Population imaging of neural activity in awake behaving mice by Piatkevich, Kiryl D., Bensussen, Seth, Tseng, Hua-an, Shroff, Sanaya N., Lopez-Huerta, Violeta Gisselle, Park, Demian, Jung, Erica E., Shemesh, Or A., Straub, Christoph, Gritton, Howard J., Romano, Michael F., Costa, Emma, Sabatini, Bernardo L., Fu, Zhanyan, Boyden, Edward S., Han, Xue

“…Here we describe a genetically encoded fluorescent voltage indicator, SomArchon, which exhibits millisecond response times and is compatible with optogenetic control, and which increases the sensitivity, signal-to-noise ratio, and number of neurons observable several-fold over previously published fully genetically encoded reagents1–8. …”
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Targeting thalamic circuits rescues motor and mood deficits in PD mice by Zhang, Ying, Roy, Dheeraj S, Zhu, Yi, Chen, Yefei, Aida, Tomomi, Hou, Yuanyuan, Shen, Chenjie, Lea, Nicholas E, Schroeder, Margaret E, Skaggs, Keith M, Sullivan, Heather A, Fischer, Kyle B, Callaway, Edward M, Wickersham, Ian R, Dai, Ji, Li, Xiao-Ming, Lu, Zhonghua, Feng, Guoping

“…Whereas chemogenetically manipulating CPu-projecting PF neurons led to a long-term restoration of locomotion, optogenetic long-term potentiation (LTP) at PF→STN synapses restored motor learning behaviour in an acute mouse model of PD. …”
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High-Throughput Single-Cell Manipulation in Brain Tissue by Steinmeyer, Joseph Daly, Yanik, Mehmet Fatih

“…Our platform could also be used to rapidly deliver, both ex vivo and in vivo, a variety of genetic vectors, including optogenetic and cell-type specific agents, as well as fast-acting reagents such as labeling dyes, calcium sensors, and voltage sensors to manipulate and track neuronal circuit activity at single-cell resolution.…”
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The Projection From Ventral CA1, Not Prefrontal Cortex, to Nucleus Accumbens Core Mediates Recent Memory Retrieval of Cocaine-Conditioned Place Preference by Yiming Zhou, Enhui Yan, Deqin Cheng, Huiwen Zhu, Zhiyuan Liu, Xi Chen, Lan Ma, Xing Liu

“…Furthermore, chemogenetic inhibition of the AcbC-projecting vCA1 neurons, but not the AcbC-projecting mPFC neurons, decreased the expression of cocaine-CPP. Optogenetic inhibition of the vCA1–AcbC projection, but not the mPFC–AcbC projection, also reduced the preference for the cocaine-paired compartment. …”
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Blue light excited retinal intercepts cellular signaling by Kasun Ratnayake, John L. Payton, O. Harshana Lakmal, Ajith Karunarathne

“…Using live cell imaging and optogenetic signaling control, we uncovered that blue light-excited ATR and 11CR irreversibly change/distort plasma membrane (PM) bound phospholipid; phosphatidylinositol 4,5 bisphosphate (PIP2) and disrupt its function. …”
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Caffeine Functions by Inhibiting Dorsal and Ventral Hippocampal Adenosine 2A Receptors to Modulate Memory and Anxiety, Respectively by Yawei Xu, Yalei Ning, Yan Zhao, Yan Peng, Fen Luo, Yuanguo Zhou, Ping Li

“…These results, together with the enhanced memory of dorsal hippocampus A2AR knockout mice and greater anxiety-like behavior of ventral hippocampus A2AR knockout mice without caffeine, indicates a dissociation between the roles of ventral and dorsal hippocampal A2A receptors in caffeine’s effects on anxiety-like and memory-related behavioral measures, respectively. Furthermore, optogenetic activation of dorsal or ventral hippocampal A2ARs reversed the behavioral alterations caused by drinking caffeine, leading to impaired memory or decreased anxiety-like behaviors, respectively. …”
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Multidimensional characterization of inducible promoters and a highly light-sensitive LOV-transcription factor by Vojislav Gligorovski, Ahmad Sadeghi, Sahand Jamal Rahi

“…Using budding yeast, we characterize GAL1pr, GALL, MET3pr, CUP1pr, PHO5pr, tetOpr, terminator-tetOpr, Z3EV, blue-light inducible optogenetic systems El222-LIP, El222-GLIP, and red-light inducible PhyB-PIF3. …”
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Inhibitory feedback from the motor circuit gates mechanosensory processing in Caenorhabditis elegans. by Sandeep Kumar, Anuj K Sharma, Andrew Tran, Mochi Liu, Andrew M Leifer

“…By performing high-throughput optogenetic perturbations triggered on behavior, we show that turning-associated neurons SAA, RIV, and/or SMB suppress mechanosensory-evoked reversals during turns. …”
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Dopamine neurons do not constitute an obligatory stage in the final common path for the evaluation and pursuit of brain stimulation reward. by Ivan Trujillo-Pisanty, Kent Conover, Pavel Solis, Daniel Palacios, Peter Shizgal

“…We re-evaluated this relationship by psychophysical, pharmacological, optogenetic, and computational means. In rats working for direct, optical activation of midbrain dopamine neurons, we varied the strength and opportunity cost of the stimulation and measured time allocation, the proportion of trial time devoted to reward pursuit. …”
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What do we gain from gamma? Local dynamic gain modulation drives enhanced efficacy and efficiency of signal transmission by Ulf Knoblich, Joshua H Siegle, Dominique L Pritchett, Christopher I Moore

