An essential role for Grk2 in Hedgehog signalling downstream of Smoothened by Zhao, Zhonghua, Lee, Raymond Teck Ho, Pusapati, Ganesh V., Iyu, Audrey, Rohatgi, Rajat, Ingham, Philip William

“…Zebrafish embryos lacking all Grk2 activity are refractory to both Sonic hedgehog (Shh) and oncogenic Smoothened (Smo) activity, but remain responsive to inhibition of cAMP-dependent protein kinase (PKA) activity. …”
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Biomarkers of cellular senescence and skin aging by Wang, Audrey S., Dreesen, Oliver

“…Cellular senescence is an irreversible growth arrest that occurs as a result of different damaging stimuli, including DNA damage, telomere shortening and dysfunction or oncogenic stress. Senescent cells exert a pleotropic effect on development, tissue aging and regeneration, inflammation, wound healing and tumor suppression. …”
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Computational cell fate modelling for discovery of rewiring in apoptotic network for enhanced cancer drug sensitivity by Chua, Huey Eng, Zhang, Fan, Zheng, Jie, Mishra, Shital Kumar, Bhowmick, Sourav Saha

“…Hence comparative analysis of normal and oncogenic signal transduction pathways may provide insights into mechanisms of cancer drug-resistance and facilitate the discovery of novel and effective anti-cancer therapies. …”
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Nanoparticle-encapsulated camptothecin: epigenetic modulation in DNA repair mechanisms in colon cancer cells by Farhana, Aisha, Ee, Avin Hwan Koh, Jia, Bei Tong, Alsrhani, Abdullah, Subbiah, Suresh Kumar, Pooi, Ling Mok

“…Molecular crosstalk between the cellular epigenome and genome converge as a synergistic driver of oncogenic transformations. Besides other pathways, epigenetic regulatory circuits exert their effect towards cancer progression through the induction of DNA repair deficiencies. …”

OncomiR-138 targets genes involved in senescence and its inhibition induces growth arrest of malignant gliomas. by Malini Rethnam.

“…Microarray validation showed up regulation of senescence associated genes, which include cytokines and chemokines upon miR-138 knock down and the increased phosphorylated p38 MAPK detection upon miR-138 knock down, suggest an oncogene-induced senescence relayed by an interleukin-dependent inflammatory network involving p38 MAPK pathway. …”
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The pattern of Ki-67 and bcl-2 expression in Lymphoid Malignancies by Wang, P.L., Peh, S.C.

“…Ki-67 antigen is a proliferation-related nuclear antigen and bcl-2 oncogene product is known to inhibit apoptosis. This study aimed to detennine the pattern of expression of Ki-67 antigen and bcl-2 oncoprotein in various grades of NHL. …”

A role for collagen XXIII in cancer cell adhesion, anchorage-independence and metastasis. by Spivey, K.A., Chung, I., Banyard, J., Adini, I., Feldman, H.A., Zetter, B.R.

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Epstein-Barr Virus Latent Membrane Protein 1 (Lmp-1) Expression And Its Association With Expression Of Dna Damage Repair Proteins In Nasopharyngeal Carcinoma (Npc) – An Evaluation... by Yu, Wei Chiuen

“…Nasopharyngeal carcinoma (NPC) is the third most occurring cancer in Malaysian males, and is unique in its association with Epstein-Barr virus (EBV). LMP-1 is the major oncogenic protein of the EBV. EBV LMP-1 acts by constitutive regulation of host signalling pathways leading to dysregulated cell growth and has been considered a potential therapeutic target for LMP-1 expressing tumours. …”
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NUHS-MD anderson pathology update Singapore 27-29 Oktober 2011 by Seng, Ch'ng Ewe

“…High expression of Sema4D was significantly associated with higher expression of the oncogene, Her-2 (p =0.037). Conclusion: Invasive ductal carcinomas mostly express Sema4D at the tumor front. …”
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Identification Of Novel 14-3-3 Sigma Homodimer Stabiliser In Nasopharyngeal Carcinoma by Jabal, Ghazi Ahmad Al

“…14-3-3σ is an acidic homodimer protein with more than one hundred different protein partners associated with oncogenic signalling and cell cycle regulation. Previous studies have shown that 14-3-3σ functions as a potential tumour suppressor and its expression is commonly downregulated in many types of cancer including nasopharyngeal carcinoma (NPC). …”
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Membrane curvature sensing of the lipid-anchored K-Ras small GTPase by Liang, Hong, Mu, Huanwen, Jean-Francois, Frantz, Lakshman, Bindu, Sarkar-Banerjee, Suparna, Zhuang, Yinyin, Zeng, Yongpeng, Gao, Weibo, Zaske, Ana Maria, Nissley, Dwight V., Gorfe, Alemayehu A., Zhao, Wenting, Zhou, Yong

“…We show that the spatiotemporal organization and signaling of an oncogenic mutant K-RasG12V favor flatter membranes with low curvature. …”
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A rapid CRISPR competitive assay for in vitro and in vivo discovery of potential drug targets affecting the hematopoietic system by Shen, Yunbing, Jiang, Long, Iyer, Vaishnavi Srinivasan, Raposo, Bruno, Dubnovitsky, Anatoly, Boddul, Sanjaykumar V., Kasza, Zsolt, Wermeling, Fredrik

