Correction: Rate of opioid use disorder in adults who received prescription opioid pain therapy-A secondary data analysis. by Johannes M Just, Norbert Scherbaum, Michael Specka, Marie-Therese Puth, Klaus Weckbecker

Get full text

The Missing Link Between Opioid Use Disorder and Seizures During Opioid Withdrawal: A Case Series from North India by Rohit Gondwal, Priyaranjan Avinash, Robin Victor, Dharuvika

Get full text

Prenatal opioid-exposed infant extracellular miRNA signature obtained at birth predicts severity of neonatal opioid withdrawal syndrome by Amanda H. Mahnke, Melissa H. Roberts, Lawrence Leeman, Xingya Ma, Ludmila N. Bakhireva, Rajesh C. Miranda

“…Abstract Prenatal opioid exposure (POE) is commonly associated with neonatal opioid withdrawal syndrome (NOWS), which is characterized by a broad variability in symptoms and severity. …”
Get full text

Patient Perceptions and Potential Utility of Pharmacogenetic Testing in Chronic Pain Management and Opioid Use Disorder in the Camden Opioid Research Initiative by Dara Kusic, Jessica Heil, Stefan Zajic, Andrew Brangan, Oluseun Dairo, Gretchen Smith, Diego Morales-Scheihing, Russell J. Buono, Thomas N. Ferraro, Rachel Haroz, Matthew Salzman, Kaitlan Baston, Elliot Bodofsky, Michael Sabia, Alissa Resch, Laura B. Scheinfeldt

Subjects: Get full text

Machine learning nonresponse adjustment of patient-reported opioid consumption data to enable consumption-informed postoperative opioid prescribing guidelines by Chris J. Kennedy, Jayson S. Marwaha, Brendin R. Beaulieu-Jones, P. Nina Scalise, Kortney A. Robinson, Brandon Booth, Aaron Fleishman, Larry A. Nathanson, Gabriel A. Brat

“…Background: Post-discharge opioid consumption is a crucial patient-reported outcome informing opioid prescribing guidelines, but its collection is resource-intensive and vulnerable to inaccuracy due to nonresponse bias. …”
Get full text

Mortality and causes of death among patients with opioid use disorder receiving opioid agonist treatment: a national register study by Anne Berit Bech, Thomas Clausen, Helge Waal, Jūratė Šaltytė Benth, Ivar Skeie

Subjects: “…Opioid agonist treatment…”
Get full text

Analysis of opioid-mediated analgesia in Phase III studies of methylnaltrexone for opioid-induced constipation in patients with chronic noncancer pain [Corrigendum] by Webster LR, Brenner DM, Barrett AC, Paterson C, Bortey E, Forbes WP

Get full text

Regional Anesthesia Decreases Early Perioperative Opioid Demand but Increases Late Opioid Demand in Ankle and Distal Tibia Fracture Surgery by Daniel J. Cunningham MD, Ariana Paniagua, Isabel DeLaura, Gloria X. Zhang, Billy I. Kim, Jonathan Kim, Terry Lee, Micaela LaRose, Samuel B. Adams MD, Mark Gage

“…However, the pragmatic effects of this treatment on inpatient and outpatient opioid demand are unclear. The hypothesis was that RA would decrease inpatient opioid consumption and have little effect on outpatient opioid demand in patients undergoing ankle and distal tibia fracture surgery. …”
Get full text

Evaluation of Morphine with Imiquimod as Opioid Growth Factor Receptor or Nalmefene as Opioid Blocking Drug on Leishmaniasis Caused by Leishmania major in Vitro by Javad JABARI, Fatemeh GHAFFARIFAR, John HORTON, Abdolhosein DALIMI, Zohreh SHARIFI

“…Background: In this research, the effect of morphine on promastigotes and amastigotes of Leishmania major has been investigated in the presence of nalmefene as a blocking opioid drug and imiquimod as an opioid growth factor receptor. …”
Get full text

High-affinity naloxone binding to filamin a prevents mu opioid receptor-Gs coupling underlying opioid tolerance and dependence. by Hoau-Yan Wang, Maya Frankfurt, Lindsay H Burns

