Physical exercise restores adult neurogenesis deficits induced by simulated microgravity by Alexandra Gros, Fandilla Marie Furlan, Vanessa Rouglan, Alexandre Favereaux, Bruno Bontempi, Jean-Luc Morel

“…We studied the proliferation, survival and maturation of newborn cells in the following neurogenic niches: the subventricular zone (SVZ)/olfactory bulb (OB) and the dentate gyrus (DG) of the hippocampus, at different delays following various periods of SMG. …”
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Pαx6 expression in postmitotic neurons mediates the growth of axons in response to SFRP1. by Alvaro Sebastián-Serrano, Africa Sandonis, Marcos Cardozo, Fernanda M Rodríguez-Tornos, Paola Bovolenta, Marta Nieto

“…There are however exceptions and high Pax6 protein levels are found, for example, in postmitotic retinal ganglion cells (RGCs), dopaminergic neurons of the olfactory bulb and the limbic system in the telencephalon. …”
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Single-nucleus chromatin landscape dataset of mouse brain development and aging by Yuting Ma, Sicheng Guo, Yixi Chen, Yushan Peng, Xi Su, Hui Jiang, Xiumei Lin, Jianguo Zhang

“…In this study, we employed single-nucleus ATAC-seq to generate comprehensive chromatin accessibility maps, incorporating data from 69,178 cells obtained from four distinct brain regions – namely, the olfactory bulb (OB), cerebellum (CB), prefrontal cortex (PFC), and hippocampus (HP) – across key developmental time points at 7 P, 3 M, 12 M, and 18 M. …”
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Expression of the ACE2 Virus Entry Protein in the Nervus Terminalis Reveals the Potential for an Alternative Route to Brain Infection in COVID-19 by Katarzyna Bilinska, Christopher S. von Bartheld, Rafal Butowt

“…We show that a small fraction of CHAT-labeled nervus terminalis neurons, and the large majority of GnRH-labeled nervus terminalis neurons with cell bodies in the region between the olfactory epithelium and the olfactory bulb express ACE2 and cathepsins B and L. Nervus terminalis neurons therefore may provide a direct route for the virus from the nasal epithelium, possibly via innervation of Bowman’s glands, to brain targets, including the telencephalon and diencephalon. …”
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Parkinson’s disease – the role of the digestive tract in pathogenesis by Ewelina Bucior, Magdalena Konopko, Halina Sienkiewicz-Jarosz

“…Many studies indicate that this process may begin in the olfactory bulb and the enteric nervous system, and then spread through the vagus nerve and the olfactory route to further areas of the brain, many years before the onset of motor symptoms. …”
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Expression of the Tuberous Sclerosis 2 Gene Product, Tuberin, in Adult and Developing Nervous System Tissues by Robert T. Geist, Anita J. Reddy, Jie Zhang, David H. Gutmann

“…Tuberin expression in the adult CNS is restricted to the olfactory bulb, several CNS neuronal populations, brainstem nuclei, cerebellar Purkinje cells, and motor neurons in the ventral spinal cord. …”
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In vivo fate analysis reveals the multipotent and self-renewal features of embryonic AspM expressing cells. by Cinzia Marinaro, Erica Butti, Andrea Bergamaschi, Alessandro Papale, Roberto Furlan, Giancarlo Comi, Gianvito Martino, Luca Muzio

“…We further demonstrated that AspM is expressed by proliferating cells of the adult mouse SVZ that can generate neuroblasts fated to become olfactory bulb neurons.…”
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Global 3D imaging of Yersinia ruckeri bacterin uptake in rainbow trout fry. by Maki Ohtani, Kasper Rømer Villumsen, Erling Olaf Koppang, Martin Kristian Raida

“…Later, bacterin uptake was detected on other mucosal surfaces such as skin and olfactory bulb from 5 to 30 minutes post vaccination. …”
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Neuropathogenesis of a highly pathogenic avian influenza virus (H7N1) in experimentally infected chickens by Chaves Aida J, Busquets Núria, Valle Rosa, Rivas Raquel, Vergara-Alert Júlia, Dolz Roser, Ramis Antonio, Darji Ayub, Majó Natàlia

“…No viral antigen was observed in olfactory sensory neurons, while the olfactory bulb showed only weak staining, suggesting that the virus did not use this pathway to enter into the brain. …”
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Head and Neck Veins of the Mouse. A Magnetic Resonance, Micro Computed Tomography and High Frequency Color Doppler Ultrasound Study. by Marcello Mancini, Adelaide Greco, Enrico Tedeschi, Giuseppe Palma, Monica Ragucci, Maria Grazia Bruzzone, Anna Rita Daniela Coda, Enza Torino, Alessandro Scotti, Ileana Zucca, Marco Salvatore

“…Instead, the mouse Internal Jugular Veins are tiny vessels receiving the sigmoid sinuses and tributaries from cerebellum, occipital lobe and midbrain, while the majority of the cerebral blood, i.e. from the olfactory bulbs and fronto-parietal lobes, is apparently drained through skull base connections into the External Jugular Vein. …”
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Loss of STOP protein impairs peripheral olfactory neurogenesis. by Karelle Benardais, Basem Kasem, Alice Couegnas, Brigitte Samama, Sebastien Fernandez, Christiane Schaeffer, Maria-Cristina Antal, Didier Job, Annie Schweitzer, Annie Andrieux, Anne Giersch, Astrid Nehlig, Nelly Boehm

