Transducer-like enhancer of split 1 (TLE1) expression as a diagnostic immunohistochemical marker for synovial sarcoma and its association with morphological features by Bakrin, Ikmal Hisyam, Hussain, Faezahtul Arbaeyah, Tuan Sharif, Sharifah Emilia

“…Synovial sarcoma (SS) is a malignant soft tissue tumour of uncertain histogenesis which is defined by the translocation t(X;18) that produces the fusion oncogenes SYT-SSX. The emergence of transducer-like enhancer of split 1 (TLE1) as a new immunohistochemical (IHC) marker for SS has offered an alternative to pathologists in differentiating SS from other histological mimics, especially in the setting of limited molecular facilities. …”
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Zerumbone and small interference RNA induced apoptosis in MCF-7 cell and mammary gland tumor via β-catenin protein inhibition by Fadl, Safa Abd Elfatah Amin

“…Among these is the Wnt/β-catenin pathway, of which β-catenin is one of the main oncogenes of the Wnt signaling pathway implicated in the adhesion of cancer and non-cancer cells. …”
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Effect of Leptin of N-Methyl-N’-Nitro-N- nitrosoguanidine induced histological and genetic changes in stomach of male sprague-dawley rats / Faizatul Isyraqiah Ahmad Muhammad by Ahmad Muhammad, Faizatul Isyraqiah

“…Compared to control, 25% of LEPT-treated stomachs showed hyperplasia and dysplasia, and upregulated genes include Furin (protein maturation), Eef1a1 and Eif4g2 (translation factors), Tmed2 (vesicular trafficking), Rab7a (plasma membrane trafficking), Rfwd2 (protein degradation), Fth1 and Ftl1 (oxygen transport), Tspan8, Tspan1, Fxyd3, and Rack1 (cell migration), Pde4d (signal transduction), Nupr1 and Ybx1 (transcription factors), Ptma and Tmem134 (oncogenes), Srsf2 (mRNA maturation), and Reep5 (cell proliferation). …”
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Long noncoding RNA UCA1 in gastrointestinal cancers: Molecular regulatory roles and patterns, mechanisms, and interactions by Suaidah Ramli, Maw Shin Sim, Rhanye Mac Guad, Subash C. B Gopinath, Vetriselvan Subramaniyan, Shivkanya Fuloria, Neeraj K. Fuloria, Ker Woon Choy, Sohel Rana, Yuan, Seng Wu

“…LncRNAs, particularly urothelial carcinoma-associated 1 (UCA1), are oncogenes involved in regulating cancer progression, such as cell proliferation, invasion, migration, and chemoresistance, particularly in GI cancer. ,is review was aimed to present an updated focus on the molecular regulatory roles and patterns of lncRNA UCA1 in progression and chemoresistance of different GI cancers, as well as deciphering the underlying mechanisms and its interactions with key molecules involved, together with a brief presentation on its diagnostic and prognostic values. ,e regulatory roles of lncRNA UCA1 are implicated in esophageal cancer, gastric cancer, pancreatic cancer, hepatobiliary cancer, and colorectal cancer, where they shared similar molecular mechanisms in regulating cancer phenotypes and chemoresistance. …”
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Identification of Differentially Expressed Genes in Human Bladder Cancer using Oligonucleotide Microarray by Nik Hassan, Nik Norliza

“…These genes are associated with cell adhesion molecules, protein synthesis, oncogenes, apoptosis markers, growth factors, immunology, cell cycle regulators, transcription factors and angiogenesis. …”
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Identification of Microrna-21 as a Pro-Invasive Taget in Urothelial Cell Carninoma by Tan, Keai Sinn

“…There are emerging evidences suggesting that miRNA plays a critical role in cancer initiation and progression, acting either as tumor suppressors or oncogenes. This study is aimed at identifying mRNA expression patterns associated with the invasiveness of Urothelial Cell Carcinoma (UCC) cell lines and functional targeting of specific miRNAs that potentially regulate these target genes. …”
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Molecular Detection of High Risk Human Papilloma Virus Subtypes in Neoplastic Cervical Tissues by Kamaluddin, Nor Rizan

“…The detection of E7 oncogene transcripts of high-risk human papillomavirus type 16, 18, 31, 33, 35, 39, 45, 51, 52 and 56 may be a sensitive indicator of the direct involvement of viral oncogenes in the development of cervical intraepithelial neoplasia and carcinoma. …”
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Effects of gamma-secretase inhibitor GSI-34 on bladder cancer cell viability, migration and notch-associated gene expression levels by Roslan, Nadzatul Nabila

“…On a molecular level, activating mutations of oncogenes such as Fibroblast Growth Factor Receptor, FGFR3 and the loss-of-function of tumour-suppressor genes such as p53 and pRb have been associated with bladder cancer progression. …”
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Isolation and Characterization of MYB-Related Genes from Oil Palm (Elaeis Guineensis Jacq.) by Teoh, Wan Chin

“…Plant Myb proteins represent a group of transcription factors which have a DNA-binding domain similar to that found in the products of the animal myb proto-oncogenes. Some of the functions, which have so far been assigned to plant myb genes, include regulation of phenylpropanoid biosynthesis, control of cellular differentiation, and contribution to control of plant responses to hormones and various stresses. …”
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Anti-metastatic and anti-angiogenic effects of curcumin analog DK1 on human osteosarcoma cells in vitro by Muhammad Nazirul Mubin Aziz, Nurul Fattin Che Rahim, Yazmin Hussin, Yeap, Swee Keong, Mas Jaffri Masarudin, Nurul Elyani Mohamad, Muhammad Nadeem Akhtar, Mohd Azuraidi Osman, Cheah, Yoke Kqueen, Noorjahan Banu Alitheen

