An investigation into the genetic basis of anxiety by Dutton, R

“…</p> <p>In conclusion, this thesis identified a number of genes and genetic variants, some of which do seem to affect murine anxiety levels. …”

Exploring the atmosphere of Neoproterozoic Earth: The effect of O2 on haze formation and composition by Hörst, S, He, C, Ugelow, MS, Jellinek, AM, Pierrehumbert, RT, Tolbert, MA

“…Both the particle size and number density decrease with increasing O2, indicating that O2 affects particle nucleation and growth. …”

Functional consequences of human immunodeficiency virus escape from an HLA-B*13-restricted CD8+ T-cell epitope in p1 Gag protein. by Prado, J, Honeyborne, I, Brierley, I, Puertas, M, Martinez-Picado, J, Goulder, P

“…The observed association between HLA-B*13 and control of human immunodeficiency virus type 1 (HIV-1) infection has been linked to the number of Gag-specific HLA-B*13-restricted cytotoxic T-cell (CTL) responses identified. …”

Investigating white matter fibre density and morphology using fixel-based analysis by Raffelt, D, Tournier, J, Smith, R, Vaughan, D, Jackson, G, Ridgway, G, Connelly, A

“…To obtain a more complete measure related to the total number of white matter axons, information from both within-voxel microscopic fibre density and macroscopic morphology must be combined. …”

Adaptive immune evasion in clinically latent HIV infection by Andrews, S

“…In performing this study, a number of limitations came to light regarding how bifurcate analyses are used to interpret flow cytometric data collected in studies of receptor modulation. …”

Coordinated regulation of hormone-sensitive lipase and lipoprotein lipase in human adipose tissue in vivo: implications for the control of fat storage and fat mobilization. by Frayn, K, Coppack, S, Fielding, B, Humphreys, S

“…Thus, fat storage and fat mobilization during normal daily life are controlled by coordinated regulation of a number of enzymatic processes in white adipose tissue.…”

Efgartigimod efficacy and safety in refractory myasthenia gravis: UK’s first real-world experience by Moniz Dionísio, J, Ambrose, P, Burke, G, Farrugia, ME, Garcia-Reitboeck, P, Hewamadduma, C, Hill, M, Howard, RS, Jacob, S, Kullmann, D, Leite, MI, Miller, J, Pinto, A, Pritchard, J, Riswick, T, Sathasivam, S, Thambirajah, N, Viegas, S, Norwood, F, Spillane, J

“…All patients had used non-steroidal immunosuppressant treatments, the average number tried was 2.6 (range 1–6). 51% had received rituximab. 54.2% of patients required regular intravenous immunoglobulin/plasma exchange. 75% of patients had a mean reduction in the MG-ADL of≥2 points in the first cycle and this remained stable throughout the study. …”

Recorded quality of primary care for patients with diabetes in England before and after the introduction of a financial incentive scheme: a longitudinal observational study. by Kontopantelis, E, Reeves, D, Valderas, J, Campbell, S, Doran, T

“…After 3 years of the incentives, recorded levels of care varied significantly for patient gender, age, years of previous care, number of co-morbid conditions and practice diabetes prevalence. …”

Cost-effectiveness analysis of a randomized clinical trial of early versus deferred endovenous ablation of superficial venous reflux in patients with venous ulceration by Epstein, DM, Gohel, MS, Heatley, F, Liu, X, Bradbury, A, Bulbulia, R, Cullum, N, Nyamekye, I, Poskitt, KR, Renton, S, Warwick, J, Davies, AH, Evra Trial Investigators

“…CONCLUSION:Early treatment of superficial reflux is highly likely to be cost-effective in patients with venous leg ulcers over 1 year. Registration number: ISRCTN02335796 (http://www.isrctn.com).…”

ALOIS: Alzheimer's and cognitive improvement studies register, a free, on-line register of dementia and cognitive enhancement trials (http://www.medicine.ox.ac.uk/alois/) by Malouf, R, Noel-Storr, A, Collins, H, McShane, R, Schneider, L

“…As well as citations, the displayed data include: study design/blinding, participants and health condition, intervention and dosage, number of participants, outcomes, date of study, website links and related Cochrane reviews/protocols. …”

Assessing flooding extent and potential exposure to river pollution from urbanizing peripheral rivers within Greater Dhaka watershed by Khan, NS, Shawal, S, Hossain, MA, Tasnim, N, Whitehead, PG, Rahman, M

“…The estimated population exposed to flooding was over 668,000 in 2019, and this number increased by 1.53 times in 2020, totaling over one million. …”

Effects of a platelet-activating factor antagonist on lung injury and ventilation after cardiac operation. by Taggart, D

