Heterogenous expression of ERG oncoprotein in Malaysian men with adenocarcinoma of the prostate by Tan, Jia Shin Jessica, Ong, Kien Chai, Ong, Diana Bee Lan, Razack, Azad, Lim, Jasmine, Yunus, Rosna, Sundram, Murali, Rhodes, Anthony

“…Tumour expression of the ERG oncogene occurs in the majority of patients with prostate cancer in Western studies. …”

PPARs and tumor microenvironment : the emerging roles of the metabolic master regulators in tumor stromal–epithelial crosstalk and carcinogenesis by Cheng, Hong Sheng, Yip, Yun Sheng, Lim, Eldeen Kai Yi, Wahli, Walter, Tan, Nguan Soon

“…To conclude, PPARs in the tumor microenvironment exhibit oncogenic activities which are highly controversial and dependent on many factors such as stromal cell types, cancer types, and oncogenesis stages. …”
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Unravelling the role of obesity and lipids during tumor progression by Zhao, Junzhe, Lee, Keene, Toh, Han Chong, Lam, Kong Peng, Neo, Shi Yong

“…The dysregulation of the biochemical pathways in cancer promotes oncogenic transformations and metastatic potential. …”
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Hypoxia-induced tumor exosomes promote M2-like macrophage polarization of infiltrating myeloid cells and microRNA-mediated metabolic shift by Park, Jung Eun, Dutta, Bamaprasad, Tse, Shun Wilford, Gupta, Nikhil, Tan, Chee Fan, Low, Jee Keem, Yeoh, Kheng Wei, Kon, Oi Lian, Tam, James P., Sze, Siu Kwan

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LMTK3 confers chemo-resistance in breast cancer by Stebbing, Justin, Shah, Kalpit, Lit, Lei Cheng, Gagliano, Teresa, Ditsiou, Angeliki, Wang, Tingting, Wendler, Franz, Simon, Thomas, Szabó, Krisztina Sára, O’Hanlon, Timothy, Dean, Michael, Roslani, April Camilla, Cheah, Swee Hung, Lee, Soo Chin, Giamas, Georgios

“…Lemur tyrosine kinase 3 (LMTK3) is an oncogenic kinase that is involved in different types of cancer (breast, lung, gastric, colorectal) and biological processes including proliferation, invasion, migration, chromatin remodeling as well as innate and acquired endocrine resistance. …”

Konsep-Konsep Baru Dalam Penelitian Onkologi Dasar by Perpustakaan UGM, i-lib

“…Key Words: oncology-cancer epidemiology-breast cancer oncogen-immunohistoclinical signs -prognostic index…”

Potential miRNAs for miRNA-based therapeutics in breast cancer by Wong, Jun Sheng, Cheah, Yoke Kqueen

“…The aberrant expressions of oncogenic or tumor suppressor miRNAs have been associated with cancer progression and malignancies. …”
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Altered gut microbiota of obesity subjects promotes colorectal carcinogenesis in mice by Kang, Xing, Ng, Siu-Kin, Liu, Changan, Lin, Yufeng, Zhou, Yunfei, Kwong, Thomas N. Y., Ni, Yunbi, Lam, Thomas Y. T., Wu, William K. K., Wei, Hong, Sung, Joseph Jao Yiu, Yu, Jun, Wong, Sunny Hei

“…AOM-treated mice receiving feces from obese individuals showed impaired intestinal barrier function and significant upregulation of pro-inflammatory cytokines and activation of oncogenic Wnt signaling pathway. Consistently, transferring feces from obese individuals to germ-free mice led to increased colonic cell proliferation, intestinal barrier function impairment, and induction of oncogenic and proinflammatory gene expression. …”
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Comparative transcriptomics unravels prodigiosin's potential cancer-specific activity between human small airway epithelial cells and lung adenocarcinoma cells by Davient, Bala, Ng, Jessica Pei Zhen, Xiao, Qiang, Li, Liang, Yang, Liang

“…In HSAEC, co-upregulation of oncogenic and tumor-suppressive genes was observed. …”
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RUNX3 interactome reveals novel centrosomal targeting of RUNX family of transcription factors by Chuang, Linda Shyue Huey, Lai, Soak Kuan, Murata-Hori, Maki, Yamada, Ayumi, Li, Hoi-Yeung, Gunaratne, Jayantha, Ito, Yoshiaki

“…This is supported by well-documented evidence of functional interaction of RUNX with components of major oncogenic or tumor suppressive signaling pathways such as TGFβ and Wnt. …”
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Differential metabolic profiles mediated SLC1A2 confer resistance in glioblastoma therapies : stratification goals and implementation by Koh, Lynnette Wei Hsien

