Viral proteases activate the CARD8 inflammasome in the human cardiovascular system by Nadkarni, Rhea, Chu, Wern Cui, Lee, Cheryl Q. E., Mohamud, Yasir, Yap, Lynn, Toh, Gee Ann, Beh, Sheryl, Lim, Radiance, Fan, Michelle Yiyun, Zhang, Lyanne Yizhuo, Robinson, Kim, Tryggvason, Karl, Luo, Honglin, Zhong, Franklin, Ho, Lena

“…Nucleotide-binding oligomerization domain (NBD), leucine-rich repeat (LRR) containing protein family (NLRs) are intracellular pattern recognition receptors that mediate innate immunity against infections. …”
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Alternative splicing in the DBD linker region of p63 modulates binding to DNA and iASPP in vitro by Lotz, R, Osterburg, C, Chaikuad, A, Weber, S, Akutsu, M, Machel, AC, Beyer, U, Gebel, J, Löhr, F, Knapp, S, Dobbelstein, M, Lu, X, Dötsch, V

“…Here we characterize the interaction of iASPP with p63 and show that it binds to the linker region between the DNA binding domain and the oligomerization domain. We further demonstrate that this binding site is removed in a splice variant of p63 where a stretch of five amino acids is replaced with a single alanine residue. …”

Structural and biochemical mechanisms of NLRP1 inhibition by DPP9 by Huang, Menghang, Zhang, Xiaoxiao, Toh, Gee Ann, Gong, Qin, Wang, Jia, Han, Zhifu, Wu, Bin, Zhong, Franklin, Chai, Jijie

“…Formation of the complex prevents UPA-mediated higher-order oligomerization of UPA-CARD fragments and strengthens ZU5-mediated NLRP1 autoinhibition. …”
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High-resolution HDX-MS reveals distinct mechanisms of RNA recognition and activation by RIG-I and MDA5 by Liu, Chuan-Fa, Zheng, Jie, Yong, Hui Yee, Panutdaporn, Nantika, Tang, Kai, Luo, Dahai

“…We also present a high-resolution protein surface mapping technique that refines the cooperative oligomerization model of neighboring MDA5 molecules on long duplex RNA. …”
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Metal-organic framework-based nanovaccine for relieving immunosuppressive tumors via hindering efferocytosis of macrophages and promoting pyroptosis and cuproptosis of cancer cells by Liu, Yang, Niu, Rui, Zhang, Xiaodong, Zhang, Bin, Chen, Xiaokai, Guo, Jingjing, Song, Shuyan, Wang, Yinghui, Zhang, Hongjie, Zhao, Yanli

“…Meanwhile, Cu-THBQ/AX can also induce the oligomerization of dihydrolipoamide S-acetyltransferase to trigger tumor cell cuproptosis. …”
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Viroporin activity of the foot-and-mouth disease virus non-structural 2B protein by Ao, Da, Guo, Hui-Chen, Sun, Shi-Qi, Sun, De-Hui, Fung, To Sing, Wei, Yan-Quan, Han, Shi-Chong, Yao, Xue-Ping, Cao, Sui-Zhong, Liu, Ding Xiang, Liu, Xiang-Tao

“…Viroporins form transmembrane pores in host cells via oligomerization, thereby destroying cellular homeostasis and inducing cytopathy for virus replication and virion release. …”
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Identification and application of self-binding zipper-like sequences in SARS-CoV spike protein by Zhang, Si Min, Liao, Ying, Neo, Tuan Ling, Lu, Yanning, Liu, Ding Xiang, Vahlne, Anders, Tam, James Pingkwan

“…Peptide C6 containing the Cluster I consensus sequence was shown to oligomerize and form amyloid-like fibrils. Taking advantage of this, C6 was further applied to detect the S protein expression in vitro by fluorescence staining. …”
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Single-site nanozymes with a highly conjugated coordination structure for antitumor immunotherapy via cuproptosis and cascade-enhanced T lymphocyte activity by Liu, Yang, Niu, Rui, Zhao, Huan, Wang, Yinghui, Song, Shuyan, Zhang, Hongjie, Zhao, Yanli

“…This surge of reactive oxygen species (ROS) leads to impaired mitochondrial function and insufficient ATP supply, impacting the function of copper-transporting ATPase-1 and causing dihydrolipoamide S-acetyltransferase oligomerization-mediated cuproptosis. Moreover, multiple ROS storms and glutathione peroxidase 4 depletion also induce lipid peroxidation and trigger ferroptosis. …”
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NMR structure and activity relationship of defensin-analogous peptides by Bai, Yang

“…The results show that the binding affinity, partitioning into the lipid bilayer, the ability to oligomerize and form well defined structures upon interactions with biological phases (e.g. bacterial membranes, peptidoglycans and LPS layers) may contribute to condensation of positive charges in AMP macrostructures resulting in membrane remodeling and eventual lysis of bacteria. …”
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Filamentous oligomer structure reconstruction and a new filament picking method for Cryo-EM micrographs by Xu, Chenrui

“…Facilitated by NAIP5 and activates downstream ASC-CASP1 inflammasome signaling axis, the CARD domain in NLRC4 relays the activation signal via a cooperative oligomerization process. NLRP1 and CARD8 are two similar innate immune receptors that undergo auto-proteolytic activation, when encountering the right triggering signals from cellular damage or pathogen infection, and release a filament-forming CARD domains. …”
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