Integration of regulatory networks by NKX3-1 promotes androgen-dependent prostate cancer survival by Tan, Peck Yean, Chang, Cheng Wei, Chng, Kern Rei, Wansa, K. D. Senali Abayratna, Sung, Wing-Kin, Cheung, Edwin

“…NKX3-1- and AR-coregulated genes include those found in the “protein trafficking” process, which integrates oncogenic signaling pathways. Moreover, we demonstrate that NKX3-1, AR, and FoxA1 promote prostate cancer cell survival by directly upregulating RAB3B, a member of the RAB GTPase family. …”
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MicroRNA-138 is a prognostic biomarker for triple-negative breast cancer and promotes tumorigenesis via TUSC2 repression by Nama, Srikanth, Muhuri, Manish, Di Pascale, Federica, Quah, Shan, Aswad, Luay, Fullwood, Melissa, Sampath, Prabha

“…Our report of miR-138 as an oncogenic driver in TNBC, positions it as a viable target for oligonucleotide therapeutics and we envision the potential value of using antimiR-138 as an adjuvant therapy to alleviate this therapeutically intractable cancer.…”
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Small molecules targeting the inactive form of the Mnk1/2 kinases by Kannan, Srinivasaraghavan, Pradhan, Mohan R., Cherian, Joseph, Joseph, Thomas L., Poh, Zhi Ying, Hai Yan, Yang, Melvyn, Ho, Boping, Liu, Jeffrey, Hill, Nacro, Kassoum, Verma, Chandra Shekhar

“…Both mitogen-activated protein kinases-interacting kinases 1 and 2 (Mnk1/2) activate the oncogene eIF4E through posttranslational modification (phosphorylating it at the conserved Ser209). …”
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MYC overexpression leads to increased chromatin interactions at superenhancers and MYC binding sites by See, Yi Xiang, Chen, Kaijing, Fullwood, Melissa Jane

“…The MYC oncogene encodes for the MYC protein and is frequently dysregulated across multiple cancer cell types, making it an attractive target for cancer therapy. …”
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Super enhancer-mediated upregulation of HJURP promotes growth and survival of t(4;14)-positive multiple myeloma by Jia, Yunlu, Zhou, Jianbiao, Tan, Tze King, Chung, Tae-Hoon, Chen, Yongxia, Chooi, Jing-Yuan, Sanda, Takaomi, Fullwood, Melissa Jane, Xiong, Sinan, Toh, Sabrina H. M., Balan, Kalpnaa, Wong, Regina W. J., Lim, Julia S. L., Zhang, Enfan, Cai, Zhen, Shen, Peng, Chng, Wee Joo

“…Recently, essential oncogenic drivers in a wide range of cancers have been shown to be controlled by super-enhancers (SE). …”
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DNA/RNA structure and processing in vitro and in cells: from probing to prediction by Korsakova, Anna

“…For example, DNA and RNA G-quadruplex (G4) structures were found to affect oncogene expression and to be attractive therapeutic targets. …”
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Sustained activation of non-canonical NF-κB signalling drives glycolytic reprogramming in doxorubicin-resistant DLBCL by Lim, Shen Kiat, Peng, Chen Chen, Low, Shannon, Vijay, Varsheni, Budiman, Andrea, Phang, Beng Hooi, Lim, Jing Quan, Jeyasekharan, Anand D., Lim, Soon Thye, Ong, Choon Kiat, Tan, Suet Mien, Li, Yinghui

“…Doxorubicin-induced stress in resistant cells activates a distinct transcriptional signature that is enriched in metabolic reprogramming and oncogenic signalling. Selective and sustained activation of non-canonical NF-κB signalling in these resistant cells exacerbated their survival by augmenting glycolysis. …”
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Regulation of Epstein-Barr virus gene expression via CRISPR-mediated targeting of DNA methylation enzymes by Auni Afiqoh Binte Roseazam

“…Epstein-Barr virus (EBV) can establish an oncogenic presence in cells to cause transformation. …”
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Dichotomous transactivation domains contribute to growth inhibitory and promotion functions of TAp73 by Li, Dan, Kok, Catherine Yen Li, Wang, Chao, Ray, Debleena, Osterburg, Susanne, Dötsch, Volker, Ghosh, Sujoy, Sabapathy, Kanaga

“…Interestingly, the C-TAD targets are also regulated by the oncogenic, amino-terminal-deficient DNp73β isoform. …”
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Cannabidiol (CBD) is a novel inhibitor for Exosome and Microvesicle (EMV) release in cancer by Kosgodage, Uchini S., Mould, Rhys, Henley, Aine B., Nunn, Alistair V., Guy, Geoffrey W., Thomas, E. Louise, Inal, Jameel, Bell, Jimmy D., Lange, Sigrun