“…Better elucidation of key oncogenic nodes as well as metabolic regulators driving the proliferation and drug resistance of glioma-propagating cells (GPCs) will be imperative for development of more efficacious therapeutic strategies. …”
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The role of fibroblasts in cancer progression, therapy resistance and field cancerization by Chan, Jeremy Soon Kiat

“…Indeed, epithelial cells at various stages of oncogenic transformation exhibited a differential response to H2O2 in terms of proliferation and invasiveness. …”
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Treatment of colorectal cancer cells with nanocarrier encap-sulated camptothecin reveals histone modifier genes in the Wnt signaling pathway as important molecular cues for cancer... by Aisha Farhana, Koh, Avin Ee Hwan, Kothandan, Sangeetha, Alsrhani, Abdullah, Mok, Pooi Ling, Subbiah, Suresh Kumar

“…Therapeutic mechanisms have been developed to combat this by taking advantage of the underlying oncogenic mechanisms through chemical modulation. Camptothecin (CPT) is an example of this type of drug. …”
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Elevation of adenylate energy charge by angiopoietin-like 4 enhances epithelial–mesenchymal transition by inducing 14-3-3γ expression by Teo, Ziqiang, Sng, Ming Keat, Chan, Jeremy Soon Kiat, Lim, Maegan Miang Kee, Li, Yinliang, Li, Luchun, Phua, Terri, Lee, J. Y. H., Tan, Zhen Wei, Zhu, Pengcheng, Tan, Nguan Soon

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Expression of notch signaling genes in putative bladder cancer stem cells by Thirumorthy, Arcana

“…For example, NOTCH2 receptor mutation has an oncogenic role in bladder cancer. Nevertheless, the role of Notch signalling in putative bladder cancer stem cells (CSCs) remains poorly understood. …”
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FAM3C in circulating tumor-derived extracellular vesicles promotes non-small cell lung cancer growth in secondary sites by Thuya, Win Lwin, Kong, Li Ren, Syn, Nicholas L., Ding, Ling-Wen, Cheow, Esther Sok Hwee, Wong, Regina Tong Xin, Wang, Tingting, Goh, Robby Miguel Wen-Jing, Song, Hongyan, Jayasinghe, Migara K., Le, Minh Tn, Hu, Jian Cheng, Yong, Wei-Peng, Lee, Soo-Chin, Wong, Andrea Li-Ann, Sethi, Gautam, Hung, Huynh The, Ho, Paul Chi-Lui, Thiery, Jean-Paul, Sze, Siu Kwan, Guo, Tiannan, Soo, Ross A., Yang, Henry, Lim, Yaw Chyn, Wang, Lingzhi, Goh, Boon-Cher

“…The oncogenicity transduced by FAM3C is executed via a novel interaction with the Ras-related protein RalA, triggering the downstream activation of the Src/Stat3 signaling cascade. …”
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Cancer-associated fibroblasts enact field cancerization by promoting extratumoral oxidative stress by Li, Liang, Chan, Jeremy Soon Kiat, Tan, Ming Jie, Sng, Ming Keat, Teo, Ziqiang, Phua, Terri, Choo, Chee Chong, Zhu, Pengcheng, Tan, Nguan Soon

“…This suggests the presence of a regional carcinogenic signal that spreads oncogenic transformation and field cancerization. We observed an abundance of mutagenic reactive oxygen species in the stroma of cryosectioned patient tumor biopsies, indicative of extratumoral oxidative stress. …”
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Comparative docking studies of rosmarinic acid and sinesitin to inhibit HSP70 by V., Mansoureh Nazari, Mahmood, Syed, Subashini, Raman

“…the HSP70 family of proteins can be thought of as a potent buffering system for cellular stress either from extrinsic (physiological, viral and environmental) or intrinsic (replicative or oncogenic) stimuli. Not surprisingly, cancer cells rely heavily on this buffering system for survival. …”
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Chromatin interactions and regulatory elements in cancer : from bench to bedside by See, Yi Xiang, Wang, Benny Zhengjie, Fullwood, Melissa Jane

“…It has been recognized that in cancer, chromatin interactions can be dysregulated, leading to aberrant oncogene expression. Chromatin interactions may potentially serve as biomarkers, or be modulated via CRISPR therapy and small molecule inhibitors against transcription. …”
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Dual functional dinuclear platinum complex with selective reactivity towards c-myc G-quadruplex by He, Lei, Meng, Zhenyu, Xu, Dechen, Shao, Fangwei

“…G-quadruplexes (GQ) folded by the oncogenic G-rich sequences are the promising targets for developing anticancer therapeutic molecules. …”
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