Alternative Pre-mRNA Splicing of the Mu Opioid Receptor Gene, <i>OPRM1</i>: Insight into Complex Mu Opioid Actions by Shan Liu, Wen-Jia Kang, Anna Abrimian, Jin Xu, Luca Cartegni, Susruta Majumdar, Patrick Hesketh, Alex Bekker, Ying-Xian Pan

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<it>In vivo </it>antinociception of potent mu opioid agonist tetrapeptide analogues and comparison with a compact opioid agonist - neurokinin 1 receptor antagonist chimera by Guillemyn Karel, Kleczkowska Patrycja, Novoa Alexandre, Vandormael Bart, Van den Eynde Isabelle, Kosson Piotr, Asim Muhammad, Schiller Peter W, Spetea Mariana, Lipkowski Andrzej W, Tourwé Dirk, Ballet Steven

Subjects: “…Opioid tetrapeptides…”
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A multi-disciplinary program for opioid sparse arthroplasty results in reduced long-term opioid consumption: a four year prospective study by D-Yin Lin, Anthony J. Samson, Freeda D’Mello, Brigid Brown, Matthew G. Cehic, Christopher Wilson, Hidde M. Kroon, Ruurd L. Jaarsma

“…Postoperative prescriptions of opioids contribute, with reported opioid prescription rates following arthroplasty as high as 89%. …”
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4023 Catecholamines and Opioid Therapy Requirements for the Management of Acute Post-Procedural Pain: The clinical Trend to Identify Remarkable Elements in Opioid Drug Dependency by Armando Uribe Rivera, Ana Carolina Machado Perez, Hans Malmstrom, Yang-Fan Ren, Linda Rasubala, Adam J Carinci

“…Based on our preliminary results, we suggest that COMT and MAOA genetic variations could impact opioid drug use and the current opioid dependency and epidemics in the U.S. …”
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Association Between Interorganizational Collaboration in Opioid Response and Treatment Capacity for Opioid Use Disorder in Counties of Five States: A Cross-Sectional Study by William L Swann, Michael DiNardi, Terri L Schreiber

“…Background: Local governments on the front lines of the opioid epidemic often collaborate across organizations to achieve a more comprehensive opioid response. …”
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A randomized, prospective, masked clinical trial comparing an opioid-free vs. opioid-sparing anesthetic technique in adult cats undergoing ovariohysterectomy by Maxime Rufiange, Helene L. M. Ruel, Beatriz P. Monteiro, Ryota Watanabe, Inga-Catalina Cruz Benedetti, Javier Benito, Paulo V. M. Steagall, Paulo V. M. Steagall

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Placental microRNA methylome signatures may serve as biomarkers and therapeutic targets for prenatally opioid-exposed infants with neonatal opioid withdrawal syndrome by Uppala Radhakrishna, Swapan K. Nath, Lavanya V. Uppala, Avinash Veerappa, Ariadna Forray, Srinivas B. Muvvala, Raghu P. Metpally, Richard C. Crist, Wade H. Berrettini, Wade H. Berrettini, Lori M. Mausi, Sangeetha Vishweswaraiah, Ray O. Bahado-Singh

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Men’s and women’s response to treatment and perceptions of outcomes in a randomized controlled trial of injectable opioid assisted treatment for severe opioid use disorder by Heather Palis, Kirsten Marchand, Daphne Guh, Suzanne Brissette, Kurt Lock, Scott MacDonald, Scott Harrison, Aslam H. Anis, Michael Krausz, David C. Marsh, Martin T. Schechter, Eugenia Oviedo-Joekes

Subjects: “…Opioid-dependence…”
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The Endogenous Opioid System in Schizophrenia and Treatment Resistant Schizophrenia: Increased Plasma Endomorphin 2, and κ and μ Opioid Receptors Are Associated with Interleukin-6 by Shatha Rouf Moustafa, Khalid F. Al-Rawi, Drozdstoi Stoyanov, Arafat Hussein Al-Dujaili, Thitiporn Supasitthumrong, Hussein Kadhem Al-Hakeim, Michael Maes

