The Rural Opioid Initiative Consortium description: providing evidence to Understand the Fourth Wave of the Opioid Crisis by Richard A. Jenkins, Bridget M. Whitney, Robin M. Nance, Todd M. Allen, Hannah L. F. Cooper, Judith Feinberg, Rob Fredericksen, Peter D. Friedmann, Vivian F. Go, Wiley D. Jenkins, P. Todd Korthuis, William C. Miller, Mai T. Pho, Abby E. Rudolph, David W. Seal, Gordon S. Smith, Thomas J. Stopka, Ryan P. Westergaard, April M. Young, William A. Zule, Joseph A. C. Delaney, Judith I. Tsui, Heidi M. Crane, the Rural Opioid Initiative

Subjects: “…Opioids…”
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Socioeconomic correlates of incident and fatal opioid overdose among Swedish people with opioid use disorder by Disa Dahlman, Henrik Ohlsson, Alexis C. Edwards, Jan Sundquist, Anders Håkansson, Kristina Sundquist

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The interaction of depression and prior opioid use on pain and opioid requirements after total joint arthroplasty by William Rubenstein, MD, Trevor Grace, MD, Rhiannon Croci, BSN, RN-BC, Derek Ward, MD

“…Background: Preoperative opioid use causes increased pain and opioid requirements after total joint arthroplasty (TJA), but the effect of depression on this relationship is not well defined. …”
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Opioids drive breast cancer metastasis through the δ-opioid receptor and oncogenic STAT3 by Sabrina Tripolt, Heidi A. Neubauer, Vanessa M. Knab, Dominik P. Elmer, Fritz Aberger, Richard Moriggl, Daniela A. Fux

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Time on shift in the emergency department and decision to prescribe opioids to patients without chronic opioid use by Isha Agarwal, Joshua W. Joseph, Leon D. Sanchez

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Provider confidence in opioid prescribing and chronic pain management: results of the Opioid Therapy Provider Survey by Pearson AC, Moman RN, Moeschler SM, Eldrige JS, Hooten WM

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Biphalin—A Potent Opioid Agonist—As a Panacea for Opioid System-Dependent Pathophysiological Diseases? by Patrycja Redkiewicz, Jolanta Dyniewicz, Aleksandra Misicka

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Positive Association between Peri-Surgical Opioid Exposure and Post-Discharge Opioid-Related Outcomes by Kibum Kim, Joseph E. Biskupiak, Jennifer L. Babin, Sabrina Ilham

Subjects: “…persistent opioid use…”
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Association between Prescribers’ Perceptions of the Utilization of Medication for Opioid Use Disorder and Opioid Dependence Treatability by David Adzrago, Angela Di Paola, Jialing Zhu, Alejandro Betancur, J. Michael Wilkerson

Subjects: “…medication for opioid use disorder…”
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Correction: High-Dose Opioid Prescribing and Opioid-Related Hospitalization: A Population-Based Study. by PLOS ONE Staff

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Preoperative Opioid Prescription is a Risk Factor for Extended Opioid Filling After Ankle Arthroscopy by William S. Polachek, Cody Lee, Bryan L. Scott, Kelly K. Hynes MD

“…Category: Arthroscopy; Ankle; Sports; Other Introduction/Purpose: Opioids can be an important tool in the management of postoperative pain, however, increased prescribing of these medications following orthopaedic procedures has significantly contributed to the current opioid crisis. …”
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Mu Opioid Splice Variant MOR-1K Contributes to the Development of Opioid-Induced Hyperalgesia. by Folabomi A Oladosu, Matthew S Conrad, Sandra C O'Buckley, Naim U Rashid, Gary D Slade, Andrea G Nackley

“…<h4>Background</h4>A subset of the population receiving opioids for the treatment of acute and chronic clinical pain develops a paradoxical increase in pain sensitivity known as opioid-induced hyperalgesia. …”
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Interactions Between Opioids and Dextroamphetamine on Locomotor Activity: Influence of an Opioid's Relative Efficacy at the Mu Receptor by Mark A. Smith, Shannon L. Ballard, Clarise F. Ballesteros, Samantha A. Bonge, Alexander T. Casimir, Lauren M. Childs, Max A. Feinstein, Annie K. Griffith, Alexandra N. Johansen, Daegeon Lee, A. Caroline Mauser, Cassidy M. Moses, Ian J. Robertson, Javier U. Robles, Justin C. Strickland, Mary E. Walters, Seeley J. Yoo

“…Opioids and stimulants are often used in combination for both recreational and non-recreational purposes. …”
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Does the Strengthen Opioid Misuse Prevention Act Reduce Opioid Prescriptions Associated With Hand Surgery? by Chelsea Viscardi, MS, Yifan Guo, MD, Richard S. Zeri, MD, Tom Reisler, MBChB, BSc(Hons), MRCSEd, Karen Buckley, MD, William Irish, PhD

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Pain control is comparable between opioid versus non‐opioid management after otolaryngology procedures by Ashwini Sarathy, Clemens An, Ty Bever, Peter Callas, Mayo H. Fujii, Mirabelle Sajisevi

Subjects: “…opioids…”
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Insights into the Current and Possible Future Use of Opioid Antagonists in Relation to Opioid-Induced Constipation and Dysbiosis by Nariman Essmat, Dávid Árpád Karádi, Ferenc Zádor, Kornél Király, Susanna Fürst, Mahmoud Al-Khrasani

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Mechanism of opioid addiction and its intervention therapy: Focusing on the reward circuitry and mu‐opioid receptor by Jia‐Jia Zhang, Chang‐Geng Song, Ji‐Min Dai, Ling Li, Xiang‐Min Yang, Zhi‐Nan Chen

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Patient Satisfaction and Opioid Use With a Postoperative Opioid Protocol After Common Hand Procedures by Kyra A. Benavent, BS, Nomee D. Altschul, MS, PA-C, Lindsay F. Lincoln, PA-C, Cassandra M. Chruscielski, BS, Kevin F. Kennedy, MS, Brandon E. Earp, MD

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Opioids, sleep, analgesia and respiratory depression: Their convergence on Mu (μ)-opioid receptors in the parabrachial area by Nicole Lynch, Janayna D. Lima, Richard L. Spinieli, Satvinder Kaur

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A Chimeric Analysis of the Opioid Receptor Domains Critical for the Binding Selectivity of μ Opioid Ligands by Brendon Watson, Fan Meng, Huda Akil

“…The μ opioid receptor plays a key role in mediating the physiological, pharmacological, and behavioral effects of endogenous opioids and of opiate drugs such as morphine and heroin. …”
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