Identification of a novel AU-rich-element-binding protein which is related to AUF1 by Dean, J, Sully, G, Wait, R, Rawlinson, L, Clark, A, Saklatvala, J

“…The AU-rich element (ARE) is an important instability determinant for a large number of early-response-gene mRNAs. AREs also mediate the stabilization of certain pro-inflammatory mRNAs, such as tumour necrosis factor (TNF)-α and cyclooxygenase-2 (COX-2), in response to inflammatory stimuli. …”

On the variability and forced response of atmospheric regime systems by Dorrington, JCF

“…The regime hypothesis – the idea that the continuous range of atmospheric flow states can be meaningfully partitioned into a small number of large scale ‘regimes’ – provides a conceptual framework from which to understand the impacts of internal variability and external forcing on the Euro-Atlantic. …”

Recruitment of a myeloid cell subset (CD11b/Gr1mid) via CCL2/CCR2 promotes the development of colorectal cancer liver metastasis by Zhao, L, Lim, S, Gordon-Weeks, A, Tapmeier, T, Im, J, Cao, Y, Beech, J, Allen, D, Smart, S, Muschel, R

“…These cells increased in number dramatically during establishment of liver metastases and were recruited from bone marrow by tumor-derived CCL2. …”

Sustainable supply chains – a framework for best practice assessment: results of the pilot study, BestLog project. by Piotrowicz, W, Cuthbertson, R, Islei, G

“…Hard metrics such as costs, utilisation or number of accidents are relatively easy to measure, while the soft metrics will require judgment to determine their relative value. …”

The Efficacy of Mindfulness-Based Interventions in Primary Care: A Meta-Analytic Review. by Demarzo, M, Montero-Marin, J, Cuijpers, P, Zabaleta-Del-Olmo, E, Mahtani, K, Vellinga, A, Vicens, C, López-Del-Hoyo, Y, García-Campayo, J

“…CONCLUSION: Although the number of randomized controlled trials applying MBIs in primary care is still limited, our results suggest that these interventions are promising for the mental health and quality of life of primary care patients. …”

Thyroid peroxidase: evidence for disease gene exclusion in Pendred's syndrome. by Gausden, E, Armour, J, Coyle, B, Coffey, R, Hochberg, Z, Pembrey, M, Britton, K, Grossman, A, Reardon, W, Trembath, R

“…DESIGN: A highly informative variable number tandem repeat (VNTR), located 1.5 kb downstream of exon 10 of the TPO gene, was used to search for genetic linkage in multiple sibships affected by Pendred's syndrome. …”

The spatiotemporal dynamics of neural activity in the neocortex during waking and sleep in mice by Cui, N

“…This was manifested in reduced number and amplitude of EEG slow waves and increased incidence of isolated slow waves. …”

Active bacterial populations and grazing impact revealed by an in situ experiment in a shallow aquifer by Nagaosa, K, Maruyama, T, Welikala, N, Yamashita, Y, Saito, Y, Kato, K, Fortin, D, Nanba, K, Miyasaka, I, Fukunaga, S

“…On August 19, 2003, the total number of bacteria (TDC) decreased from 1.5 × 106 cells ml-1 at 2.2 m depth to 3.0 × 105 cells ml-1 at 10 m depth. …”

Multivariate analysis of paired data: a review of methods for paired organ systems by Chiocchia, V, Kirtley, S, Dutton, S

“…Robust sandwich estimate of the covariance matrix[1], generalized linear model[2] and use of mixed models and random effects[3] are some of the methods that have been proposed and used to deal with the correlation/clustering of these data. Still, a number of studies involving paired organ systems data either do not report or do not use methods to account for this effect. …”

Declining fitness and physical education lessons in UK adolescents by Weedon, B, Liu, F, Mahmoud, W, Jones, A, Et al.

“…Interactions with fitness and body mass index (BMI) were tested. The number of PE lessons reported in the UK Annual School Workforce Census between 2010 and 2019 for all state-funded secondary schools was analysed. …”

Patterns of osteocytic endothelial nitric oxide synthase expression in the femoral neck cortex: differences between cases of intracapsular hip fracture and controls. by Loveridge, N, Fletcher, S, Power, J, Caballero-Alías, A, Das-Gupta, V, Rushton, N, Parker, M, Reeve, J, Pitsillides, A

“…A reduction in their number, coupled to an increase in their remoteness from canal surfaces, may thus permit the irreversible merging of resorbing osteons, and thus contribute to the marked increase in the fragility of osteoporotic bone.…”

