Yin/Yang associated differential responses to Psoralea corylifolia Linn. In rat models: an integrated metabolomics and transcriptomics study by Ming-Liang Zhang, Xu Zhao, Wei-Xia Li, Xiao-Yan Wang, Ming Niu, Hui Zhang, Yu-Long Chen, De-Xin Kong, Yuan Gao, Yu-Ming Guo, Zhao-Fang Bai, Yan-Ling Zhao, Jin-Fa Tang, Xiao-He Xiao

“…Furthermore, 4 DEGs (aldehyde dehydrogenase 1 family member B1 (Aldh1b1), solute carrier family 25 member 25 (Slc25a25), Pim-3 proto-oncogene, serine/threonine kinase (Pim3), out at first homolog (Oaf)) and 4 metabolites (phosphatidate, phosphatidylcholine, N-Acetylleucine, biliverdin) in the Yangsyn group and 1 DEG [galectin 5 (Lgals5)] and 1 metabolite (5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate) in Yinsyn group were significantly correlated to the ALT and AST levels of BGZ treated and untreated groups (receiver operating characteristic (ROC) ≥ 0.9). …”
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Brazilian Multiethnic Association Study of Genetic Variant Interactions among <i>FOS, CASP8</i>, <i>MMP2</i> and <i>CRISPLD2</i> in the Risk of Nonsyndromic Cleft Lip with or witho... by Renato Assis Machado, Lilianny Querino Rocha de Oliveira, Ana Lúcia Carrinho Ayroza Rangel, Silvia Regina de Almeida Reis, Rafaela Scariot, Daniella Reis Barbosa Martelli, Hercílio Martelli-Júnior, Ricardo D. Coletta

“…Associations of <i>CRISPLD2</i> (cysteine-rich secretory protein LCCL domain containing 2) and genes belonging to its activation pathway, including <i>FOS</i> (Fos proto-oncogene), <i>CASP8</i> (caspase 8) and <i>MMP2 (matrix metalloproteinase 2),</i> with nonsyndromic orofacial cleft risk, have been reported, but the results are yet unclear. …”
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CRISPR/Cas9-edited ROS1 + non-small cell lung cancer cell lines highlight differential drug sensitivity in 2D vs 3D cultures while reflecting established resistance profiles by Marc Terrones, Christophe Deben, Felicia Rodrigues-Fortes, Anne Schepers, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer

“…Abstract Introduction The study of resistance-causing mutations in oncogene-driven tumors is fundamental to guide clinical decisions. …”
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LINFOMA DE ZONA MARGINAL (MALT) EM GLÂNDULA LACRIMAL - UM RELATO DE CASO by PC Gontijo, MMM Zarife, MGT Carvalho, LCM Peixoto, L Alves, MC Piancastelli, MAS Ullmann

“…Para localizar publicações foram incluídas palavras chaves nas estratégias de buscas, sendo essas “(Lymphoma, B-Cell) AND (Lacrimal Apparatus); (Lymphoma, B-Cell) AND ((Proto-Oncogene Proteins c-bcl-2) OR (Ki-67 Antigen) OR (Antigens, CD20) OR (AE Proteins)); (Lymphoma, B-Cell) AND (R-CHOP)”. …”
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LEUCEMIA MIELOIDE CRÔNICA - A QUEBRA DE PARADIGMAS NA HISTÓRIA DA MEDICINA by LF Alves, CCB Silva, PLS Araujo, SP Silva, TC Rezende, MBS Nascimento, LKA Rocha

“…Introdução/Objetivos: Em 1960 Peter Nowell e David Hungerford identificaram o cromossomo Filadélfia, que mais tarde foi descoberto ser o responsável pela produção do gene BCR-ABL. Esse oncogene ativa várias vias de sinalização durante a maturação das células mieloides na medula óssea, o que resulta em maior adesão celular ao estroma e à matriz extracelular, inibição da apoptose e aumento da capacidade de proliferação e de sobrevivência celular. …”
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Preliminary verification of the anti-hypoxia mechanism of Gentiana straminea maxim based on UPLC-triple TOF MS/MS and network pharmacology by Xiu mei Kong, Dan Song, Jie Li, Yi Jiang, Xiao ying Zhang, Xiao Jun Wu, Ming juan Ge, Jiao jiao Xu, Xiao min Gao, Qin Zhao