“…Ultra-low-dose opioid antagonists enhance opioid analgesia and reduce analgesic tolerance and dependence by preventing a G protein coupling switch (Gi/o to Gs) by the mu opioid receptor (MOR), although the binding site of such ultra-low-dose opioid antagonists was previously unknown. …”
Get full text

Assessment of opioid administration patterns following lower extremity fracture among opioid-naïve inpatients: retrospective multicenter cohort study by Majed Ramadan, Yahya Alnashri, Amjad Ilyas, Omar Batouk, Khalid A. Alsheikh, Laila Alhelabi, Suliman Abdulah Alnashri

“…BACKGROUND: Prescribing habits during admission have largely contributed to the opioid epidemic. Orthopedic surgeons represent the third-highest opioid-prescribing specialty. …”
Get full text

DEVELOPMENT OF COMPLEX PHARMACOTHERAPY OF SEVERE AND MODERATE PAIN. PART I. MULTITARGETED COMBINATION OF OPIOIDS AND NON-OPIOID ANALGESICS WITH CENTRAL EFFECTS by A. V. Sosnov, F. M. Semchenko, M. I. Vlasov, V. N. Tohmahchi, A. A. Sosnova

“…Medicines based on opioid analgesics are the basic means of pharmacotherapy of severe pain at present. …”
Get full text

Improving the management of chronic pain, opioid use, and opioid use disorder in older adults: study protocol for I-COPE study by Ainur Kagarmanova, Heather Sparkman, Neda Laiteerapong, Katherine Thompson, Linda Rosul, Danielle Lazar, Erin Staab, Wen Wan, Amanda Kass, Mim Ari

Subjects: Get full text

The effects of opioid policy changes on transitions from prescription opioids to heroin, fentanyl and injection drug use: a qualitative analysis by Julia Dickson-Gomez, Sarah Krechel, Antoinette Spector, Margaret Weeks, Jessica Ohlrich, H. Danielle Green Montaque, Jianghong Li

Subjects: Get full text

Mental health and substance use disorder comorbidities among Medicaid beneficiaries: Associations with opioid use disorder and prescription opioid misuse by James A. Swartz, Dana Franceschini, Kamryn Scamperle

Subjects: “…opioid use disorder…”
Get full text

Phosphorylation-deficient G-protein-biased μ-opioid receptors improve analgesia and diminish tolerance but worsen opioid side effects by A. Kliewer, F. Schmiedel, S. Sianati, A. Bailey, J. T. Bateman, E. S. Levitt, J. T. Williams, M. J. Christie, S. Schulz

“…Tolerance and other side effects are important limitations to the use of opioids as analgesics. In this study, the authors generated mice lacking phosphorylation sites on the µ-opioid receptor to assess their contribution to the analgesic, tolerance and side effect profile of opioid analgesics.…”
Get full text

Impact of expanded strong opioid availability on opioid prescription patterns in patients with cancer: A population-wide cohort study in Taiwan by Tsung-Che Wu, Chih-Hung Hsu, Wei-Zen Sun, Ho-Min Chen, Chih-Peng Lin, Yu-Yun Shao

Subjects: Get full text

Sex work involvement among women with long-term opioid injection drug dependence who enter opioid agonist treatment by Marchand Kirsten, Oviedo-Joekes Eugenia, Guh Daphne, Marsh David C, Brissette Suzanne, Schechter Martin T

Subjects: Get full text

Examining the benefit of a higher maintenance dose of extended-release buprenorphine in opioid-injecting participants treated for opioid use disorder by Mark K. Greenwald, Katharina L. Wiest, Barbara R. Haight, Celine M. Laffont, Yue Zhao

“…Abstract Background BUP-XR (SUBLOCADE®) is the first buprenorphine extended-release subcutaneous injection approved in the USA for monthly treatment of moderate-to-severe opioid use disorder (OUD). Among patients with OUD, those who inject or use high doses of opioids likely require higher doses of buprenorphine to maximize treatment efficacy. …”
Get full text

Influence of opioid-related side effects on disability, mood, and opioid misuse risk among patients with chronic pain in primary care by Robert N. Jamison, Kathleen Dorado, Anna Mei, Robert R. Edwards, Marc O. Martel

“…The aim of this study was to investigate the impact of frequently reported side effects on mood, disability, and opioid misuse in patients with chronic pain prescribed opioids within primary care. …”
Get full text