“…Whilst for MG-63, the significantly down-regulated oncogenes were Serpin E1, AKT2, VEGF, uPA, PD-ECGF, and Endoglin. …”
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Are there “Magic Bullets” for cancer theraphy by Seow, Heng Fong

“…However, progress made in understanding the behavior of tumour cells has led to advances in the creation of ‘magic bullets’ for treating cancer as exemplified by imatinib, an inhibitor that targets an oncogenic kinase, namely, bcr-abl. This article will focus on the seminal discoveries made in oncogenes, growth factor receptors and tyrosine phosphorylation and contributions from my research on signal transduction, adoptive immunotherapy and drug discovery. …”
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Anti-metastatic and anti-angiogenic effects of curcumin analog DK1 on human osteosarcoma cells in vitro by Aziz, Muhammad Nazirul Mubin, Che Rahim, Nurul Fattin, Hussin, Yazmin, Yeap, Swee Keong, Masarudin, Mas Jaffri, Mohamad, Nurul Elyani, Akhtar, Muhammad Nadeem, Osman, Mohd Azuraidi, Cheah, Yoke Kqueen, Alitheen, Noorjahan Banu

“…Whilst for MG-63, the significantly down-regulated oncogenes were Serpin E1, AKT2, VEGF, uPA, PD-ECGF, and Endoglin. …”

Potential chemoprevention of primary liver cancer using optimized formulation of Strobilanthus crispus (L.) blume and Centella asiatica L. juices by Hussin, Faridah

“…Finally the last part of the study was to observe the changes in the c-myc, c-fos and cerbB2 oncogenes expression induced by the Centella asiatica and Strobilanthes crispus juices. …”
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My small world in biomedical research by Othman, Fauziah

“…There were destruction of the cytoskeletal protein, structural and ultrastructural changes, as well as molecular changes of the oncogenes which enlightened the important biological discoveries of apoptosis in the cancer cells, however, not in the normal cells.The oncolytic effect of Newcastle Disease Virus AF2240 on Allografted 4T1 Breast Cancer Cells In Balb/c mice was well demonstrated and NDV-AF2240 was detected via In situ reverse transcriptase polymerase chain reaction (in situ RT-PCR), polyclonal chicken antibody and goat anti-chicken antibody conjugated with fluorescein isothiocynate (FITC) using confocal laser scanning microscopy (CLSM) and negative staining transmission electron microscopy (NSTEM). …”
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Development of a single-chain fragment variable fused-mutant HALT-1 recombinant immunotoxin against G12V mutated KRAS colorectal cancer cells by Teo, Michelle Yee Mun, Ng, Jeremy Jeack Ceen, Jung, Yin Fong, Jung, Shan Hwang, Song, Adelene Ai Lian, Lim, Renee Lay Hong, In, Lionel Lian Aun

“…Background: KRAS oncogenes harboring codon G12 and G13 substitutions are considered gatekeeper mutations which drive oncogenesis in many cancers. …”
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Biochemical and molecular evaluation of jatropha meal as biofeed by Oskoueian, Ehsan

“…The expression of the PKC-β II gene from signal transduction pathway, c-Fos, c-Jun and c-Myc from proto-oncogenes, and IL-1β and Cox2 genes from inflammatory pathway, on 12 h treatment with isolated phorbol esters and PMA at the CC50 concentrations, showed significant (p≤0.01) overexpression in all of the genes, with values ranging from 1.3 to 5.1 fold increase as compared to the untreated cells. …”
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Interleukin-6 Is Required for Pancreatic Cancer Progression by Promoting MAPK Signaling Activation and Oxidative Stress Resistance by Zhang, Yaqing, Yan, Wei, Collins, Meredith A., Bednar, Filip, Rakshit, Sabita, Zetter, Bruce R., Stanger, Ben Z., Chung, Ivy, Rhim, Andrew D., di Magliano, Marina Pasca

“…Pancreatic cancer, one of the deadliest human malignancies, is almost invariably associated with the presence of an oncogenic form of Kras. Mice expressing oncogenic Kras in the pancreas recapitulate the stepwise progression of the human disease. …”

Genotypic and functional comparisons of Epstein-barr virus latent membrane protein-1 from different stages of nasopharyngeal carcinoma by Tan, Eng Lai, Sam, Choon Kook

“…One of the most important EBV latent genes expressed in NPC is the viral oncogene, latent membrane protein-1 (LMP1).…”
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Effects of single nucleotide polymorphisms on the binding of afatinib to EGFR : a potential patient stratification factor revealed by modeling studies by Kannan, Srinivasaraghavan, Tan, Daniel Shao-Weng, Verma, Chandra Shekhar

“…The anticancer drug afatinib has been found to be more effective at inhibiting the oncogenic EGFR mutant exon 19 deletion (19del) over the oncogenic EGFR mutant L858R. …”
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Optimizing protocols for monitoring in vivo replication of a novel chimeric Marek’s Disease vaccine with an insertion of the Long Terminal Repeat of Reticuloendotheliosis Virus in... by Faiz, Nik M., Cortes, Aneg L., Phang, Yuen-fun, Gimeno, Isabel M.

“…The load of oncogenic MDV DNA was evaluated at 21 days in the FP in 20 chickens per group. …”