Characterizing opioid-involved overdose risk in local communities: An opioid overdose vulnerability assessment across Indiana, 2017 by Jared L. Sawyer, Shikhar Shrestha, Jennifer C. Pustz, Robert Gottlieb, Deborah Nichols, Michelle Van Handel, Cailyn Lingwall, Thomas J. Stopka

Subjects: “…Opioid vulnerability assessment…”
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Comparison of two combinations of opioid and non-opioid analgesics for acute periradicular abscess: a randomized clinical trial by Manuela Favarin Santini, Ricardo Abreu da Rosa, Maria Beatriz Cardoso Ferreira, Maria Isabel Fischer, Erick Miranda Souza, Marcus Vinícius Reis Só

“…Objective: The aim of this study was to compare the overall analgesic effectiveness of two combinations of opioid and non-opioid analgesics for acute periradicular abscess. …”
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The Use of Peripheral μ-Opioid Receptor Antagonists (PAMORA) in the Management of Opioid-Induced Constipation: An Update on Their Efficacy and Safety by Pergolizzi JV Jr, Christo PJ, LeQuang JA, Magnusson P

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Chronic ethanol consumption in rats produces opioid antinociceptive tolerance through inhibition of mu opioid receptor endocytosis. by Li He, Jennifer L Whistler

“…It is well known that the mu-opioid receptor (MOR) plays an important role in the rewarding properties of ethanol. …”
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First-time admissions for opioid treatment: cross-sectional and descriptive study of new opioid users seeking treatment by Flórez G, López-Durán A, Triñanes Y, Osorio J, Fraga J, Fernández JM, Becoña E, Arrojo M

“…Women are likely to seek help earlier, which reduces their duration of opioid use. The younger the patient, the shorter the duration of opioid use and the greater the likelihood of cessation of intravenous use. …”
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One shot to control Pain: Decreasing postoperative opioid use in gynecologic oncology patients with intrathecal opioid injection by Yevgeniya Ioffe, Ruofan Yao, Eileen Hou, Michelle Wheeler, Mohamed Nour, Wei Yun Wang, Linda Hong

Subjects: “…Intrathecal opioid…”
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Feasibility and postoperative opioid sparing effect of an opioid-free anaesthesia in adult cardiac surgery: a retrospective study by Clément Aguerreche, Gaspard Cadier, Antoine Beurton, Julien Imbault, Sébastien Leuillet, Alain Remy, Cédrick Zaouter, Alexandre Ouattara

Subjects: “…Opioid-free anaesthesia…”
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Metabolic clearance of select opioids and opioid antagonists using hepatic spheroids and recombinant cytochrome P450 enzymes by Wing Y. Tuet, Samuel A. Pierce, Matthieu Conroy, Justin N. Vignola, Justin Tressler, Robert C. diTargiani, Bryan J. McCranor, Benjamin Wong

“…Abstract The opioid crisis is a pressing public health issue, exacerbated by the emergence of more potent synthetic opioids, particularly fentanyl and its analogs. …”
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Anxiety enhances pain in a model of osteoarthritis and is associated with altered endogenous opioid function and reduced opioid analgesia by Amanda Lillywhite, Stephen G. Woodhams, Sara V. Gonçalves, David J.G. Watson, Li Li, James J. Burston, Peter R.W. Gowler, Meritxell Canals, David A. Walsh, Gareth J. Hathway, Victoria Chapman

“…Negative affect, including anxiety and depression, is prevalent in chronic pain states such as osteoarthritis (OA) and associated with greater use of opioid analgesics, potentially contributing to present and future opioid crises. …”
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Opioid Agonist Therapies and Pregnancy Outcomes for Pregnant People With Opioid Use Disorder: Protocol for a Systematic Review by Lindsay A Wilson, Preet Gandhi

“…In order to reduce the risk of these outcomes, the standard of care for OUD during pregnancy in many jurisdictions within the United States and Canada is opioid agonist therapy (OAT). OAT refers to prescription medications that alleviate or eliminate opioid withdrawal symptoms, so that opioid use can be managed more safely. …”
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Does Preoperative Opioid Consumption Increase the Risk of Chronic Postoperative Opioid Use After Total Joint Arthroplasty? by Samuel T. Kunkel, MD, MS, James J. Gregory, MD, Matthew J. Sabatino, MD, MS, Tracy M. Borsinger, MD, Yale A. Fillingham, MD, David S. Jevsevar, MD, MBA, Wayne E. Moschetti, MD, MS