“…Likewise, the groups were similar with respect to duration of cardiopulmonary bypass and the number and type of grafts. Maximum lung injury occurred at 48 hours when the arterial oxygen tension and percent saturation reached a nadir (both p &lt; 0.001) accompanied by the maximum increase in the alveolar arterial gradient (p &lt; 0.001). …”

A panel of kallikrein markers can reduce unnecessary biopsy for prostate cancer: data from the European Randomized Study of Prostate Cancer Screening in Goteborg, Sweden. by Vickers, A, Cronin, A, Aus, G, Pihl, C, Becker, C, Pettersson, K, Scardino, P, Hugosson, J, Lilja, H

“…Using a 20% risk of prostate cancer as the threshold for biopsy would have reduced the number of biopsies by 424 (57%) and missed only 31 out of 152 low-grade and 3 out of 40 high-grade cancers. …”

Inference of recombination properties in bacteria from whole genomes by Ansari, M

“…We use the model to infer the boundaries of clusters on a phylogenetic tree that correspond to ecologically distinct lineages. we characterise our method using simulated datasets and show that it is conservative in estimating the number of adaptive events. Finally we apply our method to two bacterial datasets of <em>Salmonella enterica</em> and <em>Vibrionaceae</em>. …”

The microsomal triglyceride transfer protein gene-493T variant lowers cholesterol but increases the risk of coronary heart disease. by Ledmyr, H, McMahon, A, Ehrenborg, E, Nielsen, L, Neville, M, Lithell, H, MacFarlane, P, Packard, C, Karpe, F

“…These unexpected findings prompted the investigation of non-plasma lipid factors that could associate the MTP gene with CHD risk. In a limited number of subjects (n=18), heart muscle biopsies showed a MTP-493T genotype-specific depression of MTP mRNA expression. …”

Transcriptome and genome evolution during HER2-amplified breast neoplasia by Lu, P, Foley, J, Zhu, C, McNamara, K, Sirinukunwattana, K, Vennam, S, Varma, S, Fehri, H, Srivastava, A, Zhu, S, Rittscher, J, Mallick, P, Curtis, C, West, R

“…Results By combining the HER2-FISH with the laser capture microdissection (LCM) Smart-3SEQ method, we found that HER2 amplification in DCIS alters the transcriptomic profiles and increases diversity of copy number variations (CNVs). Particularly, interferon signaling pathway is activated by HER2 amplification in DCIS, which may provide a prolonged interferon signaling activation in HER2-positive breast cancer. …”

FGF-2 is bound to perlecan in the pericellular matrix of articular cartilage, where it acts as a chondrocyte mechanotransducer. by Vincent, T, McLean, C, Full, L, Peston, D, Saklatvala, J

“…OBJECTIVE: We have shown previously that cutting or loading articular cartilage resulted in a fibroblast growth factor-2 (FGF-2) dependent activation of the extracellularly regulated kinase (ERK), and induction of a number of chondrocyte regulatory proteins including tissue inhibitor of metalloproteinase-1 and matrix metalloproteinases 1 and 3. …”

Targeting TRIM37-driven centrosome dysfunction in 17q23-amplified breast cancer by Yeow, ZY, Lambrus, B, Marlow, R, Zhan, K, Durin, M-A, Evans, L, Scott, P, Phan, T, Park, E, Ruiz, L, Moralli, D, Knight, E, Badder, L, Novo, D, Haider, S, Green, C, Tutt, A, Lord, C, Chapman, J, Holland, A

“…Here we show that centrosome depletion induces synthetic lethality in cancer cells that contain the 17q23 amplicon, a recurrent copy number aberration that defines about 9% of all primary breast cancer tumours and is associated with high levels of genomic instability4,5,6. …”

On dynamics of fluidic jet switching and shear layer instabilities by Mair, M

“…This can be attributed to a change in the shear layer characteristics as the Reynolds number increases. </p> <p>In addition, ambiguous data obtained from both Large-Eddy Simulation and Particle Image Velocimetry suggest a fundamental different relationship between the natural shear layer instability and the jet preferred mode with respect to the currently accepted point of view. …”

Sensory axon-derived neuregulin-1 is required for axoglial signaling and normal sensory function but not for long-term axon maintenance. by Fricker, F, Zhu, N, Tsantoulas, C, Abrahamsen, B, Nassar, M, Thakur, M, Garratt, A, Birchmeier, C, McMahon, S, Wood, J, Bennett, D

“…Sensory neuron-specific neuregulin-1 ablation resulted in abnormally large Remak bundles with axons clustered in "polyaxonal" pockets. The total number of axons in the sural nerve was unchanged, but a greater proportion was unmyelinated. …”