Dopamine Suppresses Synaptic Responses of Fan Cells in the Lateral Entorhinal Cortex to Olfactory Bulb Input in Mice by Shaolin Liu

“…We addressed these questions in the present study by combing optogenetic and electrophysiological approaches with four major findings: (1) selective activation of OB input elicited glutamate-mediated monosynaptic responses in all fan cells, the major output neurons in layer II of the LEC; (2) this excitatory synaptic transmission exhibited robust paired-pulse facilitation (PPF), a presynaptically derived short-term synaptic plasticity; (3) DA dramatically attenuated the strength of the OB input-fan cell synaptic transmission via activation of D1 receptors; and (4) DA altered the PPF of this transmission but neither intrinsic properties of postsynaptic neurons nor the kinetic profile of postsynaptic responses, suggesting that presynaptic mechanisms underlie the DA inhibitory actions. …”
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A Population of Projection Neurons that Inhibits the Lateral Horn but Excites the Antennal Lobe through Chemical Synapses in Drosophila by Kazumichi Shimizu, Mark Stopfer

“…However, little is known about the properties and functions of vPNs at their dendritic branches in the AL. Here, we used optogenetic and patch clamp techniques to investigate the functional roles of vPNs in the AL. …”
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A Rac1-FMNL2 signaling module affects cell-cell contact formation independent of Cdc42 and membrane protrusions. by Hanna Grobe, Andrea Wüstenhagen, Christian Baarlink, Robert Grosse, Katharina Grikscheit

“…CRISPR/Cas9-mediated loss of FMNL2 in human MCF10A cells combined with optogenetic control of Rac1 activity confirmed its critical function in the establishment of intercellular contacts. …”
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Cerebellum encodes and influences the initiation, performance, and termination of discontinuous movements in mice by Michael A Gaffield, Britton A Sauerbrei, Jason M Christie

“…In a subpopulation of PCs, climbing-fiber-evoked responses also increased during lick-bout initiation, but not termination, highlighting differences in how cerebellar input pathways represent task-related information. Optogenetic perturbation of PC activity disrupted the behavior by degrading lick-bout rhythmicity in addition to initiating and terminating licking bouts confirming a causative role in movement organization. …”
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Barrel cortex VIP/ChAT interneurons suppress sensory responses in vivo. by Amir Dudai, Nadav Yayon, Vitaly Lerner, Gen-Ichi Tasaka, Yair Deitcher, Karin Gorfine, Naomi Niederhoffer, Adi Mizrahi, Hermona Soreq, Michael London

“…Analysis of long-range inputs to VChIs with monosynaptic rabies virus tracing revealed that direct thalamic projections are a significant input source to these cells. Optogenetic activation of VChIs in the barrel cortex of awake mice suppresses the sensory responses of excitatory neurons in intermediate amplitudes of whisker deflections while increasing the evoked spike latency. …”
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Alpha-synuclein aggregates trigger cardiolipin externalization and mitophagy by Rebeca Martín-Jiménez, Olivier Lurette, Etienne Hebert-Chatelain

“…In this punctum, we describe our recent work in which we used a newly developed optogenetic tool to control the aggregation of α-syn and examine the impact on mitochondria. …”
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Compartmentalised cAMP signalling in the primary cilium by Ester Paolocci, Manuela Zaccolo

“…We review evidence that ciliary membrane localization of G-Protein Coupled Receptors (GPCRs) determines their downstream function and discuss how optogenetic tools have contributed to establish that cAMP generated in the primary cilium can drive cystogenesis.…”
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Red Photoactivatable Genetic Optical-Indicators by Wessal Hussein, Shai Berlin

“…Today, major efforts are devoted toward optimizing red-emitting [red fluorescent protein (RFP)-based] GECIs (R-GECI), as these provide several advantages over GFP-based reporters, for instance, increased imaging depth, reduced photodamage by longer imaging wavelengths and, in principle, are better suited for use with prevalent blue-absorbing optogenetic tools (e.g., channelrhodopsin). However, excessive fluorescence from intersecting neighboring cells in very dense tissues, notably the brain, hinders the ability to collect signals from single cells and their processes. …”
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Paradoxical Onset of Arrhythmic Waves from Depolarized Areas in Cardiac Tissue Due to Curvature-Dependent Instability by Alexander S. Teplenin, Hans Dierckx, Antoine A. F. de Vries, Daniël A. Pijnappels, Alexander V. Panfilov

“…We paradoxically find that, for any studied geometry of the depolarized region in optogenetically modified monolayers of cardiac cells, primary ectopic excitation originates at areas of maximal curvature of the boundary, where the stimulating electrotonic currents are minimal. …”
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Antagonistic regulation of salt and sugar chemotaxis plasticity by a single chemosensory neuron in Caenorhabditis elegans. by Masahiro Tomioka, Yusuke Umemura, Yutaro Ueoka, Risshun Chin, Keita Katae, Chihiro Uchiyama, Yasuaki Ike, Yuichi Iino

