Phorbol esters from Jatropha meal triggered apoptosis, activated PKC-δ, Caspase-3 proteins and down-regulated the proto-oncogenes in MCF-7 and HeLa cancer cell lines by Oskoueian, Ehsan, Abdullah, Norhani, Ahmad, Syahida

“…The PEs isolated from Jatropha meal activated the PKC-δ and down-regulated the proto-oncogenes (c-Myc, c-Fos and c-Jun). These changes probably led to the activation of Caspase-3 protein and apoptosis cell death occurred in MCF-7 and HeLa cell lines upon 24 h treatment with PEs and PMA. …”
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The curcumin analogue 1,5-bis(2-hydroxyphenyl)-1,4-pentadiene-3-one induces apoptosis and downregulates E6 and E7 oncogene expression in HPV16 and HPV18-infected cervical cancer cells by Paulraj, Felicia, Abas, Faridah, Lajis, Nordin, Othman, Iekhsan, Syed Hassan, Sharifah, Naidu, Rakesh

“…Furthermore, its role in down-regulation of HPV-associated oncogenes responsible for cancer progression merits further investigation into its chemotherapeutic role for cervical cancer…”
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The MYC-independent effects of BET inhibitor JQ1 on super-enhancers in cancer by Chia, Boon Jun

“…One reason is due to the invasion of super-enhancer regions by MYC upstream of oncogenes, often resulting in activation of oncogenic pathways and poorer prognosis. …”
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Molecular and Cytoskeletal Changes in Breast Cancer Cell Lines Treated With Newcastle Disease Virus Strain Af2240 by Eshak, Zolkapli

“…Studies were conducted to investigate the cytoskeletal protein structure and the molecular changes of the oncogenes. The AF2240 strain of NDV was propagated in 11 days old embryonated eggs for 72 hours. …”
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Overexpression of RasV12 and its role in promoting the robustness of HEK293T cells. by Chow, Peiyi Vicki.

“…To overcome such limitations, cell engineering, such as the overexpression of oncogenes, has been employed in recent years (Mohan et al., 2008). …”
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Development of bioinformatics methods and platforms to characterize chromatin interactions by Chen, Kaijing

“…Then we asked about the possibility of using drug treatments that affect oncogenes regulated by super-silencers as potential therapies for cancer. …”
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Obtusilactone B from Machilus Thunbergii targets barrier-to-autointegration factor to treat cancer by Kim, Wanil, Lyu, Ha-Na, Kwon, Hyun-Sook, Kim, Ye Seul, Lee, Kyung-Ha, Kim, Do-Yeon, Chakraborty, Goutam, Choi, Kwan Yong, Yoon, Ho Sup, Kim, Kyong-Tai

“…However, the continued development of novel molecular targeting inhibitors is required to target the various oncogenes associated with the diverse types and stages of cancer. …”
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Investigation of new properties and applications of g-quadruplex DNA and I-motif DNA by Luo, Ji

“…Some sequences of DNA that possess certain guanine or cytosine-riched stretches are capable of associating into two types of four-stranded DNA structures, namely G-quadruplex and i-motif respectively, which could exist in some biologically important regions of DNA such as the end of chromosomes and the regulatory regions of oncogenes. With the aim of exploring new properties and applications of quadruplex DNA during my graduate studies, we have investigated the factors that affect the G-quadruplex that could undergo self-cleavage reactions, and developed certain fluorescence-tagged circular i-motifs to be used as molecular probes.…”
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The Effect Of Otub1 Overexpression On Human Cervical Cancer Hela by Abdul Hamid, Fitrah Mujahidah

“…There is growing recognition that mutated deubiquitinating enzyme (DUBs) in human cancers suggesting their roles as oncogenes and tumor suppressors.…”
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Anticancer Studies Of Koetjapic Acid Purified From Sandoricum Koetjape MERR by Nassar, Zeyad D.

