The regulatory role of microRNAs in breast cancer by Loh, Hui Yi, Norman, Brendan P., Lai, Kok Song, Nik Abd Rahman, Nik Mohd Afizan, Mohammed Alitheen, Noorjahan Banu, Osman, Mohd Azuraidi

“…Different cellular pathways of breast cancer development such as cell proliferation, apoptotic response, metastasis, cancer recurrence and chemoresistance are regulated by either the oncogenic miRNA (oncomiR) or tumor suppressor miRNA (tsmiR). …”
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Properties of vanillin and its effects on colorectal cancer in vitro and in vivo by Ho, Ket Li

“…RNA was extracted from colon for DNA repair, apoptosis, cell cycle, antiinflammation, proto-oncogene, colorectal cancer biomarker and tumor suppressor gene expressions study. …”
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Association of DNA methylation status, gene and protein expression of her family in colorectal adenocarcinoma by Othman @ Jaffar, Rosfayati

“…Overexpression of HER family members (EGFR, HER2, HER3 and HER4) has been associated with oncogenic transformation via DNA methylation of the promoter regions. …”
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A structural and functional study on Cot (MAPKKK8) by Wu, Binhui

“…Cot (cancer Osaka thyroid, also known as Tpl-2), a proto-oncogenic kinase, is a member of the MAPKKK family and plays a key role in the regulation of the immune response to pro-inflammatory stimuli such as LPS (lipopolysaccharide) and TNF- (tumor necrosis factor-). …”
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c-Abl, an accomplice in mutant p53 gain-of-function? by Liu, Di

“…Therefore, it is important to investigate the molecular mechanisms mediating these pro-oncogenic functions. Towards this goal, the Abelson tyrosine kinase (c-Abl) was identified as a potential accomplice in mediating mutp53 GOF. …”
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Is c-myc super-enhancer invasion associated with aberrant chromatin interactions in cancer? by Fu, Shufeng

“…c-Myc is an oncogenic transcription factor being over-expressed in approximately 70% of human cancers. …”
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Role of DDX3X in T-lymphocyte migration and haematolymphoid malignancies by Loh, Xinpeng

“…Studies on DDX3X have yielded conflicting conclusions, with findings of both oncogenic and tumour suppressive effects in various tumour models. …”
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Delaying emergence of resistance to KRAS inhibitors with adaptive therapy: “treatment-to-contain” instead of “treatment-to-cure” by Hamdi, Amir Imran Faisal, Stanslas, Johnson

“…KRAS mutations are among the most common oncogenic abnormalities in cancer. Until recently, drug discovery pursuing KRAS did not produce therapeutic benefits for patients. …”

SRRM2 organizes splicing condensates to regulate alternative splicing by Xu, Shaohai, Lai, Soak-Kuan, Sim, Donald Yuhui, Ang, Warren Shou Leong, Li, Hoi Yeung, Roca, Xavier

“…SRRM2 induces a FES splice isoform that attenuates innate inflammatory responses, and MUC1 isoforms that undergo shedding with oncogenic properties. We conclude that SRRM2 acts as a scaffold to organize nuclear speckles, regulating alternative splicing in innate immunity and cell homeostasis.…”
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NF-κB/p52 augments ETS1 binding genome-wide to promote glioma progression by Sim, Nicholas, Li, Yinghui

“…NF-κB factors typically dimerise with its own family members, but emerging evidence of their promiscuous interactions with other oncogenic factors has been reported to promote transcription of new target genes and function. …”
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Myeloid-intrinsic cell cycle-related kinase drives immunosuppression to promote tumorigenesis by Zhou, Jingying, Wang, Huanyu, Shu, Ting, Wang, Jing, Yang, Weiqin, Li, Jingqing, Ding, Lipeng, Liu, Man, Sun, Hanyong, Wong, John, Lai, Paul Bo-San, Tsang, Shun-Wa, Ward, Simon E., Chow, King-Lau, Sung, Joseph Jao Yiu, Cheng, Alfred Sze-Lok

“…Beyond tumor-intrinsic oncogenicity, here we demonstrated that CCRK is upregulated in myeloid cells in tumor-bearing mice and in patients with HCC. …”
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Reactive oxygen species : a volatile driver of field cancerization and metastasis by Liao, Zehuan, Chua, Damien, Tan, Nguan Soon

“…Extracellular ROS help to propagate, amplify, and effectively create a mutagenic and oncogenic field which facilitate the formation of multifoci tumors and act as a springboard for metastatic tumor cells. …”
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Stability and expression of K-ras mimotopes in freeze-dried recombinant Lactococcus lactis NZ3900-fermented milk powder during storage in vacuum packaging by How, Yu Hsuan, Teo, Michelle Yee Mun, In, Lionel Lian Aun, Yeo, Siok Koon, Bhandari, Bhesh, Yusof, Yus Aniza, Pui, Liew Phing

