Single- and two-photon imaging of human micrometastases and disseminated tumour cells with conjugates of nanobodies and quantum dots by Fernanda Ramos-Gomes, Julia Bode, Alyona Sukhanova, Svetlana V. Bozrova, Mara Saccomano, Miso Mitkovski, Julia Eva Krueger, Anja K. Wege, Walter Stuehmer, Pavel S. Samokhvalov, Daniel Baty, Patrick Chames, Igor Nabiev, Frauke Alves

Get full text

Fragile X Mental Retardation Protein Regulates Activity-Dependent Membrane Trafficking and Trans-Synaptic Signaling Mediating Synaptic Remodeling by James C. Sears, Kendal Broadie, Kendal Broadie, Kendal Broadie

“…Consistent with FXS hyperexcitation, FMRP loss defects are phenocopied by heightened sensory experience and targeted optogenetic hyperexcitation during this critical period. …”
Get full text

3177 Determining mechanisms underlying hippocampal network disruption in early amyloid pathology by Adam Caccavano, P. Lorenzo Bozzelli, Katherine Conant, Stefano Vicini

“…These findings provide a foundation for future in vivo studies employing optogenetic stimulation to this neuronal sub-type, to determine if restoring physiological network balance can ameliorate memory decline.…”
Get full text

Theta-Nested Gamma Oscillations in Next Generation Neural Mass Models by Marco Segneri, Hongjie Bi, Hongjie Bi, Simona Olmi, Simona Olmi, Alessandro Torcini, Alessandro Torcini

“…In a series of recent experiments in vitro it has been possible to replicate with an optogenetic theta frequency stimulation several features of cross-frequency coupling (CFC) among theta and gamma rhythms observed in behaving animals. …”
Get full text

The effect of reactive Bergmann glia on short-term synaptic plasticity in cerebellar neurodegenerative models, caused by chronic activation of ChR2 and expression of the mutant ata... by Аnton N. Shuvaev, Оlga S. Belozor, Oleg I. Mozjei, Daria A. Yakovleva, Аndrey N. Shuvaev, Marina V. Smolnikova, Еlena A. Pozhilenkova, S. . Каsparov, Vladimir V. Salmin, Аlla B. Salmina

“…This study aimed to investigate the effect of the astrocytic link on paired-pulse facilitation (PPF) in cerebellar cortical synapses of mice, using a set of immunohistochemical, optogenetic, and electrophysiological analysis methods. …”
Get full text

Sensorimotor transformation and information coding across cortex during perceptual decisions by Pho, Gerald N. (Gerald Norman)

Get full text

Rewiring neural conduits : engineering neuromuscular tissues for bidirectional neuroprosthetic interfacing by Srinivasan, Shriya, author.

Get full text

Investigating translaminar signaling from layer 5 Pyramidal subpopulations to layer 2/3 in Somatosensory Cortex by Von Klemperer, A

“…In the first series of experiments, transgenic mice expressing the optogenetic activator, channelrhodopsin-2 (ChR2), were used to stimulate a non-specific population of L5 pyramidal neurons. …”

Engineering rhodopsin-based artificial photosynthesis by Tu, W

“…In this work, <em>Gloeobacter</em> rhodopsin (GR) was employed as an optogenetic tool to engineer <em>Ralstonia eutropha</em> H16 and <em>Shewanella oneidensis</em> MR-1 for CO2 fixation and H2 production, respectively. …”

Striatal GABA transporter regulation of dopamine release and dysfunction in Parkinsonian models by Roberts, BM

“…Furthermore, GABA receptor antagonists significantly enhanced DA release evoked by optogenetic stimulation, indicating that DA release is under tonic inhibition by striatal GABA. …”

Investigating the effect of melanopsin gene therapy in the degenerate retina by De Silva, S

“…Therefore with further development, this optogenetic strategy has great potential for the treatment of patients with end-stage retinal degeneration.…”

Striatal Cholinergic Interneurons Modulate Spike-Timing in Striosomes and Matrix by an Amphetamine-Sensitive Mechanism by Crittenden, Jill R, Lacey, Carolyn Jane, Weng, Feng-Ju, Garrison, Catherine E., Gibson, Daniel J, Lin, Yingxi, Graybiel, Ann M

“…We show here, by slice electrophysiology in transgenic mice, that repetitive evoked firing patterns in striosomal and matrix striatal projection neurons (SPNs) are interrupted by optogenetic activation of cholinergic interneurons either by the addition or the deletion of spikes. …”
Get full text
Get full text
Get full text

Cerebellar modulation of anxiety: serotonergic involvement examined via a new 5-HT sensor by Chin, Pei Wern, Wan, Jinxia, Li, Yulong, Augustine, George James

“…To determine whether 5-HT levels affect anxiety, we optogenetically controlled the activity of serotonergic axons in lobule VII of a transgenic mouse line expressing channelrhodopsin or archaerhodopsin in serotonergic neurons (PNAS 102:16472). …”
Get full text

Corticofugal regulation of predictive coding by Alexandria MH Lesicko, Christopher F Angeloni, Jennifer M Blackwell, Mariella De Biasi, Maria N Geffen

“…We tested the effect of optogenetic inactivation of the auditory cortico-collicular feedback in awake mice on responses of IC neurons to stimuli designed to test prediction error and repetition suppression. …”
Get full text

Chronic Pain and the Endocannabinoid System: Smart Lipids – A Novel Therapeutic Option? by Walter Zieglgänsberger, Rudolf Brenneisen, Achim Berthele, Carsten T. Wotjak, Borwin Bandelow, Thomas R. Tölle, Beat Lutz

“…The advent of novel genomic, optogenetic, and viral tracing and imaging techniques will help to further detail therapeutically relevant functional and structural features. …”
Get full text

Iso-response methods provide direct insight into dendritic computations. by Stefan Häusler, Christoph Kirst

“…These results demonstrate that iso-response methods are well suited to unravel complex dendritic computations in model neurons and that they can provide a powerful tool for experimental research with applications in multi-patch or optogenetic recordings.…”
Get full text

Network response of brain microvasculature to neuronal stimulation by James R Mester, Matthew W Rozak, Adrienne Dorr, Maged Goubran, John G Sled, Bojana Stefanovic

“…Using 3D two-photon fluorescence microscopy data, we quantified blood volume and flow changes in the brain vessels in response to spatially targeted optogenetic activation of cortical pyramidal neurons. …”
Get full text

Reliable Sensory Processing in Mouse Visual Cortex through Cooperative Interactions between Somatostatin and Parvalbumin Interneurons by Rikhye, Rajeev Vijay, Yildirim, Murat, Han, Ming-Hu, Breton-Provencher, Vincent, Sur, Mriganka

“…To dissect the role of this circuit in pyramidal neuron activity, we used temporally limited optogenetic activation and inactivation of SST and PV interneurons during periods of reliable and unreliable pyramidal cell firing. …”
Get full text

Intracellular chloride and hydrogen ion dynamics in the nervous system by Raimondo, J

“…These principles were extended to demonstrate that popular optogenetic strategies for silencing neural activity have different effects upon GABAAR transmission. …”

Using human induced pluripotent stem cells to reveal astrocyte-neuron interactions in health and disease by Hedegaard, A

“…Next, I develop an optogenetic paradigm for directly eliciting membrane depolarisation and Ca²⁺ events in astrocytes. …”