Therapeutic potential of mangiferin in cancer: Unveiling regulatory pathways, mechanisms of action, and bioavailability enhancements – An updated review by Humaira Iqbal, Muhammad Inam‐Ur‐Raheem, Seemal Munir, Roshina Rabail, Sadia Kafeel, Arashi Shahid, Amin Mousavi Khaneghah, Rana Muhammad Aadil

“…This review paper reveals MGF's therapeutic, curative and protective potential impact against lung, liver, ovarian, prostate, breast, stomach, and oral cancers. MGF is used in various types of research in the form of powder, liquid extract, intramuscular, intravenous, nanoparticles coated with gold, in the form of a solution, or in combination with other drugs to evaluate synergistic effects. …”
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A Novel MDM2-Binding Chalcone Induces Apoptosis of Oral Squamous Cell Carcinoma by Guilherme Freimann Wermelinger, Lucas Rubini, Anna Carolina Carvalho da Fonseca, Gabriel Ouverney, Rafael P. R. F. de Oliveira, Acácio S. de Souza, Luana S. M. Forezi, Gabriel Limaverde-Sousa, Sergio Pinheiro, Bruno Kaufmann Robbs

“…Oral squamous cell carcinoma (OSCC) represents ~90% of all oral cancers, being the eighth most common cancer in men. …”
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Recent progress in carbon dots for anti-pathogen applications in oral cavity by Yuying Jiang, Yuying Jiang, Chuqiang Yin, Jianning Mo, Jianning Mo, Xiaoyu Wang, Xiaoyu Wang, Ting Wang, Guotai Li, Qihui Zhou

“…Their progress not only results in the irreversible destruction of teeth and other oral tissues but also closely links to oral cancers and systemic diseases. However, traditional treatment against oral infections by antibiotics is not effective enough due to microbial resistance and drug blocking by oral biofilms, along with the passive dilution of the drug on the infection site in the oral environment.Aim of reviewBesides the traditional antibiotic treatment, carbon dots (CDs) recently became an emerging antimicrobial and microbial imaging agent because of their excellent (bio)physicochemical performance. …”
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Role of Hemidesmosomes in Oral Carcinogenesis: A Systematic Review by Jordan Nguyen, Tze Wei Chong, Hafsa Elmi, Jiani Ma, John Madi, Asha Mamgain, Eileen Melendez, Julian Messina, Nikhil Mongia, Sanjana Nambiar, Tsu Jie Ng, Huy Nguyen, Michael McCullough, Federica Canfora, Lorraine A. O’Reilly, Nicola Cirillo, Rita Paolini, Antonio Celentano

“…Background: Oral cancers have limited diagnostic tools to aid clinical management. …”
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The role of altered microRNA expression in premalignant and malignant head and neck lesions with epithelial origin by Alieh Farshbaf, Farnaz Mohajertehran, Amirhossein Sahebkar, Yasaman Garmei, Parisa Sabbagh, Nooshin Mohtasham

“…Although more investigations are required to identify the most favorable miRNA candidate, altered expression of some miRNAs could be used as biomarkers in premalignant lesions and oral cancers with high sensitivity and specificity.…”
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Amount of DNA in plasma and cancer risk: A prospective study by Gormally, E, Hainaut, P, Caboux, E, Airoldi, L, Autrup, H, Malaveille, C, Dunning, A, Garte, S, Matullo, G, Overvad, K, Tjonneland, A, Clavel-Chapelon, F, Boffetta, P, Boeing, H, Trichopoulou, A, Palli, D, Krogh, V, Tumino, R, Panico, S, Bueno-De-Mesquita, H, Peeters, P, Lund, E, Gonzalez, C, Martinez, C, Dorronsoro, M

“…An elevated and statistically significant odds ratio (OR) was found for COPD deaths (OR = 2.53; 95% CI = 1.06-6.02), while nonsignificant increased ORs were present for oral cancers, cancers of the pharynx and larynx and leukemia. …”

Immune Checkpoint Inhibitors in Oral Cavity Squamous Cell Carcinoma and Oral Potentially Malignant Disorders: A Systematic Review by Omar Kujan, Bede van Schaijik, Camile S. Farah

“…In this systematic review, we searched five databases for keywords pertaining to oral cancers and OPMDs, along with immune checkpoint inhibitors, in order to summarize the current status of their use and efficacy in these diseases. …”
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Histomorphological evaluation of desmoplastic tumor stroma in malignant ovarian surface epithelial tumors by Sana Ahuja, Sufian Zaheer, Sunil Ranga

“…A reactive stroma rich in cancer-associated fibroblasts is associated with higher tumor grade and poorer prognosis in breast, colorectal, and oral cancers. Aims and Objectives: The present study was conducted to highlight the prognostic significance of tumor budding and fibrotic cancer stroma in malignant ovarian surface epithelial tumors with known prognostic parameters. …”
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Comparison of apoptotic bodies' count & mitotic index in oral squamous cell carcinoma with regional lymph node involvement by Maede Yousefi, Noushin Jalayer Naderi, Ahad Muhammadnejad

