AgRP neurons trigger long-term potentiation and facilitate food seeking by Chunmei Wang, Wenjun Zhou, Yang He, Tiffany Yang, Pingwen Xu, Yongjie Yang, Xing Cai, Julia Wang, Hesong Liu, Meng Yu, Chen Liang, Tingting Yang, Hailan Liu, Makoto Fukuda, Qingchun Tong, Qi Wu, Zheng Sun, Yanlin He, Yong Xu

“…A similar impairment can be also induced by optogenetic inhibition of the AgRP→PVT projections. …”
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Presence of Inhibitory Glycinergic Transmission in Medium Spiny Neurons in the Nucleus Accumbens by Braulio Muñoz, Gonzalo E. Yevenes, Benjamin Förstera, David M. Lovinger, Luis G. Aguayo

“…In D1 MSNs, we found low frequency glycinergic miniature inhibitory postsynaptic currents (mIPSCs) which were blocked by 1 μM strychnine (STN), insensitive to low (10, 50 mM) and high (100 mM) ethanol (EtOH) concentrations, but sensitive to 30 μM propofol. Optogenetic experiments confirmed the existence of STN-sensitive glycinergic IPSCs and suggest a contribution of GABA and glycine neurotransmitters to the IPSCs in nAc. …”
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Activation of the Rostral Intralaminar Thalamus Drives Reinforcement through Striatal Dopamine Release by Kara K. Cover, Utsav Gyawali, Willa G. Kerkhoff, Mary H. Patton, Chaoqi Mu, Michael G. White, Ashley E. Marquardt, Bradley M. Roberts, Joseph F. Cheer, Brian N. Mathur

“…We find that activation of rILN inputs to the DS drives cholinergic interneuron burst-firing behavior and DA D2 receptor-dependent post-burst pauses in cholinergic interneuron firing. In vivo, optogenetic activation of this pathway drives reinforcement in a DA D1 receptor-dependent manner, and chemogenetic suppression of the rILN reduces dopaminergic nigrostriatal terminal activity as measured by fiber photometry. …”
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AMPAkines potentiate the corticostriatal pathway to reduce acute and chronic pain by Fei Zeng, Qiaosheng Zhang, Yaling Liu, Guanghao Sun, Anna Li, Robert S. Talay, Jing Wang

“…Here we compared the impact of AMPAkine treatment in the NAc with optogenetic activation of the PL on pain behaviors in rats. …”
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Gamma frequency entrainment attenuates amyloid load and modifies microglia by Iaccarino, Hannah Frances, Singer, Annabelle, Martorell, Anthony, Rudenko, Andrii, Gao, Fan, Gillingham, Tyler, Mathys, Hansruedi, Seo, Jinsoo, Kritskiy, Oleg, Abdurrob, Fatema, Adaikkan, Chinnakkaruppan, Canter, Rebecca Gail, Rueda IV, Richard, Brown, Emery Neal, Boyden, Edward, Tsai, Li-Huei

“…Here we show reduced, behaviourally driven gamma oscillations before the onset of plaque formation or cognitive decline in a mouse model of Alzheimer's disease. Optogenetically driving fast-spiking parvalbumin-positive (FS-PV)-interneurons at gamma (40 Hz), but not other frequencies, reduces levels of amyloid-β (Aβ)[subscript 1-40] and Aβ [subscript 1-42] isoforms. …”
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Brain-wide mapping reveals that engrams for a single memory are distributed across multiple brain regions by Roy, Dheeraj S, Park, Young-Gyun, Kim, Minyoung E, Zhang, Ying, Ogawa, Sachie K, DiNapoli, Nicholas, Gu, Xinyi, Cho, Jae H, Choi, Heejin, Kamentsky, Lee, Martin, Jared, Mosto, Olivia, Aida, Tomomi, Chung, Kwanghun, Tonegawa, Susumu

“…The mapping was aided by an engram index, which identified 117 cFos<jats:sup>+</jats:sup> brain regions holding engrams with high probability, and brain-wide reactivation of these neuronal ensembles by recall. Optogenetic manipulation experiments revealed engram ensembles, many of which were functionally connected to hippocampal or amygdala engrams. …”
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Actuated tissue engineered muscle grafts restore functional mobility after volumetric muscle loss by Rousseau, Erin, Raman, Ritu, Tamir, Tigist, Bu, Angel, Srinivasan, Shriya, Lynch, Naomi, Langer, Robert, White, Forest M., Cima, Michael J.

“…Here we show that targeted actuation of implanted grafts, via non-invasive transcutaneous light stimulation of optogenetic engineered muscle, restores motor function to levels similar to healthy mice 2 weeks post-injury. …”
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A critical role for NMDA receptors in parvalbumin interneurons for gamma induction and behavior by Jones, S. R., Deisseroth, Karl, Carlen, Marie, Meletis, Konstantinos, Siegle, Joshua Handman, Cardin, Jessica A., Futai, Kensuke, Vierling-Claassen, Dorea L., Ruhlmann, C., Sheng, Morgan Hwa-Tze, Moore, Christopher I., Tsai, Li-Huei

“…Here, we show that mutant mice exhibit enhanced baseline cortical gamma rhythms, impaired gamma rhythm induction after optogenetic drive of PV interneurons and reduced sensitivity to the effects of NMDAR antagonists on gamma oscillations and stereotypies. …”
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Top-down control : a unified principle of cortical learning by Makino, Hiroshi

“…Recent technological advances in multi-site recordings and optogenetic approaches are beginning to reveal more direct evidence of top-down cognitive control by monitoring and perturbing activity of top-down inputs and observing its causal consequences on behavior and downstream neural dynamics. …”
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Distinct preoptic-BST nuclei dissociate paternal and infanticidal behavior in mice by Tsuneoka, Yousuke, Tokita, Kenichi, Yoshihara, Chihiro, Amano, Taiju, Esposito, Gianluca, Huang, Arthur J., Yu, Lily M. Y., Odaka, Yuri, Shinozuka, Kazutaka, McHugh, Thomas J ., Kuroda, Kumi O.

