Personalizing medicine: a systems biology perspective by Deisboeck, Thomas S.

“…At the very least, that puts considerable strains on the existing infrastructure. Also, enrollment numbers will be small, in theory down to one patient per modified regimen, with the obvious consequence that clinical institutions will have to pool and exchange such case-centric data and expertise so that new patients can benefit from past experience. (3) Even if a compound survives the elaborate evaluation processes in the current pharmaceutical ‘pipeline,’ by the time it becomes available, it lags several years behind the pace of basic research that continued while the drug was under development. …”
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Sensing animal group behavior and bio-clutter in the ocean over continental shelf scales by Srinivasan, Jagannathan

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Collective hydrodynamics of soft microparticles in quasi-two-dimensional confinement by Uspal, William Eric

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A synergistic physio-neuro rehabilitation platform to accelerate recovery of hand function after stroke by Banerji Subhasis

“…More people are surviving stroke than ever before due to advances in emergency care. However, the numbers of stroke patients that have not fully regained their ability to perform activities of daily living (ADL) have also increased. …”
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Deep learning neural network approaches for one-dimensional structure prediction from protein sequences by Shamima Banu Syed Mohamed Rashid

“…Additionally in the case of SS prediction, methods are trained on large numbers of proteins for the cross-validation based models which may result in a loss of generalization. …”
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A framework of probabilistic 3D map fusion for collaborative robots by Yue, Yufeng

“…Since maps produced by heterogeneous sensors possess diverse physical properties, an Expectation-maximization (EM) based map matching algorithm is proposed that automatically decides the numbers of voxels to be associated. To distribute the maps among robots, a time-sequential map merging framework is developed that makes fusing maps from distributed multi-robot system efficient. …”
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Qualitative research : data collection & data analysis techniques by Puvenesvary, M., Abdul Rahim, Radziah, Naidu, R. Sivabala, Badzis, Mastura, Mat Nayan, Noor Fadhilah, Abd Aziz, Noor Hashima

“…This book starts off with Chapter 1 which introduces us to qualitative research, an approach that does not deal with numbers per se, but, has guidelines and a systematic approach within a theoretical framework or design. …”
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Qualitative research : data collection & data analysis techniques by Puvenesvary, M., Abdul Rahim, Radziah, Naidu, R. Sivabala, Badzis, Mastura, Mat Nayan, Noor Fadhilah, Abd Aziz, Noor Hashima

“…This book starts off with Chapter 1 which introduces us to qualitative research, an approach that does not deal with numbers per se, but, has guidelines and a systematic approach within a theoretical framework or design. …”
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Probiotics to reduce antibiotic administration in care home residents aged 65 years and older: the PRINCESS RCT by Butler, CC, Owen-Jones, E, Lau, M, Gillespie, D, Lown, M, Calder, PC, Stanton, H, Wootton, M, Castro Herrera, V, Bayer, A, Davies, J, Edwards, A, Davoudianfar, M, Rutter, H, Hood, K, Moore, M, Little, P, Shepherd, V, Lowe, R, Miles, EA, Townson, J, Hobbs, FDR, Francis, NA

“…There was no evidence that this probiotic combination improved blood immune cell numbers, subtypes or responses to seasonal influenza vaccination.…”

Supporting Parents & Kids Through Lockdown Experiences (SPARKLE): a digital parenting support app implemented in an ongoing general population cohort study during the COVID-19 pand... by Kostyrka-Allchorne, K, Creswell, C, Byford, S, Day, C, Goldsmith, K, Koch, M, Gutierrez, WM, Palmer, M, Raw, J, Robertson, O, Shearer, J, Shum, A, Slovak, P, Waite, P, Sonuga-Barke, EJS

“…The junior statistician will be unblinded throughout. <br><strong> Numbers to be randomised (sample size)<br></strong> A total of 616 will be recruited into the trial with 308 consenting parents randomised to each treatment arm. …”

Multidimesional mechanisms underlying numeracy development: the role of affect in the relationship between executive functions and foundational stages of numeracy development by Gattas, SU

“…I focused on inhibitory control (IC) and working memory (WM), as cognitive flexibility is more difficult to index in the early years and is less affected by math anxiety due to the context within which young children use numbers (Cragg et al., 2017; Hopko et al., Lewis, 1998; Katus et al., 2023).…”

Nicotine replacement therapy versus control for smoking cessation by Hartmann-Boyce, J, Chepkin, S, Ye, W, Bullen, C, Lancaster, T