“…METHODOLOGY/PRINCIPAL FINDINGS: Immunocytochemistry and electron microscopy were used to study the structure of the glomerulus in the main olfactory bulb and neurogenesis in the neurosensorial epithelia. …”
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Dendrite Development Regulated by the Schizophrenia-Associated Gene FEZ1 Involves the Ubiquitin Proteasome System by Yasuhito Watanabe, Konstantin Khodosevich, Hannah Monyer

“…Because dendrite growth is affected both in hippocampal dentate granule cells and olfactory bulb neurons upon modifying expression of these genes, we conclude that the proposed mechanism governs neuronal development in a general fashion. : In this study, Watanabe et al. show that several components of the ubiquitin proteasome system, namely the Cdc20/APC complex and its upstream regulators BubR1 and Hdac11, modulate FEZ1 downregulation and dendrite development of postnatally born dentate granule neurons in the hippocampus.…”
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IGF-I: A key growth factor that regulates neurogenesis and synaptogenesis from embryonic to adult stages of the brain by Vanesa eNieto-Estévez, Çagla eDefterali, CARLOS eVicario-Abejón, CARLOS eVicario-Abejón

“…Although IGF-I expression is relatively high in the embryonic brain its levels drop sharply in the adult brain except in neurogenic regions, i.e., the hippocampus (HP) and the subventricular zone-olfactory bulb (SVZ-OB). By contrast, the expression of IGF-IR remains relatively high in the brain irrespective of the age of the animal. …”
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fMRI study of the role of glutamate NMDA receptor in the olfactory processing in monkeys. by Fuqiang Zhao, Marie A Holahan, Xiaohai Wang, Jason M Uslaner, Andrea K Houghton, Jeffrey L Evelhoch, Christopher T Winkelmann, Catherine D G Hines

“…Studies in rodents show that olfactory processing in the principal neurons of olfactory bulb (OB) and piriform cortex (PC) is controlled by local inhibitory interneurons, and glutamate NMDA receptor plays a role in this inhibitory control. …”
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Absence of colony stimulation factor-1 receptor results in loss of microglia, disrupted brain development and olfactory deficits. by Bryna Erblich, Liyin Zhu, Anne M Etgen, Kostantin Dobrenis, Jeffrey W Pollard

“…Despite the loss of microglia, embryonic brain development appears normal but during the post-natal period the brain architecture becomes perturbed with enlarged ventricles and regionally compressed parenchyma, phenotypes most prominent in the olfactory bulb and cortex. In the cortex there is increased neuronal density, elevated numbers of astrocytes but reduced numbers of oligodendrocytes. …”
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A role for dendritic translation of CaMKIIα mRNA in olfactory plasticity. by Marie Néant-Fery, Eléonore Pérès, Carole Nasrallah, Monica Kessner, Simona Gribaudo, Charles Greer, Anne Didier, Alain Trembleau, Isabelle Caillé

“…We studied the dendritic localization and local translation of CaMKIIα in the mouse olfactory bulb (OB), the first relay of the olfactory pathway, which exhibits a high level of plasticity in response to olfactory experience. …”
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Characterizing functional pathways of the human olfactory system by Guangyu Zhou, Gregory Lane, Shiloh L Cooper, Thorsten Kahnt, Christina Zelano

“…The central processing pathways of the human olfactory system are not fully understood. The olfactory bulb projects directly to a number of cortical brain structures, but the distinct networks formed by projections from each of these structures to the rest of the brain have not been well-defined. …”
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Functional Role of Adult Hippocampal Neurogenesis as a Therapeutic Strategy for Mental Disorders by Heechul Jun, Syed Mohammed Qasim Hussaini, Michael J. Rigby, Mi-Hyeon Jang

“…In the mammalian brain, it continues to occur well into adulthood in discrete regions, namely, the hippocampus and olfactory bulb. During the past decade, significant progress has been made in understanding the mechanisms regulating adult hippocampal neurogenesis and its role in the etiology of mental disorders. …”
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A global transcriptome analysis reveals molecular hallmarks of neural stem cell death, survival, and differentiation in response to partial FGF-2 and EGF deprivation. by Vanesa Nieto-Estévez, Jaime Pignatelli, Marcos J Araúzo-Bravo, Anahí Hurtado-Chong, Carlos Vicario-Abejón

“…Using cultures of embryonic and adult olfactory bulb stem cells (eOBSCs and aOBSCs), we analyzed the consequences of FGF-2 and EGF addition at different intervals on proliferation, cell cycle progression, cell death and differentiation, as well as on global gene expression. …”
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COVID-19 Anosmia: High Prevalence, Plural Neuropathogenic Mechanisms, and Scarce Neurotropism of SARS-CoV-2? by Fengyi Liang, De Yun Wang

“…Neuropathology of COVID-19 in the OE, olfactory bulb, and other related neural structures are also reviewed. …”
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