Tumor suppressive effects of GAS5 in cancer cells by Kaur, Jesminder, Salehen, Nur’ain, Norazit, Anwar, Abdul Rahman, Amirah, Abdul Murad, Nor Azian, Nik Abd. Rahman, Nik Mohd Afizan, Ibrahim, Kamariah

“…This review article focuses on GAS5’s tumor-suppressive effects in regulating oncogenic signaling pathways, cell cycle, apoptosis, tumor-associated genes, and treatment-resistant cells. …”

ROS release by PPARβ/δ-null fibroblasts reduces tumor load through epithelial antioxidant response by Tan, Eddie Han Pin, Sng, Ming Keat, How, Ivan Shun Bo, Chan, Jeremy Soon Kiat, Chen, Jiapeng, Tan, Chek Kun, Wahli, Walter, Tan, Nguan Soon

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Expression of p63 Cytoplasmic Aberrance, Notch1, and ALDH1A1 in Prostate Lesions by , Paranita Ferronika, , dr. Harijadi, Sp.PA(K)

“…The alteration of p63 expression is considered to have an oncogenic role in prostate cancer. This oncogenic role was also proposed associated with Notch1 expression. …”

The role of growth factor receptor bound protein 2 (GRB2) in gain of function of mutant p53. by Lau, Sok Ting.

“…Studies have attributed the ability of mutant p53 to acquire oncogenic properties such as cell proliferation, metastasis as a “gain-of-function”. …”
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Rational optimization of conformational effects induced by hydrocarbon staples in peptides and their binding interfaces by Lama, Dilraj, Lakshminarayanan, Rajamani, Lane, David P., Brown, Christopher J., Quah, Soo T., Verma, Chandra S., Beuerman, Roger W.

“…eIF4E is frequently over-expressed in different cancers and causes increased translation of oncogenic proteins via deregulated cap-dependent translation. …”
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Reclassifying tumour cell cycle activity in terms of its tissue of origin by Lundberg, Arian, Jong, Joan Jing Yi, Lindström, Linda S., Tobin, Nicholas P.

“…Whilst pan-cancer studies have broadly assessed tumour genomics and their impact on oncogenic pathways, analyses taking the baseline signalling levels in normal tissue into account are lacking. …”
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Structural diversity of G-rich DNA : from telomeric G-quadruplexes to G-junction motifs by Lim, Kah Wai

“…In particular, putative quadruplex motifs were identified in important genomic loci including telomeres and oncogenic promoters, rendering them promising therapeutic targets. …”
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Assembly and activation of the Hippo signalome by FAT1 tumor suppressor by Martin, Daniel, Degese, Maria S., Vitale-Cross, Lynn, Iglesias-Bartolome, Ramiro, Valera, Juan Luis Callejas, Wang, Zhiyong, Feng, Xiaodong, Yeerna, Huwate, Vadmal, Vachan, Moroishi, Toshiro, Thorne, Rick F., Zaida, Moraima, Siegele, Bradford, Cheong, Sok Ching, Molinolo, Alfredo A., Samuels, Yardena, Tamayo, Pablo, Guan, Kun Liang, Lippman, Scott M., Lyons, J. Guy, Gutkind, J. Silvio

“…We also show that unrestrained YAP1 acts as an oncogenic driver in HNSCC, and that targeting YAP1 may represent an attractive precision therapeutic option for cancers harboring genomic alterations in the FAT1 tumor suppressor genes.…”

Damnacanthal: a promising compound as a medicinal anthraquinone by Abu, Nadiah, Mohd Ali, Norlaily, Ho, Wan Yong, Yeap, Swee Keong, Abdul Aziz, Muhammad Yusran, Mohamed Alitheen, Noorjahan Banu

“…Damnacanthal was shown to inhibit the oncogene Ras, p56lck tyrosine kinase, NF-KB pathway and induce apoptosis in vitro. …”
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In silico and saturation transfer difference NMR approaches to unravel the binding mode of an andrographolide derivative to K-Ras oncoprotein by Shun, Ying Quah, Tan, Michelle Siying, Kok, Lian Ho, Abd Manan, Nizar, Gorfe, Alemayehu A., Deb, Pran Kishore, Sagineedu, Sreenivasa Rao, Stanslas, Johnson

“…Background: Andrographolide and its benzylidene derivatives, SRJ09 and SRJ23, potentially bind oncogenic K-Ras to exert anticancer activity. Their molecular interactions with K-Ras oncoproteins that lead to effective biological activity are of major interest. …”
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Cyclin D1 integrates G9a-mediated histone methylation by Li, Zhiping, Jiao, Xuanmao, Di Sante, Gabriele, Ertel, Adam, Casimiro, Mathew C., Wang, Min, Katiyar, Sanjay, Ju, Xiaoming, Klopfenstein, D. V., Tozeren, Aydin, Dampier, William, Chepelev, Iouri, Jeltsch, Albert, Pestell, Richard George

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DNA I-motif : application to epigenetics and biosensing. by Xu, Baochang

“…The fact that i-motif folding sequences are widely present in oncogenic regions and human telomeric DNA suggests that the formation of i-motif may be associated with the regulation of oncogene expression. …”
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Roles of mitochondria in cancer targeting therapeutics. by Sim, Kae Hwan.

