Olfactory Ensheathing Cells Express α7 Integrin to Mediate Their Migration on Laminin. by Norianne T Ingram, Rana R Khankan, Patricia E Phelps

“…We show first that α7 integrin, a laminin receptor, is highly expressed at the protein level by OECs throughout the olfactory system, i.e., in the olfactory mucosa, olfactory nerve, and olfactory nerve layer of the olfactory bulb. Then we asked if OECs use the α7 integrin receptor directly to promote neurite outgrowth on permissive and neutral substrates, in vitro. …”
Get full text

Genetics of Isolated Hypogonadotropic Hypogonadism: Role of GnRH Receptor and Other Genes by Karges Beate, Neulen Joseph, de Roux Nicolas, Karges Wolfram

“…Developmental defects of GnRH neurons and the olfactory bulb are associated with hyposmia, rarely associated with the clinical phenotypes of synkinesia, cleft palate, ear anomalies, or choanal atresia, and may be due to mutations of KAL1, FGFR1/FGF8, PROKR2/PROK2, or CHD7. …”
Get full text

The temporal and spatial expression pattern of the LGI1 epilepsy predisposition gene during mouse embryonic cranial development by Cowell John K, Wang Guanghu, Silva Jeane

“…</p> <p>Results</p> <p>During embryonic brain growth, high levels of Lgi1 expression were found in the surface ectoderm, the neuroepithelium, mesenchymal connective tissue, hippocampus, and sensory organs, such as eye, tongue, and the olfactory bulb. Lgi1 was also found in the cranial nerve nuclei and ganglia, such as vestibular, trigeminal, and dorsal ganglia. …”
Get full text

Recurrent circuitry is required to stabilize piriform cortex odor representations across brain states by Kevin A Bolding, Shivathmihai Nagappan, Bao-Xia Han, Fan Wang, Kevin M Franks

“…In recordings from head-fixed mice, we found that odor responses in olfactory bulb degrade under ketamine/xylazine anesthesia while responses immediately downstream, in piriform cortex, remain robust. …”
Get full text

Atypical Autoimmune Encephalitis With Neuropil Antibodies Against a Yet Unknown Epitope by Sharmili Edwin Thanarajah, Sharmili Edwin Thanarajah, Harald Prüss, Clemens Warnke, Michael T. Barbe, Michael Schroeter, Gereon R. Fink, Gereon R. Fink, Oezguer A. Onur

“…Here we present an atypical case of encephalitis with cerebellar and temporal dysfunction but without seizures associated with high levels of cerebrospinal fluid neuropil antibodies against a yet unknown epitope on the neuronal surface in the cerebellum, hippocampus, thalamus, and the olfactory bulb. We treated the patient successfully with corticosteroids, plasmapheresis, and rituximab.…”
Get full text

Distinct projection patterns of different classes of layer 2 principal neurons in the olfactory cortex by Camille Mazo, Julien Grimaud, Yasuyuki Shima, Venkatesh N. Murthy, C. Geoffrey Lau

“…Although it is known that SL and SP cells receive differential inputs from the olfactory bulb (OB), little is known about their projections to other olfactory regions. …”
Get full text

Encoding odorant identity by spiking packets of rate-invariant neurons in awake mice. by Olivier Gschwend, Jonathan Beroud, Alan Carleton

“…Nevertheless, in the olfactory system, there is little experimental evidence supporting such model.To study these issues, we implanted tetrodes in the olfactory bulb of awake mice to record the odorant-evoked activity of mitral/tufted (M/T) cells. …”
Get full text

Is TrpM5 a reliable marker for chemosensory cells? Multiple types of microvillous cells in the main olfactory epithelium of mice by Finger Thomas E, Hansen Anne

“…None of these cells have an axon that projects to the olfactory bulb. Tests with a large panel of cell markers indicate that the TrpM5-positive cells are not sensory since they express neither neuronal markers nor are contacted by trigeminal nerve fibers.…”
Get full text

Pax6 expression is sufficient to induce a neurogenic fate in glial progenitors of the neonatal subventricular zone. by Eun Sook Jang, James E Goldman

“…These cell types are produced in large numbers in the immediate postnatal period, the glioblasts populating the hemispheres with astrocytes and oligodendrocytes, the neuroblasts migrating to the olfactory bulb to become interneurons. How cell fate decisions are determined or stabilized in this mixed population is not clear, although previous studies indicate the importance of two transcription factors, Pax6 in neurons and Olig2 in glia, and suggest there may be reciprocal repression between these genes.In examining the SVZ of neonatal mouse and rat brain, we find that the very large majority of SVZ cells express either Pax6 or Olig2, but few express both. …”
Get full text

Top-down inputs drive neuronal network rewiring and context-enhanced sensory processing in olfaction. by Wayne Adams, James N Graham, Xuchen Han, Hermann Riecke

“…At the core of this plasticity are the granule cells of the olfactory bulb, which integrate bottom-up sensory inputs and top-down inputs delivered by vast top-down projections from cortical and other brain areas. …”
Get full text

