Optical dopamine monitoring with dLight1 reveals mesolimbic phenotypes in a mouse model of neurofibromatosis type 1 by J Elliott Robinson, Gerard M Coughlin, Acacia M Hori, Jounhong Ryan Cho, Elisha D Mackey, Zeynep Turan, Tommaso Patriarchi, Lin Tian, Viviana Gradinaru

“…NF1 mice also had more robust dopaminergic and behavioral responses to salient visual stimuli, which were independent of learning, and rescued by optogenetic inhibition of non-dopaminergic neurons in the VTA. …”
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Neuroimmune Interactions in Inflammation and Acute Kidney Injury by Tsuyoshi Inoue, Shinji Tanaka, Mark D. Okusa

“…Recent studies demonstrate a non-pharmacological organ protective effect of electrical nerve stimulation, pulsed ultrasound treatment, or optogenetic C1 neuron activation. These modalities are thought to activate the CAP and attenuate inflammation. …”
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A parabrachial to hypothalamic pathway mediates defensive behavior by Fan Wang, Yuge Chen, Yuxin Lin, Xuze Wang, Kaiyuan Li, Yong Han, Jintao Wu, Xingyi Shi, Zhenggang Zhu, Chaoying Long, Xiaojun Hu, Shumin Duan, Zhihua Gao

“…Conversely, photoinhibition of LPBCCK neurons attenuates rat or looming stimuli-induced flight responses. Optogenetic activation of LPBCCK axon terminals within the PVN or PVN glutamatergic neurons promotes defensive behaviors. …”
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Input- and Cell-Type-Specific Endocannabinoid-Dependent LTD in the Striatum by Yu-Wei Wu, Jae-Ick Kim, Vivianne L. Tawfik, Rupa R. Lalchandani, Grégory Scherrer, Jun B. Ding

“…Using region-specific Cre mouse lines combined with optogenetic techniques, we directly investigated and distinguished between corticostriatal and thalamostriatal projections. …”
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A biological camera that captures and stores images directly into DNA by Cheng Kai Lim, Jing Wui Yeoh, Aurelius Andrew Kunartama, Wen Shan Yew, Chueh Loo Poh

“…Here, in this work, we detail a method of capturing 2-dimensional light patterns into DNA, by utilizing optogenetic circuits to record light exposure into DNA, encoding spatial locations with barcoding, and retrieving stored images via high-throughput next-generation sequencing. …”
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Effects of arousal and movement on secondary somatosensory and visual thalamus by Gordon H Petty, Amanda K Kinnischtzke, Y Kate Hong, Randy M Bruno

“…This phenomenon also continued during optogenetic silencing of somatosensory and motor cortex and after lesion of superior colliculus, ruling out a motor efference copy mechanism. …”
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Parvalbumin-Expressing GABAergic Neurons in Mouse Barrel Cortex Contribute to Gating a Goal-Directed Sensorimotor Transformation by Shankar Sachidhanandam, B. Semihcan Sermet, Carl C.H. Petersen

“…After an initial outcome-invariant early sensory response, PV neurons had lower firing rates in hit trials compared to miss trials. Optogenetic inhibition of PV neurons during this time period enhanced behavioral performance. …”
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Striatal direct pathway neurons play leading roles in accelerating rotarod motor skill learning by Bo Liang, Lifeng Zhang, Yan Zhang, Craig T. Werner, Nicholas J. Beacher, Alex J. Denman, Yun Li, Rong Chen, Charles R. Gerfen, Giovanni Barbera, Da-Ting Lin

“…We found a distinct evolution trajectory for early-stage neurons during motor skill learning, with the evolution of D1 MSNs correlating strongly with performance improvement. Importantly, optogenetic inhibition of the early-stage neural activity in D1 MSNs, but not D2 MSNs, impaired accelerating rotarod learning. …”
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Rhodopsin-associated retinal dystrophy: Disease mechanisms and therapeutic strategies by Fangyuan Zhen, Fangyuan Zhen, Tongdan Zou, Ting Wang, Yongwei Zhou, Shuqian Dong, Houbin Zhang, Houbin Zhang

“…Additionally, innovative therapeutic treatment strategies, such as antisense oligonucleotide therapy, gene therapy, optogenetic therapy, and stem cell therapy, have achieved promising outcomes in preclinical disease models of rhodopsin mutations. …”
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Involvement of Mrgprd-expressing nociceptors-recruited spinal mechanisms in nerve injury-induced mechanical allodynia by Liangbiao Wang, Xiaojing Su, Jinjin Yan, Qiaofeng Wu, Xiang Xu, Xinyue Wang, Xiaoqing Liu, Xiaoyuan Song, Zhi Zhang, Wei Hu, Xinfeng Liu, Yan Zhang

“…In addition, priming chemogenetic or optogenetic activation of Mrgprd+ neurons drove mechanical allodynia and aversion to low-threshold mechanical stimuli, along with mechanical hyperalgesia. …”
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Synaptic mechanisms for associative learning in the cerebellar nuclei by Robin Broersen, Catarina Albergaria, Daniela Carulli, Megan R. Carey, Cathrin B. Canto, Chris I. De Zeeuw