“…We recently showed that optogenetic drive of fast-spiking interneurons (FS) at 40 Hz in mouse neocortex in vivo modulates the spike count and precision of sensory evoked responses. …”
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Visualization of oxytocin release that mediates paired pulse facilitation in hypothalamic pathways to brainstem autonomic neurons. by Ramón A Piñol, Heather Jameson, Anastas Popratiloff, Norman H Lee, David Mendelowitz

“…In this study, using rats, we directly show, using sniffer CHO cells that express oxytocin receptors and the Ca2+ indicator R-GECO, that optogenetic activation of channelrhodopsin-2 (ChR2) expressing PVN fibers in the brainstem activates oxytocin receptors in the dorsomotor nucleus of the vagus (DMNV). …”
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Identification of a Group of GABAergic Neurons in the Dorsomedial Area of the Locus Coeruleus. by Xin Jin, Shanshan Li, Brian Bondy, Weiwei Zhong, Max F Oginsky, Yang Wu, Christopher M Johnson, Shuang Zhang, Ningren Cui, Chun Jiang

“…Although GABA is the major inhibitory neurotransmitter of LC neurons, the modulation of LC neuronal firing activity by local GABAergic interneurons remains poorly understood with respect to their precise location, intrinsic membrane properties and synaptic modulation. Here, we took an optogenetic approach to address these questions. Channelrhodopsin (ChR2) in a tandem with the yellow fluorescent protein (YFP) was expressed in GABAergic neurons under the control of glutamic acid decarboxylase 2 (GAD2) promoter. …”
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Sodium salicylate suppresses GABAergic inhibitory activity in neurons of rodent dorsal raphe nucleus. by Yan Jin, Bin Luo, Yan-Yan Su, Xin-Xing Wang, Liang Chen, Ming Wang, Wei-Wen Wang, Lin Chen

“…We next examined whether the observed depression of GABAergic activity would cause an increase in the excitability of 5-HTergic neurons using optogenetic technique in DRN slices of the transgenic mouse with channelrhodopsin-2 expressed in GABAergic neurons. …”
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Alterations in kainate receptor and TRPM1 localization in bipolar cells after retinal photoreceptor degeneration by Jacqueline eGayet-Primo, Theresa ePuthussery

“…These findings demonstrate that Off bipolar cells retain dendritic glutamate receptors during retinal degeneration and could thus serve as a conduit for signal transmission from transplanted or optogenetically-restored photoreceptors.…”
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NMDA receptor activation induces long-term potentiation of glycine synapses. by Michelle L Kloc, Bruno Pradier, Anda M Chirila, Julie A Kauer

“…Repetitive depolarization alone of the postsynaptic GABAergic neuron also potentiated glycinergic synapses, and intracellular EGTA prevented both NMDA-induced and depolarization-induced potentiation of glycinergic IPSCs. Optogenetic activation of trpv1 lineage afferents also triggered NMDAR-dependent potentiation of glycinergic synapses. …”
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A locomotor neural circuit persists and functions similarly in larvae and adult Drosophila by Kristen Lee, Chris Q Doe

“…MDN-Pair1 connectivity is lost during early pupal stages, when both neurons are severely pruned back, but connectivity is re-established at mid-pupal stages and persist into the adult. In the adult, optogenetic activation of Pair1 resulted in arrest of forward locomotion, similar to what is observed in larvae. …”
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Monosynaptic trans-collicular pathways link mouse whisker circuits to integrate somatosensory and motor cortical signals. by Jesús Martín-Cortecero, Emilio Ulises Isaías-Camacho, Berin Boztepe, Katharina Ziegler, Rebecca Audrey Mease, Alexander Groh

“…Intersectional approaches and optogenetically assisted connectivity quantifications in vivo reveal convergence of motor and somatosensory cortical input on individual SC neurons, providing a new framework for sensory-motor integration in the SC. …”
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Dopamine Neurons Mediate Learning and Forgetting through Bidirectional Modulation of a Memory Trace by Jacob A. Berry, Anna Phan, Ronald L. Davis

“…Conditioning with a second odor restores the responses of MBOn-γ2α′1 to a previously learned odor while depressing responses to the newly learned odor, showing that learning and forgetting can occur simultaneously. Moreover, optogenetic activation of DAn-γ2α′1 is sufficient for the bidirectional modulation of MBOn-γ2α′1 response properties. …”
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Minimal size of cell assemblies coordinated by gamma oscillations. by Christoph Börgers, Giovanni Talei Franzesi, Fiona E N Lebeau, Edward S Boyden, Nancy J Kopell

“…This observation suggests explanations for recent experimental results concerning the modulation of gamma oscillations in macaque primary visual cortex by varying spatial stimulus size or attention level, and for our own experimental results, reported here, concerning the optogenetic modulation of gamma oscillations in kainate-activated hippocampal slices. …”
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Phasic and Tonic Locus Coeruleus Stimulation Associated Valence Learning Engages Distinct Adrenoceptors in the Rat Basolateral Amygdala by Tamunotonye Omoluabi, Kyron D. Power, Tayebeh Sepahvand, Qi Yuan

“…Here, we ask if phasic and tonic LC activation-associated valence learning requires different adrenoceptors in the BLA, in comparison with the odor valence learning induced by natural reward and aversive conditioning. Using optogenetic activation of the LC and local drug infusions in the BLA, we show that phasic LC activation-induced positive odor valence learning is dependent on both α1 and β-adrenoceptors, whereas tonic LC activation induced-negative odor valence learning depends on β-adrenoceptors only. …”
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