Overexpression of human alpha-Synuclein leads to dysregulated microbiome/metabolites with ageing in a rat model of Parkinson disease by Yogesh Singh, Christoph Trautwein, Joan Romani, Madhuri S. Salker, Peter H. Neckel, Isabel Fraccaroli, Mahkameh Abeditashi, Nils Woerner, Jakob Admard, Achal Dhariwal, Morten K. D. Dueholm, Karl-Herbert Schäfer, Florian Lang, Daniel E. Otzen, Hilal A. Lashuel, Olaf Riess, Nicolas Casadei

“…Although antibiotic cocktail treatment did not change α-Syn expression in the enteric nervous system of the colon, however, reduced α-Syn expression was detected in the olfactory bulbs (forebrain) of the TG rats. Conclusion Our data emphasize that the gut microbiome dysbiosis synchronous with ageing leads to a specific alteration of gut metabolites and can be modulated by antibiotics which may affect PD pathology.…”
Get full text

Mitoapocynin Attenuates Organic Dust Exposure-Induced Neuroinflammation and Sensory-Motor Deficits in a Mouse Model by Nyzil Massey, Denusha Shrestha, Sanjana Mahadev Bhat, Piyush Padhi, Chong Wang, Chong Wang, Locke A. Karriker, Jodi D. Smith, Anumantha G. Kanthasamy, Chandrashekhar Charavaryamath

“…Inhaled fluorescent LPS (FL-LPS) was detected in the nasal turbinates and olfactory bulbs. OD extract exposure induced atrophy of the olfactory epithelium with reduction in the number of nerve bundles in the nasopharyngeal meatus, loss of cilia in the upper respiratory epithelium with an increase in the number of goblet cells, and increase in the thickness of the nasal epithelium. …”
Get full text

O Herpesvírus bovino tipo 5 (BoHV-5) pode utilizar as rotas olfatória ou trigeminal para invadir o sistema nervoso central de coelhos, dependendo da via de inoculação Bovine herpes... by Diego Gustavo Diel, Erika Toledo da Fonseca, Soraia Figueiredo de Souza, Alexandre Mazzanti, Fernando Bauermann, Rudi Weiblen, Eduardo Furtado Flores

“…To address the role of this pathway in the pathogenesis of neurological infection in a laboratory model, 30 days old rabbits had the main olfactory bulbs (MOBs) surgically removed and were subsequently inoculated intranasally (IN) or conjunctivally (IC) with a highly neurovirulent BoHV-5 strain (SV-507). …”
Get full text