“…There are only a few data on immune and endogenous opioid system (EOS) interactions in SCZ and treatment resistant SCZ. …”
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Effectiveness of Policies for Addressing the US Opioid Epidemic: A Model-Based Analysis from the Stanford-Lancet Commission on the North American Opioid Crisis by Isabelle J. Rao, Keith Humphreys, Margaret L. Brandeau

“…Introduction: The U.S. opioid crisis has been exacerbated by COVID-19 and the spread of synthetic opioids (e.g., fentanyl). …”
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Heterodimerization of Mu Opioid Receptor Protomer with Dopamine D₂ Receptor Modulates Agonist-Induced Internalization of Mu Opioid Receptor by Lakshmi Vasudevan, Dasiel O. Borroto-Escuela, Jelle Huysentruyt, Kjell Fuxe, Deepak K. Saini, Christophe Stove

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Trends in mortality from alcohol, opioid, and combined alcohol and opioid poisonings by sex, educational attainment, and race and ethnicity for the United States 2000–2019 by Charlotte Buckley, Yu Ye, William C. Kerr, Nina Mulia, Klajdi Puka, Jürgen Rehm, Charlotte Probst

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Evaluating comparative effectiveness of psychosocial interventions adjunctive to opioid agonist therapy for opioid use disorder: A systematic review with network meta-analyses. by Danielle Rice, Kimberly Corace, Dianna Wolfe, Leila Esmaeilisaraji, Alan Michaud, Alicia Grima, Bradley Austin, Reuben Douma, Pauline Barbeau, Claire Butler, Melanie Willows, Patricia A Poulin, Beth A Sproule, Amy Porath, Gary Garber, Sheena Taha, Gord Garner, Becky Skidmore, David Moher, Kednapa Thavorn, Brian Hutton

“…Primary outcomes were treatment retention and opioid use (measured by urinalysis for opioid use and opioid abstinence outcomes). …”
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Trends in pediatric prescription-opioid overdoses in U.S. emergency departments from 2008–2020: An epidemiologic study of pediatric opioid overdose ED visits by Audrey Lu, Megan Armstrong, Robin Alexander, Eurella Vest, Jonathan Chang, Motao Zhu, Henry Xiang

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A multidisciplinary opioid-reduction pathway for robotic prostatectomy: outcomes at year one by Michael W. Manning, John Whittle, Matthew Fuller, Sara H. Cooper, Erin L. Manning, Joe Chapman, Judd W. Moul, Timothy E. Miller

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Preventing opioid overdose with peer-administered naloxone: findings from a rural state by Bridget L. Hanson, Rebecca R. Porter, Amanda L. Zöld, Heather Terhorst-Miller

Subjects: “…Opioid overdose…”
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Trends in Israeli community-based opioid prescribing, 2010–2020, an observational study of the country’s largest HMO by Reuven L. Dressler, Ehud Kaliner, Matan J. Cohen

Subjects: “…Opioid use…”
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Frontline Perspectives on Buprenorphine for the Management of Chronic Pain by Adler J, Mallick-Searle T, Garofoli M, Zimmerman A

Subjects: “…opioid analgesics…”
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Are thyrotropin‐releasing hormone (TRH) and analog taltirelin viable reversal agents of opioid‐induced respiratory depression? by Marieke Hyke Algera, Joseph F. Cotten, Monique vanVelzen, Marieke Niesters, Martijn Boon, Daniel S. Shoham, Kaye E. Dandrea, Rutger van derSchrier, Albert Dahan

Subjects: “…opioid…”
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Bis-Cyclic Guanidine Heterocyclic Peptidomimetics as Opioid Ligands with Mixed μ-, κ- and δ-Opioid Receptor Interactions: A Potential Approach to Novel Analgesics by Jay P. McLaughlin, Ramanjaneyulu Rayala, Ashley J. Bunnell, Mukund P. Tantak, Shainnel O. Eans, Khadija Nefzi, Michelle L. Ganno, Colette T. Dooley, Adel Nefzi

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