“…The projections from cMPOA to BSTrh were largely GABAergic. Optogenetic or pharmacogenetic activation of cMPOA attenuated infanticide in virgin males. …”
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Propagation of orientation selectivity in a spiking network model of layered primary visual cortex. by Benjamin Merkt, Friedrich Schüßler, Stefan Rotter

“…Our theory can also be used to design novel optogenetic stimulation experiments, thus facilitating further exploration of the interplay between connectivity and function.…”
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Rab8, Rab11, and Rab35 coordinate lumen and cilia formation during zebrafish left-right organizer development. by Abrar A Aljiboury, Eric Ingram, Nikhila Krishnan, Favour Ononiwu, Debadrita Pal, Julie Manikas, Christopher Taveras, Nicole A Hall, Jonah Da Silva, Judy Freshour, Heidi Hehnly

“…We identified that nascent KV cells form cilia at their centrosomes at random intracellular positions that then move towards a forming apical membrane containing cystic fibrosis transmembrane conductance regulator (CFTR). Using optogenetic clustering approaches, we found that Rab35 positive membranes recruit Rab11 to modulate CFTR delivery to the apical membrane, which is required for lumen opening, and subsequent cilia extension into the lumen. …”
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Anterior Commissure Regulates Neuronal Activity of Amygdalae and Influences Locomotor Activity, Social Interaction and Fear Memory in Mice by Tsan-Ting Hsu, Tzyy-Nan Huang, Yi-Ping Hsueh

“…Results from in vivo optogenetic stimulation suggest that AC transection impairs mutual activation between two basolateral amygdalae. …”
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In vivo recording of suprachiasmatic nucleus dynamics reveals a dominant role of arginine vasopressin neurons in circadian pacesetting. by Yusuke Tsuno, Yubo Peng, Shin-Ichi Horike, Mohan Wang, Ayako Matsui, Kanato Yamagata, Mizuki Sugiyama, Takahiro J Nakamura, Takiko Daikoku, Takashi Maejima, Michihiro Mieda

“…In contrast, in vivo calcium rhythms of both AVP and vasoactive intestinal peptide (VIP) neurons in the SCN of freely moving mice demonstrated stably lengthened periods similar to the behavioral rhythm upon AVP neuron-specific CK1δ deletion, without changing the phase relationships between each other. Furthermore, optogenetic activation of AVP neurons acutely induced calcium increase in VIP neurons in vivo. …”
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Open-MAC: A low-cost open-source motorized commutator for electro- and opto-physiological recordings in freely moving rodents by Sampath K.T. Kapanaiah, Dennis Kätzel

“…Different Open-MAC versions can support electrophysiology with up to 64 recording channels using the Open-Ephys / IntanTM recording systems as well as miniature endoscope (miniscope) recordings using the UCLA Miniscope v3/4, and can host a fibre for optogenetic modulation.…”
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Green monomeric photosensitizing fluorescent protein for photo-inducible protein inactivation and cell ablation by Yemima Dani Riani, Tomoki Matsuda, Kiwamu Takemoto, Takeharu Nagai

“…Conclusion Development of SuperNova Green has expanded the photosensitizing protein toolbox to optogenetically control protein inactivation and cell ablation.…”
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How Do Neurons Signal Itch? by Martin Schmelz

“…However, in contrast to an assumed inherent exclusivity, recent results have shown that even within itch-specific pathways in the spinal cord, temporal discharge patterns are important as sustained pruriceptor is required to allow successful transsynaptic signal progression. Also, optogenetic activation of pruriceptors suggest that the combination of neuronal specificity and temporal pattern determines the sensory effect: tonic activation of pruriceptors is required to induce scratching behavior whereas short-lasting stimulation rather causes withdrawal. …”
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Characterization of the neural circuitry of the auditory thalamic reticular nucleus and its potential role in salicylate-induced tinnitus by Qian Dai, Tong Qu, Guoming Shen, Haitao Wang

“…Furthermore, the mapped sensory inputs to the auditory TRN suggest possibilities for employing optogenetic or sensory stimulations to manipulate thalamocortical activities. …”
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The anterior cingulate cortex controls the hyperactivity in subthalamic neurons in male mice with comorbid chronic pain and depression. by Ying-Di Wang, Shu-Ting Bao, Yuan Gao, Jin Chen, Tao Jia, Cui Yin, Jun-Li Cao, Cheng Xiao, Chunyi Zhou

“…Pain responses in STN neurons were attenuated in both naïve and SNI mice when ACC neurons were inhibited. Furthermore, optogenetic activation of the ACC-STN pathway induced bilateral hyperalgesia and depression-like behaviors in naive mice; conversely, inhibition of this pathway is sufficient to attenuate hyperalgesia and depression-like behaviors in SNI mice and naïve mice subjected to stimulation of STN neurons. …”
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The Basolateral Amygdala to Ventral Hippocampus Circuit Controls Anxiety-Like Behaviors Induced by Morphine Withdrawal by Cuola Deji, Peng Yan, Yuanyuan Ji, Xinyue Yan, Yue Feng, Jincen Liu, Yige Liu, Shuguang Wei, Yongsheng Zhu, Jianghua Lai

“…KORs in the BLA to vHip projections were significantly increased in the Mor-A group. Optogenetic/chemogenetic inhibition of BLA inputs ameliorated anxiety-like behaviors and facilitated conditioned place preference (CPP) extinction in Mor-A mice. …”
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