“…Aims: This study aims to evaluate the storage stability of the freeze-dried recombinant Lactococcus lactis NZ3900-fermented milk powder expressing K-ras (Kristen rat sarcoma viral oncogene homolog) mimotopes targeting colorectal cancer in vacuum packaging. …”
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Prospective therapeutic strategies for cervical cancer by Mhd Zain, Nor Aini Lubis, Razak, Mohd Nasharudin, Abdul Razak, Mariatulqabtiah

“…It is used to target the abnormal gene, to increase cells’ susceptibility towards drugs or conventional therapy, to induce tumour cells apoptosis, to enhance tumour cell immunogenicity recognition and to inhibit the oncogene expression. The objective of this minireview is to add to the general knowledge on aforementioned therapeutic strategies against cervical cancer.…”
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Knockdown of antizyme inhibitor decreases prostate tumor growth in vivo by Olsen, R.R., Chung, I., Zetter, B.R.

“…The endogenous protein antizyme inhibitor (AZI) is a potential oncogene which promotes cell growth by both inhibiting antizyme (AZ) activity and releasing ornithine decarboxylase (ODC) from AZ-mediated degradation. …”
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Role of inflammatory mediators, macrophages, and neutrophils in glioma maintenance and progression: mechanistic understanding and potential therapeutic applications by Basheer, Abdul Samad, Abas, Faridah, Othman, Iekhsan, Naidu, Rakesh

“…In addition, an inhibition of the key signaling pathways such as NF-κB, JAK/STAT, MAPK, PI3K/Akt/mTOR, and TLRs, which are activated during neuroinflammation and have an oncogenic role in glioblastoma (GBM), can exert more pronounced anti-glioma effects.…”

A transcriptional repressor co-regulatory network governing androgen response in prostate cancers by Chng, Kern Rei, Chang, Cheng Wei, Tan, Si Kee, Yang, Chong, Hong, Shu Zhen, Sng, Noel Yan Wei, Cheung, Edwin

“…Taken together, our results highlight a novel mechanism by which, ERG working together with oncogenic corepressors including HDACs and the polycomb protein, EZH2, could impede epithelial differentiation and contribute to prostate cancer progression, through directly modulating the transcriptional output of AR.…”
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Src is activated by the nuclear receptor peroxisome proliferator-activated receptor β/δ in ultraviolet radiation-induced skin cancer by Chan, Jeremy Soon Kiat, Montagner, Alexandra, Tallichet-Blanc, Corinne, Mottaz, Hélène, Degueurce, Gwendoline, Lippi, Yannick, Moret, Catherine, Baruchet, Michael, Antsiferova, Maria, Werner, Sabine, Hohl, Daniel, Al Saati, Talal, Michalik, Liliane, Wahli, Walter, Delgado, Maria B., Sng, Ming K., Farmer, Pierre J., Tan, Nguan S.

“…Here, we unveil a cascade of events involving peroxisome proliferator-activated receptor (PPAR) β/δ and the oncogene Src, which promotes the development of ultraviolet (UV)-induced skin cancer in mice. …”
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Transcriptional regulation during aberrant activation of NF-κB signalling in cancer by Deka, Kamalakshi, Li, Yinghui

“…Finally, we provide a perspective on the potential role of aberrant NF-κB activation in altering the chromatin landscape to support oncogenic development.…”
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PRL3-zumab as an immunotherapy to inhibit tumors expressing PRL3 oncoprotein by Thura, Min, Al-Aidaroos, Abdul Qader, Gupta, Abhishek, Chee, Cheng Ean, Lee, Soo Chin, Hui, Kam Man, Li, Jie, Guan, Yeoh Khay, Yong, Wei Peng, So, Jimmy, Chng, Wee Joo, Ng, Chin Hin, Zhou, Jianbiao, Wang, Ling Zhi, Yuen, John Shyi Peng, Ho, Henry Sun Sien, Yi, Sim Mei, Chiong, Edmund, Choo, Su Pin, Ngeow, Joanne, Ng, Matthew Chau Hsien, Chua, Clarinda, Yeo, Eugene Shen Ann, Tan, Iain Bee Huat, Sng, Joel Xuan En, Tan, Nicholas Yan Zhi, Thiery, Jean Paul, Goh, Boon Cher, Zeng, Qi

“…A humanized antibody, PRL3-zumab, specifically binds to an intracellular oncogenic phosphatase PRL3, which is frequently expressed in several cancers. …”
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