Human Papillomavirus 16 E6 and E7 Oncoproteins Alter the Abundance of Proteins Associated with DNA Damage Response, Immune Signaling and Epidermal Differentiation by Kerry Dust, Michael Carpenter, Julie Chih-yu Chen, Chris Grant, Stuart McCorrister, Garret R. Westmacott, Alberto Severini

“…The high-risk human papillomaviruses are oncogenic viruses associated with almost all cases of cervical carcinomas, and increasing numbers of anal, and oral cancers. Two oncogenic HPV proteins, E6 and E7, are capable of immortalizing keratinocytes and are required for HPV associated cell transformation. …”
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Immunoexpression of Podoplanin in Leukoplakia and Oral Squamous Cell Carcinoma and its Correlation with Survival: A Research Protocol by Samiha Jameel Ahmed Khan, Madhuri Gawande, Alka Hande, Swati Patil, Archana Sonone

“…A high PDPN expression, specifically in oral cancers, shows a significant relation to the metastasis of lymph nodes and poor patient survival, suggesting its substantial role in identifying the malignant transformation of a lesion by its expression in initial oral tumourigenesis. …”
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Predicting survival in patients with buccal cancer: A study based on SEER database and external validation in China by Yongmei Tan, Guoxing Huang, Jintao Hu, Shaoping Zhao, Yanyan Li, Zhihui Wen, Liansheng Wang, Suling Chen, Rongxi Chen, Haotian Cao, Jinsong Li

“…Abstract Objective Buccal mucosa cancer (BMC) is one of the most common oral cancers and has poor prognosis. The study aimed to develop and validate nomograms for predicting the 1‐, 3‐, and 5‐year overall survival (OS) and cancer‐specific survival (CSS) of BMC patients. …”
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Epidemiological study of lip cancer between 2004 and 2016 in public hospitals of Tehran, Iran: Squamous cell carcinoma as the most common cancer by Nafiseh Shamloo, Alireza Ghannadan, Roohollah Safarpour

“…Background: The majority of oral cancers, which make up 25% to 30% of all malignancies in the oral area, are lip cancers (LCs). …”
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The prosthodontic rehabilitation of a hemimandibulectomy patient by Bálint Jász, János König, Tamás Déri, László Kádár, Péter Hermann, Szandra Körmendi

“…Across Europe, Hungary ranks first in the incidence and the prevalence of oral cancers, which are usually detected in a relatively late stage. …”
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Effect of radiotherapy on head and neck cancer tissues in patients receiving radiotherapy: a bioinformatics analysis-based study by Zhenjie Guan, Jie Liu, Lian Zheng

“…Abstract Radiotherapy is pivotal in treating head and neck cancers including nasopharyngeal, tongue, hypopharyngeal, larynx, maxillary sinus, parotid gland, and oral cancers. It holds the potential for curative effects and finds application in conjunction with chemotherapy, either as a radical method to preserve organ function or as an adjuvant postoperative treatment. …”
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Prognosis of Midkine and AT1R expression in resectable head and neck squamous cell carcinoma by Tai-Jan Chiu, Chang-Han Chen, Yi-Ju Chen, Yinshen Wee, Ching-Shuen Wang, Sheng‑Dean Luo

“…We previously observed Angiotensin II receptor blockers (ARBs) improve the survival rates of patients with oral cancers. These findings have prompted us to investigate whether MDK can influence the RAS pathway, mainly through its association with angiotensin II type 1 receptor (AT1R), which contributes to the observed poor prognosis in head and neck squamous cell carcinoma (HNSCC) patients. …”
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Promoting HPV vaccination at school: a mixed methods study exploring knowledge, beliefs and attitudes of French school staff by Aurélie Bocquier, Marion Branchereau, Aurélie Gauchet, Stéphanie Bonnay, Maïa Simon, Marie Ecollan, Karine Chevreul, Judith E. Mueller, Amandine Gagneux-Brunon, Nathalie Thilly, the PrevHPV Study Group

“…Results Less than half of respondents knew that HPV can cause genital warts or oral cancers and only 18% that no antiviral treatment exists. …”
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Differential Regulation of Innate Lymphoid Cells in Human and Murine Oral Squamous Cell Carcinoma by Sofia Ali Syed, Muhammad Asif Qureshi, Saeed Khan, Rajesh Kumar, Iqbal A. Muhammad Khyani, Bilal Ahmed Khan, Jawad Safdar

“…We present novel data on the differential expansion/downsizing of ILCs in OSCC, which provides a pivotal basis to dive deeper into molecular circuitry and the OSCC tumor niche to devise novel diagnostic, therapeutic, and prognostic strategies to prevent/treat oral cancers.…”
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In silico analysis reveals a shared immune signature in CASP8-mutated carcinomas with varying correlations to prognosis by Yashoda Ghanekar, Subhashini Sadasivam

