Disrupting epileptiform activity by preventing parvalbumin interneuron depolarization block by Călin, A, Ilie, AS, Akerman, C

“…The underlying cellular processes therefore represent potential targets for understanding and preventing the propagation of seizure activity. Here we use an optogenetic strategy to test the hypothesis that depolarization block in PV interneurons is a significant factor during the loss of inhibitory restraint. …”

Prefrontal-amygdalar oscillations related to social behavior in mice by Nahoko Kuga, Reimi Abe, Kotomi Takano, Yuji Ikegaya, Takuya Sasaki

“…Frequency-specific optogenetic manipulations replicating social approach-related LFP patterns restored social interaction behavior in socially deficient mice. …”
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Dopaminergic Neuromodulation of Spike Timing Dependent Plasticity in Mature Adult Rodent and Human Cortical Neurons by Emma Louise Louth, Emma Louise Louth, Rasmus Langelund Jørgensen, Anders Rosendal Korshoej, Jens Christian Hedemann Sørensen, Marco Capogna, Marco Capogna, Marco Capogna

“…DA was either bath-applied or optogenetically released in slices from mice. Classical STDP induction protocols triggered non-hebbian excitatory synaptic depression in the mouse or no plasticity at human cortical synapses. …”
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Inducing Partner Preference in Mice by Chemogenetic Stimulation of CA2 Hippocampal Subfield by Adi Cymerblit-Sabba, Adam S. Smith, Adam S. Smith, Sarah K. Williams Avram, Sarah K. Williams Avram, Michelle Stackmann, Michelle Stackmann, Austin C. Korgan, Austin C. Korgan, Maria C. Tickerhoof, W. Scott Young

“…The CA2 hippocampal subfield plays a crucial role in social memory and optogenetic stimulation of inputs to the dorsal CA2 field during a short memory acquisition period can enhance and extend social memories in mice. …”
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Dendrite-Specific Amplification of Weak Synaptic Input during Network Activity In Vivo by Leiron Ferrarese, Jean-Sébastien Jouhanneau, Michiel W.H. Remme, Jens Kremkow, Gergely Katona, Balázs Rózsa, Susanne Schreiber, James F.A. Poulet

“…Using subcellular two-photon stimulation of Channelrhodopsin2-expressing layer 2/3 pyramidal neurons in somatosensory cortex, nucleus-specific thalamic optogenetic stimulation, and paired recordings, we show that slow, depolarized network activity amplifies small-amplitude synaptic inputs targeted to basal dendrites but reduces the amplitude of all inputs from apical dendrites and the cell soma. …”
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Top-down input modulates visual context processing through an interneuron-specific circuit by Georgia Bastos, Jacob T. Holmes, Jordan M. Ross, Anna M. Rader, Connor G. Gallimore, Joseph A. Wargo, Darcy S. Peterka, Jordan P. Hamm

“…Two-photon imaging in the V1 revealed that mainly pyramidal neurons exhibited deviance detection, while contextually redundant stimuli increased vasoactive intestinal peptide (VIP)-positive interneuron (VIP) activity and decreased somatostatin-positive interneuron (SST) activity. Optogenetic drive of ACa-V1 inputs at 10 Hz activated V1-VIPs but inhibited V1-SSTs, mirroring the dynamics present during the oddball paradigm. …”
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Superior colliculus drives stimulus-evoked directionally biased saccades and attempted head movements in head-fixed mice by Sebastian H Zahler, David E Taylor, Joey Y Wong, Julia M Adams, Evan H Feinberg

“…Differences in saccade endpoints across stimuli are associated with distinct stimulus-dependent relationships between initial eye position and saccade direction and amplitude. Optogenetic perturbations revealed SC drives these gaze shifts. …”
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Potential and Realized Impact of Astroglia Ca2 + Dynamics on Circuit Function and Behavior by Eunice Y. Lim, Eunice Y. Lim, Liang Ye, Martin Paukert, Martin Paukert

“…Some experiments that revealed the most compelling behavioral alterations employed chemogenetic and optogenetic manipulations to modify astroglia Ca2+ signaling. …”
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Dopamine neuron glutamate cotransmission evokes a delayed excitation in lateral dorsal striatal cholinergic interneurons by Nao Chuhma, Susana Mingote, Leora Yetnikoff, Abigail Kalmbach, Thong Ma, Samira Ztaou, Anna-Claire Sienna, Sophia Tepler, Jean-Francois Poulin, Mark Ansorge, Rajeshwar Awatramani, Un Jung Kang, Stephen Rayport

“…We have found that optogenetic activation of dStr dopamine neuron terminals in mouse brain slices pauses the firing of cholinergic interneurons in both the medial and lateral subregions, while in the lateral subregion the pause is shorter due to a subsequent excitation. …”
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Prefrontal cortical dopamine deficit may cause impaired glucose metabolism in schizophrenia by Qiongqiong Wu, Yujun Long, Xingjie Peng, Chuhan Song, Jingmei Xiao, Xiaoyi Wang, Furu Liu, Peng Xie, Jinqing Yang, Zhe Shi, Zhonghua Hu, Colin McCaig, David St Clair, Bing Lang, Renrong Wu