“…The critical targets were TNF, Jun proto-oncogene (JUN), tumor protein p53 (TP53), and threonine kinase 1 (AKT1). …”
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Towards Developing Novel Prostate Cancer Recurrence Suppressors: Acute Toxicity of Pseurotin A, an Orally Active PCSK9 Axis-Targeting Small-Molecule in Swiss Albino Mice by Oliver C. McGehee, Hassan Y. Ebrahim, Ashkan H. Rad, Khaldoun S. Abdelwahed, Ethar A. Mudhish, Judy A. King, Iman E. Helal, Sharon A. Meyer, Khalid A. El Sayed

“…Preliminary studies revealed that pseurotin A (PsA), a spiro-heterocyclic γ-lactam alkaloid from several marine and terrestrial <i>Aspergillus</i> and <i>Penicillium</i> species, has the ability to dually suppress the PCSK9 expression and protein–protein interaction (PPI) with LDLR, resulting in an anti-hypercholesterolemic effect and modulating the oncogenic role of PCSK9 axis in breast and prostate cancers progression and recurrence. …”
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Metabolic Reprogramming in Response to Alterations of Mitochondrial DNA and Mitochondrial Dysfunction in Gastric Adenocarcinoma by Tzu-Ching Chang, Hui-Ting Lee, Siao-Cian Pan, Shih-Han Cho, Chieh Cheng, Liang-Hung Ou, Chia-I Lin, Chen-Sung Lin, Yau-Huei Wei

“…After effective knockdown of TFAM, TFAM-KD-B/C cells expressed higher levels of hexokinase II (HK-II) and v-akt murine thymoma viral oncogene homolog 1 gene (<i>AKT</i>)-encoded AKT, but lower levels of phosphorylated pyruvate dehydrogenase (p-PDH) than did the NT/PT AGS cells. …”
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Prevención y detección precoz del cáncer de páncreas by Hanns Lembach Jahnsen

“…These groups include carriers of certain oncogenic germline mutations, patients with strong family history for PDAC, and patients diagnosed with mucinous cystic neoplasms of the pancreas. …”
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Cervical screening with primary HPV testing or cytology in a population of women in which those aged 33 years or younger had previously been offered HPV vaccination: Results of the... by Karen Canfell, Michael Caruana, Val Gebski, Jessica Darlington-Brown, Stella Heley, Julia Brotherton, Dorota Gertig, Chloe J Jennett, Annabelle Farnsworth, Jeffrey Tan, C David Wrede, Philip E Castle, Marion Saville

“…In the first phase, consenting women aged 25-64 years presenting for routine screening at 47 primary practices in Victoria, Australia, provided a cervical sample and were randomised at a central laboratory at a 1:2:2 allocation to (i) image-read LBC screening with HPV triage of low-grade cytology ('LBC screening'), (ii) HPV screening with those HPV16/18 positive referred to colposcopy and with LBC triage for other oncogenic (OHR) types ('HPV+LBC triage'), or (iii) HPV screening with those HPV16/18 positive referred to colposcopy and with dual-stained cytology triage for OHR types ('HPV+DS triage'). …”
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Modulation of FLT3-ITD Localization and Targeting of Distinct Downstream Signaling Pathways as Potential Strategies to Overcome FLT3-Inhibitor Resistance by Maximilian Fleischmann, Mike Fischer, Ulf Schnetzke, Colin Fortner, Joanna Kirkpatrick, Florian H. Heidel, Andreas Hochhaus, Sebastian Scholl

“…Different pharmacological approaches can affect FLT3-ITD-driven oncogenic pathways by the modulation of FLT3-ITD localization. …”
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[Withdrawn] Regulation of insulin resistance by myostatin by Sabeera Bonala