Parallel Multi-Gene Panel Testing for Diagnosis of Idiopathic Hypogonadotropic Hypogonadism/Kallmann Syndrome by Manickavasagam Senthilraja, Aaron Chapla, Felix K. Jebasingh, Dukhabhandhu Naik, Thomas V. Paul, Nihal Thomas

“…The subject with a PROKR2 mutation had a normal perception of smell and normal olfactory bulbs on imaging. The subject with a KAL1 gene mutation had anosmia and a hypoplastic olfactory bulb.…”
Get full text

Theta oscillations optimize a speed-precision trade-off in phase coding neurons. by Adrián F Amil, Albert Albesa-González, Paul F M J Verschure

“…Extending the analysis beyond the hippocampus, we propose that theta oscillations could also support efficient stimulus encoding in the visual cortex and olfactory bulb. More broadly, our framework lays the foundation for studying how system features, such as noise, constrain the optimal sampling frequencies in both biological and artificial brains.…”
Get full text

Co-transplantation of olfactory ensheathing cells from mucosa and bulb origin enhances functional recovery after peripheral nerve lesion. by Nicolas Guérout, Alexandre Paviot, Nicolas Bon-Mardion, Célia Duclos, Damien Genty, Laetitia Jean, Olivier Boyer, Jean-Paul Marie

“…Olfactory ensheathing cells (OECs) represent an interesting candidate for cell therapy and could be obtained from olfactory mucosa (OM-OECs) or olfactory bulbs (OB-OECs). Recent reports suggest that, depending on their origin, OECs display different functional properties. …”
Get full text

Mucoadhesive microemulsion of ibuprofen: design and evaluation for brain targeting efficiency through intranasal route by Surjyanarayan Mandal, Snigdha Das Mandal, Krishna Chuttani, Bharat Bhushan Subudhi

“…Following single intranasal administration of MMEI and MEI at a dose of 2.86 mg/kg, uptake of ibuprofen in the olfactory bulb was around 3.0 and 1.7 folds compared with intravenous injection of ibuprofen solution (IDS). …”
Get full text

Axon fasciculation in the developing olfactory nerve by Miller Alexandra M, Maurer Lydia R, Zou Dong-Jing, Firestein Stuart, Greer Charles A

“…<p>Abstract</p> <p>Olfactory sensory neuron (OSN) axons exit the olfactory epithelium (OE) and extend toward the olfactory bulb (OB) where they coalesce into glomeruli. …”
Get full text

The Impact of Tissue Storage Conditions on Rat Olfactory Ensheathing Cell Yield and the Future Clinical Implications by Modinat Olushanu, Andrew Collins, Ying Li, Daqing Li

“…Transplantation of OECs, in particular from the olfactory bulb (OB), is considered one of the most promising therapeutic strategies for the repair of CNS injuries, including spinal cord injury. …”
Get full text

The Ca2+ sensor protein swiprosin-1/EFhd2 is present in neurites and involved in kinesin-mediated transport in neurons. by Pavitra Purohit, Francesc Perez-Branguli, Iryna Prots, Eva Borger, Frank Gunn-Moore, Oliver Welzel, Kristina Loy, Eva Maria Wenzel, Teja W Grömer, Sebastian Brachs, Max Holzer, Rolf Buslei, Kristin Fritsch, Martin Regensburger, Konrad J Böhm, Beate Winner, Dirk Mielenz

“…To elucidate this question, we analyzed EFhd2-/-/lacZ reporter mice and showed that lacZ was strongly expressed in the cortex, the dentate gyrus, the CA1 and CA2 regions of the hippocampus, the thalamus, and the olfactory bulb. Immunohistochemistry and western blotting confirmed this pattern and revealed expression of EFhd2 during neuronal maturation. …”
Get full text

Yokukansankachimpihange Improves the Social Isolation-Induced Sleep Disruption and Allopregnanolone Reduction in Mice by Kenta Murata, Feng Li, Kanako Shinguchi, Misaki Ogata, Nina Fujita, Ryuji Takahashi

“…Furthermore, we showed that YKSCH treatment improved the decrease in allopregnanolone content and its synthase expression levels in the olfactory bulb. These results suggest that YKSCH treatment improved social isolation stress-induced insomnia via the GABAergic pathway and that the mechanism of action of YKSCH is partly due to improvement of allopregnanolone levels of expression.…”
Get full text

Delta protocadherin 10 is regulated by activity in the mouse main olfactory system by Eric O Williams, Heather M Sickles, Alison L Dooley, Sierra ePalumbos, Adam J Bisogni, David M Lin

“…We show pcdh10 is expressed in the nasal epithelium and olfactory bulb in patterns consistent with providing guidance information to OSNs. …”
Get full text

Spatiotemporal analyses of neural lineages after embryonic and postnatal progenitor targeting combining different reporters by Maria eFigueres-Oñate, Jorge eGarcía-Marqués, Jorge eGarcía-Marqués, Maria ePedraza, Maria ePedraza, Juan Andrés De Carlos, Laura eLópez-Mascaraque

“…To address this issue, we performed postnatal and in utero co-electroporations of different fluorescent reporters to label, in both cerebral cortex and olfactory bulb, the progeny of SVZ neural progenitors. …”
Get full text