AGA induces sub-G1 cell cycle arrest and apoptosis in human colon cancer cells through p53-independent/p53-dependent pathway by Bou-Yue Peng, Abhinay Kumar Singh, Chun-Hao Chan, Yue-Hua Deng, Pin-Ying Li, Chun-Wei Su, Chia-Yu Wu, Win-Ping Deng

“…AGA is a combination of traditional Chinese medicine Antler’s extract (A), Ganoderma lucidum (G), and Antrodia camphorata (A); it contains a lot of biomolecules like polysaccharides, fatty acids, and triterpenoids that are known to exerting anti-oxidative, anti-inflammatory, anti-microbial and anti-tumor activities in oral cancer. In this study, we investigate AGA anti-proliferative, anti-metastatic and apoptotic activity to explore its anti-cancer activity against colon cancer cells and its underlying mechanism. …”
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The Relationships Between Social Media and Human Papillomavirus Awareness and Knowledge: Cross-sectional Study by Soojung Jo, Keenan A Pituch, Nancy Howe

“…However, fewer respondents were knowledgeable about the relationships between HPV and penile cancer (19.18%), anal cancer (18.33%), and oral cancer (19.86%). Although social media usage is associated with HPV awareness, HPV vaccine awareness, and knowledge of cervical cancer, these associations were not significant after adjusting for demographic variables. …”
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Fabrication of a Three-Dimensional Spheroid Culture System for Oral Squamous Cell Carcinomas Using a Microfabricated Device by Reiko Ikeda-Motonakano, Fumika Hirabayashi-Nishimuta, Naomi Yada, Ryota Yamasaki, Yoshie Nagai-Yoshioka, Michihiko Usui, Kohji Nakazawa, Daigo Yoshiga, Izumi Yoshioka, Wataru Ariyoshi

“…These results suggest that our spheroid culture system may be a high-throughput tool for producing uniform CSCs in large numbers from oral cancer cells.…”
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Compositional and functional changes in the salivary microbiota related to oral leukoplakia and oral squamous cell carcinoma: a case control study by Qingying Lan, Chang Zhang, Hong Hua, Xiaosheng Hu

“…The oral microbiota may influence oral cancer progression, but the salivary bacterial composition and functional changes in OSCC and OLK have not been comprehensively elucidated. …”
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Licochalcone B Induces ROS-Dependent Apoptosis in Oxaliplatin-Resistant Colorectal Cancer Cells via p38/JNK MAPK Signaling by Ah-Won Kwak, Woo-Keun Kim, Seung-On Lee, Goo Yoon, Seung-Sik Cho, Ki-Taek Kim, Mee-Hyun Lee, Yung Hyun Choi, Jin-Young Lee, Jin Woo Park, Jung-Hyun Shim

“…Licochalcone B (LCB) exhibits anticancer activity in oral cancer, lung cancer, and hepatocellular carcinoma cells. …”
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Therapeutic Potential of Dimethyl Fumarate in Counteract Oral Squamous Cell Carcinoma Progression by Modulating Apoptosis, Oxidative Stress and Epithelial–Mesenchymal Transition by Rossella Basilotta, Marika Lanza, Alessia Filippone, Giovanna Casili, Deborah Mannino, Federica De Gaetano, Giulia Chisari, Lorenzo Colarossi, Gianmarco Motta, Michela Campolo, Salvatore Cuzzocrea, Irene Paterniti, Emanuela Esposito

“…Therefore, based on these results, the use of DMF could be considered a promising strategy to counteract oral cancer progression.…”
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Collagen Induces a More Proliferative, Migratory and Chemoresistant Phenotype in Head and Neck Cancer via DDR1 by Sook Ling Lai, May Leng Tan, Robert J. Hollows, Max Robinson, Maha Ibrahim, Sandra Margielewska, E. Kenneth Parkinson, Anand Ramanathan, Rosnah Binti Zain, Hisham Mehanna, Rachel J. Spruce, Wenbin Wei, Ivy Chung, Paul G. Murray, Lee Fah Yap, Ian C. Paterson

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The Nasopharyngeal Carcinoma and Its Effect on the Infectious Eye Disease: A Nationwide Cohort Study by Chia-Yi Lee, Ming-Ju Hsieh, Jing-Yang Huang, Yih-Shiou Hwang, Chao-Kai Chang, Hung-Chi Chen, Shun-Fa Yang

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PGC-1α inhibits the NLRP3 inflammasome via preserving mitochondrial viability to protect kidney fibrosis by Bo Young Nam, Jong Hyun Jhee, Jimin Park, Seonghun Kim, Gyuri Kim, Jung Tak Park, Tae-Hyun Yoo, Shin-Wook Kang, Je-Wook Yu, Seung Hyeok Han

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Establishment of a <i>p53</i> Null Murine Oral Carcinoma Cell Line and the Identification of Genetic Alterations Associated with This Carcinoma by Kuo-Wei Chang, Chia-En Lin, Hsi-Feng Tu, Hsin-Yao Chung, Yi-Fen Chen, Shu-Chun Lin

“…This study describes the establishment and characterization of the MPC-1 cell line and this new cell model should help to advance genetic research into oral cancer.…”
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Genetically predicted circulating levels of cytokines and the risk of oral cavity and pharyngeal cancer: a bidirectional mendelian-randomization study by Kehan Wu, Qianhui Sun, Dongxu Liu, Jiayi Lu, Deyu Wen, Xiyan Zang, Li Gao