“…To explore this, we optogenetically and chemogenetically inhibited the ventral tegmental area (VTA)-medial prefrontal cortex (mPFC) dopamine projection in mice and found both procedures caused glucose intolerance. …”
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Selective integration of diverse taste inputs within a single taste modality by Julia U Deere, Arvin A Sarkissian, Meifeng Yang, Hannah A Uttley, Nicole Martinez Santana, Lam Nguyen, Kaushiki Ravi, Anita V Devineni

“…We investigated this question in the Drosophila bitter taste system, which contains diverse bitter-sensing cells residing in different taste organs. First, we optogenetically activated subsets of bitter neurons within each organ. …”
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Dissociation of impulsive traits by subthalamic metabotropic glutamate receptor 4 by Lukasz Piszczek, Andreea Constantinescu, Dominic Kargl, Jelena Lazovic, Anton Pekcec, Janet R Nicholson, Wulf Haubensak

“…In vivo recorded STN neural activity encoded impulsive action as a separable state from basic motor control, characterized by decoupled STN/substantia nigra pars reticulata (SNr) mesoscale networks. Optogenetic modulation of STN activity bidirectionally controlled impulsive behavior. …”
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Role of the postinspiratory complex in regulating swallow–breathing coordination and other laryngeal behaviors by Alyssa Huff, Marlusa Karlen-Amarante, Luiz M Oliveira, Jan-Marino Ramirez

“…Here, we study the role of the postinspiratory complex (PiCo) in coordinating breathing and swallowing. Using optogenetic approaches in freely breathing anesthetized ChATcre:Ai32, Vglut2cre:Ai32 and intersectional recombination of ChATcre:Vglut2FlpO:ChR2 mice reveals PiCo mediates airway protective behaviors. …”
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Adrenergic modulation of melanocortin pathway by hunger signals by Nilufer Sayar-Atasoy, Connor Laule, Iltan Aklan, Hyojin Kim, Yavuz Yavuz, Tayfun Ates, Ilknur Coban, Fulya Koksalar-Alkan, Jacob Rysted, Debbie Davis, Uday Singh, Muhammed Ikbal Alp, Bayram Yilmaz, Huxing Cui, Deniz Atasoy

“…This pattern is recapitulated by the innervating catecholaminergic axon terminals originating from NTSTH-neurons. Optogenetic activation of rostral-NTSTH → PVN projection elicited strong motivation to eat comparable to overnight fasting whereas its inhibition attenuated both fasting-induced & hypoglycemic feeding. …”
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New Insights of SF1 Neurons in Hypothalamic Regulation of Obesity and Diabetes by Anna Fosch, Sebastián Zagmutt, Núria Casals, Rosalía Rodríguez-Rodríguez

“…In the last 15 years, investigations using transgenic models, optogenetic, and chemogenetic approaches have revealed that SF1 neurons in the ventromedial hypothalamus are a specific lead in the brain’s ability to sense glucose levels and conduct insulin and leptin signaling in energy expenditure and glucose homeostasis, with minor feeding control. …”
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An increase of inhibition drives the developmental decorrelation of neural activity by Mattia Chini, Thomas Pfeffer, Ileana Hanganu-Opatz

“…This process is accompanied by a concomitant tilting of excitation-inhibition (E-I) ratio toward inhibition. Using optogenetic manipulations and neural network modeling, we show that the two phenomena are mechanistically linked, and that a relative increase of inhibition drives the decorrelation of neural activity. …”
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Spatiotemporal control of necroptotic cell death and plasma membrane recruitment using engineered MLKL domains by Amir Taslimi, Kaiah M. Fields, Kristin D. Dahl, Qi Liu, Chandra L. Tucker

“…In additional studies, we re-engineered MLKL to block its cell-killing capacity but retain light-mediated membrane recruitment, developing a new single-component optogenetic tool that allows modulation of protein function at the plasma membrane.…”
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Cholinergic Signals in Mouse Barrel Cortex during Active Whisker Sensing by Emmanuel Eggermann, Yves Kremer, Sylvain Crochet, Carl C.H. Petersen

“…However, a whisking-related cortical state change persists after thalamic inactivation, which is mediated at least in part by acetylcholine, as we show here by using whole-cell recordings, local pharmacology, axonal calcium imaging, and optogenetic stimulation. During whisking, we find prominent cholinergic signals in the barrel cortex, which suppress spontaneous cortical activity. …”
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Reduced Insulin-Like Growth Factor-I Effects in the Basal Forebrain of Aging Mouse by Jonathan A. Zegarra-Valdivia, Jonathan A. Zegarra-Valdivia, Jonathan A. Zegarra-Valdivia, Jonathan A. Zegarra-Valdivia, Irene Chaves-Coira, Maria Estrella Fernandez de Sevilla, Maria Estrella Fernandez de Sevilla, Laura Martinez-Rachadell, Laura Martinez-Rachadell, Julio Esparza, Ignacio Torres-Aleman, Ignacio Torres-Aleman, Ignacio Torres-Aleman, Angel Nuñez

“…IGF-I increased the activity of optogenetically-identified cholinergic neurons in young animals, suggesting that most of the IGF-I-induced excitatory effects were mediated by activation of these neurons. …”
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Genetic Constructs for the Control of Astrocytes’ Activity by Anastasia A. Borodinova, Pavel M. Balaban, Ilya B. Bezprozvanny, Alla B. Salmina, Olga L. Vlasova

“…Practical applications of optogenetic approaches utilizing different genetically encoded opsins to control astroglia activity were evaluated. …”
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