Microglia Express Mu Opioid Receptor: Insights From Transcriptomics and Fluorescent Reporter Mice by Tando Maduna, Tando Maduna, Tando Maduna, Tando Maduna, Emilie Audouard, Emilie Audouard, Emilie Audouard, Emilie Audouard, Doulaye Dembélé, Doulaye Dembélé, Doulaye Dembélé, Doulaye Dembélé, Nejma Mouzaoui, Nejma Mouzaoui, Nejma Mouzaoui, Nejma Mouzaoui, Nejma Mouzaoui, David Reiss, David Reiss, David Reiss, David Reiss, Dominique Massotte, Claire Gaveriaux-Ruff, Claire Gaveriaux-Ruff, Claire Gaveriaux-Ruff, Claire Gaveriaux-Ruff, Claire Gaveriaux-Ruff

“…We determined whether CX3cR1-eGFP positive microglial cells expressed MOR-mCherry protein by imaging various brain areas including the Frontal Cortex, Nucleus Accumbens, Ventral Tegmental Area, Central Amygdala, and Periaqueductal Gray matter, as well as spinal cord.Results:Oprm1 expression was found in all 12 microglia datasets from mouse whole brain, in 7 out of 8 from cerebral cortex, 3 out of 4 from hippocampus, 1 out of 1 from striatum, and 4 out of 5 from mouse or rat spinal cord. …”
Get full text

Neuroimmune circuits involved in β-lactoglobulin-induced food allergy by Luísa Lemos, Helder Carvalho Assis, Juliana Lima Alves, Daniela Silva Reis, Maria Cecilia Campos Canesso, Mariana Almeida Oliveira, Thais Garcias Moreira, Barbara Kaori Miranda Sato, Luara Augusta Batista, Julia Gomes Lenzi, Muiara Aparecida Moraes, Luciana Melo, Bruna Resende, Danielle Aguiar, Bruno Rezende Souza, Denise Carmona Cara, Ana Cristina Gomes-Santos, Ana Maria Caetano Faria

“…On the other hand, when mice were sensitized to OVA and received a mixture of BLG and OVA in the oral challenge, mice preferred to drink this mixture, despite their aversion to OVA, which was associated with neuron activation in the nucleus accumbens, an area related to reward behavior. …”
Get full text

Brain tissue- and cell type-specific eQTL Mendelian randomization reveals efficacy of FADS1 and FADS2 on cognitive function by Xueyan Wu, Lei Jiang, Hongyan Qi, Chunyan Hu, Xiaojing Jia, Hong Lin, Shuangyuan Wang, Lin Lin, Yifang Zhang, Ruizhi Zheng, Mian Li, Tiange Wang, Zhiyun Zhao, Min Xu, Yu Xu, Yuhong Chen, Jie Zheng, Yufang Bi, Jieli Lu

“…Tissue-specific MR showed an effect of increased FADS1 expression in cerebellar hemisphere and FADS2 expression in nucleus accumbens basal ganglia on maintaining cognitive function, while decreased FADS1 expression in nine brain tissues on maintaining cognitive function [colocalization probability (PP.H4) ranged from 71.7% to 100.0%]. …”
Get full text

A Novel and Selective Dopamine Transporter Inhibitor, <i>(S)</i>-MK-26, Promotes Hippocampal Synaptic Plasticity and Restores Effort-Related Motivational Dysfunctions by Shima Kouhnavardi, Alev Ecevitoglu, Vladimir Dragačević, Fabrizio Sanna, Edgar Arias-Sandoval, Predrag Kalaba, Michael Kirchhofer, Jana Lubec, Marco Niello, Marion Holy, Martin Zehl, Matthias Pillwein, Judith Wackerlig, Rita Murau, Andrea Mohrmann, Kathryn R. Beard, Harald H. Sitte, Ernst Urban, Claudia Sagheddu, Marco Pistis, Roberto Plasenzotti, John D. Salamone, Thierry Langer, Gert Lubec, Francisco J. Monje

“…Moreover, in in vivo microdialysis experiments, (<i>S</i>)-MK-26 significantly increased extracellular DA levels in the prefrontal cortex and in nucleus accumbens core and shell. These studies highlight (<i>S</i>)-MK-26 as a potent enhancer of transsynaptic DA and promoter of synaptic plasticity, with predominant beneficial effects on effort-related behaviors, thus proposing therapeutic potentials for (<i>S</i>)-MK-26 in the treatment of low-effort exertion and motivational dysfunctions characteristic of depression and aging-related disorders.…”
Get full text

