Evidence in Support of Potential Applications of Lipid Peroxidation Products in Cancer Treatment by Erejuwa, Omotayo O., Sulaiman, Siti A., Wahab, Mohd S. Ab

“…Cancer cells generate reactive oxygen species (ROS) resulting frommitochondrial dysfunction, stimulation of oncogenes, abnormal metabolism, and aggravated inflammatory activities. …”
Get full text

An insight into anti-angiogenic and anti-metastatic effects of oridonin: current knowledge and future potentials by Abdullah, Nurul Akmaryanti, Md Hashim, Nur Fariesha, Ammar, Aula, Muhamad Zakuan, Noraina

“…Oridonin’s anti-cancer effects are mediated through the modulation of several signaling pathways which include upregulation of oncogenes and pro-angiogenic growth factors. Furthermore, oridonin also inhibits cell migration, invasion and metastasis via suppressing epithelial-to-mesenchymal transition and blocking downstream signaling targets in the cancer metastasis process. …”

65 years of the double helix : the advancements of gene editing and potential application to hereditary cancer by Tan, Zi Ying, Huang, Taosheng, Ngeow, Joanne

“…Such germline mutations in tumour suppressor genes, oncogenes and genes encoding for proteins essential in DNA repair pathways and cell cycle control can cause overall chromosomal instability in the genome and increase risk in developing cancers. …”
Get full text

Mode of action of Jatropha curcas phorbol esters in bovine kidney cells by Oskoueian, Ehsan, Abdullah, Norhani, Noura, Reza, Ebrahimi, Mahdi, Ahmad, Syahida, Shakeri, Majid

“…Moreover, the PEs up-regulated the expressions of PKC-βII, proto-oncogenes, pro-inflammatory cytokines and elevated the caspase-3 activity in the cells. …”
Get full text

Characterizing the interplay between super enhancers and chromatin interactions in cancer by Choudhary, Ruchi

“…We propose that SEs use chromatin loops to drive gene transcription, and altering chromatin interactions can downregulate SEs and disrupt enhancer-promoter interactions controlling oncogenes and tumor progression. We associated SEs with chromatin interactions in acute myeloid leukemia (AML) and nasopharyngeal cancer (NPC) samples. …”
Get full text

MicroRNA-based therapy and breast cancer: a comprehensive review of novel therapeutic strategies from diagnosis to treatment by Rahmat, Asmah, Ling, King Hwa, Ismail, Patimah, Kaboli, Parham Jabbarzadeh

“…Different strategies and challenges, including nucleic acid-based (miRNA mimics, antagomiRs, and miRNA sponges) and drug-based (drug resistance, drugs/miRNA interaction, nanodelivery, and sensing systems) approaches to suppress specific oncogenes and/or activate target tumor suppressors are discussed. …”
Get full text

MYC overexpression in cancer increases chromatin interactions at superenhancers and c-Myc binding sites by See, Yi Xiang

“…The MYC oncogene encodes for the c-Myc protein and is frequently dysregulated across multiple cancer cell types, making it an attractive target for cancer therapy. …”
Get full text

Lung cancer: risk factors, management, and prognosis by Murtaza Mustafa, AR. Jamalul Azizi, EL. IIIzam, A. Nazirah, AM, Sharifa, SA. Abbas

“…Pathogenesis is similar to other cancers, by activation of oncogenes or inactivation of tumor suppressor genes. …”
Get full text
Get full text

Investigations in the molecular events of transitional cell carcinoma of the bladder by Kadhim, Haider Sabah, Abdulamir, Ahmed Sahib, Hafidh, Rand Riadh, Abu Bakar, Fatimah, Abbas, Kassim Ali

“…Conclusions: There was a significant oncogenic role of p53 and bcl-2 on TCC in terms of muscle invasion and tumor grade. …”
Get full text

A subset of flavaglines inhibits KRAS nanoclustering and activation by Yurugi, Hajime, Zhuang, Yinyin, Siddiqui, Farid A., Liang, Hong, Rosigkeit, Sebastian, Zeng, Yongpeng, Abou-Hamdan, Hussein, Bockamp, Ernesto, Zhou, Yong, Abankwa, Daniel, Zhao, Wenting, Désaubry, Laurent, Rajalingam, Krishnaraj

“…The RAS oncogenes are frequently mutated in human cancers and among the three isoforms (KRAS, HRAS and NRAS), KRAS is the most frequently mutated oncogene. …”
Get full text

Resistance of DNA G-quadruplex against oxidative stress by Wee, Xue Xin

“…Furthermore, the formation of GQs at promoter regions of oncogenes is capable of regulating the transcription of malignant proteins in the diseased cell lines. …”
Get full text

Structure of a new nucleic-acid-binding motif in eukaryotic transcriptional elongation factor TFIIS by Weiss, Michael A., Qian, Xiuqu, Jeon, Choon Ju, Yoon, Ho Sup, Agarwal, Kan

“…Analogous eukaryotic mechanisms are not well understood5, but may control expression of proto-oncogenes6,7 and viruses, including the human immunodeficiency virus HIV-1 (ref. 8). …”
Get full text
Get full text

p53-independent regulation of p21Waf1/Cip1 expression and senescence by PRMT6 by Phalke, Sameer, Mzoughi, Slim, Bezzi, Marco, Jennifer, Nancy, Mok, Wei Chuen, Thike, Aye Aye, Tan, Puay Hoon, Voorhoeve, P. Mathijs, Guccione, Ernesto, Low, Diana H. P., Kuznetsov, Vladimir A.