“…Background: Epidemiological research has established associations between various inflammatory cytokines and the occurrence of oral cancer and oropharyngeal cancer (OCPC). We performed a Mendelian randomization (MR) analysis to systematically investigate the causal relationship between inflammatory cytokines and OCPC.Methods: We performed a bidirectional two-sample MR analysis using OCPC from 12 studies (6,034 cases and 6,585 controls) and genome-wide association study (GWAS) results for 41 serum cytokines from 8,293 Finns, respectively. …”
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Clinicopathological Significance of Cancer Stem Cell Markers (OCT-3/4 and SOX-2) in Oral Submucous Fibrosis and Oral Squamous Cell Carcinoma by Divyambika Catakapatri Venugopal, Cynthia Leslie Caleb, Nandhini Priyadarshini Kirupakaran, Vidyarani Shyamsundar, Soundharya Ravindran, Madhavan Yasasve, Arvind Krishnamurthy, Thamizhchelvan Harikrishnan, Sathasivasubramanian Sankarapandian, Vijayalakshmi Ramshankar

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A cost-effectiveness analysis of glass ionomer cement as fissure sealant in school-based fissure sealant programme in the district of Pontian, Johor by Yacob, Habibah

“…Introduction: Community oral Health Care mainly focused on preventive measures such fluoridation, oral health promotion, oral cancer screening and school-based fissure sealant programme. …”
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Lymph node metastasis in oral squamous cell carcinoma: Where we are and where we are going by Lei‐Ming Cao, Nian‐Nian Zhong, Zi‐Zhan Li, Fang‐Yi Huo, Yao Xiao, Bing Liu, Lin‐Lin Bu

“…Abstract Background Oral cancer is a common malignant tumour in the head and neck region, with over 90% of cases being oral squamous cell carcinoma (OSCC). …”
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Cytotoxic Tumour-Selective 1,5-Diaryl-3-Oxo-1,4-Pentadienes Mounted on a Piperidine Ring by Praveen K. Roayapalley, Hiroshi Sakagami, Keitaro Satoh, Shigeru Amano, Kenjiro Bandow, Renato J. Aguilera, Karla G. Cano Hernandez, Austre Y. Schiaffino Bustamante, Stephen G. Dimmock, Rajendra K. Sharma, Umashankar Das, Jonathan R. Dimmock

“…The highest specificity for oral cancer cells was displayed by <b>2e</b> and <b>2r</b>. …”
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Polygenic risk score-based phenome-wide association study of head and neck cancer across two large biobanks by Young Chan Lee, Sang-Hyuk Jung, Manu Shivakumar, Soojin Cha, Woong-Yang Park, Hong-Hee Won, Young-Gyu Eun, Penn Medicine Biobank, Dokyoon Kim

“…Methods We derived PRSs for HNSCC and its subgroups, oropharyngeal cancer and oral cancer, using large-scale genome-wide association study summary statistics from the Genetic Associations and Mechanisms in Oncology Network. …”
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Oral squamous cell carcinoma (OSCC) tumors from heavy alcohol consumers are associated with higher levels of TLR9 and a particular immunophenotype: Impact on patient survival by Nicolás Bolesina, Gerardo Gatti, Silvia López de Blanc, Sabrina Dhooge, Darío Rocha, Elmer Fernandez, Ruth Ferreyra, Vanesa Palla, Verónica Grupe, Rosana Morelatto, Mariana Maccioni

“…Oral squamous cell carcinoma (OSCC) is one of the most frequent types of oral cancer in developing countries and its burden correlates with exposure to tobacco and excessive alcohol consumption. …”
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A novel 3-miRNA network regulates tumour progression in oral squamous cell carcinoma by Aditi Patel, Parina Patel, Dushyant Mandlik, Kaustubh Patel, Pooja Malaviya, Kaid Johar, Krishna B.S Swamy, Shanaya Patel, Vivek Tanavde

“…Therefore, it is important to identify robust biomarkers that are detectable using non-invasive liquid biopsy techniques to facilitate the early diagnosis of oral cancer. This study identified potential salivary exosome-derived miRNA biomarkers and crucial miRNA-mRNA networks/underlying mechanisms responsible for OSCC progression. …”
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Behavioral phenotyping of cancer pain in domesticated cats with naturally occurring squamous cell carcinoma of the tongue: initial validation studies provide evidence for regional... by Yen-Hao Erik Lai, B. Duncan X. Lascelles, Michael W. Nolan

“…Based on these preliminary assessments, the assays described herein had reasonable inter-rater reliability, and they were able to both discriminate between cats with and without oral cancer, and respond in a predictable manner to analgesic therapy. …”
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Comparison of Absolute Expression and Turnover Number of COX-1 and COX-2 in Human and Rodent Cells and Tissues by Li L, Sun R, Zenga J, Himburg H, Wang L, Duan S, Liu J, Bui D, Xie Z, Du T, Xie L, Yin T, Wong S, Gao S, Hu M

“…LPS stimulation increased COX-2 protein expression in three cell lines (Raw 264.7, SCC9 and EOMA) as expected but unexpectedly increased COX-1 protein expression (13.8-fold) in EOMA cells.Conclusion: In human oral cancer tissues and cells as well as Pirc rat colon, COX-1 plays an unexpectedly but more important role than COX-2 in abnormal PGE2 production since COX-1 expression is much higher than COX-2. …”
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