Genetic variability on adiponectin gene affects myocardial infarction risk: The role of endothelial dysfunction by Antonopoulos, A, Tousoulis, D, Antoniades, C, Miliou, A, Hatzis, G, Papageorgiou, N, Demosthenous, M, Tentolouris, C, Stefanadis, C

“…However, carriers of the T allele at rs1501299 were at increased myocardial infarction (MI) risk, independently of classic risk factors (OR = 2.558 [95%CI = 1.587-4.123], p = 0.0001). The number of T alleles in both SNPs was strongly associated with MI history (p = 0.0001). …”

Therapeutic response to Dihydroartemisinin-Piperaquine for P. falciparum and P. vivax nine years after its introduction in Southern Papua, Indonesia by Poespoprodjo, JR, Kenangalem, E, Wafom, J, Chandrawati, F, Puspitasari, AM, Ley, B, Trianti, L, Korten, Z, Surya, A, Syafruddin, D, Anstey, NM, Marfurt, J, Noviyanti, R, Price, RN

“…Molecular analysis of P. falciparum parasites showed that none (0/61) had K13 mutations associated previously with artemisinin resistance or increased copy number of plasmepsin 2-3 (0/61). In the absence of artemisinin resistance, DHP has retained high efficacy for the treatment of uncomplicated malaria despite extensive drug pressure over a 9-year period.…”

Genome-wide association identifies diverse causes of common variable immunodeficiency. by Orange, J, Glessner, J, Resnick, E, Sullivan, K, Lucas, M, Ferry, B, Kim, C, Hou, C, Wang, F, Chiavacci, R, Kugathasan, S, Sleasman, J, Baldassano, R, Perez, E, Chapel, H, Cunningham-Rundles, C, Hakonarson, H

“…OBJECTIVE: To address the underlying immunopathogenesis of CVID and comorbidities, we conducted the first genome-wide association and gene copy number variation (CNV) study in patients with CVID. …”

Media reporting of tenofovir trials in Cambodia and Cameroon

“…The primary reasons cited for the Cameroon trial closure were: inadequate access to care for seroconverters (69%); participants not sufficiently informed of risks (69%); inadequate number of staff (46%); participants being exploited (46%) and an unethical study design (38%). …”

A monograph of the Bradoriid arthropods from the Lower Cambrian of SW China by Hou, X, Siveter, D, Williams, M, Feng, X

“…Of bradoriid faunas world-wide, Chinese occurrences yield the greatest number of specimens and a comparatively high diversity at all taxonomic levels. …”

Sparse labeling PELDOR spectroscopy on multimeric mechanosensitive membrane channels by Ackermann, K, Pliotas, C, Valera, S, Naismith, J, Bode, B

“…Data demonstrate that distance distributions can be significantly improved with either approach compared to the standard PELDOR measurement, and confirm that λ < 1/(n-1) is needed to sufficiently suppress multispin effects (with n being the number of spins in the system). A clear advantage of the sparse labeling approach is demonstrated for the cytosolic mutants due to a significantly smaller loss in sensitivity. …”

Temperature dependence of OH yield, translational energy, and vibrational branching in the reaction of O(3P)(g) with liquid squalane by Allan, M, Bagot, P, Costen, M, McKendrick, K

“…We discuss the interpretation of these findings, taking account of earlier experimental work, which has indicated significant contributions from distinct "direct" and "trapping-desorption" reaction mechanisms, and new molecular dynamics simulations of the surface structure. There are a number of factors that may contribute, including both energetic and structural effects. …”

Characterizing the general surgery workforce in rural America. by Thompson, M, Lynge, D, Larson, E, Tachawachira, P, Hart, L

“…Any decline in their numbers could have profound effects on access to adequate health care in such areas. …”

Search for the decays B_{(s)};{0} --> e;{+} micro;{-} and B_{(s)};{0} --> e;{+} e;{-} in CDF run II. by Aaltonen, T, Adelman, J, Akimoto, T, Alvarez González, B, Amerio, S, Amidei, D, Anastassov, A, Annovi, A, Antos, J, Apollinari, G, Apresyan, A, Arisawa, T, Artikov, A, Ashmanskas, W, Attal, A, Aurisano, A, Azfar, F, Azzurri, P, Badgett, W, Barbaro-Galtieri, A, Barnes, V, Barnett, B, Bartsch, V, Bauer, G, Beauchemin, P

“…The analysis uses data corresponding to 2 fb;{-1} of integrated luminosity of pp[over ] collisions at sqrt[s] = 1.96 TeV collected with the upgraded Collider Detector (CDF II) at the Fermilab Tevatron. The observed number of B0 and B_{s};{0} candidates is consistent with background expectations. …”