“…Consistent with this role, p21 is a downstream target of several tumour suppressors and oncogenes, and it is downregulated in the majority of tumours, including breast cancer. …”
Get full text
Get full text

Array comparative genomic hybridization analysis identified the chromosomal aberrations and putative genes involved in prostate tumorigenesis of Malaysian men by Nenny Noorina Saaid, Reena Rahayu Md. Zin, Siti Aishah Md Ali, Sharifah Noor Akmal Syed Hussain, Zulkifli Zainuddin, Zubaidah Zakaria

“…The identification of chromosomal aberrations in prostate cancer has been widely studied with several known oncogenes and tumor suppressor genes have successfully been discovered. …”
Get full text

Long Noncoding RNA UCA1 in Gastrointestinal Cancers:Molecular Regulatory Roles and Patterns, Mechanisms,and Interactions by Suaidah Ramli, Maw Shin Sim, Rhanye M. Guad, Subash C. B Gopinath, Vetriselvan Subramaniyan, Shivkanya Fuloria, Neeraj K. Fuloria, Ker Woon Choy, Sohel Rana, Yuan Seng Wu

“…LncRNAs, particularly urothelial carcinoma-associated 1 (UCA1), are oncogenes involved in regulating cancer progression, such as cell proliferation, invasion, migration, and chemoresistance, particularly in GI cancer. ,is review was aimed to present an updated focus on the molecular regulatory roles and patterns of lncRNA UCA1 in progression and chemoresistance of different GI cancers, as well as deciphering the underlying mechanisms and its interactions with key molecules involved, together with a brief presentation on its diagnostic and prognostic values. ,e regulatory roles of lncRNA UCA1 are implicated in esophageal cancer, gastric cancer, pancreatic cancer, hepatobiliary cancer, and colorectal cancer, where they shared similar molecular mechanisms in regulating cancer phenotypes and chemoresistance. …”
Get full text
Get full text

MicroRNAs as therapeutic strategy for hepatitis B virus-associated hepatocellular carcinoma : current status and future prospects by Tan, Yi Lin Jane, Chen, Wei Ning

“…Apart from miRNAs acting as either oncogenes or tumour-suppressors, we also look at how miRNAs may function as biomarkers that may possibly serve as better candidates than those currently employed in the diagnosis of HBV infection or HBV-related HCC. …”
Get full text
Get full text

Targeting cancer addiction for SALL4 by shifting its transcriptome with a pharmacologic peptide by Liu, Bee Hui, Jobichen, Chacko, Chia, Brian C. S., Chan, Tim Hon Man, Tang, Jing Ping, Chung, Theodora X. Y., Li, Jia, Poulsen, Anders, Hung, Alvin W., Koh-Stenta, Xiaoying, Tan, Yaw Sing, Verma, Chandra Shekhar, Tan, Hong Kee, Wu, Chan-Shuo, Li, Feng, Hill, Jeffrey, Joy, Joma, Chai, Li, Sivaraman, J., Tenen, Daniel G.

“…This study supports the SALL4-NuRD complex as a drug target and FFW as a viable drug candidate, showcasing an effective strategy to accurately target oncogenes previously considered undruggable.…”
Get full text

Super-enhancers, phase-separated condensates, and 3D genome organization in cancer by Tang, Seng Chuan, Vijayakumar, Udhaya, Zhang, Ying, Fullwood, Melissa Jane

“…Cancer cells can hijack super-enhancers to drive oncogenic transcription to promote cell survival and proliferation. …”
Get full text

MicroRNA profiling in MDA-MB-231 human breast cancer cell exposed to the Phaleria macrocarpa (Boerl.) fruit ethyl acetate fraction (PMEAF) through IIlumina Hi-Seq technologies and... by Kavitha, Nowroji, Vijayarathna, Soundararajan, Shanmugapriya, -, Oon, Chern Ein, Chen, Yeng, Kanwar, Jagat Rakesh, Punj, Vasu, Sasidharan, Sreenivasan

“…Meanwhile, results from DAVID Bioinformatics Resources 6.8 specified the functional annotation of the upregulated miRNAs involvement in cancer pathway by suppressing the oncogenes and downregulating miRNAs by expressing the tumour suppressor genes in the regulation of apoptosis pathway. …”

Transducer-like enhancer of split 1 (TLE-1) expression as a diagnostic immunohistochemical marker for synovial sarcoma and its association with morphological features by Bakrin, Ikmal Hisyam, Hussain, Faezahtul Arbaeyah, Tuan Sharif, Sh. Emilia

“…Synovial sarcoma (SS) is a malignant soft tissue tumour of uncertain histogenesis which is defined by the translocation t(X;18) that produces the fusion oncogenes SYT-SSX. The emergence of transducer-like enhancer of split 1 (TLE1) as a new immunohistochemical (IHC) marker for SS has offered an alternative to pathologists in differentiating SS from other histological mimics, especially in the setting of limited molecular facilities. …”
Get full text