese, Joanna K. Bright, Conor Owens-Walton, Sarah Al-Bachari, Tim J. Anderson, Francesca Assogna, Tim D. van Balkom, Henk W. Berendse, Fernando Cendes, John C. Dalrymple-Alford, Ines Debove, Michiel F. Dirkx, Jason Druzgal, Hedley C. A. Emsley, Jean-Paul Fouche, Gaëtan Garraux, Rachel P. Guimarães, Rick C. Helmich, Michele Hu, Odile A. van den Heuvel, Dmitry Isaev, Ho-Bin Kim, Johannes C. Klein, Christine Lochner, Corey T. McMillan, Tracy R. Melzer, Benjamin Newman, Laura M. Parkes, Clelia Pellicano, Fabrizio Piras, Toni L. Pitcher, Kathleen L. Poston, Mario Rango, Leticia F. Ribeiro, Cristiane S. Rocha, Christian Rummel, Lucas S. R. Santos, Reinhold Schmidt, Petra Schwingenschuh, Letizia Squarcina, Dan J. Stein, Daniela Vecchio, Chris Vriend, Jiunjie Wang, Daniel Weintraub, Roland Wiest, Clarissa L. Yasuda, Neda Jahanshad, Paul M. Thompson, Ysbrand D. van der Werf, Boris A. Gutman

“…Notably, we observed incrementally thinner putamen from HY1, caudate nucleus and amygdala from HY2, hippocampus, nucleus accumbens, and thalamus from HY3, and globus pallidus from HY4–5. …”
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Patterns of Convergence and Divergence Between Bipolar Disorder Type I and Type II: Evidence From Integrative Genomic Analyses by Yunqi Huang, Yunqi Huang, Yunqi Huang, Yunjia Liu, Yunjia Liu, Yunjia Liu, Yulu Wu, Yulu Wu, Yulu Wu, Yiguo Tang, Yiguo Tang, Yiguo Tang, Mengting Zhang, Mengting Zhang, Mengting Zhang, Siyi Liu, Siyi Liu, Siyi Liu, Liling Xiao, Liling Xiao, Liling Xiao, Shiwan Tao, Shiwan Tao, Shiwan Tao, Min Xie, Min Xie, Min Xie, Minhan Dai, Minhan Dai, Minhan Dai, Mingli Li, Mingli Li, Mingli Li, Hongsheng Gui, Hongsheng Gui, Qiang Wang, Qiang Wang, Qiang Wang

“…TWAS data implicated different genes affecting BD I and II through expression in specific brain regions (nucleus accumbens for BD I). Cross-phenotype analyses indicated that BD I and II share continuous genetic structures with schizophrenia and major depressive disorder, which help fill the gaps left by the dichotomy of mental disorders.Conclusion: These combined evidences illustrate genetic convergence and divergence between BD I and II and provide an underlying biological and trans-diagnostic insight into major psychiatric disorders.…”
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Effects of mango and mint pod-based e-cigarette aerosol inhalation on inflammatory states of the brain, lung, heart, and colon in mice by Alex Moshensky, Cameron S Brand, Hasan Alhaddad, John Shin, Jorge A Masso-Silva, Ira Advani, Deepti Gunge, Aditi Sharma, Sagar Mehta, Arya Jahan, Sedtavut Nilaad, Jarod Olay, Wanjun Gu, Tatum Simonson, Daniyah Almarghalani, Josephine Pham, Samantha Perera, Kenneth Park, Rita Al-Kolla, Hoyoung Moon, Soumita Das, Min Kwang Byun, Zahoor Shah, Youssef Sari, Joan Heller Brown, Laura E Crotty Alexander

“…JUUL aerosol exposure induced upregulation of cytokine and chemokine gene expression and increased HMGB1 and RAGE in the nucleus accumbens in the central nervous system. Inflammatory gene expression increased in the colon, while gene expression was more broadly altered by e-cigarette aerosol inhalation in the lung. …”
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Multiple integrated social stress induces depressive-like behavioral and neural adaptations in female C57BL/6J mice by Xiaojing Zhai, Lin Ai, Dandan Chen, Dongyu Zhou, Yi Han, Ran Ji, Mengfan Hu, Qing Wang, Moruo Zhang, Yuxin Wang, Chunyan Zhang, Jun-Xia Yang, Ankang Hu, He Liu, Jun-Li Cao, Hongxing Zhang

“…Compared with controls, MISS females exhibited decreased c-Fos activation in their anterior cingulate cortex, prefrontal cortex, nucleus accumbens and some other depression-related brain regions. …”
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The Epistemological Consequences of Artificial Intelligence, Precision Medicine, and Implantable Brain-Computer Interfaces by Ian Stevens

“…Another deep brain stimulation lead, other than the one implanted for epilepsy, was placed in the patient’s right nucleus accumbens and ventral pallidum region given the correlation these nuclei had with OCD symptoms in prior research. …”
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(Mis)treating Substance Use Disorder With Prison by Kaitlin Puccio

“…All addictive drugs stimulate the release of dopamine in the nucleus accumbens. An individual may inherit an atypical response to opiates, for example, where the drug makes him feel euphoric and thus is highly reinforcing. …”
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The sequel to COVID-19: the antithesis to life by Sudhir Bhandari, Ajit Singh Shaktawat, Bhoopendra Patel, Amitabh Dube, Shivankan Kakkar, Amit Tak, Jitendra Gupta, Govind Rankawat

“…Enduring increases in anxiety-like behavior and rapid nucleus accumbens dopamine signaling in socially isolated rats. …”
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Impulsive Behavior and Nicotinic Acetylcholine Receptors by Yu Ohmura, Iku Tsutsui-Kimura, Mitsuhiro Yoshioka

“…Keywords:: nicotine, inhibitory control, impulsive action, attention-deficit/hyperactivity disorder (ADHD), nucleus accumbens…”
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Study on the Mechanism for SIRT1 during the Process of Exercise Improving Depression by Xiao Qiu, Pengcheng Lu, Xinyu Zeng, Shengjie Jin, Xianghe Chen

“…Silent information regulator 1 (SIRT1) is a key player in regulating energy metabolism, and it can regulate depression by mediating the inflammatory response (e.g., nuclear factor-kappa B (NF-κB), tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β)), gene expression in the nucleus accumben (NAc) and CA1 region of the hippocampus (e.g., nescient helix-loop-helix2 (NHLH2), monoamine oxidase (MAO-A), and 5-Hydroxyindole-3-acetic acid (5-HIAA)), and neuronal regeneration in the CA3 region of the hippocampus. …”
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Expression of NAC1 Restrains the Memory Formation of CD8⁺ T Cells during Viral Infection by Liqing Wang, Anil Kumar, Jugal Kishore Das, Yijie Ren, Hao-Yun Peng, Darby Jane Ballard, Xiaofang Xiong, Jacob Rance Davis, Xingcong Ren, Jin-Ming Yang, Jianxun Song

“…Nucleus accumbens-associated protein 1 (NAC1) is a transcription co-factor that has been shown to possess multiple roles in stem cell and cancer biology. …”
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