“…Additionally, elevated Mstn levels were found to activate the IRS1 specific E3 ligase, Cblb (Casitas B-lineage lymphoma proto-oncogene b) which degraded IRS1 protein to induce insulin resistance. …”
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Determination of phosphatidylinositol-3-kinase gene copy number and protein expression in nasopharyngeal carcinoma by real-time PCR and immunohistochemistry by Firoozinia, Mohammad

“…The pathway, with PTEN gene (tumor suppressor) and PIK3CA oncogene, is implicated in the insensitivity of cancer tumors to IGF1 and insulin AKT is recruited to the cell membrane using the PH domain ahead PI3K activation, and phosphatidyl-3,4,5-triphosphate (PIP3) is created. …”
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Low WT1 transcript levels at diagnosis predicted poor outcomes of acute myeloid leukemia patients with t(8;21) who received chemotherapy or allogeneic hematopoietic stem cell trans... by Ya-Zhen Qin, Yu Wang, Hong-Hu Zhu, Robert Peter Gale, Mei-Jie Zhang, Qian Jiang, Hao Jiang, Lan-Ping Xu, Huan Chen, Xiao-Hui Zhang, Yan-Rong Liu, Yue-Yun Lai, Bin Jiang, Kai-Yan Liu, Xiao-Jun Huang

“…This study aimed to evaluate the impact of Wilm tumor gene-1 (WT1) transcript levels and cellular homolog of the viral oncogene v-KIT receptor tyrosine kinase (C-KIT) mutations at diagnosis, and RUNX1-RUNX1T1 transcript levels after the second consolidation chemotherapy cycle on outcomes. …”
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Impact of weight loss on cancer-related proteins in serum: results from a cluster randomised controlled trial of individuals with type 2 diabetesResearch in context by Caroline J. Bull, Emma Hazelwood, Danny N. Legge, Laura J. Corbin, Tom G. Richardson, Matthew Lee, James Yarmolinsky, Karl Smith-Byrne, David A. Hughes, Mattias Johansson, Ulrike Peters, Sonja I. Berndt, Hermann Brenner, Andrea Burnett-Hartman, Iona Cheng, Sun-Seog Kweon, Loic Le Marchand, Li Li, Polly A. Newcomb, Rachel Pearlman, Alex McConnachie, Paul Welsh, Roy Taylor, Mike E.J. Lean, Naveed Sattar, Neil Murphy, Marc J. Gunter, Nicholas J. Timpson, Emma E. Vincent

“…Findings: Nine proteins were modified by the intervention: glycoprotein Nmb; furin; Wnt inhibitory factor 1; toll-like receptor 3; pancreatic prohormone; erb-b2 receptor tyrosine kinase 2; hepatocyte growth factor; endothelial cell specific molecule 1 and Ret proto-oncogene (Holm corrected P-value <0.05). Mendelian randomization analyses indicated a causal relationship between predicted circulating furin and glycoprotein Nmb on breast cancer risk (odds ratio (OR) = 0.81, 95% confidence interval (CI) = 0.67–0.99, P-value = 0.03; and OR = 0.88, 95% CI = 0.78–0.99, P-value = 0.04 respectively), though these results were not supported in sensitivity analyses examining violations of MR assumptions. …”
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Vagus nerve stimulation‐induced stromal cell‐derived factor‐l alpha participates in angiogenesis and repair of infarcted hearts by Yan Wang, Yun Liu, Xing‐yuan Li, Lu‐yuan Yao, MagdaleenaNaemi Mbadhi, Shao‐Juan Chen, Yan‐xia Lv, Xin Bao, Long Chen, Shi‐You Chen, Jing‐xuan Zhang, Yan Wu, Jing Lv, Liu‐liu Shi, Jun‐ming Tang