“…Exome sequencing of oral cancers, a subset of Head and Neck Squamous cell Carcinomas (HNSCs) common among tobacco-chewing populations, revealed that ∼34% of the affected patients harbor mutations in the CASP8 gene. …”
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Transition of Immunohistochemical Expression of E-Cadherin and Vimentin from Premalignant to Malignant Lesions of Oral Cavity and Oropharynx by Kafil Akhtar, Anjum Ara, Shahid A Siddiqui, Rana K Sherwani

“…These biomolecules can also be used as biomarkers for further research on the microinvasion of oral cancers for early diagnosis.…”
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Assessment of Changes in Birefringence and Orientation of Collagen Fibres in Different Grades of Oral Submucous Fibrosis and Oral Squamous Cell Carcinoma using Picrosirius Red and... by Ashwini Chikkanayakanahalli Prabhakar, HC Girish, Varsha Vimal Kumar, Umapathy Thimmegowda, Praveen Mallavalli Nagaraj Shetty

“…It is characterised by the fibroelastic changes due to excessive deposition of collagen which results in dense fibrous bands and epithelial changes. About 90-95% of oral cancers are Oral Squamous Cell Carcinoma (OSCC). …”
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Prevalence of Oral Lesions and Nicotine Dependency among Tobacco Users in an Urban Community of Vellore, South India by Libin Benance Jacob, JS Jesija, Madhu Mohan, Ruby Angeline Pricilla, Jasmin Helan Prasad

“…This emphasises the need for community‑based oral health awareness programs highlighting the consequences of tobacco usage in order to prevent the incidence of oral cancers.…”
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A Critical Role for p53 during the HPV16 Life Cycle by Christian T. Fontan, Claire D. James, Apurva T. Prabhakar, Molly L. Bristol, Raymonde Otoa, Xu Wang, Elmira Karimi, Pavithra Rajagopalan, Devraj Basu, Iain M. Morgan

“…ABSTRACT Human papillomaviruses (HPV) are causative agents in ano-genital and oral cancers; HPV16 is the most prevalent type detected in human cancers. …”
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Mitochondrial impairment and downregulation of Drp1 phosphorylation underlie the antiproliferative and proapoptotic effects of alantolactone on oral squamous cell carcinoma cells by Yafei Zhang, Bingqian Yang, Chengwei Tu, Yifan Ping, Shuhong Chen, Tong Wu, Zheyu Zhao, Yixin Mao, Zhan Yang, Zelin Cao, Jianmin Li, Kate Huang, Xi Ding, Gang Wu, Peng Zou, Zhennan Deng, Xiaoyu Sun

“…Abstract Background Oral squamous cell carcinoma (OSCC) is one of the most prevalent and fatal oral cancers. Mitochondria-targeting therapies represent promising strategies against various cancers, but their applications in treating OSCC are limited. …”
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Updates and Original Case Studies Focused on the NMR-Linked Metabolomics Analysis of Human Oral Fluids Part I: Emerging Platforms and Perspectives by Martin Grootveld, Georgina Page, Mohammed Bhogadia, Mark Edgar

“…¹H NMR-based metabolomics analysis of human saliva, other oral fluids, and/or tissue biopsies serves as a valuable technique for the exploration of metabolic processes, and when associated with ’state-of-the-art’ multivariate (MV) statistical analysis strategies, provides a powerful means of examining the identification of characteristic metabolite patterns, which may serve to differentiate between patients with oral health conditions (e.g., periodontitis, dental caries, and oral cancers) and age-matched heathy controls. This approach may also be employed to explore such discriminatory signatures in the salivary ¹H NMR profiles of patients with systemic diseases, and to date, these have included diabetes, Sjörgen’s syndrome, cancers, neurological conditions such as Alzheimer’s disease, and viral infections. …”
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Chemoselective Synthesis of Mannich Adducts from 1,4-Naphthoquinones and Profile as Autophagic Inducers in Oral Squamous Cell Carcinoma by Amanda A. Borges, Michele P. de Souza, Anna Carolina C. da Fonseca, Guilherme F. Wermelinger, Ruan C. B. Ribeiro, Adriane A. P. Amaral, Cláudio José C. de Carvalho, Lucas S. Abreu, Lucas Nicolau de Queiroz, Elan C. P. de Almeida, Vitor W. Rabelo, Paula A. Abreu, Bruno Pontes, Vitor F. Ferreira, Fernando de C. da Silva, Luana da S. M. Forezi, Bruno K. Robbs

“…Oral squamous cell carcinoma (OSCC) is a worldwide public health problem, accounting for approximately 90% of all oral cancers, and is the eighth most common cancer in men. …”
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