“…The majority of studies were conducted in adults and had similar numbers of men and women. People enrolled in the studies typically smoked at least 15 cigarettes a day at the start of the studies. …”

Bisphosphonates to reduce bone fractures in stage 3B+ chronic kidney disease: a propensity score-matched cohort study by Robinson, DE, Ali, MS, Strauss, VY, Elhussein, L, Abrahamsen, B, Arden, NK, Ben-Shlomo, Y, Caskey, F, Cooper, C, Dedman, C, Delmestri, A, Judge, A, Javaid, M, Prieto-Alhambra, D

“…Bias analyses suggested that these findings were due to inappropriate adjustment for pre-treatment risk. work packages 3 and 4 were based on small numbers of events and participants, respectively. …”

Novel imaging and circulating biomarkers in hepatic malignancies by Winter, H

“…The analysis of macrophages revealed giant cell reactions around microspheres with increased numbers of tumour-associated macrophages. The results from the ctDNA revealed high concordance of KRAS status up to 1127 days from primary CRC to ctDNA results. …”

Safety of a controlled human infection model of tuberculosis with aerosolised, live-attenuated Mycobacterium bovis BCG versus intradermal BCG in BCG-naive adults in the UK: a dose-... by Satti, I, Marshall, JL, Harris, SA, Wittenberg, R, Tanner, R, Lopez Ramon, R, Wilkie, M, Ramos Lopez, F, Riste, M, Wright, D, Peralta Alvarez, MP, Williams, N, Morrison, H, Stylianou, E, Folegatti, P, Jenkin, D, Vermaak, S, Rask, L, Cabrera Puig, I, Powell Doherty, R, Lawrie, A, Moss, P, Hinks, T, Bettinson, H, McShane, H

“…Participants in this trial were randomly assigned (9:12), by variable block randomisation and using sequentially numbered sealed envelopes, to receive aerosol BCG (1&thinsp;&times;&thinsp;10⁷&nbsp;CFU) and intradermal saline or intradermal BCG (1&thinsp;&times;&thinsp;10⁶&nbsp;CFU) and aerosol saline. …”

Electronic structure of defects in crystals by Hunter, I

“…F-centres cannot be produced in undoped crystals in sufficient numbers for detection by esr or Faraday rotation, and X-irradiation of hydrogen-doped crystals produces strongly perturbed F-centres, whose F-band is severely broadened and shifted as compared with normal F-centres. …”

Still safe? Still in their hands? An evaluation of NHS privatisation in England since 2010 by Goodair, B

“…We find that hospitals converting from public to private ownership status tend to make higher profits, primarily through the selective intake of patients and reducing staff numbers. We also find that aggregate increases in privatisation are frequently corresponding with worse health outcomes for patients. …”

James Dennis - Thesis submitted in partial fulfilment of the degree of Doctor of Clinical Psychology (DClinPsych) by Dennis, J

“…Limitations were identified, including low ethnic diversity in study samples and relatively low numbers of the oldest autistic older adults. Taken together, and applying ideas from the power threat meaning framework, this review indicates that clinicians must not underestimate the capability of this group in often having found, over time, inventive ways to make features of their autism support their adaptive functioning. …”

Routine versus clinically driven laboratory monitoring and first-line antiretroviral therapy strategies in African children with HIV (ARROW): a 5-year open-label randomised factori... by Kekitiinwa, A, Cook, A, Nathoo, K, Mugyenyi, P, Nahirya-Ntege, P, Bakeera-Kitaka, S, Thomason, M, Bwakura-Dangarembizi, M, Musiime, V, Munderi, P, Naidoo-James, B, Vhembo, T, Tumusiime, C, Katuramu, R, Crawley, J, Prendergast, A, Musoke, P, Walker, A, Gibb, D

“…Randomisation used computer-generated sequentially numbered tables incorporated securely within the database. …”

Bisphosphonates to reduce bone fractures in stage 3B+ chronic kidney disease: a propensity score-matched cohort study by Robinson, DE, Ali, MS, Strauss, VY, Elhussein, L, Abrahamsen, B, Arden, NK, Ben-Shlomo, Y, Caskey, F, Cooper, C, Dedman, D, Delmestri, A, Judge, A, Javaid, MK, Prieto-Alhambra, D

“…Bias analyses suggested that these findings were due to inappropriate adjustment for pre-treatment risk. work packages 3 and 4 were based on small numbers of events and participants, respectively. …”