Oncogenes in immune cells as potential therapeutic targets by Zakiryanova GK, Wheeler S, Shurin MR

Subjects: “…oncogenes…”
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Activation of proto-oncogenes by disruption of chromosome neighborhoods by Hnisz, D., Day, D. S., Valton, A.-L., Bak, R. O., Goldmann, J., Lajoie, B. R., Sigova, A. A., Lee, T. I., Porteus, M. H., Dekker, J., Weintraub, Abraham Selby, Li, Charles Han, Reddy, Jessica, Borges-Rivera, Diego Ramon, Jaenisch, Rudolf, Fan, Zi Peng, Young, Richard A.

“…Oncogenes are activated through well-known chromosomal alterations such as gene fusion, translocation, and focal amplification. …”
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An oncogene regulating chromatin favors response to immunotherapy<subtitle>Oncogene CHAF1A and immunotherapy outcomes</subtitle> by Leqian Ying, Zhangmin Hu, Yi Lu, Qing Tao, Fen Xiong, Yongqian Shu, Yufei Yang, Xuehan Qiao, Chen Peng, Yuchun Jiang, Miao Han, Min Xu, Xiaoqin Li, Deqiang Wang

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Oncogenic activation of EEF1A2 expression: a journey from a putative to an established oncogene by Saket Awadhesbhai Patel, Md. Khurshidul Hassan, Manjusha Dixit

“…Abnormal “switch on” of the EEF1A2 gene in normal tissues is witnessed and is seen as a cause of oncogenic transformation in a wide variety of solid tumors. …”
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Retroviruses hijack chromatin loops to drive oncogene expression and highlight the chromatin architecture around proto-oncogenic loci. by Jillian M Pattison, Jason B Wright, Michael D Cole

“…Through use of mapped retroviral integrations and translocation breakpoints, our studies highlight the importance of chromatin looping in oncogene expression, elucidate the epigenetic mechanisms crucial for distal cis-regulation, and in one particular instance, explain how a translocation event drives tumorigenesis through upregulation of a proto-oncogene.…”
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Elevated enhancer-oncogene contacts and higher oncogene expression levels by recurrent CTCF inactivating mutations in acute T cell leukemia by Willem K. Smits, Carlo Vermeulen, Rico Hagelaar, Shunsuke Kimura, Eric M. Vroegindeweij, Jessica G.C.A.M. Buijs-Gladdines, Ellen van de Geer, Marjon J.A.M. Verstegen, Erik Splinter, Simon V. van Reijmersdal, Arjan Buijs, Niels Galjart, Winfried van Eyndhoven, Max van Min, Roland Kuiper, Patrick Kemmeren, Charles G. Mullighan, Wouter de Laat, Jules P.P. Meijerink

“…Reduced CTCF levels or deletion of the intervening CTCF site abrogates enhancer insulation by weakening competitive looping while favoring TLX3 promoter to BCL11B enhancer looping, which elevates oncogene expression levels and leukemia burden.…”
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Os Oncogenes e a Etiologia do Câncer by Hector Seaunez Abreu

Subjects: “…Oncogenes…”
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Human Gammaherpesvirus 8 Oncogenes Associated with Kaposi’s Sarcoma by Amanda de Oliveira Lopes, Pedro do Nascimento Marinho, Letícia d’Ambrosio de Souza Medeiros, Vanessa Salete de Paula

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<i>Myc</i>-family oncogenes as therapeutic targets by T. O. Kabilova, Ye. L. Chernolovskaya

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Rethinking the role of oncogenes in papillary thyroid cancer initiation by Mario eVitale

Subjects: “…Oncogenes…”
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Clinically relevant fusion oncogenes: detection and practical implications by Maksim Sorokin, Elizaveta Rabushko, Julian Markovich Rozenberg, Tharaa Mohammad, Aleksander Seryakov, Marina Sekacheva, Anton Buzdin

“…They may have various molecular peculiarities like increased stability of an oncogenic part, self-activation of tyrosine kinase receptor moiety, and altered transcriptional regulation activities. …”
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Paradoxical Behavior of Oncogenes Undermines the Somatic Mutation Theory by Noemi Monti, Roberto Verna, Aurora Piombarolo, Alessandro Querqui, Mariano Bizzarri, Valeria Fedeli

“…Intriguing results have demonstrated that several critical genes may act differently, as oncogenes or tumor suppressors, while phenotypic reversion of cancerous cells/tissues can be achieved by modifying the microenvironment, the mutations they are carrying notwithstanding. …”
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Small genomic insertions form enhancers that misregulate oncogenes by Hnisz, Denes, Li, Zhaodong, Weichert-Leahey, Nina, Rahman, Sunniyat, Liu, Yu, Etchin, Julia, Li, Benshang, Shen, Shuhong, Zhang, Jinghui, Look, A. Thomas, Mansour, Marc R., Abraham, Brian Joseph, Weintraub, Abraham Selby, Kwiatkowski, Nick, Li, Charles Han, Lee, Tong Ihn, Young, Richard A.

“…Among the 102 tumour cell genomes we analyse, small insertions are frequently observed in enhancer DNA sequences near known oncogenes. Further study of one insertion, somatically acquired in primary leukaemia tumour genomes, reveals that it nucleates formation of an active enhancer that drives expression of the LMO2 oncogene. …”
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Selective Inhibition of Tumor Oncogenes by Disruption of Super-Enhancers by Loven, Jakob, Hoke, Heather Ashley, Lin, Charles Y., Lau, Ashley, Orlando, David A., Vakoc, Christopher R., Bradner, James E., Lee, Tong Ihn, Young, Richard A.

“…Here, we investigate how inhibition of the widely expressed transcriptional coactivator BRD4 leads to selective inhibition of the MYC oncogene in multiple myeloma (MM). BRD4 and Mediator were found to co-occupy thousands of enhancers associated with active genes. …”
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SIRT3: Oncogene and Tumor Suppressor in Cancer by Margalida Torrens-Mas, Jordi Oliver, Pilar Roca, Jorge Sastre-Serra

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IQGAP1 is an oncogenic target in canine melanoma. by Becky H Lee, Poornima H Neela, Michael S Kent, Ashley M Zehnder

“…IQGAP1 is a signaling scaffold that regulates oncogenic ERK1/2 MAPK signaling in human Ras- and Raf- driven cancers, including melanomas. …”
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Editorial: Immunotherapy for NSCLC with oncogenic driver variants by Yijia Du, Qian Chu, Yanyan Lou, Yong He, Hongbo Hu, Qipeng Hu, Meijuan Huang

Subjects: “…oncogenic driver variants…”
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Targeting Non-Oncogene Addiction for Cancer Therapy by Hae Ryung Chang, Eunyoung Jung, Soobin Cho, Young-Jun Jeon, Yonghwan Kim

Subjects: “…non-oncogene addiction…”
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Targeting Oncogenic BRAF: Past, Present, and Future by Aubhishek Zaman, Wei Wu, Trever G. Bivona

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Oncogenic Deregulation of Cell Adhesion Molecules in Leukemia by Roland Windisch, Nina Pirschtat, Christian Kellner, Linping Chen-Wichmann, Jörn Lausen, Andreas Humpe, Daniela S. Krause, Christian Wichmann

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