“…Western blotting was used to detect the levels of SDF‐1α, V‐akt murine thymoma viral oncogene homolog (AKT), phosphorylated AKT (pAKT), specificity protein 1 (Sp1) and phosphorylation of Sp1 in HCAECs. …”
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Transcriptomic analyses of ovarian clear-cell carcinoma with concurrent endometriosis by Kaitlyn E. Collins, Kaitlyn E. Collins, Xiyin Wang, Xiyin Wang, Yuliya Klymenko, Yuliya Klymenko, Noah B. Davis, Maria C. Martinez, Chi Zhang, Chi Zhang, Kaman So, Kaman So, Aaron Buechlein, Douglas B. Rusch, Chad J. Creighton, Shannon M. Hawkins, Shannon M. Hawkins, Shannon M. Hawkins

“…MiR-10a overexpression in vitro was correlated with decreased expression of predicted miR-10a target genes critical for proliferation, cell-cycle regulation, and cell survival including [SERPINE1 (3-fold downregulated; P&lt; 0.05), CDK6 (2.4-fold downregulated; P&lt; 0.05), and RAP2A (2-3-fold downregulated; P&lt; 0.05)].DiscussionThese studies in OCCC suggest that miR-10a-5p is an impactful, potentially oncogenic molecule, which warrants further studies.…”
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Efficacy and safety of iruplinalkib (WX-0593) in ALK-positive crizotinib-resistant advanced non-small cell lung cancer patients: a single-arm, multicenter phase II study (INTELLECT... by Yuankai Shi, Jianhua Chen, Helong Zhang, Zhihong Zhang, Yiping Zhang, Zhehai Wang, Shucai Zhang, Jian Zhao, Chunling Liu, Xiuwen Wang, Yanqiu Zhao, Changlu Hu, Lei Yang, Xuezhi Hao, Lin Wang, Yunpeng Liu, Yan Yu, Jun Zhao, Mengzhao Wang, Liangming Zhang, Sanyuan Sun, Yanping Hu, Kangsheng Gu, Xiaosheng Hang, Jinlu Shan, Yu Zhang, Bangxian Tan, Weihua Yang, Runxiang Yang, Meimei Si, Huaize Geng, Hui Li, Xiaoyan Kang

“…Abstract Background Iruplinalkib (WX-0593) is an anaplastic lymphoma kinase (ALK)/c-ros oncogene 1 (ROS1) tyrosine kinase inhibitor. Here we reported the single-arm, phase II study (INTELLECT) results of the efficacy and safety of iruplinalkib for ALK-positive crizotinib-resistant advanced non-small cell lung cancer (NSCLC) patients. …”
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ESTRATÉGIAS PARA IMPLANTAÇÃO DA TÉCNICA DE SEQUENCIAMENTO GENÉTICO NA REGIÃO NORDESTE DO BRASIL: DESAFIOS E RESULTADOS PRELIMINARES by FBD Filho, LPR Rebouças, DMP Lima, CAD Oliveira, JVA Duarte, IA Duarte, RLM Guedes, MC Cervato, TEJD Santos, FB Duarte

“…Nessa mesma linha de pensamento, a concomitância da mutação do gene TP53 no acometimento das citopenias, principalmente LMA e SMD, tem-se demonstrado a aberração mais frequente na coorte analisada com uma fração alélica relevante para um critério de um mau prognóstico. Ademais, o proto-oncogene ROS1, o qual é responsável por dirigir inibidores de tirosina quinase (TKIs) que são terapêticamente ativos contra cânceres, vem apresentando um número elevado de mutações nas doenças hematológicas o que sugere o sua participação nos marcadores de mau prognóstico no curso de tais patologias. …”
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Prevalencia de infección por virus de papiloma humano (VPH) de alto riesgo y factores asociados en embarazadas derechohabientes del IMSS en el estado de Morelos The prevalence of h... by Carlos Hernández-Girón, Jennifer S Smith, Attila Lorincz, Emilio Arreola Cháidez, Eduardo Lazcano, Mauricio Hernández-Ávila, Jorge Salmerón

“…This study seeks to determine the prevalence of oncogenic HPV infecton in a sample of pregnant Mexican women and its possible risk factors. …”
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