“…As proof of principle, we present examples studying various aspects related to hematopoietic cells (T cell development in vivo and activation in vitro, differentiation of macrophages and dendritic cells, as well as a leukemia-like phenotype induced by overexpressing a proto-oncogene). In conclusion, we present a rapid experimental approach to identify potential drug targets related to mature immune cells, as well as normal and malignant hematopoiesis.…”
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YWHAG deficiency disrupts the EMT-associated network to induce oxidative cell death and prevent metastasis by Lee, Jeannie Xue Ting, Tan, Wei Ren, Low, Zun Siong, Lee, Jia Qi, Chua, Damien, Yeo, Wisely Duan Chi, See, Benedict, Vos, Marcus Ivan Gerard, Yasuda, Tomohiko, Nomura, Sachiyo, Cheng, Hong Sheng, Tan, Nguan Soon

“…To address this gap, hub genes with broad engagement across various human cancers by analyzing the transcriptomes of different cancer cell types undergoing EMT are identified. The oncogenic signaling adaptor protein tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma (YWHAG) is ranked top for its clinical relevance and impact. …”
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NRAS and BRAF mutation frequency in primary oral mucosal melanoma by Buery, R.R., Siar, C.H., Katase, N., Gunduz, M., Lefeuvre, M., Fujii, M., Inoue, M., Setsu, K., Nagatsuka, H.

“…The classical V600E BRAF mutation was not found; instead a novel V600L was observed suggesting that the oncogenic event in OMM is different from that in skin melanoma. …”
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Molecular regulatory roles of long non-coding RNA HOTTIP: An overview in gastrointestinal cancers by Ummi Zulaiqha Hamid, Maw Shin Sim, Rhanye Mac Guad, Vetriselvan Subramaniyan, Mahendran Sekar, Neeraj Kumar Fuloria, Shivkanya Fuloria, Choy Ker Woon, Ismail Muhamad Fareez, Srinivasa Reddy Bonam, Yuan Seng Wu

“…Amongst lncRNAs, HOTTIP has demonstrated a prominent oncogenic regulation in cancer progression, particularly in GI cancers, including oesophageal cancer, gastric cancer, hepatocellular carcinoma, pancreatic cancer, and colorectal cancer. …”
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Predicting deleterious non-synonymous single nucleotide polymorphisms nsSNPs of HRAS gene and in-silico evaluation of their structural and functional consequences towards diagnosis... by Chai, Chuan-Yu, Maran, Sathiya, Thew, Hin-Yee, Tan, Yong-Chiang, Nik Abd Rahman, Nik Mohd Afizan, Cheng, Wan-Hee, Lai, Kok-Song, Loh, Jiun-Yan, Yap, Wai-Sum

“…The Harvey rat sarcoma (HRAS) proto-oncogene belongs to the RAS family and is one of the pathogenic genes that cause cancer. …”

Pathogen interactions with cytokines and host defence: an overview by Seow, Heng Fong

“…Other strategies include the alterations in cytokine expression such as demonstrated with the hepatitis B virus (HBV) core protein and terminal protein which can inhibit interferon-β gene expression, the interactions of the hepatitis C virus core protein to lymphotoxin-β receptor and the effects of the interferon signal transduction pathway by adenovirus EIA oncogene and HBV by reducing levels or activity of the cytosolic latent transcriptional factors (STATS). …”
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S1PR1 drives a feedforward signaling loop to regulate BATF3 and the transcriptional programme of Hodgkin lymphoma cells by Vrzalikova, K., Ibrahim, M., Vockerodt, M., Perry, T., Margielewska, S., Lupino, L., Nagy, E., Soilleux, E., Liebelt, D., Hollows, R., Last, A., Reynolds, G., Abdullah, M., Curley, H., Care, M., Krappmann, D., Tooze, R., Allegood, J., Spiegel, S., Wei, W., Woodman, C. B. J., Murray, P. G.

“…Our data suggest that disruption of this potentially oncogenic feedforward S1P signalling loop could provide novel therapeutic opportunities for patients with HL.…”
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S1PR1 drives a feed forward signaling loop to regulate BATF3 and the transcriptional programme of Hodgkin lymphoma cells by Vrzalikova, Katerina, Ibrahim, M., Vockerodt, Martina, Perry, Tracy, Margielewska, S., Lupino, L., Nagy, Ester, Soilleux, E., Liebelt, D., Hollows, R., Last, A., Reynolds, G., Abdullah, Maizatul Atmadini, Curley, H., Care, M., Krappmann, D., Tooze, R., Allegood, J., Spiegel, S., Wei, W., Woodman, C. B. J., Murray, Paul G.

“…Our data suggest that disruption of this potentially oncogenic feedforward S1P signalling loop could provide novel therapeutic opportunities for patients with HL.…”
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Cellular Homeostasis and Antioxidant Response in Epithelial HT29 Cells on Titania Nanotube Arrays Surface by SMN Mydin, Rabiatul Basria, Sreekantan, Srimala, Hazan, Roshasnorlyza, Farid Wajidi, Mustafa Fadzil, Mat, Ishak

“…The cell fate decision on TNA-nanoenvironment has been reported to possibly regulate proliferative activities via expression of p27 and BCL2 tumor suppressor proteins, cogent with SKP2 and BCL2 oncogenic proteins suppression. Findings suggested that epithelial HT29 cells on the surface of TNA may have a positive regulation via cell-homeostasis mechanisms: a careful circadian orchestration between cell proliferation, survival, and death. …”
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