“…Background & objectives: In early stages of oral cancers, 20-40 per cent of cases have occult metastasis in cervical lymph nodes. …”
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Detection of Human Herpesvirus Type-1 Antigen in Tissues of Oral Squamous Cell Carcinoma by Direct Immunofluorecent Assay by Najwa Ahmed Mohammed, Areej Atiyah Hussein, Ahlam Hameed Majeed

“…Conclusion: The detection of human herpesvirus -1 antigen in oral squamous cell carcinoma and apparently healthy control indicates virus with other factor such as chemicals and radiation, which play important role in the development of oral cancers …”
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Flavonoids as Strong Inhibitors of MAPK3: A Computational Drug Discovery Approach by Amir Taherkhani, Parita Khodadadi, Lida Samie, Zahra Azadian, Zeynab Bayat

“…Mitogen-activated protein kinase 3 (MAPK3) mediates the onset, progression, metastasis, drug resistance, and poor prognosis in various malignancies, including glioma, liver, ovarian, thyroid, lung, breast, gastric, and oral cancers. Negative regulation of MAPK3 expression using miRNAs has led to therapeutic effects in cancer. …”
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CD44 Sorted Cells Have an Augmented Potential for Proliferation, Epithelial-Mesenchymal Transition, Stemness, and a Predominantly Inflammatory Cytokine and Angiogenic Secretome by Shankargouda Patil

“…The genetic and secretome profiling of the CD44+ CSCs could serve as diagnostic and prognostic tools in the treatment of oral cancers.…”
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Detection of Human Herpesvirus Type-1 Antigen in Tissues of Oral Squamous Cell Carcinoma by Direct Immunofluorecent Assay by Najwa Ahmed Mohammed, Areej Atiyah Hussein, Ahlam Hameed Majeed

“…Conclusion: The detection of human herpesvirus -1 antigen in oral squamous cell carcinoma and apparently healthy control indicates virus with other factor such as chemicals and radiation, which play important role in the development of oral cancers …”
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Inter professional initiative using service training to enable a fisher folk community to quit tobacco habits by Rajani Mary George

“…Dentists are in a strategic position to diagnose oral cancerous and precancerous lesions and facilitate tobacco cessation. …”
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Evaluation of human papillomavirus antibodies and risk of subsequent head and neck cancer. by Kreimer, A, Johansson, M, Waterboer, T, Kaaks, R, Chang-Claude, J, Drogen, D, Tjønneland, A, Overvad, K, Quirós, JR, González, C, Sánchez, M, Larrañaga, N, Navarro, C, Barricarte, A, Travis, R, Khaw, K, Wareham, N, Trichopoulou, A, Lagiou, P, Trichopoulos, D, Peeters, P, Panico, S, Masala, G, Grioni, S, Tumino, R

“…METHODS: We identified 638 participants with incident head and neck cancers (patients; 180 oral cancers, 135 oropharynx cancers, and 247 hypopharynx/larynx cancers) and 300 patients with esophageal cancers as well as 1,599 comparable controls from within the European Prospective Investigation Into Cancer and Nutrition cohort. …”

Adult height and the risk of cause-specific death and vascular morbidity in 1 million people: individual participant meta-analysis. by Emerging Risk Factors Collaboration

“…Height was negatively associated with death from coronary disease, stroke subtypes, heart failure, stomach and oral cancers, chronic obstructive pulmonary disease, mental disorders, liver disease and external causes. …”

Factors related to the waiting time for scheduling an oral biopsy in Brazil: a multilevel analysis by Alessandro Diogo De-Carli, Amanda Ramos da Cunha, Gleyson Kleber do Amaral-Silva, Jader Vasconcelos, Mara Lisiane de Moraes dos Santos, Livia Fernandes Probst

“…Abstract Background Timely diagnosis of oral cancers is critical, and performing biopsies of oral lesions with suspected malignancy is a crucial step in achieving this goal. …”
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Immunity from NK Cell Subsets Is Important for Vaccine-Mediated Protection in HPV+ Cancers by Madison P. O’Hara, Ananta V. Yanamandra, K. Jagannadha Sastry

“…High-risk human papillomaviruses (HPVs) are associated with genital and oral cancers, and the incidence of HPV+ head and neck squamous cell cancers is fast increasing in the USA and worldwide. …”
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Adapting waterpipe-specific pictorial health warning labels to the Tunisian context using a mixed method approach. by Nadia Ben Mansour, Salsabil Rejaibi, Asma Sassi Mahfoudh, Sarra Ben Youssef, Habiba Ben Romdhane, Michael Schmidt, Kenneth D Ward, Wasim Maziak, Taghrid Asfar

“…<h4>Results</h4>The top-ranked HWLs were those showing oral cancers, orally transmitted diseases, and a sick child. …”
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Isolation of Oral Bacteria, Measurement of the C-Reactive Protein, and Blood Clinical Parameters in Dogs with Oral Tumor by Chanokchon Setthawongsin, Duangdaow Khunbutsri, Sirinun Pisamai, Wuttinun Raksajit, Suchanit Ngamkala, Thitichai Jarudecha, Nattakan Meekhanon, Anudep Rungsipipat

“…Canine oral cancers have a poor prognosis and are related to chronic inflammation. …”
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