“…ASEL activity increases when glucose concentration decreases. Optogenetic ASEL stimulation promotes forward movements; however, after glucose conditioning, it promotes turning, suggesting that after glucose conditioning, the behavioral output of ASEL activation switches toward glucose. …”
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Dipole source localization of mouse electroencephalogram using the Fieldtrip toolbox. by Chungki Lee, Robert Oostenveld, Soo Hyun Lee, Lae Hyun Kim, Hokun Sung, Jee Hyun Choi

“…Known sources to evaluate the performance of the localization methods were provided using optogenetic tools. The accuracy was quantified based on the receiver operating characteristic (ROC) analysis. …”
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Light induces oxidative damage and protein stability in the fungal photoreceptor Vivid. by Carmen Noemí Hernández-Candia, Sergio Casas-Flores, Braulio Gutiérrez-Medina

“…Flavin-binding photoreceptor proteins sense blue-light (BL) in diverse organisms and have become core elements in recent optogenetic applications. The light-oxygen-voltage (LOV) protein Vivid (VVD) from the filamentous fungus Neurospora crassa is a classic BL photoreceptor, characterized by effecting a photocycle based on light-driven formation and subsequent spontaneous decay of a flavin-cysteinyl adduct. …”
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Sensory neurons couple arousal and foraging decisions in Caenorhabditis elegans by Elias Scheer, Cornelia I Bargmann

“…Neuromodulatory mutants and optogenetic manipulations that increase roaming have a coupled increase in leaving rates, and similarly acute manipulations that inhibit feeding induce both roaming and leaving. …”
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Non-invasive neuromodulation: an emerging intervention for visceral pain in gastrointestinal disorders by Md Jahangir Alam, Jiande D. Z. Chen

“…Neuromodulation intervenes in the central, peripheral, or autonomic nervous system by alternating or modulating nerve activity using electrical, electromagnetic, chemical, or optogenetic methodologies. Here, we review a few emerging noninvasive neuromodulation approaches with promising potential for alleviating pain associated with functional dyspepsia, gastroparesis, irritable bowel syndrome, inflammatory bowel disease, and non-cardiac chest pain. …”
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Neurotransmitter content heterogeneity within an interneuron class shapes inhibitory transmission at a central synapse by Dimitri Dumontier, Caroline Mailhes-Hamon, Stéphane Supplisson, Stéphane Dieudonné

“…We then pair GrCs recordings with optogenetic stimulations of single GoCs, which preserve the intracellular transmitter mixed content. …”
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Nucleus accumbens D1/D2 circuits control opioid withdrawal symptoms in mice by Yongsheng Zhu, Kejia Wang, Tengfei Ma, Yuanyuan Ji, Yin Lou, Xiaoyu Fu, Ye Lu, Yige Liu, Wei Dang, Qian Zhang, Fangyuan Yin, Kena Wang, Bing Yu, Hongbo Zhang, Jianghua Lai, Yunpeng Wang

“…Furthermore, the paraventricular nucleus of thalamus (PVT) to NAc D2 MSN pathway controls naloxone-induced acute withdrawal symptoms. Optogenetically induced long-term potentiation with κ-opioid receptor (KOR) antagonism enhanced BLA to NAc D1 MSN signaling and also altered the excitation/inhibition balance of NAc D2 MSN signaling. …”
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Spatiotemporal sensitivity of mesoderm specification to FGFR signalling in the Drosophila embryo by V. Yadav, N. Tolwinski, T. E. Saunders

“…To begin to address this challenge, we have developed an optogenetic version of the FGFR Heartless in Drosophila (Opto-htl). …”
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Cellular Composition of the Preoptic Area Regulating Sleep, Parental, and Sexual Behavior by Yousuke Tsuneoka, Hiromasa Funato, Hiromasa Funato

“…This review addresses the current understanding of the molecular and cellular architecture of POA neurons in relation to sleep and reproductive behavior. Optogenetic and pharmacogenetic studies have revealed a diverse group of neurons within the POA that exhibit different neural activity patterns depending on vigilance states and whose activity can enhance or suppress wake, non-rapid eye movement (NREM) sleep, or rapid eye movement (REM) sleep. …”
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Whole-brain opto-fMRI map of mouse VTA dopaminergic activation reflects structural projections with small but significant deviations by Horea-Ioan Ioanas, Bechara John Saab, Markus Rudin

“…In this article we use optogenetic stimulation directed at VTA dopaminergic neurons in combination with functional Magnetic Resonance Imaging (fMRI), a method widely used in human deep brain imaging. …”
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Advances in Gene Delivery Methods to Label and Modulate Activity of Upper Motor Neurons: Implications for Amyotrophic Lateral Sclerosis by Mouna Haidar, Aida Viden, Bradley J. Turner

“…Functional targeting of UMNs in vivo with the advent of optogenetic and chemogenetic technology is also discussed. …”
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