Shape analysis of subcortical structures in obsessive‐compulsive disorder and the relationship with comorbid anxiety, depression, and medication use: A meta‐analysis by the OCD Bra... by Jean‐Paul Fouche, Nynke A. Groenewold, Tatum Sevenoaks, Sarah Heany, Christine Lochner, Pino Alonso, Marcelo C. Batistuzzo, Narcis Cardoner, Christopher R. K. Ching, Stella J. deWit, Boris Gutman, Marcelo Q. Hoexter, Neda Jahanshad, Minah Kim, Jun Soo Kwon, David Mataix‐Cols, Jose M. Menchon, Euripedes C. Miguel, Takashi Nakamae, Mary L. Phillips, Jesus Pujol, Yuki Sakai, Je‐Yeon Yun, Carles Soriano‐Mas, Paul M. Thompson, Kei Yamada, Dick J. Veltman, Odile A. vanden Heuvel, Dan J. Stein

“…OCD patients with comorbid depression had lower shape surface area in the thalamus, caudate nucleus, putamen, hippocampus, and nucleus accumbens and higher shape surface area in the pallidum. …”
Get full text

Environmental Enrichment and Social Isolation Mediate Neuroplasticity of Medium Spiny Neurons through the GSK3 Pathway by Federico Scala, Miroslav N. Nenov, Elizabeth J. Crofton, Aditya K. Singh, Oluwarotimi Folorunso, Yafang Zhang, Brent C. Chesson, Norelle C. Wildburger, Thomas F. James, Musaad A. Alshammari, Tahani K. Alshammari, Hannah Elfrink, Claudio Grassi, James M. Kasper, Ashley E. Smith, Jonathan D. Hommel, Cheryl F. Lichti, Jai S. Rudra, Marcello D’Ascenzo, Thomas A. Green, Fernanda Laezza

“…Transcriptomic studies in the nucleus accumbens from EC and IC rats predicted low levels of GSK3β and SCN8A mRNA as a protective phenotype associated with reduced excitability in medium spiny neurons (MSNs). …”
Get full text

Mild traumatic brain injury impacts associations between limbic system microstructure and post-traumatic stress disorder symptomatology by Valerie J. Sydnor, Sylvain Bouix, Ofer Pasternak, Elisabeth Hartl, Laura Levin-Gleba, Benjamin Reid, Yorghos Tripodis, Jeffrey P. Guenette, David Kaufmann, Nikos Makris, Catherine Fortier, David H. Salat, Yogesh Rathi, William P. Milberg, Regina E. McGlinchey, Martha E. Shenton, Inga K. Koerte

“…In the PTSD and mTBI cohort, more severe PTSD symptoms were associated with higher FA bilaterally in the amygdala-hippocampus complex, with higher FA bilaterally in the nucleus accumbens, with lower FA bilaterally in the cingulate cortex, and with higher MD in the right amygdala-hippocampus complex. …”
Get full text

Patterns of Convergence and Divergence Between Bipolar Disorder Type I and Type II: Evidence From Integrative Genomic Analyses by Yunqi Huang, Yunqi Huang, Yunqi Huang, Yunjia Liu, Yunjia Liu, Yunjia Liu, Yulu Wu, Yulu Wu, Yulu Wu, Yiguo Tang, Yiguo Tang, Yiguo Tang, Mengting Zhang, Mengting Zhang, Mengting Zhang, Siyi Liu, Siyi Liu, Siyi Liu, Liling Xiao, Liling Xiao, Liling Xiao, Shiwan Tao, Shiwan Tao, Shiwan Tao, Min Xie, Min Xie, Min Xie, Minhan Dai, Minhan Dai, Minhan Dai, Mingli Li, Mingli Li, Mingli Li, Hongsheng Gui, Hongsheng Gui, Qiang Wang, Qiang Wang, Qiang Wang

“…TWAS data implicated different genes affecting BD I and II through expression in specific brain regions (nucleus accumbens for BD I). Cross-phenotype analyses indicated that BD I and II share continuous genetic structures with schizophrenia and major depressive disorder, which help fill the gaps left by the dichotomy of mental disorders.Conclusion: These combined evidences illustrate genetic convergence and divergence between BD I and II and provide an underlying biological and trans-diagnostic insight into major psychiatric disorders.…”
Get full text

Deep brain stimulation in treatment resistant schizophrenia: A pilot randomized cross-over clinical trial by Iluminada Corripio, Alexandra Roldán, Salvador Sarró, Peter J. McKenna, Anna Alonso-Solís, Mireia Rabella, Anna Díaz, Dolors Puigdemont, Víctor Pérez-Solà, Enric Álvarez, Antonio Arévalo, Pedro P. Padilla, Jesus M. Ruiz-Idiago, Rodrigo Rodríguez, Joan Molet, Edith Pomarol-Clotet, Maria J. Portella

“…This trial aimed to examine the effectiveness of nucleus accumbens (NAcc) and subgenual anterior cingulate cortex (subgenual ACC) targeted DBS; the primary outcome measure was PANSS total score, as assessed fortnightly. …”
Get full text