“…The disease is characterized by extensive angiogenesis and perturbation of a variety of oncogenes and tumor suppressor genes including, p53, Wnt, hypoxia, NF-кB, Notch, MAP kinase. …”
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Characterization of a novel P53 target gene, Heme Oxygenase (decycling) 1 (HMOX1) by Nam, Shin Yuen

“…Multiple stress signals that activate p53 include hypoxia, telomere erosion, oncogenes and DNA damage, which is the best studied of them all. …”
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Quantitative model of R-loop forming structures reveals a novel level of RNA–DNA interactome complexity by Wongsurawat, Thidathip, Jenjaroenpun, Piroon, Kwoh, Chee Keong, Kuznetsov, Vladimir

“…This structure can be involved in the hyper-mutation and dsDNA breaks in mammalian immunoglobulin (Ig) genes, oncogenes and neurodegenerative disease related genes. …”
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Morphological and Molecular Characterisation of Ethanolic Neem (Azadirachta Indica) Leaf Extract In an in Vivo Breast Cancer Model by Lam, Tsuey Peng

“…Neem 500 mglkg group also showed a better suppression of c-myc, c-erbB2 and c-fos oncogenes expression in mean distribution and intensity score (pc 0.05) in the 4T1 breast cancer model. …”
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Structural properties of DNA G-quadruplexes with applications in colloidal assembly by Vineeth Thachappilly Mukundan

“…Such structures have the potential to form in many important regions of the genome such as telomere ends, promoter regions of many oncogenes. They exhibit a wide range of topologies depending on the nature of the sequences. …”
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Development of novel gene delivery system for cancer therapy by Yang, Chengbin

“…The formulation and usage of BCPV-based siRNA carriers cause significant inhibition of targeted abnormal proto‐oncogenes expression in adherent growth cells (pancreatic cancer cell line) and non-adherent growth cells (leukemia cell line), resulting in obvious inhibition of cancer cell bioactivity. …”
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Profiling of 3D genome organization in nasopharyngeal cancer needle biopsy patient samples by a modified Hi-C approach by Animesh, Sambhavi, Choudhary, Ruchi, Wong, Bertrand Jern Han, Koh, Charlotte Tze Jia, Ng, Xin Yi, Tay, Joshua Kai Xun, Chong, Wan-Qin, Jian, Han, Chen, Leilei, Goh, Boon Cher, Fullwood, Melissa Jane

“…We observed that the genomic features are shared at some important oncogenes, but the patients also display extensive heterogeneity at certain genomic loci. …”
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High throughput mutational profiling of signaling molecules in oral cancer by Zanaruddin, S.N.S., Cheong, S.C., Rahman, Z.A.A., Abd Ghani, W.M.N.W., Mustafa, W.M.W., Zain, R.B., Kong, Y.H., Hor, S.Y., Teo, S.H.

“…It is well established that a plethora of mutations that occur in oncogenes and tumor-suppressor genes are the main drivers of tumorigenesis. …”
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Investigating the role of ras-regulated non-coding RNAs involved in cell growth and transformation. by Chan, Li Fang.

“…Oncogenic Ras promotes growth and proliferation in cancer cells but could lead to growth arrest in normal primary cells by inducing the expression of tumour suppressor genes such as p16INK4A and p53. …”
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Human papillomavirus type 18 E2 protein and its effects on differentiation and cell cycle in keratinocytes. by Goh, Belinda Jun Yi.

“…Critical for malignant transformation is the manifestation of the viral E6 and E7 oncogenes, which is associated with viral genome integration and the loss of E2 open reading frame (ORF). …”
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The role of FGFR1 signaling in cancer by Jiang, Qiuzhen

“…The aberrant FGFR signaling is often correlated with misregulation of oncogenes and tumorigenesis. Previous study in the laboratory has demonstrated FGFRs as potential therapeutic target of breast cancer and bone sarcoma. …”
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