“…In particular, recent findings show that reversible protein phosphorylation, which is a crucial but largely overlooked means of mitochondrial post translational modification, regulates the mitochondrial functions in the oncogenic signaling network. Comprehensive understanding of mitochondrial phosphoproteomics will thus help in breakthrough of cancer therapy. …”
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Nucleic acid structure and conjugation for drug design by Tan, Derrick Jing Yang

“…This thesis investigates the structural features of QDHs found in PIM1 oncogene. In addition, strategies for targeting of G4 with vacant sites were also developed. …”
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Mapping the structural and dynamical features of multiple p53 DNA binding domains : insights into loop 1 intrinsic dynamics by Lukman, Suryani., Lane, David P., Verma, Chandra S.

“…We propose (1) a novel mechanism underlying the dynamics of loop 1 and the possible tread-milling of p53 on DNA and (2) possible mutations on loop 1 residues to restore the transcriptional activity of an oncogenic mutation at a distant site.…”
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Structural insights reveal a recognition feature for tailoring hydrocarbon stapled-peptides against the eukaryotic translation initiation factor 4E protein by Lama, Dilraj, Liberatore, Anne-Marie, Frosi, Yuri, Nakhle, Jessica, Tsomaia, Natia, Bashir, Tarig, Lane, David P., Brown, Christopher J., Verma, Chandra Shekhar, Auvin, Serge

“…We have used a structure-guided approach to rationally develop a set of hydrocarbon stapled-peptides with high binding affinities and residence times against the oncogenic eukaryotic translation initiation factor 4E (eIF4E) protein. …”
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Simulations of mutant p53 DNA binding domains reveal a novel druggable pocket by Siau, Jia Wei, Kannan, Srinivasaraghavan, Ouaray, Zohra, Kwoh, Chee Keong, Ghadessy, Farid, Pradhan, Mohan Rajan, Nguyen, Minh N., Lane, David P., Verma, Chandra Shekhar

“…The DNA binding domain (DBD) of the tumor suppressor p53 is the site of several oncogenic mutations. A subset of these mutations lowers the unfolding temperature of the DBD. …”
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Topography of transcriptionally active chromatin in glioblastoma by Xu, Liang, Chen, Ye, Huang, Yulun, Sandanaraj, Edwin, Yu, John S., Lin, Ruby Yu-Tong, Dakle, Pushkar, Ke, Xin-Yu, Chong, Yuk Kien, Koh, Lynnette, Mayakonda, Anand, Nacro, Kassoum, Hill, Jeffrey, Huang, Mo-Li, Gery, Sigal, Lim, See Wee, Huang, Zhengyun, Xu, Ying, Chen, Jianxiang, Bai, Longchuan, Wang, Shaomeng, Wakimoto, Hiroaki, Yeo, Tseng Tsai, Ang, Beng Ti, Müschen, Markus, Tang, Carol, Tan, Tuan Zea, Koeffler, H. Phillip

“…Moreover, this study reveals core oncogenic dependency on super-enhancer–driven transcriptional factors, long noncoding RNAs, and druggable targets in GBM. …”
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Engineering the first chimeric antibody in targeting intracellular PRL-3 oncoprotein for cancer therapy in mice by Guo, Ke, Tang, Jing Ping, Jie, Li, Hong, Cheng William, Tan, Cheng Peow Bobby, Park, Jung Eun, Varghese, Leyon, Feng, Zhiwei, Zhou, Jianbiao, Chng, Wee Joo, Zeng, Qi, Al-Aidaroos, Abdul Qader O.

“…It is believed that antibodies are too large to routinely enter the cytosol, thus antibody therapeutic approach has been limited to extracellular or secreted proteins expressed by cancer cells. However, many oncogenic proteins are localized within the cell. To explore the possibility of antibody therapies against intracellular targets, we generated a chimeric antibody targeting the intracellular PRL-3 oncoprotein to assess its antitumor activities in mice. …”
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Down-regulation of LPA receptor 5 contributes to aberrant LPA signalling in EBV-associated nasopharyngeal carcinoma by Yap, L.F., Velapasamy, S., Lee, H.M., Thavaraj, S., Rajadurai, P., Wei, W.B., Vrzalikova, K., Ibrahim, M.H., Khoo, A.S.B., Tsao, S.W., Paterson, I.C., Taylor, G.S., Dawson, C.W., Murrray, P.G.

“…Our data point to a central role for EBV in mediating the oncogenic effects of LPA in NPC and identify LPA signalling as a potential therapeutic target in this disease. …”
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