Investigating translaminar signaling from layer 5 Pyramidal subpopulations to layer 2/3 in Somatosensory Cortex by Von Klemperer, A

“…In the first series of experiments, transgenic mice expressing the optogenetic activator, channelrhodopsin-2 (ChR2), were used to stimulate a non-specific population of L5 pyramidal neurons. …”

Engineering rhodopsin-based artificial photosynthesis by Tu, W

“…In this work, <em>Gloeobacter</em> rhodopsin (GR) was employed as an optogenetic tool to engineer <em>Ralstonia eutropha</em> H16 and <em>Shewanella oneidensis</em> MR-1 for CO2 fixation and H2 production, respectively. …”

Striatal GABA transporter regulation of dopamine release and dysfunction in Parkinsonian models by Roberts, BM

“…Furthermore, GABA receptor antagonists significantly enhanced DA release evoked by optogenetic stimulation, indicating that DA release is under tonic inhibition by striatal GABA. …”

Investigating the effect of melanopsin gene therapy in the degenerate retina by De Silva, S

“…Therefore with further development, this optogenetic strategy has great potential for the treatment of patients with end-stage retinal degeneration.…”

Striatal Cholinergic Interneurons Modulate Spike-Timing in Striosomes and Matrix by an Amphetamine-Sensitive Mechanism by Crittenden, Jill R, Lacey, Carolyn Jane, Weng, Feng-Ju, Garrison, Catherine E., Gibson, Daniel J, Lin, Yingxi, Graybiel, Ann M

“…We show here, by slice electrophysiology in transgenic mice, that repetitive evoked firing patterns in striosomal and matrix striatal projection neurons (SPNs) are interrupted by optogenetic activation of cholinergic interneurons either by the addition or the deletion of spikes. …”
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Cerebellar modulation of anxiety: serotonergic involvement examined via a new 5-HT sensor by Chin, Pei Wern, Wan, Jinxia, Li, Yulong, Augustine, George James

“…To determine whether 5-HT levels affect anxiety, we optogenetically controlled the activity of serotonergic axons in lobule VII of a transgenic mouse line expressing channelrhodopsin or archaerhodopsin in serotonergic neurons (PNAS 102:16472). …”
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Corticofugal regulation of predictive coding by Alexandria MH Lesicko, Christopher F Angeloni, Jennifer M Blackwell, Mariella De Biasi, Maria N Geffen

“…We tested the effect of optogenetic inactivation of the auditory cortico-collicular feedback in awake mice on responses of IC neurons to stimuli designed to test prediction error and repetition suppression. …”
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Chronic Pain and the Endocannabinoid System: Smart Lipids – A Novel Therapeutic Option? by Walter Zieglgänsberger, Rudolf Brenneisen, Achim Berthele, Carsten T. Wotjak, Borwin Bandelow, Thomas R. Tölle, Beat Lutz

“…The advent of novel genomic, optogenetic, and viral tracing and imaging techniques will help to further detail therapeutically relevant functional and structural features. …”
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Iso-response methods provide direct insight into dendritic computations. by Stefan Häusler, Christoph Kirst

“…These results demonstrate that iso-response methods are well suited to unravel complex dendritic computations in model neurons and that they can provide a powerful tool for experimental research with applications in multi-patch or optogenetic recordings.…”
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Network response of brain microvasculature to neuronal stimulation by James R Mester, Matthew W Rozak, Adrienne Dorr, Maged Goubran, John G Sled, Bojana Stefanovic

“…Using 3D two-photon fluorescence microscopy data, we quantified blood volume and flow changes in the brain vessels in response to spatially targeted optogenetic activation of cortical pyramidal neurons. …”
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Reliable Sensory Processing in Mouse Visual Cortex through Cooperative Interactions between Somatostatin and Parvalbumin Interneurons by Rikhye, Rajeev Vijay, Yildirim, Murat, Han, Ming-Hu, Breton-Provencher, Vincent, Sur, Mriganka

“…To dissect the role of this circuit in pyramidal neuron activity, we used temporally limited optogenetic activation and inactivation of SST and PV interneurons during periods of reliable and unreliable pyramidal cell firing. …”
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Intracellular chloride and hydrogen ion dynamics in the nervous system by Raimondo, J

“…These principles were extended to demonstrate that popular optogenetic strategies for silencing neural activity have different effects upon GABAAR transmission. …”

Using human induced pluripotent stem cells to reveal astrocyte-neuron interactions in health and disease by Hedegaard, A

“…Next, I develop an optogenetic paradigm for directly eliciting membrane depolarisation and Ca²⁺ events in astrocytes. …”

Cellular mechanisms and function of hippocampal gamma oscillations by Antonoudiou, P

“…Here, we took advantage of optogenetic techniques to test the involvement of parvalbumin- and somatostatinexpressing interneurons in a well studied model of carbachol-induced gamma oscillations in the hippocampal CA3 in vitro. …”

Monitoring and controlling GABAergic interneuron subtypes during epileptiform activity by Calin, A

“…To investigate the impact of this process, I use a light-activated optogenetic tool to induce brief hyperpolarisations of the PV interneuron membrane potential. …”

Cholinergic neurons in the dorsomedial hypothalamus regulate mouse brown adipose tissue metabolism by Jae Hoon Jeong, Dong Kun Lee, Clemence Blouet, Henry H. Ruiz, Christoph Buettner, Streamson Chua, Jr., Gary J. Schwartz, Young-Hwan Jo

“…Physiological studies in response to optogenetic stimulation of DMH cholinergic neurons were combined with gene expression and immunocytochemical analyses. …”
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Dysfunction of the Hippocampal-Lateral Septal Circuit Impairs Risk Assessment in Epileptic Mice by Yi Cao, Yi Cao, Chongyang Sun, Jianyu Huang, Jianyu Huang, Peng Sun, Peng Sun, Lulu Wang, Shuyu He, Jianxiang Liao, Zhonghua Lu, Yi Lu, Cheng Zhong

“…In particular, the dorsal dentate gyrus and CA3 somatostatin-positive neurons and dorsal lateral septum cholecystokinin-positive neurons are selectively vulnerable to damage after temporal lobe epilepsy. Optogenetic activation of the hippocampal glutamatergic neurons or chemogenetic inhibition of the hippocampal somatostatin neurons directly disrupts RA, suggesting that an excitation/inhibition imbalance in the dHPC dorsal lateral septum circuit results in the impairment of RA behavior. …”
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Multiplex Neural Circuit Tracing With G-Deleted Rabies Viral Vectors by Toshiaki Suzuki, Nao Morimoto, Nao Morimoto, Akinori Akaike, Fumitaka Osakada, Fumitaka Osakada, Fumitaka Osakada, Fumitaka Osakada

“…Pseudotyping of RVΔG with the foreign envelope EnvA permits expression of transgenes such as fluorescent proteins, genetically-encoded sensors, or optogenetic tools in cells expressing TVA, a cognate receptor for EnvA. …”
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Gender difference in the associations between health literacy and problematic mobile phone use in Chinese middle school students by Dan-Lin Li, Sizhe Wang, Daoxu Zhang, Rong Yang, Jie Hu, Yanni Xue, Xuexue Huang, Yuhui Wan, Chen-Wei Pan, Jun Fang, Shichen Zhang

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Advancing homogeneous networking principles for the development of fatigue-resistant, low-swelling and sprayable hydrogels for sealing wet, dynamic and concealed wounds in vivo by Yi Zhang, Yanjun Pan, Ronghang Chang, Kangli Chen, Kun Wang, Haoqi Tan, Meng Yin, Changsheng Liu, Xue Qu

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