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Long-Term Opioid Therapy in Spine Center Outpatients: Protocol for the Spinal Pain Opioid Cohort (SPOC) Study by Manniche, Claus, Stokholm, Lonny, Ravn, Sophie L, Andersen, Tonny E, Brandt, Lars PA, Rubin, Katrine H, Schiøttz-Christensen, Berit, Andersen, Lars L, Skousgaard, Søren G

“…ObjectiveThe main aims of this study are to describe baseline and follow-up characteristics of the Spinal Pain Opioid Cohort (SPOC), to evaluate the general use of opioids in spinal pain when an acute pain episode occurs, and to demonstrate the prevalence of long-term opioid therapy (LTOT). …”
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Opioids Aware: a general practice audit of high-dose opioid prescribing NHS England Midlands and East by Ruth Bastable, Sarah Rann

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Opioid withdrawal behavior in spiny mice: A novel preclinical model of neonatal opioid withdrawal syndrome (NOWS) by Sarah Stevens, Shekher Mohan

Subjects: “…Opioids…”
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Are There Any Advantages of the Low Opioid Anaesthesia and Non-Opioid Postoperative Analgesia Protocol: A Clinical Observational Study by Kościuczuk U, Tarnowska K, Rynkiewicz-Szczepanska E

“…Urszula Kościuczuk, Katarzyna Tarnowska, Ewa Rynkiewicz-Szczepanska Department of Anaesthesiology and Intensive Therapy, Medical University in Bialystok, Bialystok, PolandCorrespondence: Urszula Kościuczuk, Department of Anaesthesiology and Intensive Therapy, Medical University of Bialystok, Kilinskiego Street 1, Bialystok, Poland, Email urszula.kosciuczuk@umb.edu.plPurpose: The methods of perioperative analgesia and pain control have changed. The principle of opioid-based analgesia has been modified to multimodal analgesia, followed by LOA (low opioid anaesthesia) and OFA (opioid-free anaesthesia). …”
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Prescription quantity and duration predict progression from acute to chronic opioid use in opioid-naïve Medicaid patients. by Drake G Johnson, Vy Thuy Ho, Jennifer M Hah, Keith Humphreys, Ian Carroll, Catherine Curtin, Steven M Asch, Tina Hernandez-Boussard

“…Opiates used for acute pain are an established risk factor for chronic opioid use (COU). Patient characteristics contribute to progression from acute opioid use to COU, but most are not clinically modifiable. …”
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Exploring profile, effects and toxicity of novel synthetic opioids and classical opioids via Twitter: A qualitative study by Abdullah Al-Hamid, Carys Tudor, Sulaf Assi

Subjects: “…Novel synthetic opioids…”
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Characteristics of opioid-users whose death was related to opioid-toxicity: a population-based study in Ontario, Canada. by Parvaz Madadi, Doris Hildebrandt, Albert E Lauwers, Gideon Koren

“…The impact of the prescription opioid public health crisis has been illustrated by the dramatic increase in opioid-related deaths in North America. …”
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Intraoperative Opioid Waste and Association of Intraoperative Opioid Dose with Postoperative Adverse Outcomes: A Hospital Registry Study by Simone Redaelli, Aiman Suleiman, Dario von Wedel, Sarah Ashrafian, Ricardo Munoz-Acuna, Guanqing Chen, Mitra Khany, Catriona Stewart, Nikolai Ratajczak, John Hertig, Sarah Nabel, Maximilian S. Schaefer, Satya Krishna Ramachandran

Subjects: “…Opioids…”
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At-a-glance - Concurrent monitoring of opioid prescribing practices and opioid-related deaths: the context in Nova Scotia, Canada by Emily Schleihauf, Kirstin Crabtree, Carolyn Dohoo, Sarah Fleming, Heather McPeake, Matthew Bowes

Subjects: “…public health surveillance, opioid-related disorders, prescription drug monitoring programs, coroners and medical examiners…”
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