“…Here, we probed the ability of these inputs to support associative learning in mice, and investigated structural and cell-physiological changes within the cerebellar nuclei during learning. We find that optogenetic stimulation of mossy fiber afferents to the anterior interposed nucleus (AIP) can substitute for a conditioned stimulus and is sufficient to elicit conditioned responses (CRs) that are adaptively well-timed. …”
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Cerebellar modulation of synaptic input to freezing-related neurons in the periaqueductal gray by Christopher E Vaaga, Spencer T Brown, Indira M Raman

“…In freely moving mice, optogenetically stimulating glutamatergic vlPAG neurons that express Chx10 reliably induces freezing. …”
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Inhibition of the Prefrontal Projection to the Nucleus Accumbens Enhances Pain Sensitivity and Affect by Haocheng Zhou, Haocheng Zhou, Erik Martinez, Harvey H. Lin, Runtao Yang, Jahrane Antonio Dale, Kevin Liu, Dong Huang, Jing Wang, Jing Wang

“…To answer this question, we disrupted this circuit using an optogenetic strategy. We expressed halorhodopsin in pyramidal neurons from the PFC, and then selectively inhibited the axonal projection from these neurons to neurons in the NAc core. …”
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Elevated prelimbic cortex-to-basolateral amygdala circuit activity mediates comorbid anxiety-like behaviors associated with chronic pain by Feng Gao, Jie Huang, Guo-Bin Huang, Qiang-Long You, Shan Yao, Shen-Ting Zhao, Jian Liu, Cui-Hong Wu, Gui-Fu Chen, Shi-Min Liu, Zongyan Yu, Yan-Ling Zhou, Yu-Ping Ning, Shenquan Liu, Bing-Jie Hu, Xiang-Dong Sun

“…We report that PrL neurons projecting to the basolateral amygdala (PrLBLA) and those projecting to the ventrolateral periaqueductal gray (PrLl/vlPAG) were segregated and displayed elevated and reduced neuronal activity, respectively, during pain chronicity. Consistently, optogenetic suppression of the PrL-BLA circuit reversed anxiety-like behaviors, whereas activation of the PrL-l/vlPAG circuit attenuated hyperalgesia in mice with chronic pain. …”
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AAV for Gene Therapy in Ocular Diseases: Progress and Prospects by Xiaoyu He, Yidian Fu, Liang Ma, Yizheng Yao, Shengfang Ge, Zhi Yang, Xianqun Fan

“…We discuss the progress of AAV in ocular optogenetic therapy. We also summarize the application of AAV-mediated gene therapy in animal models and the difficulties in its clinical transformation.…”
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Selective plasticity of layer 2/3 inputs onto distal forelimb controlling layer 5 corticospinal neurons with skilled grasp motor training by Yoshio Takashima, Jeremy S. Biane, Mark H. Tuszynski

“…We seek to identify the nature and extent of the plasticity of these projections with motor learning. Using optogenetic and viral intersectional tools to selectively stimulate distinct neuronal subsets in rat primary motor cortex, we simultaneously record from pairs of corticospinal neurons associated with distinct features of motor output control: distal forelimb vs. proximal forelimb. …”
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Columnar neurons support saccadic bar tracking in Drosophila by Giovanni Frighetto, Mark A Frye

“…We combined physiological and behavioral experiments to show that T3 neurons respond omnidirectionally to the same visual stimuli that elicit bar tracking saccades, silencing T3 reduced the frequency of tracking saccades, and optogenetic manipulation of T3 acted on the saccade rate in a push–pull manner. …”
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Long-range inhibitory neurons mediate cortical neurovascular coupling by Catherine F. Ruff, Fernanda Juarez Anaya, Samuel J. Dienel, Adiya Rakymzhan, Alain Altamirano-Espinoza, Jay Couey, Mitsuhiro Fukuda, Alan M. Watson, Aihua Su, Kenneth N. Fish, Maria E. Rubio, Bryan M. Hooks, Sarah E. Ross, Alberto L. Vazquez

“…Additionally, through optogenetic experiments, we demonstrate that Tacr1 neurons are instrumental in mediating CBF through the relaxation of mural cells in a similar fashion to whisker stimulation. …”
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A medullary hub for controlling REM sleep and pontine waves by Amanda L. Schott, Justin Baik, Shinjae Chung, Franz Weber

“…Chemogenetic manipulation also induced prolonged changes in P-wave frequency, while brief optogenetic activation reliably triggered P-waves along with transiently accelerated theta oscillations in the electroencephalogram (EEG). …”
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Controlling periodic long-range signalling to drive a morphogenetic transition by Hugh Z Ford, Angelika Manhart, Jonathan R Chubb

“…Combining imaging and optogenetic perturbation of cell signalling states, we find that migration is triggered by an increase in wave frequency generated at the signalling centre. …”
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