Effects of mango and mint pod-based e-cigarette aerosol inhalation on inflammatory states of the brain, lung, heart, and colon in mice by Alex Moshensky, Cameron S Brand, Hasan Alhaddad, John Shin, Jorge A Masso-Silva, Ira Advani, Deepti Gunge, Aditi Sharma, Sagar Mehta, Arya Jahan, Sedtavut Nilaad, Jarod Olay, Wanjun Gu, Tatum Simonson, Daniyah Almarghalani, Josephine Pham, Samantha Perera, Kenneth Park, Rita Al-Kolla, Hoyoung Moon, Soumita Das, Min Kwang Byun, Zahoor Shah, Youssef Sari, Joan Heller Brown, Laura E Crotty Alexander

“…JUUL aerosol exposure induced upregulation of cytokine and chemokine gene expression and increased HMGB1 and RAGE in the nucleus accumbens in the central nervous system. Inflammatory gene expression increased in the colon, while gene expression was more broadly altered by e-cigarette aerosol inhalation in the lung. …”
Get full text

Multiple integrated social stress induces depressive-like behavioral and neural adaptations in female C57BL/6J mice by Xiaojing Zhai, Lin Ai, Dandan Chen, Dongyu Zhou, Yi Han, Ran Ji, Mengfan Hu, Qing Wang, Moruo Zhang, Yuxin Wang, Chunyan Zhang, Jun-Xia Yang, Ankang Hu, He Liu, Jun-Li Cao, Hongxing Zhang

“…Compared with controls, MISS females exhibited decreased c-Fos activation in their anterior cingulate cortex, prefrontal cortex, nucleus accumbens and some other depression-related brain regions. …”
Get full text

(Mis)treating Substance Use Disorder With Prison by Kaitlin Puccio

“…All addictive drugs stimulate the release of dopamine in the nucleus accumbens. An individual may inherit an atypical response to opiates, for example, where the drug makes him feel euphoric and thus is highly reinforcing. …”
Get full text

Circuit-specific hippocampal ΔFosB underlies resilience to stress-induced social avoidance by Andrew L. Eagle, Claire E. Manning, Elizabeth S. Williams, Ryan M. Bastle, Paula A. Gajewski, Amber Garrison, Alexis J. Wirtz, Seda Akguen, Katie Brandel-Ankrapp, Wilson Endege, Frederick M. Boyce, Yoshinori N. Ohnishi, Michelle Mazei-Robison, Ian Maze, Rachel L. Neve, Alfred J. Robison

“…Here, the authors report the role of the transcription factor ΔFosB in driving activity changes in response to stress in glutamatergic neurons in the ventral hippocampus that project to nucleus accumben.…”
Get full text

The sequel to COVID-19: the antithesis to life by Sudhir Bhandari, Ajit Singh Shaktawat, Bhoopendra Patel, Amitabh Dube, Shivankan Kakkar, Amit Tak, Jitendra Gupta, Govind Rankawat

“…Enduring increases in anxiety-like behavior and rapid nucleus accumbens dopamine signaling in socially isolated rats. …”
Get full text

Impulsive Behavior and Nicotinic Acetylcholine Receptors by Yu Ohmura, Iku Tsutsui-Kimura, Mitsuhiro Yoshioka

“…Keywords:: nicotine, inhibitory control, impulsive action, attention-deficit/hyperactivity disorder (ADHD), nucleus accumbens…”
Get full text

Study on the Mechanism for SIRT1 during the Process of Exercise Improving Depression by Xiao Qiu, Pengcheng Lu, Xinyu Zeng, Shengjie Jin, Xianghe Chen

“…Silent information regulator 1 (SIRT1) is a key player in regulating energy metabolism, and it can regulate depression by mediating the inflammatory response (e.g., nuclear factor-kappa B (NF-κB), tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β)), gene expression in the nucleus accumben (NAc) and CA1 region of the hippocampus (e.g., nescient helix-loop-helix2 (NHLH2), monoamine oxidase (MAO-A), and 5-Hydroxyindole-3-acetic acid (5-HIAA)), and neuronal regeneration in the CA3 region of the hippocampus. …”
Get full text

Expression of NAC1 Restrains the Memory Formation of CD8⁺ T Cells during Viral Infection by Liqing Wang, Anil Kumar, Jugal Kishore Das, Yijie Ren, Hao-Yun Peng, Darby Jane Ballard, Xiaofang Xiong, Jacob Rance Davis, Xingcong Ren, Jin-Ming Yang, Jianxun Song

“…Nucleus accumbens-associated protein 1 (NAC1) is a transcription co-factor that has been shown to possess multiple roles in stem cell and cancer biology. …”
Get full text

Changes in surface expression of N-methyl-D-aspartate receptors in the striatum in a rat model of Parkinson&#39;s disease by Gan J, Qi C, Mao LM, Liu ZG

“…GluN1 and GluN2B expression in the distinct surface compartment underwent upregulation in striatal neurons after selective lesions of the dopaminergic pathway by 6-OHDA.Keywords: glutamate, excitatory amino acid, NMDA, GluN, dopamine, 6-hydroxydopamine, caudate putamen, nucleus accumbens…”
Get full text