“…EMV release is also associated with various pathologies, including cancer, where increased EMV release is amongst other associated with chemo-resistance and active transfer of pro-oncogenic factors. Recent studies show that EMV-inhibiting agents can sensitize cancer cells to chemotherapeutic agents and reduce cancer growth . …”
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Peptidylarginine Deiminase Isozyme-Specific PAD2, PAD3 and PAD4 Inhibitors Differentially Modulate Extracellular Vesicle Signatures and Cell Invasion in Two Glioblastoma Multiforme... by Uysal-Onganer, Pinar, MacLatchy, Amy, Mahmoud, Rayan, Kraev, Igor, Thompson, Paul R., Inal, Jameel, Lange, Sigrun

“…The PAD3 inhibitor was most effective in modulating EVs to anti-oncogenic signatures (reduced miR21 and miR210, and elevated miR126), to reduce cell invasion and to modulate protein expression of pro-GBM proteins in LN229 cells, while the PAD2 and PAD4 inhibitors were more effective in LN18 cells. …”
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Mir-21 expression and its correlation with demographics, subtypes, and tumour suppressor genes; PTEN and PDCD4 in breast cancer tissues in Malaysia by Wong, Sharon Rachel, Chong, Pei Pei, Mohd Islahuddin, Mohd Tamrin, Baghawi, Anita, Gew, Lai Ti, Singaram, Nallammai, Lee, Sau Har

“…Hence, microribonucleic acid-21 (miRNA-21), which is known to be an oncogenic stimulator of BC will be investigated by comparing its expression between breast tumour tissues and normal adjacent tissues excised from 67 BC patients, ethnic groups, age groups distribution, neo-adjuvant chemotherapy (NAC) treated and untreated patients, as well as BC subtypes. …”
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The expressions of Ret/PTC and p53 in normal, benign and malignant thyroid lesions by Omar, Effat, Madhavan, M., Othman, Nor Hayati

“…Ret/PTC is a recently discovered oncogene which is solely related to papillary carcinoma. …”
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An inducible and reversible genetics platform for novel drug target discovery by Leong, Mei Ling

“…The Wnt signalling pathway has been implicated in colorectal cancer, but there are contradictory views on whether Tcf7l2 acts as an oncogene or tumour suppressor gene in this context. …”
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HUBUNGAN KEBIASAAN MEROKOK DENGAN TITER IgA-EBV DIANTARA ORANG SEHAT by , BENNY HERMAWAN, , Jajah Fachiroh, S.P., M.Si., Ph.D.

“…BACKGROUND: Epstein Barr Virus (EBV) infects more than 90% of the world population and is classified as oncogenic virus. EBV is associated with various epithelial and lymphoid malignancies including nasopharyngeal carcinoma (NPC). …”

Linkage of the potent leukemogenic activity of Meis1 to cell-cycle entry and transcriptional regulation of cyclin D3 by Argiropoulos, B., Yung, E., Xiang, P., Lo, C.Y., Kuchenbauer, F., Palmqvist, L., Reindl, C., Heuser, M., Sekulovic, S., Rosten, P., Muranyi, A., Goh, Siew-Lee, Featherstone, M., Humphries, R.K.

“…Expression of Meis1 is ratelimiting in MLL-associated leukemias and potently interacts with Hox and NUP98-HOX genes in leukemic transformation to promote self-renewal and proliferation of hematopoietic progenitors. The oncogenicity of MEIS1 has been linked to its transcriptional activation properties. …”

Expression of HER4 isoforms and HER4 localisation in HER2 negative breast cancer cell lines by Ali, Nursyazana Aqilah

“…Among the HER family receptors, the role of HER4 in breast cancer is uncertain where some reports suggest a tumour suppressive function while others suggest an oncogenic function. The conflicting role of HER4 is due to the presence of different isoforms and nuclear translocation of HER4. …”
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Exploiting vulnerabilities of cancer by targeting nuclear receptors of stromal cells in tumor microenvironment by Cheng, Hong Sheng, Lee, Jeannie Xue Ting, Wahli, Walter, Tan, Nguan Soon

“…Nuclear receptors are master regulators of physiological processes and are known to play pro−/anti-oncogenic activities in tumor cells. However, the actions of nuclear receptors in tumor-supporting cells have not been widely studied. …”
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Profiling of the Chromatin-associated Proteome Identifies HP1BP3 as a Novel Regulator of Cell Cycle Progression by Dutta, Bamaprasad, Ren, Yan, Hao, Piliang, Sim, Kae Hwan, Cheow, Esther, Tam, James Pingkwan, Sze, Siu Kwan, Adav, Sunil S.

“…The chromatin-associated proteome (chromatome) regulates cellular gene expression by restricting access of transcriptional machinery to template DNA, and dynamic re-modeling of chromatin structure is required to regulate critical cell functions including growth and replication, DNA repair and recombination, and oncogenic transformation in progression to cancer. …”
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Increased expression of phosphatidylinositol 3-kinase p110α and gene amplification of PIK3CA in nasopharyngeal carcinoma by Yip, Wai Kien, He, Pei Yuan, Abdullah, Maizaton Atmadini, Yusoff, Suryati, Seow, Heng Fong

“…Molecular alterations in PIK3CA oncogene that encodes the p110α catalytic subunit of phosphatidylinositol 3-kinase (PI3K p110α) are commonly found in human cancers. …”
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